专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2004113285A1 PROCESS FOR THE PREPARATION OF RACEMIC 2-{[2-(4-HYDROXYPHENYL)ETHYL]THIO}-3-[4-(2-{4-[(METHYLSULFONYL)OXY]PHENOXY}ETHYL)PHENYL]-PROPANOIC ACID 审中-公开
标题翻译：制备2 - {[2-（4-羟基苯基）乙基]硫代} -3- [4-（2- {4 - [（甲基氟）氧基]乙基]苯基] - 丙酸的方法
公开(公告)号：WO2004113285A1
公开(公告)日：2004-12-29
申请号：PCT/GB2004/002599
申请日：2004-06-16
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , ANDERSSON, Kjell , LINDSTEDT-ALSTERMARK, Eva-Lotte , SORENSEN, Henrik
发明人： ANDERSSON, Kjell , LINDSTEDT-ALSTERMARK, Eva-Lotte , SORENSEN, Henrik
IPC分类号： C07C323/56
CPC分类号： C07F7/1896 , C07C319/20 , C07C323/56
摘要： The present invention provides a process for the preparation of substantially racemic 2-{[2-(4-hydroxyphenyl)ethyl]thio}-3-[4-(2-{4-[(methylsulfonyl)oxy]phenoxy}ethyl)phenyl]-propanoic acid which comprises reacting 2-{[2-(4-hydroxyphenyl)ethyl]thio}-3-[4-(2-{4-[(methylsulfonyl)oxy]phenoxy}ethyl)phenyl]propanoic acid enriched in one enantiomer with a base in an inert solvent.
摘要翻译：本发明提供了制备基本上外消旋的2 - {[2-（4-羟基苯基）乙基]硫基} -3- [4-（2- {4 - [（甲基磺酰基）氧]苯氧基}乙基）苯基 ] - 丙酸，其包括富集的2 - {[2-（4-羟基苯基）乙基]硫基} -3- [4-（2- {4 - [（甲基磺酰基）氧基]苯氧基}乙基）苯基] 一种对映体与碱在惰性溶剂中反应。

2. 发明申请

WO2005080343A2 THERAPEUTIC AGENTS 审中-公开
公开(公告)号：WO2005080343A2
公开(公告)日：2005-09-01
申请号：PCT/GB2005/000534
申请日：2005-02-16
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , CHENG, Leifeng , LINDSTEDT-ALSTERMARK, Eva-Lotte , BOIJE, Anna, Maria, Persdotter
发明人： CHENG, Leifeng , LINDSTEDT-ALSTERMARK, Eva-Lotte , BOIJE, Anna, Maria, Persdotter
IPC分类号： C07D231/00
CPC分类号： C07D231/14 , C07D401/12 , C07D405/12 , C07D409/12
摘要： The present invention relates to compounds of formula (I) and processes for preparing such compounds, their use in the treatment of obesity, psychiatric and neurological disorders, to methods for their therapeutic use and to pharmaceutical compositions containing them.

3. 发明申请

WO2004113276A1 2-ETHOXY-3-PHENYLPROPIONIC ACID DERIVATIVES FOR THE TREATMENT OF LIPID DISORDERS 审中-公开
标题翻译：用于治疗脂肪障碍的2-乙氧基-3-苯基丙酸衍生物
公开(公告)号：WO2004113276A1
公开(公告)日：2004-12-29
申请号：PCT/GB2004/002619
申请日：2004-06-16
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , LINDSTEDT-ALSTERMARK, Eva-Lotte
发明人： LINDSTEDT-ALSTERMARK, Eva-Lotte
IPC分类号： C07C309/66
CPC分类号： C07C309/66
摘要： A compound of formula (I) wherein T represents O, S or NR and wherein R represents a H, a C 1-6 alkyl group or a phenyl C 1-6 alkyl group and pharmaceutically acceptable salts thereof, processes for preparing such compounds, their the utility in treating clinical conditions including lipid disorders (dyslipidemias) whether or not associated with insulin resistance, methods for their therapeutic use and and pharmaceutical compositions containing them.
摘要翻译：式（I）的化合物，其中T表示O，S或NR，并且其中R表示H，C 1-6烷基或苯基C 1-6烷基及其药学上可接受的盐，其制备方法，治疗临床状况，包括是否与胰岛素抵抗相关的脂质紊乱（血脂异常），其治疗用途的方法和含有它们的药物组合物。

