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1. 发明授权

US06261247B1 Position sensing system 失效
标题翻译：位置传感系统
公开(公告)号：US06261247B1
公开(公告)日：2001-07-17
申请号：US09475312
申请日：1999-12-30
申请人： Akira Ishikawa , Nabuo Takeda , Suzanne I. Ahn , Samuel S. Ahn , Steven R. Hays , F. Andrew Gaffney
发明人： Akira Ishikawa , Nabuo Takeda , Suzanne I. Ahn , Samuel S. Ahn , Steven R. Hays , F. Andrew Gaffney
IPC分类号： A61B5103
CPC分类号： G01B7/14 , A61B5/0031 , A61B5/06 , A61B5/067 , A61B5/103 , A61B5/1076 , A61B5/113 , A61B5/435 , A61B5/6806 , A61B2090/3983 , G01B7/004 , G01S13/06
摘要： An anatomical position sensing system (100) using one or more substantially spherical transponders for measuring relative positions and distances. Transponders (P) and (S) are capable of receiving and transmitting RF signals, and communicating between themselves and with a separate CPU (112). The CPU (112) is controlled by an operator at an operator control panel (114), interacts with an alarm (120) for providing audible alerts to the operator, and a display for displaying information to the operator. The CPU (112) controls a broadband antenna (118) to transmit, at a frequency f1, a low-frequency RF power signal (122) across a wide field to energize the transponders (P) and (S). Directional components (122a) and (122b) intercept and energize the transponders (P) and (S). Once energized, transponder (P) transmits a range signal in all directions including component (124) at a very high RF frequency f2, extending from transponder (P) to transponder (S). Upon receipt of the range signal (124), transponder (S) emits a data signal at a very high RF frequency f3 in all directions, including component (126), which is directed at the antenna (118). The distance (D) is determined by measuring the attenuation of the range signal (124) as it is received by transponder (S). Transponder (S) then modulates the value of the strength of the incoming range signal (124) onto the data signal. The CPU (112) computes the distance (D) from the incoming data signal (126) from a lookup table derived from a sequence of calibration steps prior to beginning normal operation.
摘要翻译：一种使用一个或多个基本上球形的应答器来测量相对位置和距离的解剖位置感测系统（100）。应答器（P）和（S）能够接收和发射RF信号，并且在它们之间和独立的CPU（112）之间进行通信。 CPU（112）由操作员在操作员控制面板（114）处控制，与用于向操作员提供可听警报的报警器（120）相互作用，以及用于向操作者显示信息的显示器。 CPU（112）控制宽带天线（118）以f1的频率在宽的场上发射低频RF功率信号（122），以对应答器（P）和（S）供电。定向分量（122a）和（122b）拦截并激励应答器（P）和（S）。一旦通电，应答器（P）在从应答器（P）到转发器（S）延伸的非常高的RF频率f2的所有方向上传输包括分量（124）的范围信号。在接收到范围信号（124）时，应答器（S）在包括分配在天线（118）上的组件（126）的所有方向上以非常高的RF频率f3发射数据信号。通过测量由应答器（S）接收的范围信号（124）的衰减来确定距离（D）。应答器（S）然后将输入范围信号（124）的强度的值调制到数据信号上。在开始正常操作之前，CPU（112）根据从校准步骤序列导出的查找表计算来自输入数据信号（126）的距离（D）。

2. 发明授权

US06415184B1 Implantable neuro-stimulator with ball implant 失效
标题翻译：植入式神经刺激器与球植入
公开(公告)号：US06415184B1
公开(公告)日：2002-07-02
申请号：US09478592
申请日：2000-01-06
申请人： Akira Ishikawa , Nabuo Takeda , Suzanne I. Ahn , Samuel S. Ahn , Steven R. Hays , F. Andrew Gaffney
发明人： Akira Ishikawa , Nabuo Takeda , Suzanne I. Ahn , Samuel S. Ahn , Steven R. Hays , F. Andrew Gaffney
IPC分类号： A61N105
CPC分类号： A61N1/3605 , A61N1/36017 , A61N1/36082 , A61N1/37205 , A61N1/37217 , A61N1/3787
摘要： A ball semiconductor for stimulating a mass of nervous system brain tissue for therapeutic purposes. The ball (120) is embedded in a mass of nervous system tissue (215) of a brain. Electrical pulses generated and transmitted to the ball (120) by a remote electrical pulse generator system (140) are picked up by a receiving antenna of the ball (120), and are applied to an electrode pair of the ball (120) to cause the mass of nervous system tissue (215) of the brain located between output pads of the electrode to become stimulated, as therapy for a pathological condition.
摘要翻译：用于刺激大量神经系统脑组织用于治疗目的的球半导体。球（120）被嵌入大脑的大量神经系统组织（215）中。由远程电脉冲发生器系统（140）产生并传输到球（120）的电脉冲由球（120）的接收天线拾取，并被施加到球（120）的电极对以引起位于电极的输出垫之间的脑的神经系统组织（215）的质量被刺激，作为病理状况的治疗。

