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1. 发明专利

JP2008290964A Antibody-antibody conjugate and application to antibody-determining diagnostic agent 有权
标题翻译：抗体抗体结合和应用于抗体测定诊断代理
公开(公告)号：JP2008290964A
公开(公告)日：2008-12-04
申请号：JP2007137603
申请日：2007-05-24
申请人： Abbott Japan Co Ltd , アボットジャパン株式会社
发明人： TAKEDA KATSUMICHI , YOSHIDA EISAKU
IPC分类号： C07K16/46 , C07K16/08 , G01N33/569
摘要： PROBLEM TO BE SOLVED: To develop a substitute for an antigen-specific human immunoglobulin which is a positive control or a calibrator indispensable for the evaluation of the measured result in a system for measuring an antigen-specific human immunoglobulin and difficult to stably acquire.
SOLUTION: The chemical conjugation of a plurality of kinds of antibodies (immunoglobulins) provides an artificial antibody having the plurality of properties. For example, the chemical conjugation of anti-parvovirus B19 mouse IgG antibody and human IgM antibody gives an artificial antibody recognizing parvovirus B19 antigen and having the property of human IgM and the product is useful as a positive control or a calibrator used in a method for measuring anti-parvovirus B19 antigen human IgM antibody.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：开发一种抗原特异性人免疫球蛋白的替代物，该抗原特异性人免疫球蛋白是用于测定抗原特异性人免疫球蛋白的测定系统中难以稳定的测定结果所必需的阳性对照或校准物获得。解决方案：多种抗体（免疫球蛋白）的化学共轭提供具有多种性质的人造抗体。例如，抗细小病毒B19小鼠IgG抗体和人IgM抗体的化学偶联产生识别细小病毒B19抗原并具有人IgM性质的人造抗体，并且该产物可用作阳性对照或用于方法测量抗细小病毒B19抗原人IgM抗体。版权所有（C）2009，JPO＆INPIT

2. 发明专利

JP2010127827A Nonspecific interaction inhibitor, and its application to diagnostic measuring system 审中-公开
标题翻译：非相互作用抑制剂及其应用于诊断测量系统
公开(公告)号：JP2010127827A
公开(公告)日：2010-06-10
申请号：JP2008304535
申请日：2008-11-28
申请人： Abbott Japan Co Ltd , アボットジャパン株式会社
发明人： YOSHIDA EISAKU , HANDAKA MADOKA , FUJITA AKITATSU , YOSHIMURA TORU
IPC分类号： G01N33/543 , G01N33/574
摘要： PROBLEM TO BE SOLVED: To provide a technology for reducing a problem of false positive wherein a specimen to be determined to be negative is erroneously determined to be positive by a nonspecific reaction to magnetic particles in the solid phase, concerning a diagnostic agent utilizing an antigen-antibody reaction. SOLUTION: False positive in an immunodiagnostic agent can be reduced by utilizing a nonspecific reaction inhibitor comprising a protein, a polymer, salts or a combination thereof for reducing false positive by suppressing effectively a nonspecific reaction which is a problem in a diagnostic agent utilizing an antigen-antibody reaction. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种减少假阳性问题的技术，其中通过对固相中的磁性颗粒的非特异性反应将确定为阴性的样品错误地确定为阳性，涉及诊断剂利用抗原 - 抗体反应。解决方案：可以通过利用包含蛋白质，聚合物，盐或其组合的非特异性反应抑制剂来减少免疫诊断剂中的假阳性，以通过有效抑制诊断剂中的问题的非特异性反应来减少假阳性利用抗原 - 抗体反应。版权所有（C）2010，JPO＆INPIT

