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1. 发明授权

US06546268B1 Glucose sensor 失效
标题翻译：葡萄糖传感器
公开(公告)号：US06546268B1
公开(公告)日：2003-04-08
申请号：US09586200
申请日：2000-06-02
申请人： Akira Ishikawa , Nabuo Takeda , Suzanne I. Ahn , Steven R. Hays , Kevin Nelson
发明人： Akira Ishikawa , Nabuo Takeda , Suzanne I. Ahn , Steven R. Hays , Kevin Nelson
IPC分类号： A61B505
CPC分类号： A61B5/14865 , A61B5/0031 , A61B5/14532 , A61B5/14539 , A61B5/14542 , A61B5/1473 , A61M5/1723 , H01L29/0657 , H01L2924/1017
摘要： A biochemical sensor based on ball integrated circuit technology which is designed to be biocompatible for implantation within a human or animal body. A sensor media is mounted to the ball integrated circuit, the sensor media operable for sensing biochemical molecules. An onboard communication link transmits data sensed by the sensor media from the ball integrated circuit.
摘要翻译：基于球集成电路技术的生物化学传感器，其设计为与人体或动物体内植入生物相容。传感器介质安装到球集成电路，传感器介质可用于感测生化分子。车载通信链路从球集成电路传输由传感器介质感测的数据。

2. 发明授权

US06366206B1 Method and apparatus for attaching tags to medical and non-medical devices 失效
标题翻译：用于将标签附接到医疗和非医疗器械的方法和装置
公开(公告)号：US06366206B1
公开(公告)日：2002-04-02
申请号：US09586077
申请日：2000-06-02
申请人： Akira Ishikawa , Nabuo Takeda , Suzanne I. Ahn , Steven R. Hays
发明人： Akira Ishikawa , Nabuo Takeda , Suzanne I. Ahn , Steven R. Hays
IPC分类号： G08B2300
CPC分类号： G06K19/07758 , A61B90/98 , A61J2200/72 , A61J2205/60 , G06K19/077 , G06K2017/009
摘要： A method and apparatus for attaching one or more transponders to medical and non-medical products to tag respective ones of the products with identifying data contained in a memory of the transponders. The one or more transponders each include a memory containing the corresponding identifying data which is emitted by the respective transponder in response to an electromagnetic signal emitted externally of the transponder. The identifying data corresponds to at least one of the respective one or more transponders and a respective product for tagging. The one or more transponders are attached to respective ones of the products to tag the products with the corresponding identifying data.
摘要翻译：一种用于将一个或多个转发器附接到医疗和非医疗产品以通过识别包含在应答器的存储器中的数据来标记相应产品的方法和装置。一个或多个转发器各自包括存储器，其包含响应于从应答器外部发射的电磁信号由相应的应答器发射的对应的识别数据。识别数据对应于相应的一个或多个应答器中的至少一个和用于标签的相应产品。将一个或多个应答器连接到相应的产品以用相应的识别数据标记产品。