4. 发明申请

WO2005095354A1 THERAPEUTIC AGENTS 审中-公开
标题翻译：治疗药剂
公开(公告)号：WO2005095354A1
公开(公告)日：2005-10-13
申请号：PCT/GB2005/001153
申请日：2005-03-30
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , CHENG, Leifeng , LINDSTEDT-ALSTERMARK, Eva-Lotte , BOIJE, Anna, Maria, Persdotter
发明人： CHENG, Leifeng , LINDSTEDT-ALSTERMARK, Eva-Lotte , BOIJE, Anna, Maria, Persdotter
IPC分类号： C07D233/54
CPC分类号： C07D233/64 , C07D233/66 , C07D401/12 , C07D409/12
摘要： The present invention relates to compounds of formula (I) and processes for preparing such compounds, their use in the treatment of obesity, psychiatric and neurological disorders, to methods for their therapeutic use and to pharmaceutical compositions containing them.
摘要翻译：本发明涉及式（I）化合物及其制备方法，它们在治疗肥胖症，精神病学和神经障碍学中的用途及其治疗用途的方法以及含有它们的药物组合物。

5. 发明申请

WO2004113282A1 THERAPEUTIC AGENTS 审中-公开
标题翻译：治疗药剂
公开(公告)号：WO2004113282A1
公开(公告)日：2004-12-29
申请号：PCT/GB2004/002554
申请日：2004-06-16
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , LINDSTEDT-ALSTERMARK, Eva-Lotte , BOIJE, Anna, Maria, Persdotter , HOLM, Patrik
发明人： LINDSTEDT-ALSTERMARK, Eva-Lotte , BOIJE, Anna, Maria, Persdotter , HOLM, Patrik
IPC分类号： C07C317/46
CPC分类号： C07C323/56 , C07C317/46 , C07C323/60 , C07D333/18
摘要： Substituted 3-phenylpropionic acid derivatives, processes for preparing such compounds, their utility in treating clinical conditions including lipid disorders (dyslipidemias) whether or not associated with insulin resistance, methods for their therapeutic use and pharmaceutical compositions containing them.
摘要翻译：取代的3-苯基丙酸衍生物，制备这些化合物的方法，它们在治疗临床状况中的应用，包括脂质紊乱（血脂异常），无论是否与胰岛素抵抗相关，其治疗用途的方法和含有它们的药物组合物。

6. 发明申请

WO2004110984A1 PHARMACEUTICALLY USEFUL SALTS OF CARBOXYLIC ACID DERIVATES 审中-公开
标题翻译：羧甲酸衍生物的药用有效的盐
公开(公告)号：WO2004110984A1
公开(公告)日：2004-12-23
申请号：PCT/SE2004/000964
申请日：2004-06-16
申请人： ASTRAZENECA AB , AURELL, Carl-Johan , DAHLSTRÖM, Mikael , LINDSTEDT-ALSTERMARK, Eva-Lotte , MINIDIS, Anna , OHLSSON, Bengt , STÅHLE, Erica
发明人： AURELL, Carl-Johan , DAHLSTRÖM, Mikael , LINDSTEDT-ALSTERMARK, Eva-Lotte , MINIDIS, Anna , OHLSSON, Bengt , STÅHLE, Erica
IPC分类号： C07C235/20
CPC分类号： C07C235/20 , C07B2200/07
摘要： A compound selected from one or more of the following: a ( 1 R ,2 S )-2-hydroxyindan-1-amine salt of (2 S )-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid; an L-arginine salt of (2 S )-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino-2-oxoethoxyphenyl)propanoic acid; a tert -butylamine salt of (2 S )-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino-2-oxoethoxyphenyl)propanoic acid; a choline salt of (2 S )-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid; an adamantylamine salt of (2 S )-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid; a N -benzyl-2-phenylethanaminium salt of (2 S )-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid; a N -benzyl-2-(benzylamino) ethanaminium salt of (2 S )-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid; or a tris(hydroxymethyl)methylamine salt of (2 S )-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid.
摘要翻译：选自下列一种或多种的化合物：（2S）-2-乙氧基-3-（4- {2- [己基（2-苯基乙基）氨基] -2-氧代乙氧基}苯基）丙酸; （2S）-2-乙氧基-3-（4- {2- [己基（2-苯基乙基）氨基-2-氧代乙氧基苯基）丙酸的L-精氨酸盐; （2S）-2-乙氧基-3-（4- {2- [己基（2-苯基乙基）氨基-2-氧代乙氧基苯基）丙酸的叔丁基胺盐; （2S）-2-乙氧基-3-（4- {2- [己基（2-苯基乙基）氨基] -2-氧代乙氧基}苯基）丙酸的胆碱盐; （2S）-2-乙氧基-3-（4- {2- [己基（2-苯基乙基）氨基] -2-氧代乙氧基}苯基）丙酸的金刚烷基胺盐; （2S）-2-乙氧基-3-（4- {2- [己基（2-苯基乙基）氨基] -2-氧代乙氧基}苯基）丙酸的N-苄基-2-苯基乙胺盐; （2S）-2-乙氧基-3-（4- {2- [己基（2-苯基乙基）氨基] -2-氧代乙氧基}苯基）丙酸的N-苄基-2-（苄基氨基）乙胺盐; 或（2S）-2-乙氧基-3-（4- {2- [己基（2-苯基乙基）氨基] -2-氧代乙氧基}苯基）丙酸的三（羟甲基）甲胺盐。

