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1. 发明专利

IL185306A ANTIBACTERIAL PIPERIDINE DERIVATIVES 未知
公开(公告)号：IL185306A
公开(公告)日：2012-05-31
申请号：IL18530607
申请日：2007-08-15
申请人： ASTRAZENECA AB , ZHOU FEI , GRAVESTOCK MICHAEL BARRY , GREEN OLUYINKA MORENIKE , HULL KENNETH GREGORY , NI HAIHONG , HAUCK SHEILA IRENE , MULLEN GEORGE BYRON , BASARAB GREG , DANGEL BRIAN , FLEMING PAUL ROBERT , HILL PAMELA , SHERER BRIAN
发明人： ZHOU FEI , GRAVESTOCK MICHAEL BARRY , GREEN OLUYINKA MORENIKE , HULL KENNETH GREGORY , NI HAIHONG , HAUCK SHEILA IRENE , MULLEN GEORGE BYRON , BASARAB GREG , DANGEL BRIAN , FLEMING PAUL ROBERT , HILL PAMELA , SHERER BRIAN
摘要： Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use in the treatment of bacterial infections are also described.

2. 发明申请

WO2006087543A8 ANTIBACTERIAL PIPERIDINE DERIVATIVES 审中-公开
标题翻译：抗生素哌啶衍生物
公开(公告)号：WO2006087543A8
公开(公告)日：2007-10-18
申请号：PCT/GB2006000529
申请日：2006-02-16
申请人： ASTRAZENECA AB , ASTRAZENECA UK LTD , BASARAB GREG , DANGEL BRIAN , FLEMING PAUL ROBERT , GRAVESTOCK MICHAEL BARRY , GREEN OLUYINKA , HAUCK SHEILA IRENE , HILL PAMELA , HULL KENNETH GREGORY , MULLEN GEORGE , SHERER BRIAN , ZHOU FEI , NI HAIHONG
发明人： BASARAB GREG , DANGEL BRIAN , FLEMING PAUL ROBERT , GRAVESTOCK MICHAEL BARRY , GREEN OLUYINKA , HAUCK SHEILA IRENE , HILL PAMELA , HULL KENNETH GREGORY , MULLEN GEORGE , SHERER BRIAN , ZHOU FEI , NI HAIHONG
IPC分类号： C07D401/14 , A61K31/54 , C07D417/14
CPC分类号： C07D417/14 , C07D401/14 , C07D513/04
摘要： Compounds of formula (I) and their pharmaceutically acceptable salts are described: Formula (I). Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
摘要翻译：描述式（I）化合物及其药学上可接受的盐：式（I）。还描述了其制备方法，含有它们的药物组合物，其作为药物的用途及其在治疗细菌感染中的用途。

3. 发明申请

WO2006092599A3 PYRROLE DERIVATIVES AS DNA GYRASE AND TOPOISOMERASE INHIBITORS 审中-公开
标题翻译：吡咯衍生物作为DNA GYRASE和TOPOISOMERASE抑制剂
公开(公告)号：WO2006092599A3
公开(公告)日：2006-12-21
申请号：PCT/GB2006000742
申请日：2006-03-02
申请人： ASTRAZENECA AB , ASTRAZENECA UK LTD , BASARAB GREG , GRAVESTOCK MICHAEL BARRY , HAUCK SHEILA IRENE
发明人： BASARAB GREG , GRAVESTOCK MICHAEL BARRY , HAUCK SHEILA IRENE
IPC分类号： C07D403/12 , A61K31/4192 , A61P31/04 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04
CPC分类号： C07D471/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： Compounds of formula (I) and their pharmaceutically acceptable salts are described: Formula (I). Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
摘要翻译：描述式（I）化合物及其药学上可接受的盐：式（I）。还描述了其制备方法，含有它们的药物组合物，其作为药物的用途及其在治疗细菌感染中的用途。