3. 发明授权

US06264611B1 Monitor for interventional procedures 失效
标题翻译：监测介入程序
公开(公告)号：US06264611B1
公开(公告)日：2001-07-24
申请号：US09448644
申请日：1999-11-24
申请人： Akira Ishikawa , Nabuo Takeda , Suzanne I. Ahn , Samuel S. Ahn , Steven R. Hays , F. Andrew Gaffney
发明人： Akira Ishikawa , Nabuo Takeda , Suzanne I. Ahn , Samuel S. Ahn , Steven R. Hays , F. Andrew Gaffney
IPC分类号： A61B502
CPC分类号： A61B5/02055 , A61B5/0031 , A61B5/0215 , A61B5/03 , A61B5/083 , A61B5/145 , A61B5/14532 , A61B5/6848 , A61B5/6851
摘要： A ball-shaped semiconductor monitoring device (150) having one or more transducer functions for use with an instrument that is insertable into a human body. In one disclosed embodiment, a needle (130) and modified stylet (140) are inserted into intraluminal body cavities for measuring fluid pressure. The modified stylet (140) has the monitoring device (150) attached to one end. The stylet (140) has a metal annulus (142) extending throughout its length and a communication wire (144) disposed therein. The wire (144) is surrounded by an insulator (146) to electrically isolate it from the stylet (140). A recessed cavity (148) is provided at the distal end of the stylet (140) to accommodate the ball monitoring device (150). A transducer (152) is integrated on the ball device (150) to measure such quantitative conditions as pressure. The ball (150) has a ground terminal (154) and a data terminal (156). The ground terminal (154) is electrically connected to the metal annulus (142) of the stylet (140) by a solder joint (158). The data terminal (156) is connected to the communication wire (144) by a contact (160). The instrument that carries the semiconductor device to a particular site within the body may be a catheter, guidewire, stylet, needle or any other insertable instrument. The transducer can be fabricated to sense pressure, fluid flow rate, temperature and other physiological parameters and physical conditions.
摘要翻译：一种具有一个或多个换能器功能的球形半导体监测装置（150），用于可插入人体内的仪器。在一个所公开的实施例中，将针头（130）和改良的探针（140）插入管腔内空腔以测量流体压力。修改的探针（140）具有附接到一端的监视装置（150）。探针（140）具有贯穿其长度延伸的金属环（142）和设置在其中的连通线（144）。导线（144）由绝缘体（146）包围，以使其与探针（140）电隔离。在探针（140）的远端处设置有凹腔（148）以容纳球监视装置（150）。换能器（152）集成在球装置（150）上以测量诸如压力的定量条件。球（150）具有接地端子（154）和数据端子（156）。接地端子（154）通过焊接接头（158）电连接到探针（140）的金属环（142）。数据端子（156）通过触点（160）连接到通信线（144）。携带半导体器件到体内特定位置的仪器可以是导管，导丝，通丝针，针或任何其它可插入的仪器。传感器可以被制造以感测压力，流体流速，温度和其他生理参数和物理条件。

