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1. 发明专利

JP2007170992A Method for immunological measurement of homocysteines 审中-公开
标题翻译：免疫学测定方法
公开(公告)号：JP2007170992A
公开(公告)日：2007-07-05
申请号：JP2005369198
申请日：2005-12-22
申请人： Abbott Japan Co Ltd , アボットジャパン株式会社
发明人： YOSHIMURA TORU
IPC分类号： G01N33/53 , G01N33/531
CPC分类号： G01N33/6815
摘要： PROBLEM TO BE SOLVED: To provide a method for immunological measurement of homocysteines, and capable of readily and efficiently excluding the effects of immunoreaction inhibitors derived from biological samples, since it is known that measurement values vary due to the effects of immunoreaction inhibitors that have been derived from biological samples, and to provide a kit used for the same.
SOLUTION: The exclude effects of immunoreaction inhibitors can be excluded by making homocysteine react with an antibody in the presence of polyanions. A specimen and the antibody are made to react in the presence of exogenous polyanions, to immunologically measure the homocysteine contained in a biological sample according to the method.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于免疫测量同型半胱氨酸的方法，并且能够容易且有效地排除衍生自生物样品的免疫反应抑制剂的作用，因为已知测量值由于免疫反应抑制剂的作用而变化其衍生自生物样品，并提供用于其的试剂盒。解决方案：通过在聚阴离子存在下使同型半胱氨酸与抗体反应，排除免疫反应抑制剂的排除效果。使样品和抗体在外源聚阴离子存在下反应，根据该方法免疫测量生物样品中所含的同型半胱氨酸。版权所有（C）2007，JPO＆INPIT

2. 发明专利

JP2006112834A Immunoassay method using reducing reagent having improved stability 审中-公开
标题翻译：使用减少具有改善的稳定性的试剂的免疫测定方法
公开(公告)号：JP2006112834A
公开(公告)日：2006-04-27
申请号：JP2004298140
申请日：2004-10-12
申请人： Abbott Japan Co Ltd , アボットジャパン株式会社
发明人： YOSHIMURA TORU
IPC分类号： G01N33/531
摘要： PROBLEM TO BE SOLVED: To provide a measuring kit used for immunoassay method that contains a reducing agent, having improved stability in the solution state and reduced irritating odor, and the immunoassay method that uses the reducing reagent.
SOLUTION: Molecules having respectively a sulfhydryl group and an amino group and not having a negative functional group, such as a carboxylic group are used as the reducing agent. Hereby, the stability of the reducing reagent in the solution state can be improved, and the irritating odor can be reduced.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种包含还原剂，具有改善的溶液状态稳定性和降低刺激性气味的免疫测定方法的测定试剂和使用还原试剂的免疫测定方法。解决方案：使用分别具有巯基和氨基并且不具有负官能团的分子如羧基作为还原剂。因此，可以提高还原剂在溶液状态下的稳定性，并且可以降低刺激性气味。版权所有（C）2006，JPO＆NCIPI

3. 发明专利

JP2013152247A Nonspecific interaction inhibitor and application of the same to diagnostic measuring system 审中-公开
标题翻译：非特异性相互作用抑制剂及其应用于诊断测量系统
公开(公告)号：JP2013152247A
公开(公告)日：2013-08-08
申请号：JP2013083566
申请日：2013-04-12
申请人： Abbott Japan Co Ltd , アボットジャパン株式会社
发明人： YOSHIDA EISAKU , HANDAKA MADOKA , FUJITA AKITATSU , YOSHIMURA TORU
IPC分类号： G01N33/543 , G01N33/531
摘要： PROBLEM TO BE SOLVED: To provide a technique for reducing a problem of a false positive in which a specimen to be determined as negative caused by a nonspecific reaction or the like to magnetic particulates in a solid phase in a diagnostic agent utilizing an antigen-antibody reaction is incorrectly determined as positive.SOLUTION: False positive determination in immunodiagnosis or the like can be reduced by effectively suppressing a nonspecific reaction which may be a problem in a diagnostic agent utilizing an antigen-antibody reaction and utilizing a nonspecific reaction inhibitor composed of protein, a polymer, salt or their combination for reducing false positive.
摘要翻译：要解决的问题：提供一种技术，用于减少在使用抗原抗体的诊断剂中将由非特异性反应等导致的固体中的磁性颗粒确定为阴性的样品作为阴性的假阳性的问题反应错误地确定为阳性。解决方案：通过有效抑制非特异性反应，可以减少免疫诊断等中的假阳性测定，这可能是使用抗原 - 抗体反应的诊断剂中存在的问题，并且利用由蛋白质组成的非特异性反应抑制剂，聚合物，盐或其组合以减少假阳性。

