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1. 发明授权

US06853185B2 Magnetic field measurement system 有权
标题翻译：磁场测量系统
公开(公告)号：US06853185B2
公开(公告)日：2005-02-08
申请号：US10844480
申请日：2004-05-13
申请人： Akira Tsukamoto , Koichi Yokosawa , Daisuke Suzuki , Akihiko Kandori , Keiji Tsukada
发明人： Akira Tsukamoto , Koichi Yokosawa , Daisuke Suzuki , Akihiko Kandori , Keiji Tsukada
IPC分类号： A61B5/05 , G01R33/025 , G01R33/035 , G01R33/02
CPC分类号： G01R33/0358 , G01R33/025
摘要： A magnetic field measurement system for canceling an external field is provided, in which plurality of sensing magnetometers (3) for measuring a magnetic field signal in a direction perpendicular to the center axis of a cylindrical magnetic shield (1) are arranged in two dimensions on a plane parallel to the center axis and a reference magnetometer (4) for measuring the external field parallel to the center axis as a reference signal is disposed on a plane perpendicular to the plane parallel to the center axis. The reference signal multiplied by a specified factor is subtracted from a difference between signals from the adjacent sensing magnetometers (3). The magnetic field measurement system allows measurement of an extremely weak magnetic field by efficiently canceling the external field.
摘要翻译：提供了用于消除外部场的磁场测量系统，其中用于在与圆柱形磁屏蔽（1）的中心轴垂直的方向上测量磁场信号的多个感测磁力计（3）被二维地布置在平行于中心轴的平面和用于测量与中心轴平行的外场作为参考信号的参考磁力计（4）设置在垂直于平行于中心轴的平面的平面上。从相邻感测磁力计（3）的信号之间的差中减去乘以指定因子的参考信号。磁场测量系统允许通过有效地消除外部场来测量极弱的磁场。

2. 发明授权

US06815949B2 Apparatus for measuring a magnetic field 失效
标题翻译：磁场测量装置
公开(公告)号：US06815949B2
公开(公告)日：2004-11-09
申请号：US10162748
申请日：2002-06-06
申请人： Akihiko Kandori , Tsuyoshi Miyashita , Keiji Tsukada , Koichi Yokosawa , Daisuke Suzuki , Akira Tsukamoto
发明人： Akihiko Kandori , Tsuyoshi Miyashita , Keiji Tsukada , Koichi Yokosawa , Daisuke Suzuki , Akira Tsukamoto
IPC分类号： G01R33035
CPC分类号： G01R33/0356 , A61B5/04005 , A61B5/04007 , A61B5/04008 , A61B5/0522
摘要： An apparatus can detect a magnetic field with a high sensitivity using an ordinary-temperature pickup coil even when the pickup coil is arranged outside a cryostat. Specifically, the apparatus for measuring a magnetic field includes a pickup coil for detecting an external magnetic field, a SQUID electrically or magnetically connected to the pickup coil, a cryostat for holding the SQUID at low temperatures, and a driving device for driving the SQUID. The pickup coil is made of a normal-conducting material and is placed at an ordinary temperature outside the cryostat. By arranging outside the cryostat, the pickup coil can be brought close to a subject and can thereby detect a weak magnetic field in the subject with a high sensitivity.

