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1. 发明授权

US07674900B2 Chiral tertiary aminoalkylnaphthols 失效
标题翻译：手性叔氨基烷基萘酚
公开(公告)号：US07674900B2
公开(公告)日：2010-03-09
申请号：US11578708
申请日：2005-05-11
申请人： Albert Sun-Chi Chan , Gang Chen , Rongwei Guo , Jing Wu
发明人： Albert Sun-Chi Chan , Gang Chen , Rongwei Guo , Jing Wu
IPC分类号： C07F9/6544
CPC分类号： B01J31/2409 , B01J2231/44 , B01J2531/16 , B01J2531/821 , B01J2531/822 , B01J2531/824 , B01J2531/827 , B01J2531/828 , B01J2531/847 , C07F9/6512 , C07F15/0066
摘要： The present invention provides bipyrimidinyl diphosphine compounds of the formula wherein R is optionally substituted alkyl, cycloalkyl, aryl or heteroaryl; R′ and R″ are independently optionally substituted alkyl, cycloalkyl, aryl or heteroaryl; or an enantiomer thereof; or an enantiomeric mixture thereof. The compounds of the formula (I) are chiral atropisomeric bipyrimidinyl diphosphine compounds and, thus, may be employed as ligands to generate chiral transition metal catalysts which may be applied in a variety of asymmetric reactions, e.g., in palladium catalyzed asymmetric allylic substitution reactions. The compounds of the present invention are easily accessible in high enantiomeric purity according to the methods disclosed herein.
摘要翻译：本发明提供下式的二嘧啶基二膦化合物其中R是任选取代的烷基，环烷基，芳基或杂芳基; R'和R“独立地是任选取代的烷基，环烷基，芳基或杂芳基; 或其对映体; 或其对映体混合物。式（I）的化合物是手性的不对称双嘧啶基二膦化合物，因此可以用作配体以产生手性过渡金属催化剂，其可以用于各种不对称反应，例如钯催化的不对称烯丙基取代反应。根据本文公开的方法，本发明的化合物可以以高对映体纯度容易地获得。

2. 发明申请

US20080255356A1 CHIRAL TERTIARY AMINOALKYLNAPHTHOLS 失效
公开(公告)号：US20080255356A1
公开(公告)日：2008-10-16
申请号：US12133551
申请日：2008-06-05
申请人： Albert Sun-Chi Chan , Gang Chen , Rongwei Guo , Jing Wu
发明人： Albert Sun-Chi Chan , Gang Chen , Rongwei Guo , Jing Wu
IPC分类号： C07F15/00 , C07F9/6512
CPC分类号： B01J31/2409 , B01J2231/44 , B01J2531/16 , B01J2531/821 , B01J2531/822 , B01J2531/824 , B01J2531/827 , B01J2531/828 , B01J2531/847 , C07F9/6512 , C07F15/0066
摘要： The present invention provides bipyrimidinyl diphosphine compounds of the formula wherein R is optionally substituted alkyl, cycloalkyl, aryl or heteroaryl; R′ and R″ are independently optionally substituted alkyl, cycloalkyl, aryl or heteroaryl; or an enantiomer thereof; or an enantiomeric mixture thereof. The compounds of the formula (I) are chiral atropisomeric bipyrimidinyl diphosphine compounds and, thus, may be employed as ligands to generate chiral transition metal catalysts which may be applied in a variety of asymmetric reactions, e.g., in palladium catalyzed asymmetric allylic substitution reactions. The compounds of the present invention are easily accessible in high enantiomeric purity according to the methods disclosed herein.
摘要翻译：本发明提供下式的二嘧啶基二膦化合物其中R是任选取代的烷基，环烷基，芳基或杂芳基; R'和R“独立地是任选取代的烷基，环烷基，芳基或杂芳基; 或其对映体; 或其对映体混合物。式（I）的化合物是手性的不对称双嘧啶基二膦化合物，因此可以用作配体以产生手性过渡金属催化剂，其可以用于各种不对称反应，例如钯催化的不对称烯丙基取代反应。根据本文公开的方法，本发明的化合物可以以高对映体纯度容易地获得。

3. 发明申请

US20080183010A1 Method For Asymmetric Alkynylation Of Al Pha-Imino Esters 失效
标题翻译： Al Pha-Imino Esters的不对称烷化方法
公开(公告)号：US20080183010A1
公开(公告)日：2008-07-31
申请号：US11913773
申请日：2006-05-17
申请人： Albert Sun-Chi Chan , Jianxin Ji , Jing Wu
发明人： Albert Sun-Chi Chan , Jianxin Ji , Jing Wu
IPC分类号： C07C229/14
CPC分类号： C07F7/083 , C07C227/32 , Y02P20/55 , C07C229/36
摘要： Method for the preparation of asymmetric alkynylated α-amino esters of the formula wherein R1 and R2 are independently optionally substituted alkyl cycloalkyl, aryl or heteroaryl, and Y is hydrogen or a nitrogen protecting group.
摘要翻译：用于制备下式的不对称炔基化α-氨基酯的方法其中R 1和R 2独立地是任选取代的烷基环烷基，芳基或杂芳基，Y是氢或氮保护基。

