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1. 发明申请

WO2009014650A2 RECOMBINANT VIBRIO CHOLERAE EXOTOXINS 审中-公开
标题翻译：重组VIBRIO CHOLERAE EXOTOXINS
公开(公告)号：WO2009014650A2
公开(公告)日：2009-01-29
申请号：PCT/US2008/008786
申请日：2008-07-18
申请人： THE GENERAL HOSPITAL CORPORATION , SEED, Brian , WOLFE, Jia, Liu , TSAI, Chia-Lun
发明人： SEED, Brian , WOLFE, Jia, Liu , TSAI, Chia-Lun
IPC分类号： C07K14/28
CPC分类号： C07K14/28
摘要： The invention features recombinant exotoxins from Vibrio cholerae are for the therapeutic treatment of a variety of human diseases, particularly diseases characterized by an abundance or excess of undesired cells.
摘要翻译：本发明特征在于来自霍乱弧菌的重组外毒素用于治疗各种人类疾病，特别是以不希望的细胞丰度或过量为特征的疾病。

2. 发明申请

WO2008011157A3 METHODS, COMPOSITIONS, AND KITS FOR THE SELECTIVE ACTIVATION OF PROTOXINS THROUGH COMBINATORIAL TARGETING 审中-公开
公开(公告)号：WO2008011157A3
公开(公告)日：2008-01-24
申请号：PCT/US2007/016475
申请日：2007-07-20
申请人： THE GENERAL HOSPITAL CORPORATION , SEED, Brian , WOLFE, Jia, Liu , CHO, Glen, S. , TSAI, Chai-lun
发明人： SEED, Brian , WOLFE, Jia, Liu , CHO, Glen, S. , TSAI, Chai-lun
IPC分类号： A61K39/00
摘要： The present invention provides methods and compositions for treating various diseases through selective killipg of targeted cells μsing a combinatorial targeting approach. The invention features protoxin fusion proteins containing a cell targeting rηoiety and, a modifiable activation moiety which is activated by an activation moiety not riaturally operably found in, on, or in the vicinity of a target cell. These methods also include the combinatorial use of two or more therapeutic agents, at minimum comprising a protoxin and a protoxin activator, to target and destroy a specific cell population.

3. 发明申请

WO2008011157A2 METHODS, COMPOSITIONS, AND KITS FOR THE SELECTIVE ACTIVATION OF PROTOXINS THROUGH COMBINATORIAL TARGETING 审中-公开
标题翻译：组合靶向选择性激活原核蛋白的方法，组合物和试剂盒
公开(公告)号：WO2008011157A2
公开(公告)日：2008-01-24
申请号：PCT/US2007016475
申请日：2007-07-20
申请人： GEN HOSPITAL CORP , SEED BRIAN , WOLFE JIA LIU , CHO GLEN S , TSAI CHAI-LUN
发明人： SEED BRIAN , WOLFE JIA LIU , CHO GLEN S , TSAI CHAI-LUN
IPC分类号： A61K39/395
CPC分类号： C07K16/2803 , A61K38/00 , A61K47/6849 , A61K47/6889 , A61K47/6899 , B82Y5/00 , C07K14/195 , C07K14/28 , C07K14/34 , C07K2319/55 , C12N9/16
摘要： The present invention provides methods and compositions for treating various diseases through selective killipg of targeted cells µsing a combinatorial targeting approach. The invention features protoxin fusion proteins containing a cell targeting r?oiety and, a modifiable activation moiety which is activated by an activation moiety not riaturally operably found in, on, or in the vicinity of a target cell. These methods also include the combinatorial use of two or more therapeutic agents, at minimum comprising a protoxin and a protoxin activator, to target and destroy a specific cell population.
摘要翻译：本发明提供了通过组合靶向方法通过选择性杀死靶细胞来治疗各种疾病的方法和组合物。本发明的特征在于含有细胞靶向性突变的原毒素融合蛋白，以及可变活化部分，所述可修饰活化部分被在靶细胞内，靶标上或靶标细胞附近没有天然可操作发现的活化部分激活。这些方法还包括组合使用两种或更多种治疗剂，至少包含原毒素和原毒素激活剂，以靶向和破坏特定的细胞群。

