专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2010117323A8 ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS 审中-公开
标题翻译： ISOXAZOL-3（2H） - 作为治疗剂的模拟物
公开(公告)号：WO2010117323A8
公开(公告)日：2010-11-18
申请号：PCT/SE2010050375
申请日：2010-04-06
申请人： ASTRAZENECA AB , BOSTROEM JONAS , CHENG LEIFENG , FEX TOMAS , KARLE MICHAEL , PETTERSEN DANIEL , SCHELL PETER
发明人： BOSTROEM JONAS , CHENG LEIFENG , FEX TOMAS , KARLE MICHAEL , PETTERSEN DANIEL , SCHELL PETER
IPC分类号： C07D413/04 , A61K31/4523 , A61P7/04
CPC分类号： C07D413/04
摘要： Formula I or a pharmaceutically suitable salt thereof, wherein, R1 and R2 independently are hydrogen, deuterium, aryl, hetero aryl, C1-C8 alkyl, optionally being substituted with one or more substituents independently being R3, R3 is an aryl, hetero aryl, fluorine(s), a C1-C6 alkyl containing one or more fluorine, a C1-C6 alkyl containing one or more deuterium, a C1-C6 alkyl containing hydroxy, the aryl and heteroaryl optionally being substituted with one or more halogen, a fluorinated alkoxy, a fluorinated alkyl, a sulfonyl, one or more deuterium, a C1-6 alkyl, a C1-6 alkoxy, a nitrile, or R3 is a C1-6 alkyl optionally substituted with one or more of the following groups: COOR4, OCOR4, CONR5R6, NR5COR6, OR4; wherein, R4 is a C1-10 alkyl optionally substituted with one or more fluorine, deuterium, alkoxy, arylcarboxylate, alkyl carboxylate; R5 and R6 are independently selected from hydrogen, alkyl or they may together form a 4-8 membered carbon ring; or R1 and R2 form a 3-10 membered carbon ring optionally comprising O or N and optionally substituted with a C1-10 alkyl or aryl, hetero aryl optionally substituted with R3.
摘要翻译：式I或其药学上合适的盐，其中R 1和R 2独立地是氢，氘，芳基，杂芳基，任选被一个或多个取代基独立地被R 3取代的C 1 -C 8烷基，R 3是芳基，杂芳基，氟，含有一个或多个氟的C 1 -C 6烷基，含有一个或多个氘的C 1 -C 6烷基，含羟基的C 1 -C 6烷基，任选被一个或多个卤素取代的芳基和杂芳基，氟化烷氧基，氟化烷基，磺酰基，一个或多个氘，C 1-6烷基，C 1-6烷氧基，腈或R 3是任选被一个或多个下列基团取代的C 1-6烷基：COOR 4， OCOR4，CONR5R6，NR5COR6，OR4; 其中，R4为任选被一个或多个氟，氘，烷氧基，芳基羧酸酯，羧酸烷基酯取代的C 1-10烷基; R 5和R 6独立地选自氢，烷基或它们可以一起形成4-8元碳环; 或R 1和R 2形成任选地包含O或N并任选被C 1-10烷基或芳基取代的3-10元碳环，任选被R 3取代的杂芳基。

2. 发明公开

EP2417131A4 ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS 审中-公开
标题翻译： ISOXAZOL-3（2H）-ON-ANALOGA ALS THERAPEUTIKA
公开(公告)号：EP2417131A4
公开(公告)日：2014-08-27
申请号：EP10761933
申请日：2010-04-06
申请人： ASTRAZENECA AB
发明人： BOSTRÖM JONAS , CHENG LEIFENG , FEX TOMAS , KARLE MICHAEL , PETTERSEN DANIEL , SCHELL PETER
IPC分类号： C07D413/04 , A61K31/4523 , A61P7/04
CPC分类号： C07D413/04

3. 发明公开

EP2146996A4 XANTHINE COMPOUNDS HAVING A POSITIVE ALLOSTERIC GABAB RECEPTOR MODULATOR EFFECT 审中-公开
标题翻译： WITH A正变构GABA B受体调节剂作用克桑西LINKS
公开(公告)号：EP2146996A4
公开(公告)日：2011-08-03
申请号：EP08779237
申请日：2008-04-17
申请人： ASTRAZENECA AB
发明人： CHENG LEIFENG , HOLMQVIST SARA , RAUBACHER FLORIAN , SCHELL PETER
IPC分类号： C07D487/04 , A61K31/522 , A61P1/04
CPC分类号： C07D473/04 , C07D473/06 , C07F7/1856