4. 发明专利

JP2010127827A Nonspecific interaction inhibitor, and its application to diagnostic measuring system 审中-公开
标题翻译：非相互作用抑制剂及其应用于诊断测量系统
公开(公告)号：JP2010127827A
公开(公告)日：2010-06-10
申请号：JP2008304535
申请日：2008-11-28
申请人： Abbott Japan Co Ltd , アボットジャパン株式会社
发明人： YOSHIDA EISAKU , HANDAKA MADOKA , FUJITA AKITATSU , YOSHIMURA TORU
IPC分类号： G01N33/543 , G01N33/574
摘要： PROBLEM TO BE SOLVED: To provide a technology for reducing a problem of false positive wherein a specimen to be determined to be negative is erroneously determined to be positive by a nonspecific reaction to magnetic particles in the solid phase, concerning a diagnostic agent utilizing an antigen-antibody reaction. SOLUTION: False positive in an immunodiagnostic agent can be reduced by utilizing a nonspecific reaction inhibitor comprising a protein, a polymer, salts or a combination thereof for reducing false positive by suppressing effectively a nonspecific reaction which is a problem in a diagnostic agent utilizing an antigen-antibody reaction. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种减少假阳性问题的技术，其中通过对固相中的磁性颗粒的非特异性反应将确定为阴性的样品错误地确定为阳性，涉及诊断剂利用抗原 - 抗体反应。解决方案：可以通过利用包含蛋白质，聚合物，盐或其组合的非特异性反应抑制剂来减少免疫诊断剂中的假阳性，以通过有效抑制诊断剂中的问题的非特异性反应来减少假阳性利用抗原 - 抗体反应。版权所有（C）2010，JPO＆INPIT

5. 发明专利

JP2008216237A Immunodiagnostic drug with reduced nonspecific reaction 有权
标题翻译：具有减少非特异性反应的免疫抑制药物
公开(公告)号：JP2008216237A
公开(公告)日：2008-09-18
申请号：JP2007289842
申请日：2007-11-07
申请人： Abbott Japan Co Ltd , アボットジャパン株式会社
发明人： RODGERS BRIAN C , HELEN E WADE , KOBAYASHI EIJI , TANIMOTO TOMOAKI , TAKEDA KATSUMICHI , YOSHIMURA TORU
IPC分类号： G01N33/543 , G01N33/53 , G01N33/553 , G01N33/569 , G01N33/571 , G01N33/576
摘要： PROBLEM TO BE SOLVED: To provide a technology of solving problem of false-positive in which a specimen which must be determined to be negative is erroneously determined to be positive due to the nonspecific reaction of an immunodiagnostic drug on a selfantigen or an antigen solid phase magnetic particle.
SOLUTION: When the specimen to be measured is treated with an immunoassay reagent containing particles having an antigen or a selfantigen with solidified phase and containing magnetic substances, the particles having the same or similar surface raw material as or to the particles containing the magnetic substances and not containing magnetic substances are made to coexist with a reactive mixture. Consequently, the problem of the false-positive of the immunodiagnostic drug can be solved.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种解决假阳性问题的技术，其中由于免疫诊断药物在自身抗原或非自发性抗体上的非特异性反应，必须确定为阴性的标本被错误地确定为阳性抗原固相磁性颗粒。解决方案：当用含有具有凝固相和具有磁性物质的抗原或自身抗原的颗粒的免疫测定试剂处理待测量样品时，具有与或含有磁性物质的颗粒相同或相似的表面原料的颗粒使磁性物质不含磁性物质与反应性混合物共存。因此，可以解决免疫诊断药物的假阳性问题。版权所有（C）2008，JPO＆INPIT