3. 发明授权

US06261247B1 Position sensing system 失效
标题翻译：位置传感系统
公开(公告)号：US06261247B1
公开(公告)日：2001-07-17
申请号：US09475312
申请日：1999-12-30
申请人： Akira Ishikawa , Nabuo Takeda , Suzanne I. Ahn , Samuel S. Ahn , Steven R. Hays , F. Andrew Gaffney
发明人： Akira Ishikawa , Nabuo Takeda , Suzanne I. Ahn , Samuel S. Ahn , Steven R. Hays , F. Andrew Gaffney
IPC分类号： A61B5103
CPC分类号： G01B7/14 , A61B5/0031 , A61B5/06 , A61B5/067 , A61B5/103 , A61B5/1076 , A61B5/113 , A61B5/435 , A61B5/6806 , A61B2090/3983 , G01B7/004 , G01S13/06
摘要： An anatomical position sensing system (100) using one or more substantially spherical transponders for measuring relative positions and distances. Transponders (P) and (S) are capable of receiving and transmitting RF signals, and communicating between themselves and with a separate CPU (112). The CPU (112) is controlled by an operator at an operator control panel (114), interacts with an alarm (120) for providing audible alerts to the operator, and a display for displaying information to the operator. The CPU (112) controls a broadband antenna (118) to transmit, at a frequency f1, a low-frequency RF power signal (122) across a wide field to energize the transponders (P) and (S). Directional components (122a) and (122b) intercept and energize the transponders (P) and (S). Once energized, transponder (P) transmits a range signal in all directions including component (124) at a very high RF frequency f2, extending from transponder (P) to transponder (S). Upon receipt of the range signal (124), transponder (S) emits a data signal at a very high RF frequency f3 in all directions, including component (126), which is directed at the antenna (118). The distance (D) is determined by measuring the attenuation of the range signal (124) as it is received by transponder (S). Transponder (S) then modulates the value of the strength of the incoming range signal (124) onto the data signal. The CPU (112) computes the distance (D) from the incoming data signal (126) from a lookup table derived from a sequence of calibration steps prior to beginning normal operation.
摘要翻译：一种使用一个或多个基本上球形的应答器来测量相对位置和距离的解剖位置感测系统（100）。应答器（P）和（S）能够接收和发射RF信号，并且在它们之间和独立的CPU（112）之间进行通信。 CPU（112）由操作员在操作员控制面板（114）处控制，与用于向操作员提供可听警报的报警器（120）相互作用，以及用于向操作者显示信息的显示器。 CPU（112）控制宽带天线（118）以f1的频率在宽的场上发射低频RF功率信号（122），以对应答器（P）和（S）供电。定向分量（122a）和（122b）拦截并激励应答器（P）和（S）。一旦通电，应答器（P）在从应答器（P）到转发器（S）延伸的非常高的RF频率f2的所有方向上传输包括分量（124）的范围信号。在接收到范围信号（124）时，应答器（S）在包括分配在天线（118）上的组件（126）的所有方向上以非常高的RF频率f3发射数据信号。通过测量由应答器（S）接收的范围信号（124）的衰减来确定距离（D）。应答器（S）然后将输入范围信号（124）的强度的值调制到数据信号上。在开始正常操作之前，CPU（112）根据从校准步骤序列导出的查找表计算来自输入数据信号（126）的距离（D）。

4. 发明授权

US06423974B1 X-ray imaging apparatus using spherical semiconductor detectors 失效
标题翻译：使用球形半导体探测器的X射线成像装置
公开(公告)号：US06423974B1
公开(公告)日：2002-07-23
申请号：US09321862
申请日：1999-05-28
申请人： Akira Ishikawa , Nabuo Takeda , Suzanne I. Ahn , Steven R. Hays , Alex Freeman
发明人： Akira Ishikawa , Nabuo Takeda , Suzanne I. Ahn , Steven R. Hays , Alex Freeman
IPC分类号： H05G164
CPC分类号： G01T1/24 , H01L29/0657 , H01L2924/1017
摘要： A solid state X-ray detector (106) is disclosed which is comprised of a plurality of Spherical ICs (202)-(208) disposed on a substrate (210). The Spherical ICs each have a plurality of detector picture elements (pixels) (302) disposed on the surface thereof. Each of the pixels (302) is formed from a layer of hydrogenated amorphous silicon (502) with a heavy metal layer (504) of molybdenum (Mo) disposed thereon as the cathode and a metal layer (508) disposed on the lower surface thereof. The cathode is reverse biased and X-rays impinging thereon will cause a transfer of electron-holes to the lower plate, which are stored on a capacitor (608). The electrons are accumulated over a predetermined period of time and then sampled and processed for output on a display (12) in real time or for storage of a digital value in a memory (114).
摘要翻译：公开了一种固态X射线检测器（106），其包括设置在基板（210）上的多个球形IC（202） - （208）。球形IC各自具有设置在其表面上的多个检测器图像元素（像素）（302）。每个像素（302）由一层氢化非晶硅（502）形成，其中设置有作为阴极的钼（Mo）的重金属层（504）和设置在其下表面上的金属层（508）。阴极被反向偏置，并且其上的X射线将导致电子空穴传递到存储在电容器（608）上的下板。电子在预定时间段内累积，然后被采样和处理，以在显示器（12）上实时输出或用于将数字值存储在存储器（114）中。