4. 发明申请

WO1997048715A1 MODULATION OF TETRAPLEX FORMATION BY CHEMICAL MODIFICATIONS OF A G4-CONTAINING OLIGONUCLEOTIDE 审中-公开
标题翻译：含G4的寡糖化合物的化学修饰形成四面体复合物的调制
公开(公告)号：WO1997048715A1
公开(公告)日：1997-12-24
申请号：PCT/US1997009842
申请日：1997-06-09
申请人： HYBRIDON, INC. , WOLFE, Jia, Liu , GOODCHILD, John
发明人： HYBRIDON, INC.
IPC分类号： C07H21/02
CPC分类号： C12N15/113 , A61K38/00 , C12N15/1131 , C12N2310/151 , C12N2310/315 , C12N2310/321 , C12N2310/3515 , C12N2310/3521
摘要： This invention provides oligonucleotides having a region of four or more G nucleotides at or near their 5' end and in which from one to all of the 5'-most nucleotides bears a 2' substituent, preferably methoxy, the 3'-terminal nucleotide of the oligonucleotide bears a hydrophobic moiety, preferably cholesterol, or both the 3'-terminal nucleotide bears a hydrophobic moiety and the 5'-most nucleotides are 2'-substituted. Both attachment of a hydrophobic moiety to the 3'-terminal nucleotide of the oligonucleotide and 2'-substitution at the 5'-end results in increased tetraplex stability. The presence of these Hoogsteen base-paired G-quartet structures, however, does not hamper their ability to recognize and form Watson-Crick base-paired duplexes with complementary oligonucleotides. Accordingly, the invention also provides methods of using the disclosed oligonucleotides for nucleic acid expression inhibition.
摘要翻译：本发明提供了在5'末端或其附近具有四个或更多个G核苷酸的区域的寡核苷酸，其中一个至所有5个最多的核苷酸具有2'取代基，优选甲氧基，其中3'末端核苷酸寡核苷酸具有疏水部分，优选胆固醇，或者两个3'-末端核苷酸都具有疏水部分，5'-最多核苷酸是2'-取代的。疏水部分与寡核苷酸的3'-末端核苷酸的连接以及5'-末端的2'-取代导致四倍体稳定性提高。然而，这些Hoogsteen碱基配对的G-四重峰结构的存在并不妨碍其识别并形成具有互补寡核苷酸的Watson-Crick碱基配对双链体的能力。因此，本发明还提供使用所公开的寡核苷酸进行核酸表达抑制的方法。

5. 发明申请

WO2009014650A3 RECOMBINANT VIBRIO CHOLERAE EXOTOXINS 审中-公开
标题翻译：重组VIBRIO CHOLERAE EXOTOXINS
公开(公告)号：WO2009014650A3
公开(公告)日：2009-03-12
申请号：PCT/US2008008786
申请日：2008-07-18
申请人： GEN HOSPITAL CORP , SEED BRIAN , WOLFE JIA LIU , TSAI CHIA-LUN
发明人： SEED BRIAN , WOLFE JIA LIU , TSAI CHIA-LUN
IPC分类号： A61K39/106 , C07K14/195 , C07K14/28
CPC分类号： C07K14/28
摘要： The invention features recombinant exotoxins from Vibrio cholerae are for the therapeutic treatment of a variety of human diseases, particularly diseases characterized by an abundance or excess of undesired cells.
摘要翻译：本发明的特征来自霍乱弧菌的重组外毒素用于治疗性治疗各种人类疾病，特别是以不需要的细胞丰度或过量为特征的疾病。

6. 发明授权

US09953297B2 Sharing online with granularity 有权
公开(公告)号：US09953297B2
公开(公告)日：2018-04-24
申请号：US13653796
申请日：2012-10-17
申请人： Xincheng Zhang , Jia Liu
发明人： Xincheng Zhang , Jia Liu
IPC分类号： G06F15/16 , G06Q10/10
CPC分类号： G06Q10/101
摘要： Sharing online with granularity is described, including providing content for presenting to a user; receiving input from the user indicating identification of a portion of the content; associating with another user a notice of availability of the content; receiving a request from the another user, the request identifies the content; and providing the content for presenting to the another user, such that at least a part of the portion of the content is positioned for presenting without navigation input from the another user.