6. 发明专利

JP2004109062A Antivirus antibody measuring method using viral antigen having recovered immunological structure and measuring kit 有权
公开(公告)号：JP2004109062A
公开(公告)日：2004-04-08
申请号：JP2002275395
申请日：2002-09-20
申请人： Abbott Japan Co Ltd , アボットジャパン株式会社
发明人： YOSHIMURA TORU
IPC分类号： G01N33/569 , G01N33/53 , G01N33/531
摘要： PROBLEM TO BE SOLVED: To provide an antivirus antibody measuring reagent using a viral antigen with an improvement in coupling to the antivirus antibody in measurement blood, preferably such as an anti-HIV-1 antibody measuring reagent using a HIV-1 antigen for improving a coupling property to the anti-HIV-1 antibody. SOLUTION: The antivirus antibody measuring reagent contains the viral antigen from which a surface active agent coupled to the viral antigen, is removed by processing the viral antigen processed by the surface active agent by using cyclodextrin. Detection sensitivity of the antivirus antibody is drastically improved by using the viral antigen. COPYRIGHT: (C)2004,JPO

7. 发明申请

WO2015114469A3 COVERED SEQUENCE CONVERSION DNA AND DETECTION METHODS 审中-公开
标题翻译：覆盖序列转换DNA和检测方法
公开(公告)号：WO2015114469A3
公开(公告)日：2015-11-26
申请号：PCT/IB2015000726
申请日：2015-01-15
申请人： ABBOTT JAPAN CO LTD , TOKYO INST TECH
发明人： KOMIYA KEN , KOMORI MAKOTO , YOSHIMURA TORU
IPC分类号： C12Q1/68
CPC分类号： C12Q1/707 , C12Q1/682 , C12Q1/6844 , C12Q1/689 , C12Q1/703 , C12Q1/706 , C12Q2600/158 , C12Q2600/178 , C12Q2521/301 , C12Q2525/301
摘要： Disclosed are methods for detecting a target nucleic acid in sample, which include contacting the sample with an oligonucleotide having a hairpin structure, where the oligonucleotide includes, in the 5' to 3' direction, an arbitrary sequence, an endonuclease recognition site for a nicking reaction, a sequence complementary to the arbitrary sequence, and a sequence complementary to the target nucleic acid; a polymerase; and an endonuclease capable of nicking the endonuclease recognition site. The disclosure also provides compositions and kits comprising an oligonucleotide having a hairpin structure, where the oligonucleotide includes, in the 5' to 3' direction an arbitrary sequence, an endonuclease recognition site for a nicking reaction, a sequence complementary to the arbitrary sequence, and a sequence complementary to a target nucleic acid.
摘要翻译：公开了用于检测样品中的靶核酸的方法，其包括使样品与具有发夹结构的寡核苷酸接触，其中所述寡核苷酸在5'至3'方向上包括任意序列，用于切割的核酸内切酶识别位点反应，与任意序列互补的序列和与靶核酸互补的序列; 聚合酶; 和能够切割内切核酸酶识别位点的内切核酸酶。本公开还提供了包含具有发夹结构的寡核苷酸的组合物和试剂盒，其中所述寡核苷酸在5'至3'方向上包括任意序列，切口反应的核酸内切酶识别位点，与所述任意序列互补的序列和与靶核酸互补的序列。