4. 发明授权

US06254548B1 Internal thermometer 失效
标题翻译：内部温度计
公开(公告)号：US06254548B1
公开(公告)日：2001-07-03
申请号：US09448638
申请日：1999-11-24
申请人： Akira Ishikawa , Nabuo Takeda , Suzanne I. Ahn , Samuel S. Ahn , Steven R. Hays , F. Andrew Gaffney
发明人： Akira Ishikawa , Nabuo Takeda , Suzanne I. Ahn , Samuel S. Ahn , Steven R. Hays , F. Andrew Gaffney
IPC分类号： A61B500
CPC分类号： A61B5/0008 , A61B5/0031
摘要： A miniature spherical-shaped internal temperature transponder. A temperature sensor (25) is fabricated in a spherical integrated transponder circuit (15) which may be placed in the human body by ingestion, implantation, or injection. In one aspect of the invention, a passive system is disclosed whereby an external monitoring station (13) generates an energy field using a magnetic field generator (19) which is coupled to a power coil (21) of the transponder (15). The power coil (21) passes power to a power regulator (23) to provide regulated power to all transponder (15) circuits. Temperature data obtained by the temperature sensor (25) is passed to a voltage controlled oscillator (27) for conversion into an RF signal. A mixing circuit (31) receives the RF temperature signal and modulates the temperature data signal onto an oscillator frequency from an RF oscillator (29). An RF amplifier (33) receives the modulated RF signal from the mixing circuit (31) and transmits it via an antenna (35) to the external monitor station 13 which is proximate to the transponder (15). The signal is received by an RF receiver (37) and processed using a CPU (39) to extract the measured temperature data, which can then be displayed to the operator on a display (41). The transponder (15) may be powered either by the external electromagnetic radiation source (19) or an internal battery.
摘要翻译：微型球形内部温度转发器。温度传感器（25）制造在球形集成式应答器电路（15）中，其可以通过摄取，注入或注入而放置在人体内。在本发明的一个方面，公开了一种无源系统，其中外部监测站（13）使用磁场发生器（19）产生能量场，该磁场发生器耦合到应答器（15）的功率线圈（21）。电力线圈（21）将功率传递给功率调节器（23）以向所有应答器（15）电路提供稳定的电力。由温度传感器（25）获得的温度数据被传送到压控振荡器（27）以转换成RF信号。混合电路（31）接收RF温度信号，并将温度数据信号从RF振荡器（29）调制到振荡器频率上。 RF放大器（33）从混合电路（31）接收经调制的RF信号，并经由天线（35）将其发送到靠近应答器（15）的外部监视站13。信号由RF接收器（37）接收，并使用CPU（39）进行处理，以提取测量的温度数据，然后可以将其显示给显示器（41）上的操作者。应答器（15）可以由外部电磁辐射源（19）或内部电池供电。

5. 发明授权

US06447448B1 Miniature implanted orthopedic sensors 失效
标题翻译：微型植入式矫形传感器
公开(公告)号：US06447448B1
公开(公告)日：2002-09-10
申请号：US09475820
申请日：1999-12-30
申请人： Akira Ishikawa , Nabuo Takeda , Suzanne I. Ahn , Samuel S. Ahn , Steven R. Hays , F. Andrew Gaffney
发明人： Akira Ishikawa , Nabuo Takeda , Suzanne I. Ahn , Samuel S. Ahn , Steven R. Hays , F. Andrew Gaffney
IPC分类号： A61B500
CPC分类号： A61B5/4504 , A61B5/0031 , A61B5/036 , A61B5/14546 , A61B5/411 , A61B5/4514 , A61B5/4528 , A61B5/4533 , A61B2560/0219 , A61F2/32 , A61F2/34 , A61F2/36 , A61F2/3662 , A61F2/367 , A61F2/442 , A61F2/4657 , A61F2/468 , A61F2002/30332 , A61F2002/3067 , A61F2002/3071 , A61F2002/3611 , A61F2002/3625 , A61F2002/3674 , A61F2002/4666 , A61F2002/4672 , A61F2002/4674 , A61F2002/48 , A61F2002/482 , A61F2220/0033 , A61F2250/0002 , A61F2250/0085 , G06F19/00
摘要： A substantially spherical semiconductor ball implanted in orthopedic structures for sensing and/or stimulation. In one embodiment, a vertebral column (800) having a number of intervertebral discs (802) interspersed among respective vertebral bodies (804), material placed in intervertebral discs (802) allows for a semi-synthetic vertebral disc (806) to be constructed. The artificial intervertebral disk (806) contains one or more ball sensors (808) located within the body of the disk (806) in order to monitor the compression forces. Conventionally, the semi-synthetic disc (806) is monitored only retrospectively, and visualized on x-ray. In this particular embodiment, any of a number of semi-synthetic intervertebral discs (806) can be implanted with one or more ball sensors (808) such that stress and compression forces can be monitored to assure proper alignment of vertebrae (810) in the vertebral column (800), and to monitor the development of any nonphysiologic forces due to vertebral degeneration, disk malfunction, and so on.
摘要翻译：植入用于感测和/或刺激的矫形结构中的基本上球形的半导体球。在一个实施例中，具有散布在相应椎体（804）中的多个椎间盘（802）的椎骨柱（800），放置在椎间盘（802）中的材料允许构造半合成椎盘（806）。为了监测压缩力，人造椎间盘（806）包含位于盘体（806）内的一个或多个球传感器（808）。通常，半合成盘（806）仅在回顾性地监控，并且在x射线上可视化。在该特定实施例中，多个半合成椎间盘（806）中的任何一个可以植入一个或多个球传感器（808），使得可以监测应力和压缩力，以确保椎骨中的椎骨（810）的适当对准椎体柱（800），并监测由于脊椎变性，椎间盘畸形等引起的任何非生理力的发展。

