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1. 发明申请

WO2006073361A9 NOVEL PYRIDINE COMPOUNDS 审中-公开
标题翻译：新型吡啶化合物
公开(公告)号：WO2006073361A9
公开(公告)日：2007-08-02
申请号：PCT/SE2006000010
申请日：2006-01-04
申请人： ASTRAZENECA AB , BACH PETER , BOSTROEM JONAS , BRICKMANN KAY , CHENG LEIFENG , GIORDANETTO FABRIZIO , GRONEBERG ROBERT D , HARVEY DARREN MARTIN , O'SULLIVAN MICHAEL F , ZETTERBERG FREDRIK , OESTERLUND KRISTER
发明人： BACH PETER , BOSTROEM JONAS , BRICKMANN KAY , CHENG LEIFENG , GIORDANETTO FABRIZIO , GRONEBERG ROBERT D , HARVEY DARREN MARTIN , O'SULLIVAN MICHAEL F , ZETTERBERG FREDRIK , OESTERLUND KRISTER
IPC分类号： C07D401/04 , A61K31/4427 , A61P7/02 , C07D213/78 , C07D401/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
CPC分类号： C07D413/14 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/14
摘要： The present invention relates to certain novel pyridin compounds of Formula ( I ) to processes for preparing such compounds, to their utility as P2Y12 inhibitors and as anti-trombotic agents etc, and processes for their preparation, their use as medicaments in cardiovascular diseases as well as pharmaceutical compositions containing them.
摘要翻译：本发明涉及式（I）的某些新颖的吡啶化合物，用于制备这些化合物的方法，以其作为P2Y12抑制剂和抗血栓形成剂等的用途及其制备方法，它们用作心血管疾病中的药物作为含有它们的药物组合物。

2. 发明申请

WO2010117323A8 ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS 审中-公开
标题翻译： ISOXAZOL-3（2H） - 作为治疗剂的模拟物
公开(公告)号：WO2010117323A8
公开(公告)日：2010-11-18
申请号：PCT/SE2010050375
申请日：2010-04-06
申请人： ASTRAZENECA AB , BOSTROEM JONAS , CHENG LEIFENG , FEX TOMAS , KARLE MICHAEL , PETTERSEN DANIEL , SCHELL PETER
发明人： BOSTROEM JONAS , CHENG LEIFENG , FEX TOMAS , KARLE MICHAEL , PETTERSEN DANIEL , SCHELL PETER
IPC分类号： C07D413/04 , A61K31/4523 , A61P7/04
CPC分类号： C07D413/04
摘要： Formula I or a pharmaceutically suitable salt thereof, wherein, R1 and R2 independently are hydrogen, deuterium, aryl, hetero aryl, C1-C8 alkyl, optionally being substituted with one or more substituents independently being R3, R3 is an aryl, hetero aryl, fluorine(s), a C1-C6 alkyl containing one or more fluorine, a C1-C6 alkyl containing one or more deuterium, a C1-C6 alkyl containing hydroxy, the aryl and heteroaryl optionally being substituted with one or more halogen, a fluorinated alkoxy, a fluorinated alkyl, a sulfonyl, one or more deuterium, a C1-6 alkyl, a C1-6 alkoxy, a nitrile, or R3 is a C1-6 alkyl optionally substituted with one or more of the following groups: COOR4, OCOR4, CONR5R6, NR5COR6, OR4; wherein, R4 is a C1-10 alkyl optionally substituted with one or more fluorine, deuterium, alkoxy, arylcarboxylate, alkyl carboxylate; R5 and R6 are independently selected from hydrogen, alkyl or they may together form a 4-8 membered carbon ring; or R1 and R2 form a 3-10 membered carbon ring optionally comprising O or N and optionally substituted with a C1-10 alkyl or aryl, hetero aryl optionally substituted with R3.
摘要翻译：式I或其药学上合适的盐，其中R 1和R 2独立地是氢，氘，芳基，杂芳基，任选被一个或多个取代基独立地被R 3取代的C 1 -C 8烷基，R 3是芳基，杂芳基，氟，含有一个或多个氟的C 1 -C 6烷基，含有一个或多个氘的C 1 -C 6烷基，含羟基的C 1 -C 6烷基，任选被一个或多个卤素取代的芳基和杂芳基，氟化烷氧基，氟化烷基，磺酰基，一个或多个氘，C 1-6烷基，C 1-6烷氧基，腈或R 3是任选被一个或多个下列基团取代的C 1-6烷基：COOR 4， OCOR4，CONR5R6，NR5COR6，OR4; 其中，R4为任选被一个或多个氟，氘，烷氧基，芳基羧酸酯，羧酸烷基酯取代的C 1-10烷基; R 5和R 6独立地选自氢，烷基或它们可以一起形成4-8元碳环; 或R 1和R 2形成任选地包含O或N并任选被C 1-10烷基或芳基取代的3-10元碳环，任选被R 3取代的杂芳基。