8. 发明申请

WO2016059474A2 SEQUENCE CONVERSION AND SIGNAL AMPLIFIER DNA HAVING POLY DNA SPACER SEQUENCES AND DETECTION METHODS USING SAME 审中-公开
标题翻译：具有多聚DNA间隔序列的序列转换和信号扩增DNA以及使用相同的检测方法
公开(公告)号：WO2016059474A2
公开(公告)日：2016-04-21
申请号：PCT/IB2015002145
申请日：2015-10-13
申请人： ABBOTT JAPAN CO LTD , TOKYO INST TECH
发明人： KOMIYA KEN , KOMORI MAKOTO , YOSHIMURA TORU
IPC分类号： C12Q1/68 , C12Q1/34 , C12Q1/48
CPC分类号： C12Q1/682 , C12Q1/6844 , C12Q2525/113 , C12Q2525/131 , C12Q2531/119
摘要： Disclosed are methods for detecting a target nucleic acid in a sample. The methods include contacting said sample, in the presence of a polymerase and an endonuclease, with a sequence conversion oligonucleotide. Also disclosed are methods for detecting a target nucleic acid in a sample in which said sample is contacted, in the presence of a polymerase and an endonuclease, with a sequence conversion oligonucleotide and a signal amplifier oligonucleotide. The disclosure also provides compositions and kits comprising such sequence conversion and signal amplifier oligonucleotides.
摘要翻译：公开了用于检测样品中的靶核酸的方法。所述方法包括使所述样品在聚合酶和内切核酸酶的存在下与序列转化寡核苷酸接触。还公开了在聚合酶和内切核酸酶的存在下用序列转换寡核苷酸和信号放大寡核苷酸检测其中所述样品接触的样品中的靶核酸的方法。本公开还提供了包含这种序列转换和信号放大寡核苷酸的组合物和试剂盒。

9. 发明申请

WO2017057778A3 USE OF LAMININ 2 FOR DIAGNOSING HEPATOCELLULAR CARCINOMA AND PANCREATIC CANCER 审中-公开
标题翻译：层粘蛋白2在诊断肝细胞癌和胰腺癌中的应用
公开(公告)号：WO2017057778A3
公开(公告)日：2017-05-11
申请号：PCT/JP2016079711
申请日：2016-09-28
申请人： ABBOTT JAPAN CO LTD , UNIV TOKYO
发明人： YOSHIMURA TORU , YOSHIDA EISAKU , KOSHIKAWA NAOHIKO , SEIKI MOTOHARU
IPC分类号： G01N33/574
CPC分类号： G01N33/57438 , G01N2333/78 , G01N2800/50 , G01N2800/56
摘要： Disclosed herein are biomarkers for hepatocellular carcinoma and pancreatic cancer. The biomarkers may be laminin gamma 2 monomer, PIVKA-II, AFP, CEA, CA19-9, or combinations thereof. Also disclosed herein are methods of diagnosing, prognosing, classifying risk, and monitoring progression of hepatocellular carcinoma or pancreatic cancer by the detecting the level of laminin gamma 2 monomer, PIVKA-II, AFP, CEA, CA19-9, or combinations thereof.
摘要翻译：本文公开了用于肝细胞癌和胰腺癌的生物标志物。生物标志物可以是层粘连蛋白γ2单体，PIVKA-II，AFP，CEA，CA19-9或其组合。本文还公开了通过检测层粘连蛋白γ2单体，PIVKA-II，AFP，CEA，CA19-9或其组合的水平来诊断，预测，分类风险和监测肝细胞癌或胰腺癌的进展的方法。

10. 发明专利

ES2784369T3 Uso de laminina 2 para el diagnóstico de carcinoma hepatocelular y cáncer de páncreas 未知
公开(公告)号：ES2784369T3
公开(公告)日：2020-09-24
申请号：ES16788569
申请日：2016-09-28
申请人： ABBOTT JAPAN CO LTD , UNIV TOKYO
发明人： YOSHIMURA TORU , YOSHIDA EISAKU , KOSHIKAWA NAOHIKO , SEIKI MOTOHARU
IPC分类号： G01N33/574
摘要： Un método para diagnosticar carcinoma hepatocelular (HCC) en un sujeto con necesidad de ello, el método comprendiendo: (a) determinar los niveles de monómero de laminina gamma 2 y uno o ambos de antagonista-II de vitamina K inducido por proteínas (PIVKA-II) y alfa fetoproteína (AFP) en una muestra biológica obtenida del sujeto; (b) comparar el nivel de monómero de laminina gamma 2 y uno o ambos de antagonista-II de vitamina K inducido por proteínas (PIVKA-II) y alfa fetoproteína (AFP) con niveles de referencia de monómero de laminina gamma 2, PIVKA-II y/o AFP; y (c) identificar que el sujeto tiene HCC cuando los niveles de monómero de laminina gamma 2 y uno o ambos de PIVKA-II y AFP son mayores que los niveles de referencia de monómero de laminina gamma 2, PIVKA-II y/o AFP, respectivamente.

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