6. 发明授权

US06423056B1 Injectable thermal balls for tumor ablation 失效
标题翻译：注射热球用于肿瘤消融
公开(公告)号：US06423056B1
公开(公告)日：2002-07-23
申请号：US09475819
申请日：1999-12-30
申请人： Akira Ishikawa , Nabuo Takeda , Suzanne I. Ahn , Samuel S. Ahn , Steven R. Hays , F. Andrew Gaffney
发明人： Akira Ishikawa , Nabuo Takeda , Suzanne I. Ahn , Samuel S. Ahn , Steven R. Hays , F. Andrew Gaffney
IPC分类号： A61B1818
CPC分类号： A61B5/416 , A61B5/0008 , A61B5/42 , A61N1/406
摘要： A method of tumor ablation using injectable thermal-sensing balls. A catheter system (115) is used to inject a slurry (134) of thermal-sensing balls (136) into a tumor (122) located in, for example, a liver (120). The catheter system (115) comprises a catheter (128) and a specialized syringe (129) consisting of a housing (130) and a plunger (132). The housing (130) includes a cylindrical chamber having the slurry (134) of thermal-sensing balls (136). The catheter (128) is inserted retrograde into the femoral artery and passed to the site of the tumor (122). The hepatic artery (124) branches into smaller vessels, one of which is a tumor artery (126) which feeds the tumor (122). The tip of the catheter (128) is placed in the tumor artery (126) guided by conventional fluoroscopy. The injected balls (136) then receive energy from an external control system (110). The system (110) comprises a control panel (114) as an operator interface for controlling the system (110) and reading data therefrom. A CPU (112) is used for control and monitor of the operation, and transmits power and signals to the injected balls (136) via a radiating antenna (118), which energy is converted into heat to increase the temperature of the tumor (122). The temperature of the balls (136) can then be read from one or more onboard temperature sensors, and displayed to the operator for accurate control of the tumor temperature.
摘要翻译：使用注射热感应球的肿瘤消融的方法。导管系统（115）用于将热感测球（136）的浆液（134）注入位于例如肝脏（120）中的肿瘤（122）中。导管系统（115）包括由壳体（130）和柱塞（132）组成的导管（128）和专用注射器（129）。壳体（130）包括具有热敏球（136）的浆料（134）的圆柱形腔室。将导管（128）逆行插入股动脉并传递至肿瘤部位（122）。肝动脉（124）分支成较小的血管，其中一个是肿瘤（122）的肿瘤动脉（126）。将导管（128）的尖端放置在通过常规荧光透视引导的肿瘤动脉（126）中。注射的球（136）然后从外部控制系统（110）接收能量。系统（110）包括作为用于控制系统（110）并从其读取数据的操作员界面的控制面板（114）。 CPU（112）用于控制和监视操作，并且经由辐射天线（118）将功率和信号发送到注射的球（136），该辐射天线（118）将该能量转换成热量以增加肿瘤的温度（122 ）。然后可以从一个或多个车载温度传感器读取球（136）的温度，并且显示给操作者以准确控制肿瘤温度。