5. 发明授权

US06415184B1 Implantable neuro-stimulator with ball implant 失效
标题翻译：植入式神经刺激器与球植入
公开(公告)号：US06415184B1
公开(公告)日：2002-07-02
申请号：US09478592
申请日：2000-01-06
申请人： Akira Ishikawa , Nabuo Takeda , Suzanne I. Ahn , Samuel S. Ahn , Steven R. Hays , F. Andrew Gaffney
发明人： Akira Ishikawa , Nabuo Takeda , Suzanne I. Ahn , Samuel S. Ahn , Steven R. Hays , F. Andrew Gaffney
IPC分类号： A61N105
CPC分类号： A61N1/3605 , A61N1/36017 , A61N1/36082 , A61N1/37205 , A61N1/37217 , A61N1/3787
摘要： A ball semiconductor for stimulating a mass of nervous system brain tissue for therapeutic purposes. The ball (120) is embedded in a mass of nervous system tissue (215) of a brain. Electrical pulses generated and transmitted to the ball (120) by a remote electrical pulse generator system (140) are picked up by a receiving antenna of the ball (120), and are applied to an electrode pair of the ball (120) to cause the mass of nervous system tissue (215) of the brain located between output pads of the electrode to become stimulated, as therapy for a pathological condition.
摘要翻译：用于刺激大量神经系统脑组织用于治疗目的的球半导体。球（120）被嵌入大脑的大量神经系统组织（215）中。由远程电脉冲发生器系统（140）产生并传输到球（120）的电脉冲由球（120）的接收天线拾取，并被施加到球（120）的电极对以引起位于电极的输出垫之间的脑的神经系统组织（215）的质量被刺激，作为病理状况的治疗。

6. 发明授权

US06324904B1 Miniature pump-through sensor modules 失效
标题翻译：微型泵浦传感器模块
公开(公告)号：US06324904B1
公开(公告)日：2001-12-04
申请号：US09641480
申请日：2000-08-18
申请人： Akira Ishikawa , Nabuo Takeda , Suzanne I. Ahn , Steven R. Hays
发明人： Akira Ishikawa , Nabuo Takeda , Suzanne I. Ahn , Steven R. Hays
IPC分类号： F21B4712
CPC分类号： E21B47/12 , E21B47/011 , E21B47/124 , H01L29/0657 , H01L2924/1017
摘要： Sensor modules are provided which are pumped into a well by first being pumped downhole within a drill string, then passing through the drill bit and being circulated uphole in the annulus between the drill string and the borehole of the well. The sensors take measurement readings as they are being pumped uphole through the annulus. The sensors are preferably separated from the mud returns from the well, and then read at an inductive read unit. The sensor modules are provided by semiconductor substrates which measure downhole well parameters, and then store the date for retrieval at the surface. The semiconductor substrates preferably have a plurality of sides on which measurement sensors and circuitry may be formed, allowing the circuitry and the sensors to be made of smaller sizes. Such sensors include temperature sensors, three-dimensional stain gauges, which are also useful as pressure transducers, inductive pressure transducers, inclination sensors, accelerometers, gyroscopes and radiation detectors. The sensors and circuitry are preferably provided on spherically shaped semiconductor substrates.
摘要翻译：提供传感器模块，其通过首先在钻柱中被泵入井下，然后通过钻头并在钻柱和井的钻孔之间的环空中循环。传感器采集测量读数，因为它们通过环形空间被泵浦。传感器优选地与从井中返回的泥浆分开，然后在感应读取单元处读取。传感器模块由测量井下参数的半导体衬底提供，然后存储在表面上检索的日期。半导体衬底优选地具有可以形成测量传感器和电路的多个侧面，允许电路和传感器由较小的尺寸制成。这种传感器包括温度传感器，三维污染计，它们也可用作压力传感器，感应压力传感器，倾斜传感器，加速度计，陀螺仪和辐射探测器。传感器和电路优选地设置在球形半导体衬底上。