4. 发明申请

US20080269490A1 Method for Asymmetric Hydrosilylation of Ketones 有权
标题翻译：酮的不对称氢化硅烷化方法
公开(公告)号：US20080269490A1
公开(公告)日：2008-10-30
申请号：US11816139
申请日：2006-02-16
申请人： Albert Sun-Chi Chan , Jianxin Ji , Jing Wu
发明人： Albert Sun-Chi Chan , Jianxin Ji , Jing Wu
IPC分类号： C07F1/08 , C07F7/12 , C07F15/00
CPC分类号： C07C29/143 , B01J31/1815 , B01J31/2409 , B01J2231/341 , B01J2531/0266 , B01J2531/16 , C07B2200/07 , C07C33/18 , C07C33/22 , C07C33/24 , C07C33/46
摘要： Method of asymmetrically hydrosilylating substrates using catalysts having a ligand of the compound of the formula (I) wherein R is optionally substituted alkyl, cycloalkyl, aryl or heteroaryl; R′ is hydrogen, optionally substituted lower alkyl; and R″ is hydrogen, halogen, optionally substituted alkyl, hydroxy, amino (e.g., primary, secondary or tertiary), alkenyl; or an enantiomer thereof; or an enantiomeric mixture thereof with a transition metal. Particularly suitable reactions include the asymmetric hydrosilylation of ketones.
摘要翻译：使用具有式（I）化合物的配体的催化剂的不对称氢化硅烷化方法，其中R是任选取代的烷基，环烷基，芳基或杂芳基; R'是氢，任选取代的低级烷基; 和R“是氢，卤素，任选取代的烷基，羟基，氨基（例如伯，仲或叔），烯基; 或其对映体; 或其与过渡金属的对映体混合物。特别合适的反应包括酮的不对称氢化硅烷化。

5. 发明授权

US07094725B2 Biphenyldiphosphine compounds 有权
标题翻译：联苯二膦化合物
公开(公告)号：US07094725B2
公开(公告)日：2006-08-22
申请号：US10888820
申请日：2004-07-09
申请人： Albert Sun-Chi Chan , Liqin Qiu
发明人： Albert Sun-Chi Chan , Liqin Qiu
IPC分类号： B01J31/00
CPC分类号： C07F15/008 , B01J31/2409 , B01J2231/643 , B01J2231/645 , B01J2531/0266 , B01J2531/80 , C07F9/65527 , C07F15/0053
摘要： The present invention provides compounds of the formula wherein R is optionally substituted lower alkyl, cycloalkyl or aryl; R′ is alkyl or aryl; n is zero or an integer of 1 or 2; or an enantiomer thereof; or an enantiomeric mixture thereof. The compounds of formula (I) are bridged C2-symmetric biphenyldiphosphine analogs and, thus, may be employed as ligands to generate chiral transition metal catalysts which may be applied in a variety of asymmetric reactions. The compounds of the present invention are easily accessible in high diastereomeric and optical purity according to the methods disclosed herein.
摘要翻译：本发明提供下式的化合物其中R是任选取代的低级烷基，环烷基或芳基; R'是烷基或芳基; n为0或1或2的整数; 或其对映体; 或其对映体混合物。式（I）化合物是桥连的C 2 - 对称联苯基二膦类似物，因此可用作配体以产生可用于各种不对称反应的手性过渡金属催化剂。根据本文公开的方法，本发明的化合物可以以高非对映异构体和光学纯度容易地获得。

6. 发明授权

US5756799A Chiral phosphinites 失效
标题翻译：手性亚磷酸盐
公开(公告)号：US5756799A
公开(公告)日：1998-05-26
申请号：US804877
申请日：1997-02-24
申请人： Albert Sun-Chi Chan , Yao-Zhong Jiang , Ai-Qiao Mi , Ming Yan , Wen-Hao Hu
发明人： Albert Sun-Chi Chan , Yao-Zhong Jiang , Ai-Qiao Mi , Ming Yan , Wen-Hao Hu
IPC分类号： C07B53/00 , C07C227/32 , C07C229/12 , C07C229/18 , C07C229/34 , C07C229/36 , C07C231/12 , C07C233/47 , C07C233/51 , C07D209/26 , C07D307/16 , C07F9/46 , C07F9/28
CPC分类号： C07C227/32 , C07B53/00 , C07C231/12 , C07D209/26 , C07D307/16 , C07F9/46
摘要： New optically active phosphinite compounds which are useful in asymmetric catalysis have been synthesized and have been used in the preparation of rhodium catalysts. Such catalysts are particularly useful in enantioselective catalytic hydrogenation reactions.
摘要翻译：已经合成了可用于不对称催化的新的光学活性的膦系化合物，并且已经用于制备铑催化剂。这种催化剂在对映选择性催化氢化反应中特别有用。