7. 发明授权

US09661443B2 Method, apparatus, and computer program product for data distribution in wireless networks 有权
公开(公告)号：US09661443B2
公开(公告)日：2017-05-23
申请号：US14385814
申请日：2012-04-05
申请人： Canfeng Chen , Jia Liu , Yongguang Guo
发明人： Canfeng Chen , Jia Liu , Yongguang Guo
IPC分类号： H04B7/00 , H04W4/00 , H04W8/00 , H04L29/08 , H04L12/18 , H04W72/04 , H04W76/02 , H04W84/18
CPC分类号： H04W4/008 , H04L12/1845 , H04L67/06 , H04L67/1095 , H04W4/80 , H04W8/005 , H04W72/04 , H04W76/14 , H04W84/18
摘要： Method, apparatus, and computer program product example embodiments enable wireless communication devices to advertise wireless communication connections in an improved manner. In example embodiments, a method is disclosed for creating, at an apparatus, operating parameters for a wireless data channel connection and descriptive information regarding content available on the wireless data channel connection; transmitting, by the apparatus, one or more non-connectable undirected wireless advertising channel messages indicating presence of the wireless data channel connection, the operating parameters associated with the wireless data channel connection, and the descriptive information regarding the content available on the wireless data channel connection; and transmitting, by the apparatus, information on the wireless data channel connection according to the operating parameters, including the content.

8. 发明授权

US09544713B2 Using bluetooth low energy 有权
标题翻译：使用蓝牙低能量
公开(公告)号：US09544713B2
公开(公告)日：2017-01-10
申请号：US14422820
申请日：2012-08-31
申请人： Canfeng Chen , Jia Liu , Kanji Kerai , Xin Zhang
发明人： Canfeng Chen , Jia Liu , Kanji Kerai , Xin Zhang
IPC分类号： H04M1/00 , H04W4/00 , G06F1/32 , H04W48/16 , H04W76/02 , H04W48/08 , H04W88/06 , H04L29/06 , H04W52/02
CPC分类号： H04W4/008 , G06F1/3253 , H04L69/14 , H04L69/18 , H04W4/80 , H04W48/08 , H04W48/16 , H04W52/0235 , H04W76/18 , H04W88/06 , Y02D10/151 , Y02D70/124 , Y02D70/1262 , Y02D70/142 , Y02D70/144 , Y02D70/164
摘要： A method is described, the method comprising scanning for a Bluetooth Low Energy data signal, and if a Bluetooth Low Energy data signal is detected, responding to detection of the Bluetooth Low Energy data signal by suspending the performance of wireless network discovery procedures in respect of at least one network operating using a protocol other than Bluetooth Low Energy. Also described is a method comprising causing generation and transmission of a Bluetooth Low Energy data signal, the generated and transmitted Bluetooth Low Energy data signal indicating the absence of at least one network which operates using a protocol other than Bluetooth Low Energy. Also described are apparatus, computer-readable code, and non-transitory computer-readable memory media having computer readable code stored thereon for causing performance of one or both of the methods.
摘要翻译：描述了一种方法，该方法包括扫描蓝牙低能量数据信号，并且如果检测到蓝牙低能量数据信号，则通过暂停执行无线网络发现过程来响应蓝牙低能量数据信号的检测至少一个使用蓝牙低功耗以外的协议运行的网络。还描述了一种方法，包括产生和传输蓝牙低能量数据信号，生成和传输的蓝牙低能量数据信号，指示不存在使用除蓝牙低能量以外的协议操作的至少一个网络。还描述了装置，计算机可读代码和具有存储在其上的计算机可读代码的非暂时计算机可读存储介质，用于引起执行一种或两种方法。