3. 发明授权

US06681131B2 Apparatus for measuring bio-magnetic fields 有权
标题翻译：用于测量生物磁场的装置
公开(公告)号：US06681131B2
公开(公告)日：2004-01-20
申请号：US09977213
申请日：2001-10-16
申请人： Akihiko Kandori , Tsuyoshi Miyashita , Daisuke Suzuki , Koichi Yokosawa , Keiji Tsukada
发明人： Akihiko Kandori , Tsuyoshi Miyashita , Daisuke Suzuki , Koichi Yokosawa , Keiji Tsukada
IPC分类号： A61B505
CPC分类号： A61B5/04007 , A61B5/7239 , A61B5/7285
摘要： An apparatus for measuring bio-magnetic fields includes a plurality of magnetometers for detecting magnetic fields generated from a live body; a driving circuit for driving the magnetometers; a computer for collecting output signals of the driving circuit in the form of data representing at least one waveform of the magnetic fields generated from the live body and for performing an arithmetic processing on the data representing the waveform of magnetic fields, a display unit, and at least one signal processing circuit for processing output signals of the driving circuit. The computer further performs an arithmetic processing of first-order differentiation on the waveform of the magnetic fields in a z direction with respect to time in order to create an arrow map and a contour map. The apparatus can also detect mechanical movement which occurs as blood flows in organs and organs move.
摘要翻译：一种用于测量生物磁场的装置包括：用于检测从活体产生的磁场的多个磁力计; 用于驱动磁力计的驱动电路; 用于以表示从活体产生的磁场的至少一个波形的数据形式收集驱动电路的输出信号并且对表示磁场波形的数据执行算术处理的计算机，显示单元和至少一个信号处理电路，用于处理驱动电路的输出信号。计算机进一步对z方向上的磁场波形进行一阶微分的运算处理，以便产生箭头图和轮廓图。该装置还可以检测器官和器官中的血液流动时发生的机械运动。

4. 发明授权

US06528994B2 Magnetic field measurement apparatus 有权
公开(公告)号：US06528994B2
公开(公告)日：2003-03-04
申请号：US09941752
申请日：2001-08-30
申请人： Daisuke Suzuki , Atsushi Ninomiya , Tsuyoshi Miyashita , Akihiko Kandori , Keiji Tsukada , Koichi Yokosawa
发明人： Daisuke Suzuki , Atsushi Ninomiya , Tsuyoshi Miyashita , Akihiko Kandori , Keiji Tsukada , Koichi Yokosawa
IPC分类号： G01R3302
CPC分类号： G01R33/24
摘要： A magnetic field measuring apparatus has a magnetic field shielding apparatus including non-magnetic cylindrical members on which high-permeability sheets are located in a state of being partially overlapped with each other. The cylindrical members are located to surround an axis of a first direction concentrically and having a hollow portion, the cylindrical member located on an innermost-side having a first opening at one end of the first direction, a second opening at the other end of the first direction, and a third opening penetrating the cylindrical members in a direction perpendicular to the axis of the first direction. In addition, the magnetic field measuring apparatus has a living-body holder located in an inner-side space of the cylindrical member and a cryostat inserted into the third opening and maintaining SQUID magnetic-flux meters.

5. 发明授权

US06745063B2 Biomagnetic field measuring apparatus 有权
标题翻译：生物磁场测量装置
公开(公告)号：US06745063B2
公开(公告)日：2004-06-01
申请号：US09940542
申请日：2001-08-29
申请人： Keiji Tsukada , Tsuyoshi Miyashita , Akihiko Kandori , Daisuke Suzuki , Koichi Yokosawa
发明人： Keiji Tsukada , Tsuyoshi Miyashita , Akihiko Kandori , Daisuke Suzuki , Koichi Yokosawa
IPC分类号： A61B505
CPC分类号： A61B5/04005 , A61B5/4064
摘要： A biomagnetic field measuring apparatus includes a plurality of SQUID magneto-meters for measuring a biomagnetic field generated from a living body, living-body signal measuring devices and for measuring and collecting living-body signals generated periodically, an operation processing device for operation processing the biomagnetic field signal and the living-body signal measured simultaneously as pairs in a plurality of directions, and a display unit for displaying a result of the operation processing. Change in time of excitation can be grasped in detail by using a small number of maps without presumption of a magnetic field source and display of many iso-magnetic field maps.
摘要翻译：生物磁场测量装置包括多个用于测量从生物体产生的生物磁场的SQUID磁电表，生物体信号测量装置，以及用于测量和收集周期性生成的生物体信号的操作处理装置，生物磁场信号和在多个方向上成对测量的生物体信号以及用于显示操作结果的显示单元。可以通过使用少量地图来详细了解激发时间的变化，而不考虑磁场源和显示许多等磁场图。