7. 发明授权

US06264611B1 Monitor for interventional procedures 失效
标题翻译：监测介入程序
公开(公告)号：US06264611B1
公开(公告)日：2001-07-24
申请号：US09448644
申请日：1999-11-24
申请人： Akira Ishikawa , Nabuo Takeda , Suzanne I. Ahn , Samuel S. Ahn , Steven R. Hays , F. Andrew Gaffney
发明人： Akira Ishikawa , Nabuo Takeda , Suzanne I. Ahn , Samuel S. Ahn , Steven R. Hays , F. Andrew Gaffney
IPC分类号： A61B502
CPC分类号： A61B5/02055 , A61B5/0031 , A61B5/0215 , A61B5/03 , A61B5/083 , A61B5/145 , A61B5/14532 , A61B5/6848 , A61B5/6851
摘要： A ball-shaped semiconductor monitoring device (150) having one or more transducer functions for use with an instrument that is insertable into a human body. In one disclosed embodiment, a needle (130) and modified stylet (140) are inserted into intraluminal body cavities for measuring fluid pressure. The modified stylet (140) has the monitoring device (150) attached to one end. The stylet (140) has a metal annulus (142) extending throughout its length and a communication wire (144) disposed therein. The wire (144) is surrounded by an insulator (146) to electrically isolate it from the stylet (140). A recessed cavity (148) is provided at the distal end of the stylet (140) to accommodate the ball monitoring device (150). A transducer (152) is integrated on the ball device (150) to measure such quantitative conditions as pressure. The ball (150) has a ground terminal (154) and a data terminal (156). The ground terminal (154) is electrically connected to the metal annulus (142) of the stylet (140) by a solder joint (158). The data terminal (156) is connected to the communication wire (144) by a contact (160). The instrument that carries the semiconductor device to a particular site within the body may be a catheter, guidewire, stylet, needle or any other insertable instrument. The transducer can be fabricated to sense pressure, fluid flow rate, temperature and other physiological parameters and physical conditions.
摘要翻译：一种具有一个或多个换能器功能的球形半导体监测装置（150），用于可插入人体内的仪器。在一个所公开的实施例中，将针头（130）和改良的探针（140）插入管腔内空腔以测量流体压力。修改的探针（140）具有附接到一端的监视装置（150）。探针（140）具有贯穿其长度延伸的金属环（142）和设置在其中的连通线（144）。导线（144）由绝缘体（146）包围，以使其与探针（140）电隔离。在探针（140）的远端处设置有凹腔（148）以容纳球监视装置（150）。换能器（152）集成在球装置（150）上以测量诸如压力的定量条件。球（150）具有接地端子（154）和数据端子（156）。接地端子（154）通过焊接接头（158）电连接到探针（140）的金属环（142）。数据端子（156）通过触点（160）连接到通信线（144）。携带半导体器件到体内特定位置的仪器可以是导管，导丝，通丝针，针或任何其它可插入的仪器。传感器可以被制造以感测压力，流体流速，温度和其他生理参数和物理条件。