3. 发明公开

EP1838686A4 DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS 审中-公开
标题翻译：导数的异噻唑-3（2H） - 酮-1,1-二氧化物AS肝X受体调节剂
公开(公告)号：EP1838686A4
公开(公告)日：2010-02-24
申请号：EP06700350
申请日：2006-01-09
申请人： ASTRAZENECA AB
发明人： BOSTROEM JONAS , BRICKMANN KAY , BROO ANDERS , HOLM PATRIK , JUDKINS ROBERT , LI LANNA , SANDBERG PERNILLA , SWANSON MARIANNE , WESTERLUND CHRISTER
IPC分类号： C07D275/03 , A61K31/425 , A61K31/427 , A61K31/4427 , A61K31/4725 , A61K31/5377 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P25/28 , C07D417/12
CPC分类号： C07D275/03 , C07D417/12

4. 发明专利

MX2009000420A DERIVADOS DE ISOINDOLINA PARA EL TRATAMIENTO DE ARRITMIAS. 未知
公开(公告)号：MX2009000420A
公开(公告)日：2009-01-27
申请号：MX2009000420
申请日：2007-07-12
申请人： ASTRAZENECA AB
发明人： BOSTROEM JONAS , BJOERE ANNIKA , GRAN ULRIK , STRANDLUND GERT , KAJANUS JOHAN , DAVIDSSON OJVIND , EMTENAES HANS , ILIEFSKI TOMMY , OLSSON ROINE , SANDBERG LARS , SUNDELL JOHAN , YUAN ZHONG-QING
IPC分类号： C07D209/46 , A61K31/40 , A61K31/4035 , A61K31/41 , A61K31/435 , A61K31/495 , A61P9/04 , A61P9/06 , C07D401/00 , C07D403/00 , C07D413/00 , G06F3/033
摘要： Se proporcionan compuestos de la Fórmula I, en donde R1 hasta R7 tienen los significados dados en la descripción, los cuales son útiles en la profilaxis y en el tratamiento de arritmias, en particular arritmias auriculares y ventriculares.

5. 发明专利

AT399777T 未知
公开(公告)号：AT399777T
公开(公告)日：2008-07-15
申请号：AT04749150
申请日：2004-07-08
申请人： ASTRAZENECA AB
发明人： BOSTROEM JONAS , BRICKMANN KAY , HOLM PATRIK , SANDBERG PERNILLA , SWANSON MARIANNE , WESTERLUND CHRISTER
IPC分类号： C07D405/06 , A61K31/4025 , A61K31/4439 , A61P3/10 , A61P25/28 , C07D207/416 , C07D207/44 , C07D207/456 , C07D401/06 , C07D405/12 , C07D405/14 , C07D413/06
摘要： The present invention relates to certain novel compounds of the Formula I to processes for preparing such compounds, to their the utility in modulation of nuclear hormone receptors Liver X Receptor (LXR)alpha(NR1H3) and/or beta(NR1H2) and in treating and/or preventing clinical conditions including cardiovascular diseases such as atherosclerosis; inflammatory diseases, Alzheimer's disease, lipid disorders (dyslipidemias) whether or not associated with insulin resistance, type 2 diabetes and other manifestations of the metabolic syndrome, to methods for their therapeutic use and to pharmaceutical compositions containing them.

6. 发明专利

CA2594255A1 NOVEL PYRIDINE COMPOUNDS 未知
公开(公告)号：CA2594255A1
公开(公告)日：2006-07-13
申请号：CA2594255
申请日：2006-01-04
申请人： ASTRAZENECA AB
发明人： BACH PETER , BRICKMANN KAY , BOSTROEM JONAS , ZETTERBERG FREDRIK , CHENG LEIFENG , HARVEY DARREN MARTIN , GRONEBERG ROBERT D , O'SULLIVAN MICHAEL F , GIORDANETTO FABRIZIO
IPC分类号： C07D401/04 , A61K31/4427 , A61P7/02 , C07D213/78 , C07D401/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要： The present invention relates to certain novel pyridin compounds of Formula (I) to processes for preparing such compounds, to their utility as P2Y12 inhibitors and as anti-thrombotic agents etc, and processes for their preparation, their use as medicaments in cardiovascular diseases as well as pharmaceutical compositions containing them.