6. 发明授权

US06665552B2 Gradiometer integrating pickup coils and magnetic field measurement system 有权
公开(公告)号：US06665552B2
公开(公告)日：2003-12-16
申请号：US09940507
申请日：2001-08-29
申请人： Koichi Yokosawa , Daisuke Suzuki , Keiji Tsukada , Tsuyoshi Miyashita , Akihiko Kandori
发明人： Koichi Yokosawa , Daisuke Suzuki , Keiji Tsukada , Tsuyoshi Miyashita , Akihiko Kandori
IPC分类号： A61B505
CPC分类号： G01R33/022 , G01R33/0358
摘要： A gradiometer integrating pickup coils comprises pickup coils 11Xp, 11Xn magnetically connected to a SQUID through associated input coils 2, and pickup coils 11Yp, 11Yn magnetically connected to a SQUID through associated input coils 2, respectively. Two superconducting loops are connected in series to each of the SQUIDs, when viewed from Josephson junctions 5. The input coils 2 form superconducting closed loops together with the pickup coils 11Xp, 11Xn, 11Yp, 11Yn associated therewith. The SQUIDs are respectively connected to form an 8-figured shape as a whole such that currents flow in two superconducting loops of each SQUID in opposite directions to each other, with respect to the application of a uniform field, in order to reduce environmental magnetic field noise.

7. 发明授权

US07193413B2 Magnetic field measurement apparatus 有权
标题翻译：磁场测量装置
公开(公告)号：US07193413B2
公开(公告)日：2007-03-20
申请号：US10855374
申请日：2004-05-28
申请人： Akihiko Kandori , Keiji Tsukada , Daisuke Suzuki
发明人： Akihiko Kandori , Keiji Tsukada , Daisuke Suzuki
IPC分类号： G01R33/025 , G01R33/035
CPC分类号： G01R33/0354
摘要： A magnetic field measurement apparatus which reduces an interference magnetic field entering into a pick-up coil is provided. The magnetic field measurement apparatus includes a superconducting quantum interference device (SQUID) magnetometer having a pick-up coil for picking up a magnetic field generated from an examination object, a SQUID control unit for controlling the SQUID magnetometer, a magnetometer for picking up the interference magnetic field, a magnetometer control unit for controlling the magnetometer, a modulation circuit, a current converter, a current amount adjusting device, a coil which is positioned outside the pick-up coil and through which the current thus adjusted by the current amount adjusting device flows, a demodulation circuit, a low-pass filter (LPF) for extracting a low frequency element of the output voltage from the demodulation circuit, and a subtraction circuit for subtracting the output of the LPF from the output of the SQUID control unit.
摘要翻译：提供了减少进入拾取线圈的干涉磁场的磁场测量装置。磁场测量装置包括具有用于拾取从检查对象产生的磁场的拾取线圈的超导量子干涉装置（SQUID）磁力计，用于控制SQUID磁强计的SQUID控制单元，用于拾取干扰的磁力计磁场，用于控制磁力计的磁力计控制单元，调制电路，电流转换器，电流量调节装置，位于拾取线圈外部的线圈，由电流量调节装置调节的电流解调电路，用于从解调电路提取输出电压的低频元件的低通滤波器（LPF），以及从SQUID控制单元的输出中减去LPF的输出的减法电路。

8. 发明申请

US20080284413A1 Method and system for detection of biomaterials using magnetic marker 有权
标题翻译：使用磁标记检测生物材料的方法和系统
公开(公告)号：US20080284413A1
公开(公告)日：2008-11-20
申请号：US12149990
申请日：2008-05-12
申请人： Akira Tsukamoto , Daisuke Suzuki , Akihiko Kandori
发明人： Akira Tsukamoto , Daisuke Suzuki , Akihiko Kandori
IPC分类号： G01N27/74
CPC分类号： G01N33/54333
摘要： Accurate measurement cannot be performed due to magnetic signals from magnetic impurities included in a specimen container. By finding a difference between two measurement signals obtained by applying an external magnetic field for orientation to respective normal and reverse directions, the magnetic signals from the magnetic impurities included in the specimen container which are not dependent on the external magnetic field for orientation can be cancelled. The influence of the magnetic impurities included in the specimen container is reduced, and the signal of the intended bound magnetic marker can be measured with high sensitivity.
摘要翻译：由于样品容器中包含的磁性杂质的磁信号，无法进行准确的测量。通过在相应的正反方向上施加用于取向的外部磁场获得的两个测量信号之间的差异，可以取消不依赖于用于取向的外部磁场的样本容器中包含的磁性杂质的磁信号。包含在标本容器中的磁性杂质的影响减小，可以高灵敏度地测量预期的结合磁性标记的信号。