7. 发明授权

US06680385B2 Catalytic preparation of aryl methyl ketones using a molecular oxygen-containing gas as the oxidant 失效
标题翻译：使用含分子氧的气体作为氧化剂催化制备芳基甲基酮
公开(公告)号：US06680385B2
公开(公告)日：2004-01-20
申请号：US10055016
申请日：2002-01-25
申请人： Albert Sun-Chi Chan , Jian-Ying Qi , Cheng-Chao Pai , Xian-Jun Li , Li-Sheng Deng , Wen-Zao Li , Bin Sun , Jia-Yuan Hu
发明人： Albert Sun-Chi Chan , Jian-Ying Qi , Cheng-Chao Pai , Xian-Jun Li , Li-Sheng Deng , Wen-Zao Li , Bin Sun , Jia-Yuan Hu
IPC分类号： C07D23902
CPC分类号： B01J31/181 , B01J31/2243 , B01J2531/16 , B01J2531/72 , B01J2531/821 , B01J2531/845 , B01J2531/847 , C07C45/36 , C07F13/005 , C07F15/0053 , C07F15/045 , C07C49/78 , C07C49/807 , C07C49/76
摘要： A method for the preparation of aryl methyl ketones converts a variety of ethyl arenas to the corresponding aryl methyl ketones using a dioxygen-containing gas as the oxidant. The catalyst used for the reaction is a metal complex bearing general formulas as disclosed.
摘要翻译：芳基甲基酮的制备方法使用含二氧化碳的气体作为氧化剂，将各种乙基化合物转化为相应的芳基甲基酮。用于反应的催化剂是带有所公开的通式的金属络合物。

8. 发明授权

US5886182A Chiral pyridylphosphines and their application in asymmetric catalytic hydrogenation of 2-arylpropenoic acids 失效
标题翻译：手性吡啶基膦及其在2-芳基丙烯酸的不对称催化氢化中的应用
公开(公告)号：US5886182A
公开(公告)日：1999-03-23
申请号：US988376
申请日：1997-12-10
申请人： Albert Sun-Chi Chan , Cheng-Chao Pai
发明人： Albert Sun-Chi Chan , Cheng-Chao Pai
IPC分类号： C07F9/58 , C07F9/6568 , C07F9/50
CPC分类号： C07F9/65683 , C07F9/587
摘要： Novel, optically active phosphorous compounds of the formula, ##STR1## wherein R.sup.1 represents hydrogen atoms, straight or branched-chain alkyl groups having from 1 to 6 carbon atoms, R.sup.2 represents hydrogen atoms, halogen atoms, lower alkyl groups (1 to 6 carbon atoms), lower alkoxy groups (1 to 6 carbon atoms), hydroxy group, chiral hydroxyalkyl groups, and amino groups (1.degree., 2.degree., 3.degree.) vinyl groups or allyl groups and R.sup.3 represents phenyl groups, aryl groups, cyclohexyl groups, substituted and unsubstituted cycloalkyl groups, heteroaromatic rings, are described. The compounds of the formula serve as highly useful ligands in the preparation of ruthenium complexes which are effective catalysts for the asymmetric hydrogenation of 2-arylpropenoic acids leading to high valued 2-arylpropionic acids.
摘要翻译：新型的具有下式的光学活性的磷化合物，其中R1代表氢原子，具有1-6个碳原子的直链或支链烷基，R2代表氢原子，卤素原子，低级烷基（1-6个碳原子）原子），低级烷氧基（1至6个碳原子），羟基，手性羟基烷基和氨基（1，2，3）乙烯基或烯丙基，R 3表示苯基，芳基，环己基，取代和未取代的环烷基，杂芳环。该配方的化合物在钌配合物的制备中起着非常有用的配体作用，这是用于2-芳基丙烯酸的不对称氢化的有效催化剂，导致高价值的2-芳基丙酸。