3. 发明专利

JP2013152247A Nonspecific interaction inhibitor and application of the same to diagnostic measuring system 审中-公开
标题翻译：非特异性相互作用抑制剂及其应用于诊断测量系统
公开(公告)号：JP2013152247A
公开(公告)日：2013-08-08
申请号：JP2013083566
申请日：2013-04-12
申请人： Abbott Japan Co Ltd , アボットジャパン株式会社
发明人： YOSHIDA EISAKU , HANDAKA MADOKA , FUJITA AKITATSU , YOSHIMURA TORU
IPC分类号： G01N33/543 , G01N33/531
摘要： PROBLEM TO BE SOLVED: To provide a technique for reducing a problem of a false positive in which a specimen to be determined as negative caused by a nonspecific reaction or the like to magnetic particulates in a solid phase in a diagnostic agent utilizing an antigen-antibody reaction is incorrectly determined as positive.SOLUTION: False positive determination in immunodiagnosis or the like can be reduced by effectively suppressing a nonspecific reaction which may be a problem in a diagnostic agent utilizing an antigen-antibody reaction and utilizing a nonspecific reaction inhibitor composed of protein, a polymer, salt or their combination for reducing false positive.
摘要翻译：要解决的问题：提供一种技术，用于减少在使用抗原抗体的诊断剂中将由非特异性反应等导致的固体中的磁性颗粒确定为阴性的样品作为阴性的假阳性的问题反应错误地确定为阳性。解决方案：通过有效抑制非特异性反应，可以减少免疫诊断等中的假阳性测定，这可能是使用抗原 - 抗体反应的诊断剂中存在的问题，并且利用由蛋白质组成的非特异性反应抑制剂，聚合物，盐或其组合以减少假阳性。

4. 发明专利

JP2007278902A Parvovirus b19 antigen measurement method 有权
标题翻译： PARVOVIRUS B19抗原测量方法
公开(公告)号：JP2007278902A
公开(公告)日：2007-10-25
申请号：JP2006106761
申请日：2006-04-07
申请人： Abbott Japan Co Ltd , アボットジャパン株式会社
发明人： HANZAWA MIKIAKI , YOSHIDA EISAKU
IPC分类号： G01N33/569 , C07K16/08 , G01N33/531
摘要： PROBLEM TO BE SOLVED: To provide a simple and high-sensitivity measurement method that does not include a treatment process using a strongly acidic solution (pH≤4.0) or a neutralization process using an alkaline solution, which is an immunity measurement method on a human parvovirus B19 antigen that does not have the problem accompanying RHA inspection or a PCR method.
SOLUTION: An immunological measurement method on a human parvovirus B19 antigen is provided where a specimen is treated by using a solution holding guanidine, guanidine salt, or its derivative. Furthermore, as a kit used in the measurement method, a kit for immunologically measuring the B19 antigen is provided that includes a diluted specimen solution holding guanidine, guanidine salt, or its derivative.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种简单且高灵敏度的测量方法，其不包括使用强酸性溶液（pH≤4.0）的处理方法或使用作为免疫测量方法的碱性溶液的中和方法在不具有伴随RHA检查或PCR方法的问题的人细小病毒B19抗原上。解决方案：提供对人细小病毒B19抗原的免疫学测量方法，其中通过使用保持胍，胍盐或其衍生物的溶液处理样品。此外，作为测定方法中使用的试剂盒，提供了用于免疫测定B19抗原的试剂盒，其包含含有胍，胍盐或其衍生物的稀释样品溶液。版权所有（C）2008，JPO＆INPIT

5. 发明申请

WO2012161288A1 IMMUNOASSAY METHODS AND REAGENTS FOR DECREASING NONSPECIFIC BINDING 审中-公开
标题翻译：用于减少非特异性结合的免疫测定方法和试剂
公开(公告)号：WO2012161288A1
公开(公告)日：2012-11-29
申请号：PCT/JP2012063398
申请日：2012-05-15
申请人： ABBOTT JAPAN CO LTD , YOSHIMURA TARU , CHIBA RYOTARO , YOSHIDA EISAKU
发明人： YOSHIMURA TARU , CHIBA RYOTARO , YOSHIDA EISAKU
IPC分类号： G01N33/543
CPC分类号： G01N33/86
摘要： Methods and kits for reducing non-specific binding in an immunoassay for PIVKA-II in a test sample are described, in which the test sample is reacted with an anti-prothrombin antibody in the presence of one or more of the following additives: skim milk, saponin, CaCl2, MgCl2, and a sulfobetaine zwitterionic detergent.
摘要翻译：描述了在测试样品中用于降低PIVKA-II的免疫测定中的非特异性结合的方法和试剂盒，其中所述测试样品在一种或多种以下添加剂存在下与抗凝血酶原抗体反应：脱脂乳，皂角苷，CaCl 2，MgCl 2和磺基甜菜碱两性离子洗涤剂。