9. 发明授权

US09232384B2 Method, apparatus, and computer program product for adaptive device discovery in wireless networks 有权
标题翻译：用于无线网络中自适应设备发现的方法，装置和计算机程序产品
公开(公告)号：US09232384B2
公开(公告)日：2016-01-05
申请号：US14401525
申请日：2012-06-01
申请人： Canfeng Chen , Jia Liu
发明人： Canfeng Chen , Jia Liu
IPC分类号： H04B7/00 , H04W8/00 , H04W4/00 , H04W74/00
CPC分类号： H04W8/005 , H04W4/80 , H04W28/18 , H04W74/002
摘要： Method, apparatus, and computer program product example embodiments enable wireless communication devices to reduce connection latency in high device population environments. In example embodiments, a method is disclosed for creating, at an apparatus, operating parameters for a wireless data channel connection and descriptive information regarding a time interval available to the apparatus for transmission of advertising channel messages and a count of a number of previous transmissions of the advertising channel messages to reduce connection latency in high device population environments; transmitting, by the apparatus, one or more wireless advertising channel messages indicating presence of the data channel connection, the operating parameters associated with the data channel connection, and the descriptive information regarding the time interval available for transmission of advertising channel messages and the count of the number of previous transmissions of the advertising channel messages; and transmitting information on the data channel connection according to the operating parameters.
摘要翻译：方法，装置和计算机程序产品示例性实施例使无线通信设备能够减少高设备群体环境中的连接等待时间。在示例实施例中，公开了一种用于在装置处创建用于无线数据信道连接的操作参数和关于可用于传输广告信道消息的装置可用的时间间隔的描述信息的方法以及先前发送的多个广告信道消息，以减少高设备人口环境中的连接延迟; 通过该装置发送指示数据信道连接的存在的一个或多个无线广告信道消息，与数据信道连接相关联的操作参数以及关于可用于传输广告信道消息的时间间隔的描述信息和广告信道消息的先前传输的数量; 以及根据操作参数发送关于数据信道连接的信息。

10. 发明申请

US20150289081A1 METHOD, APPARATUS, AND COMPUTER PROGRAM PRODUCT FOR DATA DISTRIBUTION IN WIRELESS NETWORKS 有权
标题翻译：无线网络中数据分发的方法，设备和计算机程序产品
公开(公告)号：US20150289081A1
公开(公告)日：2015-10-08
申请号：US14385814
申请日：2012-04-05
申请人： Canfeng Chen , Jia Liu , Yongguang Guo
发明人： Canfeng Chen , Jia Liu , Yongguang Guo
IPC分类号： H04W4/00 , H04W72/04 , H04W76/02
CPC分类号： H04W4/008 , H04L12/1845 , H04L67/06 , H04L67/1095 , H04W4/80 , H04W8/005 , H04W72/04 , H04W76/14 , H04W84/18
摘要： Method, apparatus, and computer program product example embodiments enable wireless communication devices to advertise wireless communication connections in an improved manner. In example embodiments, a method is disclosed for creating, at an apparatus, operating parameters for a wireless data channel connection and descriptive information regarding content available on the wireless data channel connection; transmitting, by the apparatus, one or more non-connectable undirected wireless advertising channel messages indicating presence of the wireless data channel connection, the operating parameters associated with the wireless data channel connection, and the descriptive information regarding the content available on the wireless data channel connection; and transmitting, by the apparatus, information on the wireless data channel connection according to the operating parameters, including the content.
摘要翻译：方法，装置和计算机程序产品示例性实施例使无线通信设备能够以改进的方式发布无线通信连接。在示例实施例中，公开了用于在装置处创建用于无线数据信道连接的操作参数和关于无线数据信道连接上可用的内容的描述信息的方法; 由所述装置发送指示所述无线数据信道连接的存在的一个或多个不可连接的无向广播信道消息，与所述无线数据信道连接相关联的操作参数以及关于所述无线数据信道上可用内容的描述信息连接; 以及根据包括所述内容的操作参数，由所述装置发送关于所述无线数据信道连接的信息。

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