7. 发明授权

US06398710B1 Radiation dosimetry system 失效
标题翻译：放射剂量测定系统
公开(公告)号：US06398710B1
公开(公告)日：2002-06-04
申请号：US09478591
申请日：2000-01-06
申请人： Akira Ishikawa , Nabuo Takeda , Suzanne I. Ahn , Samuel S. Ahn , Steven R. Hays , F. Andrew Gaffney
发明人： Akira Ishikawa , Nabuo Takeda , Suzanne I. Ahn , Samuel S. Ahn , Steven R. Hays , F. Andrew Gaffney
IPC分类号： A61N500
CPC分类号： G01T1/026 , A61N5/1048 , G01T1/161
摘要： A radiation dosimetry system (110) using miniature implanted transponder balls. A patient having a tumor that is the target of the radiation treatment lies in a treatment area with the tumor positioned beneath a target (112) used for alignment purposes. The system (110) is controlled and monitored by a CPU (114) which receives instructions from a radiologist operating a control panel (116), and displays control parameters, data and graphics to the radiologist on a display (118). The CPU (114) controls an RF system operating through a broad-band antenna (120) and directed at the target area (112). The CPU (114) controls operation of a radiation source (122), which may be a conventional linear accelerator, for directing radiation at the target area (112). The radiation source (122) includes a collimator (124) or similar apparatus for shaping a radiation beam for accurate application to the target area (112). A pair of RF receivers (126) and (128) are positioned such that they are spaced apart and opposite from the CPU antenna (120) with respective antennas (130) and (132) directed at the target area (112). Communication connections (133a), (133b), (133c), (133d) and (133e) interconnect the various elements of the system (110).
摘要翻译：辐射剂量测定系统（110），使用微型植入式转发器球。具有作为放射治疗靶标的肿瘤的患者位于治疗区域中，肿瘤位于用于对准目的的靶（112）下方。系统（110）由接收来自操作控制面板（116）的放射科医生的指令的CPU（114）进行控制和监视，并在显示器（118）上向放射科医师显示控制参数，数据和图形。 CPU（114）控制通过宽带天线（120）操作并且指向目标区域（112）的RF系统。 CPU（114）控制用于将辐射引导到目标区域（112）的辐射源（122）的操作，其可以是常规的直线加速器。辐射源（122）包括准直器（124）或用于使辐射束成形以用于准确应用于目标区域（112）的类似装置。一对RF接收器（126）和（128）被定位成使得它们与CPU天线（120）间隔开并与其相对应的天线（130）和（132）指向目标区域（112）。通信连接（133a），（133b），（133c），（133d）和（133e）互连系统（110）的各种元件。

8. 发明授权

US06295466B1 Wireless EKG 失效
标题翻译：无线EKG
公开(公告)号：US06295466B1
公开(公告)日：2001-09-25
申请号：US09478320
申请日：2000-01-06
申请人： Akira Ishikawa , Nabuo Takeda , Suzanne I. Ahn , Samuel S. Ahn , Steven R. Hays , F. Andrew Gaffney
发明人： Akira Ishikawa , Nabuo Takeda , Suzanne I. Ahn , Samuel S. Ahn , Steven R. Hays , F. Andrew Gaffney
IPC分类号： A61B50402
CPC分类号： A61B5/0006 , A61B5/04004 , A61B5/0408 , A61B5/042
摘要： A wireless electrocardiogram monitor utilizing a cooperative association of miniature semiconductor balls. A side view of a surface mount cardiac monitor system (200) shows three semiconductor electrode balls (202), (204), and (206) contacting a central communication ball (208) for electrical communication therebetween. Each of the electrode balls (202), (204), and (206) have fabricated thereon a respective electrode (210), (212), and (214) for receiving electrical signals from the heart. The electrode signals are passed to the central communication ball (208) for processing, filtering, digital conversion, and transmission therefrom to a remote control system being operated by a medical technician. The data can then be displayed to medical personnel.
摘要翻译：一种使用微型半导体球的协作关联的无线心电图监视器。表面安装式心脏监测器系统（200）的侧视图示出了三个半导体电极球（202），（204）和（206）接触中心连通球（208）以在其间进行电连通。电极球（202），（204）和（206）中的每一个在其上制造有用于从心脏接收电信号的相应电极（210），（212）和（214）。电极信号被传递到中央通信球（208），用于处理，过滤，数字转换和从其传输到由医疗技术人员操作的遥控系统。然后可以向医务人员显示数据。