6. 发明申请

WO2017057778A3 USE OF LAMININ 2 FOR DIAGNOSING HEPATOCELLULAR CARCINOMA AND PANCREATIC CANCER 审中-公开
标题翻译：层粘蛋白2在诊断肝细胞癌和胰腺癌中的应用
公开(公告)号：WO2017057778A3
公开(公告)日：2017-05-11
申请号：PCT/JP2016079711
申请日：2016-09-28
申请人： ABBOTT JAPAN CO LTD , UNIV TOKYO
发明人： YOSHIMURA TORU , YOSHIDA EISAKU , KOSHIKAWA NAOHIKO , SEIKI MOTOHARU
IPC分类号： G01N33/574
CPC分类号： G01N33/57438 , G01N2333/78 , G01N2800/50 , G01N2800/56
摘要： Disclosed herein are biomarkers for hepatocellular carcinoma and pancreatic cancer. The biomarkers may be laminin gamma 2 monomer, PIVKA-II, AFP, CEA, CA19-9, or combinations thereof. Also disclosed herein are methods of diagnosing, prognosing, classifying risk, and monitoring progression of hepatocellular carcinoma or pancreatic cancer by the detecting the level of laminin gamma 2 monomer, PIVKA-II, AFP, CEA, CA19-9, or combinations thereof.
摘要翻译：本文公开了用于肝细胞癌和胰腺癌的生物标志物。生物标志物可以是层粘连蛋白γ2单体，PIVKA-II，AFP，CEA，CA19-9或其组合。本文还公开了通过检测层粘连蛋白γ2单体，PIVKA-II，AFP，CEA，CA19-9或其组合的水平来诊断，预测，分类风险和监测肝细胞癌或胰腺癌的进展的方法。

7. 发明专利

CA2806029A1 ANTIBODIES RELATING TO PIVKA-II AND USES THEREOF 未知
公开(公告)号：CA2806029A1
公开(公告)日：2012-02-09
申请号：CA2806029
申请日：2011-07-08
申请人： ABBOTT LAB , ABBOTT JAPAN CO LTD
发明人： YOSHIMURA TORU , DOWELL BARRY L , BELIGERE GANGAMANI S , YOSHIDA EISAKU
IPC分类号： C07K16/40 , G01N33/574
摘要： The present disclosure relates to antibodies and immunoassay methods for use in the diagnosis, treatment and prevention of hepatocellular carcinoma (HCC), liver cancer and related conditions.

8. 发明专利

ES2784369T3 Uso de laminina 2 para el diagnóstico de carcinoma hepatocelular y cáncer de páncreas 未知
公开(公告)号：ES2784369T3
公开(公告)日：2020-09-24
申请号：ES16788569
申请日：2016-09-28
申请人： ABBOTT JAPAN CO LTD , UNIV TOKYO
发明人： YOSHIMURA TORU , YOSHIDA EISAKU , KOSHIKAWA NAOHIKO , SEIKI MOTOHARU
IPC分类号： G01N33/574
摘要： Un método para diagnosticar carcinoma hepatocelular (HCC) en un sujeto con necesidad de ello, el método comprendiendo: (a) determinar los niveles de monómero de laminina gamma 2 y uno o ambos de antagonista-II de vitamina K inducido por proteínas (PIVKA-II) y alfa fetoproteína (AFP) en una muestra biológica obtenida del sujeto; (b) comparar el nivel de monómero de laminina gamma 2 y uno o ambos de antagonista-II de vitamina K inducido por proteínas (PIVKA-II) y alfa fetoproteína (AFP) con niveles de referencia de monómero de laminina gamma 2, PIVKA-II y/o AFP; y (c) identificar que el sujeto tiene HCC cuando los niveles de monómero de laminina gamma 2 y uno o ambos de PIVKA-II y AFP son mayores que los niveles de referencia de monómero de laminina gamma 2, PIVKA-II y/o AFP, respectivamente.

9. 发明专利

HK1211345A1 METHODS OF PROGNOSIS AND DIAGNOSIS OF CANCER 未知
公开(公告)号：HK1211345A1
公开(公告)日：2016-05-20
申请号：HK15112178
申请日：2015-12-10
申请人： ABBOTT JAPAN CO LTD , UNIV TOKYO
发明人： KOSHIKAWA NAOHIKO , NAKAGAWA MASATOSHI , YOSHIDA EISAKU , YOSHIMURA TORU , SEIKI MOTOHARU
IPC分类号： G01N20060101
摘要： Provided are methods of diagnosing cancer in a patient by detecting the presence and/or amount of a biomarker of cancer in a sample from the patient. The methods and biomarkers may be used to develop an accurate prognosis for a patient having cancer or suspected of having cancer, or to accurately diagnose a patient having, or suspected of having cancer. The methods and biomarkers may be used to identify and/or classify a patient as a candidate for a cancer therapy.

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