4. 发明专利

CO6440580A2 ANÁLOGOS DE ISOXAZOL-3(2H)-ONA COMO AGENTES TERAPÉUTICOS 未知
公开(公告)号：CO6440580A2
公开(公告)日：2012-05-15
申请号：CO11132448
申请日：2011-10-06
申请人： ASTRAZENECA AB
发明人： BOSTROM JONAS , CHENG LEIFENG , FEX TOMAS , KARLE MICHAEL , PETTERSEN DANIEL , SCHELL PETER
IPC分类号： A61K31/4523 , A61P7/04 , C07D413/04
摘要： Un compuesto de Fórmula Io una sal farmacéuticamente aceptable de este, donde R1 y R2 son independientemente hidrógeno, deuterio, arilo, heteroarilo, alquilo C1-C8, y están opcionalmente sustituidos con uno o más sustituyentes que son independientemente R3,R3 es un arilo, heteroarilo, uno o más átomos de flúor, un alquilo C1-C6 que contiene uno o más átomos de flúor, un alquilo C1-C6 que contiene uno o más átomos de deuterio, un alquilo C1-C6 que contiene hidroxi, estando el arilo y el heteroarilo opcionalmente sustituidos con uno o más halógenos, un alcoxi fluorado, un alquilo fluorado, un sulfonilo, uno o más átomos de deuterio, un alquilo C1-C6, un alcoxi C1-C6, un nitrilo,o R3 es un alquilo C1-C6 opcionalmente sustituido con uno o más de los siguientes grupos: COOR4, OCOR4, CONR5R6, NRSCOR6, OR4;donde R4 es un alquilo C1-C10 opcionalmente sustituido con uno o más átomos de flúor, deuterio, alcoxi, carboxilato de arilo, carboxilato de alquilo;R5 y R6 se seleccionan independientemente entre hidrógeno, alquilo o pueden formar conjuntamente un anillo de carbono de 4-8 miembros;o R1 y R2 forman un anillo de carbono de 3-10 miembros que comprende opcionalmente O o N y está opcionalmente sustituido con un alquilo o arilo C1-C10, heteroarilo opcionalmente sustituido con R3.

5. 发明专利

SG174463A1 ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS 未知
公开(公告)号：SG174463A1
公开(公告)日：2011-10-28
申请号：SG2011067568
申请日：2010-04-06
申请人： ASTRAZENECA AB
发明人： BOSTROEM JONAS , CHENG LEIFENG , FEX TOMAS , KARLE MICHAEL , PETTERSEN DANIEL , SCHELL PETER
摘要： Formula I or a pharmaceutically suitable salt thereof, wherein, R1 and R2 independently are hydrogen, deuterium, aryl, hetero aryl, C1-C8 alkyl, optionally being substituted with one or more substituents independently being R3, R3 is an aryl, hetero aryl, fluorine(s), a C1-C6 alkyl containing one or more fluorine, a C1-C6 alkyl containing one or more deuterium, a C1-C6 alkyl containing hydroxy, the aryl and heteroaryl optionally being substituted with one or more halogen, a fluorinated alkoxy, a fluorinated alkyl, a sulfonyl, one or more deuterium, a C1-6 alkyl, a C1-6 alkoxy, a nitrile, or R3 is a C1-6 alkyl optionally substituted with one or more of the following groups: COOR4, OCOR4, CONR5R6, NR5COR6, OR4; wherein, R4 is a C1-10 alkyl optionally substituted with one or more fluorine, deuterium, alkoxy, arylcarboxylate, alkyl carboxylate; R5 and R6 are independently selected from hydrogen, alkyl or they may together form a 4-8 membered carbon ring; or R1 and R2 form a 3-10 membered carbon ring optionally comprising O or N and optionally substituted with a C1-10 alkyl or aryl, hetero aryl optionally substituted with R3.

6. 发明专利

ZA201108119B ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS 未知
公开(公告)号：ZA201108119B
公开(公告)日：2012-07-25
申请号：ZA201108119
申请日：2011-11-04
申请人： ASTRAZENECA AB
发明人： BOSTROM JONAS , FEX TOMAS , PETTERSEN DANIEL , CHENG LEIFENG , KARLE MICHAEL , SCHELL PETER
IPC分类号： A61K20060101 , A61P20060101 , C07D20060101

7. 发明专利

CA2682301A1 XANTHINE COMPOUNDS HAVING A POSITIVE ALLOSTERIC GABAB RECEPTOR MODULATOR EFFECT 未知
公开(公告)号：CA2682301A1
公开(公告)日：2008-10-30
申请号：CA2682301
申请日：2008-04-17
申请人： ASTRAZENECA AB
发明人： SCHELL PETER , RAUBACHER FLORIAN , CHENG LEIFENG , HOLMQVIST SARA
IPC分类号： C07D487/04 , A61K31/522 , A61P1/04
摘要： The present invention relates to novel xanthine compounds of the general formula (I) wherein R1, R2, R3 and R4 are as defined, having a positive allo steric GABA Breceptor (GBR) modulator effect, methods for the preparation of said compounds and to their use, optionally in combination with a GABA Bago nist, for the inhibition of transient lower esophageal sphincter relaxations , for the treatment of gastroesophageal reflux disease, as well as for the t reatment of functional gastrointestinal disorders and irritable bowel syndro me (IBS).