9. 发明授权

US06464687B1 Implantable drug delivery system 失效
标题翻译：可植入药物输送系统
公开(公告)号：US06464687B1
公开(公告)日：2002-10-15
申请号：US09521922
申请日：2000-03-09
申请人： Akira Ishikawa , Nabuo Takeda , Suzanne I. Ahn , Samuel S. Ahn , Steven R. Hayes , F. Andrew Gaffney
发明人： Akira Ishikawa , Nabuo Takeda , Suzanne I. Ahn , Samuel S. Ahn , Steven R. Hayes , F. Andrew Gaffney
IPC分类号： A61K922
CPC分类号： G06K19/077 , A61B5/0008 , A61B5/0031 , A61B5/03 , A61B5/14532 , A61B5/14539 , A61B5/14542 , A61B5/1473 , A61B5/14865 , A61B5/416 , A61B5/4839 , A61J2200/42 , A61J2200/72 , A61J2205/60 , A61M5/14276 , A61M5/1723 , A61M2205/0244 , A61M2205/3523 , G06K19/07758 , G06K2017/009 , H01L29/0657 , H01L2924/1017
摘要： A miniature implantable drug delivery capsule system. The drug delivery system (400) comprises one or more ball semiconductor aggregations (404) and (406) facilitating release of a drug stored in a reservoir (402). The first aggregate (404) is used for sensing and memory, and a second aggregation (406) for control aspects, such as for pumping and dispensing of the drug. Notably, the aggregates (404) and (406) may be interconnected by a common bus (410) for communication purposes, or may be implemented to operate independently of each other. Each aggregate (404) and (406) is encased in a semipermeable membrane (408) to allow species which are to be monitored, and drugs to be delivered, to freely diffuse. The system (400) may communicate with a remote control system, or operate independently on local power over a long period for delivery of the drug based upon a request of the patient, timed-release under control by the system (400), or delivery in accordance with measured markers.
摘要翻译：微型可植入药物输送胶囊系统。药物递送系统（400）包括一种或多种球半导体聚集体（404）和（406），其有助于储存在储存器（402）中的药物的释放。第一聚集体（404）用于感测和记忆，以及用于控制方面的第二聚集（406），例如用于泵送和分配药物。值得注意的是，聚集体（404）和（406）可以通过用于通信目的的公共总线（410）互连，或者可以被实现为彼此独立地操作。每个骨料（404）和（406）被包裹在半透膜（408）中，以允许被监测的物质和被输送的药物自由扩散。系统（400）可以与远程控制系统进行通信，或者在长时间内基于本地电力独立地操作以基于患者的请求递送药物，由系统（400）控制的定时释放或递送根据测量标记。

10. 发明授权

US06546268B1 Glucose sensor 失效
标题翻译：葡萄糖传感器
公开(公告)号：US06546268B1
公开(公告)日：2003-04-08
申请号：US09586200
申请日：2000-06-02
申请人： Akira Ishikawa , Nabuo Takeda , Suzanne I. Ahn , Steven R. Hays , Kevin Nelson
发明人： Akira Ishikawa , Nabuo Takeda , Suzanne I. Ahn , Steven R. Hays , Kevin Nelson
IPC分类号： A61B505
CPC分类号： A61B5/14865 , A61B5/0031 , A61B5/14532 , A61B5/14539 , A61B5/14542 , A61B5/1473 , A61M5/1723 , H01L29/0657 , H01L2924/1017
摘要： A biochemical sensor based on ball integrated circuit technology which is designed to be biocompatible for implantation within a human or animal body. A sensor media is mounted to the ball integrated circuit, the sensor media operable for sensing biochemical molecules. An onboard communication link transmits data sensed by the sensor media from the ball integrated circuit.
摘要翻译：基于球集成电路技术的生物化学传感器，其设计为与人体或动物体内植入生物相容。传感器介质安装到球集成电路，传感器介质可用于感测生化分子。车载通信链路从球集成电路传输由传感器介质感测的数据。

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