4. 发明专利

JP2007326882A Antibacterial piperidine derivative 审中-公开
公开(公告)号：JP2007326882A
公开(公告)日：2007-12-20
申请号：JP2007239383
申请日：2007-09-14
申请人： Astrazeneca Ab , アストラゼネカアクチボラグ
发明人： BASARAB GREG , DANGEL BRIAN , FLEMING PAUL ROBERT , GRAVESTOCK MICHAEL BARRY , GREEN OLUYINKA , HAUCK SHEILA IRENE , HILL PAMELA , HULL KENNETH GREGORY , MULLEN GEORGE , SHERER BRIAN , ZHOU FEI , NI HAIHONG
IPC分类号： C07D401/14 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/506 , A61K31/5355 , A61P31/04 , A61P43/00 , C07D403/14 , C07D417/14
CPC分类号： C07D417/14 , C07D401/14 , C07D513/04
摘要： PROBLEM TO BE SOLVED: To provide a useful piperidine derivative. SOLUTION: The compound is represented by formula (I) or a pharmaceutically acceptable salts thereof. COPYRIGHT: (C)2008,JPO&INPIT

5. 发明专利

JP2007326883A Antibacterial piperidine derivative 审中-公开
标题翻译：抗生素哌啶衍生物
公开(公告)号：JP2007326883A
公开(公告)日：2007-12-20
申请号：JP2007239427
申请日：2007-09-14
申请人： Astrazeneca Ab , アストラゼネカアクチボラグ
发明人： BASARAB GREG , DANGEL BRIAN , FLEMING PAUL ROBERT , GRAVESTOCK MICHAEL BARRY , GREEN OLUYINKA , HAUCK SHEILA IRENE , HILL PAMELA , HULL KENNETH GREGORY , MULLEN GEORGE , SHERER BRIAN , ZHOU FEI , NI HAIHONG
IPC分类号： C07D401/14 , A61K31/454 , A61K31/4709 , A61K31/506 , A61K31/5377 , A61P31/04 , C07D405/14 , C07D417/04 , C07D417/14
CPC分类号： C07D417/14 , C07D401/14 , C07D513/04
摘要： PROBLEM TO BE SOLVED: To provide a useful piperidine derivative. SOLUTION: The compound is represented by formula (I) or a pharmaceutically acceptable salts thereof. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供有用的哌啶衍生物。化合物由式（I）表示或其药学上可接受的盐。版权所有（C）2008，JPO＆INPIT

6. 发明专利

JP2008024715A Antibacterial piperidine derivatives 审中-公开
标题翻译：抗生素哌啶衍生物
公开(公告)号：JP2008024715A
公开(公告)日：2008-02-07
申请号：JP2007239467
申请日：2007-09-14
申请人： Astrazeneca Ab , アストラゼネカアクチボラグ
发明人： BASARAB GREG , DANGEL BRIAN , FLEMING PAUL ROBERT , GRAVESTOCK MICHAEL BARRY , GREEN OLUYINKA , HAUCK SHEILA IRENE , HILL PAMELA , HULL KENNETH GREGORY , MULLEN GEORGE , SHERER BRIAN , ZHOU FEI , NI HAIHONG
IPC分类号： C07D401/14 , A61K31/454 , A61K31/4545 , A61K31/455 , A61K31/4709 , A61K31/506 , A61K31/5377 , A61P31/04 , A61P43/00 , C07D417/14 , C07D513/04
CPC分类号： C07D417/14 , C07D401/14 , C07D513/04
摘要： PROBLEM TO BE SOLVED: To provide piperidine derivatives which inhibit the DNA gyrase and topoisomerase IV of bacteria and are useful as antibacterial agents. SOLUTION: Compounds of formula (1) [R1 is H, OH, a halogen, or the like; R2 is H, OH, a halogen, or the like; R3 is H, nitro, OH, a halogen, or the like; R4 and R5 are each a substituent on carbon, such as a halogen, amino, or carboxy; (n) is 1 to 4; (m) is 0 to 4; W is -O- or the like; X is a direct bond, -CH2-, or the like; ring A is thiazole, pyridine or the like] or their pharmaceutically acceptable salt are useful as antibacterial agents. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供抑制细菌的DNA促旋酶和拓扑异构酶IV的哌啶衍生物，并且可用作抗菌剂。解决方案：式（1）的化合物[R 1是H，OH，卤素等; R2是H，OH，卤素等; R3是H，硝基，OH，卤素等; R 4和R 5各自为碳上的取代基，例如卤素，氨基或羧基; （n）为1〜4; （m）为0〜4; W是-O-等; X是直接键，-CH 2 - 等; 环A为噻唑，吡啶等]或其药学上可接受的盐可用作抗菌剂。版权所有（C）2008，JPO＆INPIT