8. 发明授权

US06254548B1 Internal thermometer 失效
标题翻译：内部温度计
公开(公告)号：US06254548B1
公开(公告)日：2001-07-03
申请号：US09448638
申请日：1999-11-24
申请人： Akira Ishikawa , Nabuo Takeda , Suzanne I. Ahn , Samuel S. Ahn , Steven R. Hays , F. Andrew Gaffney
发明人： Akira Ishikawa , Nabuo Takeda , Suzanne I. Ahn , Samuel S. Ahn , Steven R. Hays , F. Andrew Gaffney
IPC分类号： A61B500
CPC分类号： A61B5/0008 , A61B5/0031
摘要： A miniature spherical-shaped internal temperature transponder. A temperature sensor (25) is fabricated in a spherical integrated transponder circuit (15) which may be placed in the human body by ingestion, implantation, or injection. In one aspect of the invention, a passive system is disclosed whereby an external monitoring station (13) generates an energy field using a magnetic field generator (19) which is coupled to a power coil (21) of the transponder (15). The power coil (21) passes power to a power regulator (23) to provide regulated power to all transponder (15) circuits. Temperature data obtained by the temperature sensor (25) is passed to a voltage controlled oscillator (27) for conversion into an RF signal. A mixing circuit (31) receives the RF temperature signal and modulates the temperature data signal onto an oscillator frequency from an RF oscillator (29). An RF amplifier (33) receives the modulated RF signal from the mixing circuit (31) and transmits it via an antenna (35) to the external monitor station 13 which is proximate to the transponder (15). The signal is received by an RF receiver (37) and processed using a CPU (39) to extract the measured temperature data, which can then be displayed to the operator on a display (41). The transponder (15) may be powered either by the external electromagnetic radiation source (19) or an internal battery.
摘要翻译：微型球形内部温度转发器。温度传感器（25）制造在球形集成式应答器电路（15）中，其可以通过摄取，注入或注入而放置在人体内。在本发明的一个方面，公开了一种无源系统，其中外部监测站（13）使用磁场发生器（19）产生能量场，该磁场发生器耦合到应答器（15）的功率线圈（21）。电力线圈（21）将功率传递给功率调节器（23）以向所有应答器（15）电路提供稳定的电力。由温度传感器（25）获得的温度数据被传送到压控振荡器（27）以转换成RF信号。混合电路（31）接收RF温度信号，并将温度数据信号从RF振荡器（29）调制到振荡器频率上。 RF放大器（33）从混合电路（31）接收经调制的RF信号，并经由天线（35）将其发送到靠近应答器（15）的外部监视站13。信号由RF接收器（37）接收，并使用CPU（39）进行处理，以提取测量的温度数据，然后可以将其显示给显示器（41）上的操作者。应答器（15）可以由外部电磁辐射源（19）或内部电池供电。

9. 发明授权

US06447448B1 Miniature implanted orthopedic sensors 失效
标题翻译：微型植入式矫形传感器
公开(公告)号：US06447448B1
公开(公告)日：2002-09-10
申请号：US09475820
申请日：1999-12-30
申请人： Akira Ishikawa , Nabuo Takeda , Suzanne I. Ahn , Samuel S. Ahn , Steven R. Hays , F. Andrew Gaffney
发明人： Akira Ishikawa , Nabuo Takeda , Suzanne I. Ahn , Samuel S. Ahn , Steven R. Hays , F. Andrew Gaffney
IPC分类号： A61B500
CPC分类号： A61B5/4504 , A61B5/0031 , A61B5/036 , A61B5/14546 , A61B5/411 , A61B5/4514 , A61B5/4528 , A61B5/4533 , A61B2560/0219 , A61F2/32 , A61F2/34 , A61F2/36 , A61F2/3662 , A61F2/367 , A61F2/442 , A61F2/4657 , A61F2/468 , A61F2002/30332 , A61F2002/3067 , A61F2002/3071 , A61F2002/3611 , A61F2002/3625 , A61F2002/3674 , A61F2002/4666 , A61F2002/4672 , A61F2002/4674 , A61F2002/48 , A61F2002/482 , A61F2220/0033 , A61F2250/0002 , A61F2250/0085 , G06F19/00
摘要： A substantially spherical semiconductor ball implanted in orthopedic structures for sensing and/or stimulation. In one embodiment, a vertebral column (800) having a number of intervertebral discs (802) interspersed among respective vertebral bodies (804), material placed in intervertebral discs (802) allows for a semi-synthetic vertebral disc (806) to be constructed. The artificial intervertebral disk (806) contains one or more ball sensors (808) located within the body of the disk (806) in order to monitor the compression forces. Conventionally, the semi-synthetic disc (806) is monitored only retrospectively, and visualized on x-ray. In this particular embodiment, any of a number of semi-synthetic intervertebral discs (806) can be implanted with one or more ball sensors (808) such that stress and compression forces can be monitored to assure proper alignment of vertebrae (810) in the vertebral column (800), and to monitor the development of any nonphysiologic forces due to vertebral degeneration, disk malfunction, and so on.
摘要翻译：植入用于感测和/或刺激的矫形结构中的基本上球形的半导体球。在一个实施例中，具有散布在相应椎体（804）中的多个椎间盘（802）的椎骨柱（800），放置在椎间盘（802）中的材料允许构造半合成椎盘（806）。为了监测压缩力，人造椎间盘（806）包含位于盘体（806）内的一个或多个球传感器（808）。通常，半合成盘（806）仅在回顾性地监控，并且在x射线上可视化。在该特定实施例中，多个半合成椎间盘（806）中的任何一个可以植入一个或多个球传感器（808），使得可以监测应力和压缩力，以确保椎骨中的椎骨（810）的适当对准椎体柱（800），并监测由于脊椎变性，椎间盘畸形等引起的任何非生理力的发展。