9. 发明授权

US08193003B2 Method and system for detection of biomaterials using magnetic marker 有权
标题翻译：使用磁标记检测生物材料的方法和系统
公开(公告)号：US08193003B2
公开(公告)日：2012-06-05
申请号：US12149990
申请日：2008-05-12
申请人： Akira Tsukamoto , Daisuke Suzuki , Akihiko Kandori
发明人： Akira Tsukamoto , Daisuke Suzuki , Akihiko Kandori
IPC分类号： G01N33/553 , G01N33/53
CPC分类号： G01N33/54333
摘要： Accurate measurement cannot be performed due to magnetic signals from magnetic impurities included in a specimen container. By finding a difference between two measurement signals obtained by applying an external magnetic field for orientation to respective normal and reverse directions, the magnetic signals from the magnetic impurities included in the specimen container which are not dependent on the external magnetic field for orientation can be cancelled. The influence of the magnetic impurities included in the specimen container is reduced, and the signal of the intended bound magnetic marker can be measured with high sensitivity.
摘要翻译：由于样品容器中包含的磁性杂质的磁信号，无法进行准确的测量。通过在相应的正反方向上施加用于取向的外部磁场获得的两个测量信号之间的差异，可以取消不依赖于用于取向的外部磁场的样本容器中包含的磁性杂质的磁信号。包含在标本容器中的磁性杂质的影响减小，可以高灵敏度地测量预期的结合磁性标记的信号。

10. 发明授权

US07993581B2 Immunoassay system and immunoassay method 有权
标题翻译：免疫测定系统和免疫测定法
公开(公告)号：US07993581B2
公开(公告)日：2011-08-09
申请号：US11006757
申请日：2004-12-08
申请人： Yusuke Seki , Akira Tsukamoto , Daisuke Suzuki , Masahiro Yamaoka , Nami Sugita , Akihiko Kandori , Kazuo Saitoh
发明人： Yusuke Seki , Akira Tsukamoto , Daisuke Suzuki , Masahiro Yamaoka , Nami Sugita , Akihiko Kandori , Kazuo Saitoh
IPC分类号： G01N1/36 , G01N33/553
CPC分类号： G01N33/54373 , G01N27/745
摘要： The present invention provides an immunoassay technique which enables efficient detection of antigen-antibody reaction with high sensitivity by a magnetic method using magnetic particles and a SQUID magnetic sensor or sensors. A system based on the technique includes a disk-shaped sample holder which holds on a circle a plurality of sample containers for accommodating marked samples, resulting from marking of samples with magnetic particles by antigen-antibody reaction; rotating means for rotating the holder around its central shaft; magnetizing means for magnetizing the marked samples outside a magnetic shield; and a magnetic sensor for detecting, within the magnetic shield, magnetic fields generated from the marked samples which have been magnetized. By rotation of the holder, areas fixing and holding different ones of the sample containers are successively inserted into the magnetic shield, and the magnetization of the marked samples accommodated in first ones of the sample containers and the detection of magnetic fields generated from the marked samples accommodated in second ones of the sample containers are executed in parallel.
摘要翻译：本发明提供了一种免疫测定技术，其能够通过使用磁性颗粒和SQUID磁性传感器的磁性方法高灵敏度地高效检测抗原 - 抗体反应。基于该技术的系统包括：盘形样品保持器，其保持圆圈上的多个样品容器，用于容纳标记的样品，通过抗原 - 抗体反应用磁性颗粒标记样品; 用于使支架围绕其中心轴旋转的旋转装置; 用于将标记样品磁化在磁屏蔽外的磁化装置; 以及磁传感器，用于在磁屏蔽内检测从已经被磁化的标记样品产生的磁场。通过保持器的旋转，将固定和保持不同样本容器的区域依次插入到磁屏蔽中，并且标记的样品的磁化容纳在第一个样品容器中，并且检测从标记的样品产生的磁场容纳在第二个样品容器中并行执行。

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