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1. 发明申请

WO2008003114A2 IDENTIFICATION OF PATHOGENS 审中-公开
标题翻译：病原体鉴定
公开(公告)号：WO2008003114A2
公开(公告)日：2008-01-10
申请号：PCT/AT2007/000341
申请日：2007-07-05
申请人： AUSTRIAN RESEARCH CENTERS GMBH - ARC , WIESINGER-MAYR, Herbert , PICHLER, Rudolf , BODROSSY, Levente , NÖHAMMER, Christa
发明人： WIESINGER-MAYR, Herbert , PICHLER, Rudolf , BODROSSY, Levente , NÖHAMMER, Christa
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q1/6837 , C12Q1/6895 , C12Q2600/16 , G06F19/20
摘要： Disclosed is a method for identification of microbial pathogens in a body fluid sample comprising the following steps: a) providing a body fluid sample; b) lysing the microbial pathogens and performing a nucleic acid amplification reaction on the microbial DNA encoding 16S or 18S rRNA wherein or whereafter the amplified nucleic acids are labelled; c) contacting the labelled amplified nucleic acids of step b) with a microarray comprising on defined areas on the microarray's surface immobilised probes for microbial DNA encoding 16S or 18S rRNA from microbial pathogens; d) detecting the binding of one or more species of the labelled amplified nucleic acids to a probe by detecting a labelled amplified nucleic acid being specifically bound to the microarray; and e) identifying a microbial pathogen in the body fluid sample by correlating the detected binding of the labelled amplified nucleic acids with the defined areas of the immobilised probes for microbial DNA encoding 16S or 18S rRNA from microbial pathogens.
摘要翻译：公开了一种用于鉴定体液样品中的微生物病原体的方法，包括以下步骤：a）提供体液样品; b）裂解微生物病原体并对编码16S或18S rRNA的微生物DNA进行核酸扩增反应，其中扩增的核酸被标记; c）将步骤b）的标记的扩增的核酸与包含在微阵列表面上的限定区域上的微阵列接触，用于从微生物病原体编码16S或18S rRNA的微生物DNA的固定化探针; d）通过检测特异性结合于微阵列的标记的扩增核酸来检测一种或多种标记的扩增核酸与探针的结合; 和e）通过将检测到的标记的扩增的核酸的结合与来自微生物病原体的编码16S或18S rRNA的微生物DNA的固定化探针的限定区域相关联来鉴定体液样品中的微生物病原体。

2. 发明申请

WO2007115344A1 SET OF OLIGONUCLEOTIDES 审中-公开
标题翻译：一套寡妇
公开(公告)号：WO2007115344A1
公开(公告)日：2007-10-18
申请号：PCT/AT2007/000158
申请日：2007-04-10
申请人： AUSTRIAN RESEARCH CENTERS GMBH-ARC , SESSITSCH, ANgela , BODROSSY, Levente , KOSTIC, Tanja , WEILHARTER, Alexandra
发明人： SESSITSCH, ANgela , BODROSSY, Levente , KOSTIC, Tanja , WEILHARTER, Alexandra
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q2600/16 , C12Q2600/166 , Y02A50/52
摘要： The present invention provides a set of oligonucleotides specif ic for the gyrB gene of a microorganism, characterized in that at least one oligonucleotide comprises a sequence of SEQ ID NOs 1 to 71 or a fragment of a sequence of SEQ ID NOs 1 to 71 of at least 14 nucleotides, with optionally 1 or 2 point mutations, and complementary reverse sequences thereto.
摘要翻译：本发明提供了一组针对微生物的gyrB基因的寡核苷酸，其特征在于至少一种寡核苷酸包含SEQ ID NO：1至71的序列或SEQ ID NO：1至71的序列的片段至少14个核苷酸，任选1或2个点突变，以及与其互补的反向序列。

3. 发明公开

EP2046982A2 IDENTIFICATION OF PATHOGENS 有权
标题翻译：病原的
公开(公告)号：EP2046982A2
公开(公告)日：2009-04-15
申请号：EP07784579.0
申请日：2007-07-05
申请人： Austrian Research Centers Gmbh - Arc
发明人： WIESINGER-MAYR, Herbert , PICHLER, Rudolf , BODROSSY, Levente , NÖHAMMER, Christa
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q1/6837 , C12Q1/6895 , C12Q2600/16 , G06F19/20
摘要： Disclosed is a method for identification of microbial pathogens in a body fluid sample comprising the following steps: a) providing a body fluid sample; b) lysing the microbial pathogens and performing a nucleic acid amplification reaction on the microbial DNA encoding 16S or 18S rRNA wherein or whereafter the amplified nucleic acids are labelled; c) contacting the labelled amplified nucleic acids of step b) with a microarray comprising on defined areas on the microarray's surface immobilised probes for microbial DNA encoding 16S or 18S rRNA from microbial pathogens; d) detecting the binding of one or more species of the labelled amplified nucleic acids to a probe by detecting a labelled amplified nucleic acid being specifically bound to the microarray; and e) identifying a microbial pathogen in the body fluid sample by correlating the detected binding of the labelled amplified nucleic acids with the defined areas of the immobilised probes for microbial DNA encoding 16S or 18S rRNA from microbial pathogens.

4. 发明公开

EP2004851A1 SET OF OLIGONUCLEOTIDES 审中-公开
标题翻译：一套寡核苷酸
公开(公告)号：EP2004851A1
公开(公告)日：2008-12-24
申请号：EP07718375.4
申请日：2007-04-10
申请人： Austrian Research Centers Gmbh - Arc
发明人： SESSITSCH, Angela , BODROSSY, Levente , KOSTIC, Tanja , WEILHARTER, Alexandra
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q2600/16 , C12Q2600/166 , Y02A50/52
摘要： The present invention provides a set of oligonucleotides specif ic for the gyrB gene of a microorganism, characterized in that at least one oligonucleotide comprises a sequence of SEQ ID NOs 1 to 71 or a fragment of a sequence of SEQ ID NOs 1 to 71 of at least 14 nucleotides, with optionally 1 or 2 point mutations, and complementary reverse sequences thereto.
摘要翻译：本发明提供了一组特异于微生物gyrB基因的寡核苷酸，其特征在于至少一个寡核苷酸包含SEQ ID NOs 1至71的序列或至少SEQ ID NOs 1至71的序列的片段， 14个核苷酸，任选具有1或2个点突变，以及与其互补的反向序列。

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