9. 发明授权

US5990318A Soluble polyester-supported chiral phosphines 失效
标题翻译：可溶性聚酯支撑手性膦
公开(公告)号：US5990318A
公开(公告)日：1999-11-23
申请号：US72590
申请日：1998-03-06
申请人： Albert Sun-Chi Chan , Qing-Hua Fan
发明人： Albert Sun-Chi Chan , Qing-Hua Fan
IPC分类号： B01J31/06 , B01J31/16 , B01J31/24 , B01J31/40 , C07C231/12 , C07C233/47 , C07F9/50 , C07F9/572 , C08G63/692 , C07F9/02 , C07F15/02 , C07C229/72 , C07D207/00
CPC分类号： C08G63/6926 , B01J31/06 , B01J31/1658 , B01J31/2452 , B01J31/4038 , B01J31/4053 , C07C231/12 , C07F9/5027 , C07F9/5722 , B01J2231/645 , B01J2531/0266 , B01J2531/821 , Y02P20/584
摘要： Novel soluble polyester-supported chiral phosphines have been prepared and have been used in the preparation of rhodium and ruthenium catalysts. Such polymer-supported catalysts show high catalytic activities and enantioselectivities. In the case of Ru(BINAP) catalyst supported on soluble polyester, the resulting catalysts were found to be more active than those of the corresponding homogeneous Ru(BINAP) catalysts in the asymmetric hydrogenation of 2-arylpropenoic acids. These soluble polyester-supported catalysts can be easily separated from the reaction mixture and then be reused without loss of activity and selectivity.
摘要翻译：已经制备了新的可溶性聚酯负载的手性膦，并且已经用于制备铑和钌催化剂。这种聚合物负载的催化剂显示出高的催化活性和对映选择性。在负载在可溶性聚酯上的Ru（BINAP）催化剂的情况下，发现所得催化剂比2-芳基丙烯酸的不对称氢化中相应的均相Ru（BINAP）催化剂的活性更高。这些可溶性聚酯负载的催化剂可以容易地从反应混合物中分离出来，然后在不损失活性和选择性的情况下重新使用。

10. 发明授权

US5952527A Chiral aminophosphines 有权
标题翻译：手性氨基膦
公开(公告)号：US5952527A
公开(公告)日：1999-09-14
申请号：US241091
申请日：1999-02-01
申请人： Albert Sun-Chi Chan , Fu-Yao Zhang
发明人： Albert Sun-Chi Chan , Fu-Yao Zhang
IPC分类号： C07C211/60 , C07C231/18 , C07C233/47 , C07C233/87 , C07D209/26 , C07D307/52 , C07D307/54 , C07F9/46 , C07F15/00 , C07F9/02
CPC分类号： C07F9/46 , C07C211/60 , C07C231/18 , C07D209/26 , C07D307/52 , C07D307/54 , C07F15/008 , C07B2200/07 , C07C2102/10
摘要： This invention relates to (R)- and (S)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl-2,2'-diamine (R-1 and S-1) and (R)- and (S)-2,2'-bis(diarylphospinoamino)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl (R-2 and S-2) and (R)- and (S)-2,2'-bis(diaklphospinoamino)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl (R-3 and S-3); to a process for the preparation of R-1 and S-1 in which (R) or (S)-1,1'-binaphthyl-2,2'-diamine is partially hydrogenated in the presence of Adam's catalyst (5-20 wt/o of starting material) at 20-100.degree. C. for 20-100 hours in glacial acetic acid (solvent); to a process for the preparation of R-2, S-2, R-3 and S-3 in which R-1 or S-1 is reacted with chlorodiarylphosphine or chlorodialkylphosphine in the presence of n-butyllithium; and to the rhodium complexes containing 2 or 3 as effective catalysts for the asymmetric hydrogenation of prochiral substrates such as olefins to produce higher valued chiral products; and to the asymmetric catalytic hydrogenation of enamides under mild conditions using the Rh-(2) or Rh-(3) as catalyst with chemical yields as high as 100% and enantiomeric excess (e.e.) as high as 99%.
摘要翻译：本发明涉及（R） - 和（S）-5,5'，6,6'，7,7'，8,8'-八氢-1,1'-联萘-2,2'-二胺（R -1和S-1）和（R） - 和（S）-2,2'-双（二芳基磷酰氨基）-5,5'，6,6'，7,7'，8,8'-八氢-1 ，1'-联萘（R-2和S-2）和（R） - 和（S）-2,2'-双（二烷基氨基）-5,5'，6,6'，7,7'，8 ，8'-八氢-1,1'-联萘（R-3和S-3）; 涉及制备R-1和S-1的方法，其中（R）或（S）-1,1'-联萘-2,2'-二胺在Adam催化剂存在下部分氢化（5-20 wt / o的原料）在20-100℃下在冰乙酸（溶剂）中反应20-100小时; 涉及制备R-2，S-2，R-3和S-3的方法，其中R-1或S-1与氯二芳基膦或氯二烷基膦在正丁基锂存在下反应; 以及含有2或3的铑络合物作为用于前置手性底物如烯烃的不对称氢化的有效催化剂，以产生更高价值的手性产物; 和使用Rh-（2）或Rh-（3）作为催化剂的温和条件下的酰胺的不对称催化氢化，化学产率高达100％，对映体过量（e.e。）高达99％。

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