7. 发明专利

ES2430569T3 Compuestos antibacterianos derivados de piperidina 未知
公开(公告)号：ES2430569T3
公开(公告)日：2013-11-21
申请号：ES06709766
申请日：2006-02-16
申请人： ASTRAZENECA AB ASTRAZENECA AB
发明人： BASARAB GREG , DANGEL BRIAN , FLEMING PAUL ROBERT , GRAVESTOCK MICHAEL BARRY , GREEN OLUYINKA , HAUCK SHEILA IRENE , HILL PAMELA , HULL KENNETH GREGORY , MULLEN GEORGE , SHERER BRIAN , ZHOU FEI , NI HAIHONG
IPC分类号： C07D401/14 , A61K31/54 , C07D417/14
摘要： Un compuesto de la fórmula (I):**Fórmula** en donde: R1 se selecciona de hidrógeno, nitro, hidroxi, halo, ciano, alquilo C1-4, alcoxi C1-4, alquenilo C2-4, alquinilo C2-4,alcanoilo C1-4, alquilo C1-4S(O)a en donde a es 0 a 2 y cicloalquilo C3-6; en donde R1 se puede sustituir opcionalmenteen el carbono por uno o más halo o ciclopropilo; R2 se selecciona de hidrógeno, nitro, hidroxi, halo, ciano, alquilo C1-4, alcoxi C1-4, alquenilo C2-4, alquinilo C2-4,alcanoilo C1-4, alquilo C1-4S(O)a en donde a es 0 a 2 y cicloalquilo C3-6; en donde R2 se puede sustituir opcionalmenteen el carbono por uno o más halo o cicloalquilo C3-6; R3 se selecciona de hidrógeno, nitro, hidroxi, halo, ciano, -C>=N-OR' en donde R' es H o alquilo C1-4, alquilo C1-4,alcoxi C1-4, alquenilo C2-4, alquinilo C2-4, alcanoilo C1-4, alquilo C1-4S(O)a en donde a es 0 a 2 y cicloalquilo C3-6; endonde R3 se puede sustituir opcionalmente en el carbono por uno o más halo o cicloalquilo C3-6; W es -O-, -N(R6)-o -C(R7)(R8)-; X es un enlace directo, -CH2-, -C(O)-o S(O)q-(en donde q es 1 o 2); El anillo A es carbociclilo o heterociclilo; en donde si dicho heterociclilo contiene una unidad estructural -NH- elnitrógeno se puede sustituir opcionalmente por un grupo seleccionado de R9; R4 y R5 son sustituyentes en carbono y se seleccionan independientemente de halo, nitro, ciano, hidroxi,trifluorometoxi, amino, carboxi, carbamoilo, mercapto, sulfamoilo, sulfo, formilo, ureido, hidroxiiminometilo,alcoxiiminometilo C1-4, N-hidroxiformamido, Hidrazina C1-4, hidrazinocarbonilo, N-hidroxietanimidoilo,amino(hidroxiimino)metilo, alquilo C1-4, alquenilo C2-4, alquinilo C2-4, alcoxi C1-4, alcanoilo C1-4, alcanoiloxi C1-4, N-(alquilo C1-4)amino, N, N-(alquilo C1-4)2amino, alcanoilamino C1-4, N-(alquilo C1-4)carbamoilo, N, N-(alquilo C1-4)2carbamoilo, N-(alcoxi C1-4)carbamoilo, N'-(alquilo C1-4)ureido, N', N'-(alquilo C1-4)2ureido, N-(alquilo C1-4)-N-(alcoxiC1-4)carbamoilo, alquilo C1-4S(O)a en donde a es 0 a 2, alcoxicarbonilo C1-4, alcoxicarbonilamino C1-4, N-(alquilo C1-4)sulfamoilo, N, N-(alquilo C1-4)2sulfamoilo, alquilsulfonilamino C1-4, alquilsulfonilaminocarbonilo C1-4, N'-(alquilo C1-4)hidrazinocarbonilo, N', N'-(alquilo C1-4)2hidrazinocarbonilo, carbociclilo-R10-o heterociclilo-R11-; en donde R4 y R5independientemente uno del otro se puede sustituir opcionalmente en el carbono por uno o más R12; y en donde sidicho heterociclilo contiene una unidad estructural -NH- el nitrógeno se puede sustituir opcionalmente por un gruposeleccionado de R13.