7. 发明专利

CA2532056A1 PYRROLE-2, 5-DIONE DERIVATIVES AS LIVER X RECEPTOR MODULATORS 未知
公开(公告)号：CA2532056A1
公开(公告)日：2005-01-20
申请号：CA2532056
申请日：2004-07-08
申请人： ASTRAZENECA AB
发明人： HOLM PATRIK , BRICKMANN KAY , BOSTROEM JONAS , SANDBERG PERNILLA , SWANSON MARIANNE , WESTERLUND CHRISTER
IPC分类号： C07D405/06 , A61K31/4025 , A61K31/4439 , A61P3/10 , A61P25/28 , C07D207/416 , C07D207/44 , C07D207/456 , C07D401/06 , C07D405/12 , C07D405/14 , C07D413/06
摘要： The present invention relates to certain novel compounds of the Formula (I) to processes for preparing such compounds, to their the utility in modulation o f nuclear hormone receptors Liver X Receptor (LXR) .alpha. (NR1H3) and/or .bet a. (NR1H2) and in treating and/or preventing clinical conditions including cardiovascular diseases such as atherosclerosis; inflammatory diseases, Alzheimer's disease, lipid disorders (dyslipidemias) whether or not associat ed with insulin resistance, type 2 diabetes and other manifestations of the metabolic syndrome, to methods for their therapeutic use and to pharmaceutic al compositions containing them.

8. 发明专利

UY33755A NUEVOS BLOQUEADORES DE IKACH 未知
公开(公告)号：UY33755A
公开(公告)日：2012-06-29
申请号：UY33755
申请日：2011-11-29
申请人： ASTRAZENECA AB
发明人： EMTENAES HANS , BOSTROEM JONAS , KENNETH GRANBERG , MICKAEL MOGEMARK , ANTONIO LLINAS
IPC分类号： A61K31/166 , A61K31/397 , A61P9/06 , C07D205/04
摘要： La invención se refiere a compuestos de acuerdo con la Fórmula I: o una sal farmacéuticamente aceptable de los mismos, en donde m, n, R1 , R2, R3, R4, R55 ,x e y son tal como se definen en la presente. Los compuestos de acuerdo con la Fórmula I son farmacológicamente efectivos como inhibidores del canal de potasio, en particular inhibidores de la corriente del canal de potasio rectificador de entrada operada por acetilcolina (es decir bloqueadores de IKACh) y se cree que son útiles en el tratamiento de arritmias cardíacas, en particular taquiarritmias supraventriculares, tales como fibrilación auricular y palpitación auricular.

9. 发明专利

CA2657151A1 ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS 未知
公开(公告)号：CA2657151A1
公开(公告)日：2008-01-17
申请号：CA2657151
申请日：2007-07-12
申请人： ASTRAZENECA AB
发明人： ILIEFSKI TOMMY , BOSTROEM JONAS , STRANDLUND GERT , SUNDELL JOHAN , KAJANUS JOHAN , OLSSON ROINE , YUAN ZHONG-QING , SANDBERG LARS , GRAN ULRIK , EMTENAES HANS , DAVIDSSON OEJVIND , BJOERE ANNIKA
IPC分类号： C07D209/46 , A61K31/40 , A61K31/4035 , A61K31/41 , A61K31/435 , A61K31/495 , A61P9/04 , A61P9/06 , C07D401/00 , C07D403/00 , C07D413/00
摘要： There is provided compounds of formula I, wherein R1 to R7 have meanings given in the description, which are useful in the prophylaxis and in the tre atment of arrhythmias, in particular atrial and ventricular arrhythmias.

10. 发明专利

CA2592771A1 DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS 未知
公开(公告)号：CA2592771A1
公开(公告)日：2006-07-13
申请号：CA2592771
申请日：2006-01-09
申请人： ASTRAZENECA AB
发明人： JUDKINS ROBERT , LI LANNA , SANDBERG PERNILLA , HOLM PATRIK , BROO ANDERS , BOSTROEM JONAS , BRICKMANN KAY , SWANSON MARIANNE , WESTERLUND CHRISTER
IPC分类号： C07D275/03 , A61K31/425 , A61K31/427 , A61K31/4427 , A61K31/4725 , A61K31/5377 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P25/28 , C07D417/12
摘要： The present invention relates to certain novel compounds of the formula (I) to processes for preparing such compounds, to their utility in modulation of nuclear hormone receptors Liver X Receptor (LXR) alpha (NR1H3) and/or beta (NR1H2) and in treating and/or preventing clinical conditions including cardiovascular diseases such as atherosclerosis; inflammatory diseases, Alzheimer's disease, lipid disorders (dyslipidemias) whether or not associated with insulin resistance, type 2 diabetes and other manifestations of the metabolic syndrome, to methods for their therapeutic use and to pharmaceutical compositions containing them.

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