10. 发明授权

US06423056B1 Injectable thermal balls for tumor ablation 失效
标题翻译：注射热球用于肿瘤消融
公开(公告)号：US06423056B1
公开(公告)日：2002-07-23
申请号：US09475819
申请日：1999-12-30
申请人： Akira Ishikawa , Nabuo Takeda , Suzanne I. Ahn , Samuel S. Ahn , Steven R. Hays , F. Andrew Gaffney
发明人： Akira Ishikawa , Nabuo Takeda , Suzanne I. Ahn , Samuel S. Ahn , Steven R. Hays , F. Andrew Gaffney
IPC分类号： A61B1818
CPC分类号： A61B5/416 , A61B5/0008 , A61B5/42 , A61N1/406
摘要： A method of tumor ablation using injectable thermal-sensing balls. A catheter system (115) is used to inject a slurry (134) of thermal-sensing balls (136) into a tumor (122) located in, for example, a liver (120). The catheter system (115) comprises a catheter (128) and a specialized syringe (129) consisting of a housing (130) and a plunger (132). The housing (130) includes a cylindrical chamber having the slurry (134) of thermal-sensing balls (136). The catheter (128) is inserted retrograde into the femoral artery and passed to the site of the tumor (122). The hepatic artery (124) branches into smaller vessels, one of which is a tumor artery (126) which feeds the tumor (122). The tip of the catheter (128) is placed in the tumor artery (126) guided by conventional fluoroscopy. The injected balls (136) then receive energy from an external control system (110). The system (110) comprises a control panel (114) as an operator interface for controlling the system (110) and reading data therefrom. A CPU (112) is used for control and monitor of the operation, and transmits power and signals to the injected balls (136) via a radiating antenna (118), which energy is converted into heat to increase the temperature of the tumor (122). The temperature of the balls (136) can then be read from one or more onboard temperature sensors, and displayed to the operator for accurate control of the tumor temperature.
摘要翻译：使用注射热感应球的肿瘤消融的方法。导管系统（115）用于将热感测球（136）的浆液（134）注入位于例如肝脏（120）中的肿瘤（122）中。导管系统（115）包括由壳体（130）和柱塞（132）组成的导管（128）和专用注射器（129）。壳体（130）包括具有热敏球（136）的浆料（134）的圆柱形腔室。将导管（128）逆行插入股动脉并传递至肿瘤部位（122）。肝动脉（124）分支成较小的血管，其中一个是肿瘤（122）的肿瘤动脉（126）。将导管（128）的尖端放置在通过常规荧光透视引导的肿瘤动脉（126）中。注射的球（136）然后从外部控制系统（110）接收能量。系统（110）包括作为用于控制系统（110）并从其读取数据的操作员界面的控制面板（114）。 CPU（112）用于控制和监视操作，并且经由辐射天线（118）将功率和信号发送到注射的球（136），该辐射天线（118）将该能量转换成热量以增加肿瘤的温度（122 ）。然后可以从一个或多个车载温度传感器读取球（136）的温度，并且显示给操作者以准确控制肿瘤温度。

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