8. 发明专利

HK1114376A1 ANTIBACTERIAL PIPERIDINE DERIVATIVES 未知
公开(公告)号：HK1114376A1
公开(公告)日：2008-10-31
申请号：HK08102716
申请日：2008-03-07
申请人： ASTRAZENECA AB
发明人： BASARAB GREG , DANGEL BRIAN , FLEMING PAUL ROBERT , GRAVESTOCK MICHAEL BARRY , GREEN OLUYINKA , HAUCK SHEILA IRENE , HILL PAMELA , HULL KENNETH GREGORY , MULLEN GEORGE , SHERER BRIAN , ZHOU FEI , NI HAIHONG
IPC分类号： C07D20060101 , A61K20060101
摘要： Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use in the treatment of bacterial infections are also described.

9. 发明专利

CA2598423C ANTIBACTERIAL PIPERIDINE DERIVATIVES 未知
公开(公告)号：CA2598423C
公开(公告)日：2014-05-27
申请号：CA2598423
申请日：2006-02-16
申请人： ASTRAZENECA AB
发明人： BASARAB GREG , DANGEL BRIAN , FLEMING PAUL ROBERT , GRAVESTOCK MICHAEL BARRY , GREEN OLUYINKA , HAUCK SHEILA IRENE , HILL PAMELA , HULL KENNETH GREGORY , MULLEN GEORGE , SHERER BRIAN , ZHOU FEI , NI HAIHONG
IPC分类号： C07D417/14 , A61K31/454 , A61P31/04 , C07D401/14
摘要： Compounds of formula (I) and their pharmaceutically acceptable salts are described: Formula (I). Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.

10. 发明专利

UA94901C2 АНТИБАКТЕРИАЛЬНЫЕ ПРОИЗВОДНЫЕ ПИПЕРИДИНА 未知
公开(公告)号：UA94901C2
公开(公告)日：2011-06-25
申请号：UAA200710264
申请日：2006-02-16
申请人： ASTRAZENECA AB
发明人： BASARAB GREG , DANGEL BRIAN , FLEMING PAUL ROBERT , GRAVESTOCK MICHAEL BARRY , GREEN OLUYINKA , HAUCK SHEILA IRENE , HILL PAMELA , HULL KENNETH GREGORY , MULLEN GEORGE , SHERER BRIAN , ZHOU FEI
IPC分类号： C07D401/14 , A61K31/54 , C07D417/14
摘要： Описанысоединенияформулы (I) иихфармацевтическиприемлемыесоли. Такжеописаныспособыихполучения, фармацевтическиекомпозиции, которыеихсодержат, ихприменениекаклекарственныхсредстви ихприменениедлялечениябактериальныхинфекций. EMBED ISISServer (I)

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