8. 发明专利

CA2615588A1 PYRAZOLE DERIVATIVES AS CBL MODULATORS 未知
公开(公告)号：CA2615588A1
公开(公告)日：2007-01-25
申请号：CA2615588
申请日：2006-07-17
申请人： ASTRAZENECA AB
发明人： SCHELL PETER , JONFORSEN MARIA , CHENG LEIFENG
IPC分类号： C07D401/12 , A61P3/04 , A61P25/18 , A61P25/28 , C07D231/14
摘要： The present invention relates to compounds of formula (I) wherein R1 represents a group R5O- in which R5 represents a C3-7alkyl group substituted by one or more fluoro or R5 represents a C3-7alkylsulphonyl group which is optionally substituted by one or more fluoro; R2 represents a C1-4alkyl group, hydroxy, fluoro, chloro or cyano wherein each R2 is independently selected when n is >1; R3 represents a) cyclohexyl optionally substituted by one or more of the following: hydroxy, fluoro, amino, mono or diC1-3alkylamino, carboxy or a C1-4alkoxycarbonyl group b) piperidino substituted by one or more hydroxy c) unsubstituted piperidino but only when one of the following applies: R4 represents cyano or R1 represents 3-fluoropropylsulphonyloxy or R1 represents 3,3,3-trifluoropropoxy or R1 represents 3-fluoropropoxy or R2 is methyl d) phenyl substituted by one or more of the following: hydroxy, halo or a C1-4alkyl group e) pyridyl substituted by a C1-4alkyl group or f) a C4- 9alkyl group; R4 represents cyano or methyl; and n is 1, 2 or 3 and pharmaceutically acceptable salts thereof and processes for preparing such compounds, their use in the treatment of obesity, psychiatric and neurological disorders, to methods for their therapeutic use and to pharmaceutical compositions containing them.

9. 发明专利

AU2006271499A1 Pyrazole derivatives as CB1 modulators 未知
公开(公告)号：AU2006271499A1
公开(公告)日：2007-01-25
申请号：AU2006271499
申请日：2006-07-17
申请人： ASTRAZENECA AB
发明人： CHENG LEIFENG , SCHELL PETER , JONFORSEN MARIA
IPC分类号： C07D401/12 , A61P3/04 , A61P25/18 , A61P25/28 , C07D231/14
摘要： The present invention relates to compounds of formula I wherein R 1 represents a group R 5 O- in which R 5 represents a C 3-7 alkyl group substituted by one or more fluoro or R 5 represents a C 3-7 alkylsulphonyl group which is optionally substituted by one or more fluoro; R 2 represents a C 1-4 alkyl group, hydroxy, fluoro, chloro or cyano wherein each R 2 is independently selected when n is >1; R 3 represents a) cyclohexyl optionally substituted by one or more of the following: hydroxy, fluoro, amino, mono or diC 1-3 alkylamino, carboxy or a C 1-4 alkoxycarbonyl group b) piperidino substituted by one or more hydroxy c) unsubstituted piperidino but only when one of the following applies: R 4 represents cyano or R 1 represents 3-fluoropropylsulphonyloxy or R 1 represents 3,3,3-trifluoropropoxy or R 1 represents 3-fluoropropoxy or R 2 is methyl d) phenyl substituted by one or more of the following: hydroxy, halo or a C 1-4 alkyl group e) pyridyl substituted by a C 1-4 alkyl group or f) a C 4-9 alkyl group; R 4 represents cyano or methyl; and n is 1, 2 or 3 and pharmaceutically acceptable salts thereof and processes for preparing such compounds, their use in the treatment of obesity, psychiatric and neurological disorders, to methods for their therapeutic use and to pharmaceutical compositions containing them.

10. 发明专利

CA2757879C ISOXAZOL-3(2H)-ONE ANALOGS AS PLASMINOGEN BINDING INHIBITORS 未知
公开(公告)号：CA2757879C
公开(公告)日：2017-06-06
申请号：CA2757879
申请日：2010-04-06
申请人： ASTRAZENECA AB
发明人： BOSTROEM JONAS , CHENG LEIFENG , FEX TOMAS , KARLE MICHAEL , PETTERSEN DANIEL , SCHELL PETER
IPC分类号： C07D413/04 , A61K31/4523 , A61P7/04
摘要： Compounds of Formula I (see formula I) or a pharmaceutically suitable salt thereof, wherein, R1 and R2 are as defined herein. Compounds of Formula I may be used as plasminogen binding inhibitors.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式