7. 发明申请

WO2006073366A1 NON-ANILINIC DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS 审中-公开
标题翻译：作为肝脏X受体调节剂的异亮氨酸-3（2H） - 酮-1,1-二氧化物的非苯胺衍生物
公开(公告)号：WO2006073366A1
公开(公告)日：2006-07-13
申请号：PCT/SE2006/000029
申请日：2006-01-09
申请人： ASTRAZENECA AB , BROO, Anders , HOLM, Patrik , JUDKINS, Robert , LI, Lanna , LINDSTEDT-ALSTERMARK, Eva-Lotte , SANDBERG, Pernilla , SWANSON, Marianne , WEIDOLF, Lars , MRICKMANN, Kay
发明人： BROO, Anders , HOLM, Patrik , JUDKINS, Robert , LI, Lanna , LINDSTEDT-ALSTERMARK, Eva-Lotte , SANDBERG, Pernilla , SWANSON, Marianne , WEIDOLF, Lars , MRICKMANN, Kay
IPC分类号： C07D275/03 , A61K31/425 , A61K31/427 , A61K31/4427 , A61K31/454 , A61K31/4545 , A61K31/506 , A61K31/5377 , A61P25/28 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , C07D417/12
CPC分类号： C07D275/03 , C07D417/12 , C07D417/14
摘要： The present invention relates to certain novel compounds of the formula (I) to processes for preparing such compounds, to their the utility in modulation of nuclear hormone receptors Liver X Receptor (LXR) α (NR1H3) and/or β (NR1H2) and in treating and/or preventing clinical conditions including cardiovascular diseases such as atherosclerosis; inflammatory diseases, Alzheimer's disease, lipid disorders (dyslipidemias) whether or not associated with insulin resistance, type 2 diabetes and other manifestations of the metabolic syndrome, to methods for their therapeutic use and to pharmaceutical compositions containing them.
摘要翻译：本发明涉及一些式（I）化合物的制备方法，用于调节核激素受体肝X受体（LXR）a（NR1H3）和/或ß（NR1H2）和治疗和/或预防包括心血管疾病如动脉粥样硬化的临床病症; 炎性疾病，阿尔茨海默病，与胰岛素抵抗相关的脂质紊乱（血脂异常），2型糖尿病和代谢综合征的其他表现，其治疗用途的方法和含有它们的药物组合物。

8. 发明申请

WO2008108735A1 2 -SUBSTITUTED- 3 -PHENYLPROPIONIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT OF INFLAMMATORY BOWEL DISEASE 审中-公开
标题翻译： 2-取代-3-苯基丙酸衍生物及其在治疗炎症性皮肤病中的应用
公开(公告)号：WO2008108735A1
公开(公告)日：2008-09-12
申请号：PCT/SE2008/050259
申请日：2008-03-07
申请人： ALBIREO AB , BROO, Anders , GOTTFRIES, Johan , KOSSENJANS, Michael , LANNA, Li , LINDSTEDT-ALSTERMARK, Eva-Lotte , NILSSON, Kristina A , OHLSSON, Bengt , THORSTENSSON, Maria
发明人： BROO, Anders , GOTTFRIES, Johan , KOSSENJANS, Michael , LANNA, Li , LINDSTEDT-ALSTERMARK, Eva-Lotte , NILSSON, Kristina A , OHLSSON, Bengt , THORSTENSSON, Maria
IPC分类号： C07C321/20 , A61K31/216 , A61K31/421 , A61K31/4402 , A61K31/495 , A61P1/00 , C07C271/26 , C07C309/70 , C07C317/24 , C07C327/28 , C07D213/46 , C07D263/32 , C07D277/30
CPC分类号： C07C323/56 , C07C271/28 , C07C309/66 , C07C317/44 , C07C323/62 , C07C327/28 , C07D213/55 , C07D231/12 , C07D263/32 , C07D263/34 , C07D277/24 , C07D277/30 , C07D295/04
摘要： The present invention relates to 2-(substituted sulphur, sulphone or sulphoxide)-3-(substituted phenyl) propionic acid derivatives, 2-(substituted oxygen)-3-(substituted phenyl) propionic acid derivatives, benzoic acid derivatives, and derivatives of 2-methyl-2-(phenoxy or phenylthio)propanoic acid and 2-(methylor ethyl)-2-(phenoxy or phenylthio)butanoic acid, to processes for preparing such compounds, to their use in the treatment of inflammatory conditions, and to pharmaceutical compositions containing them.
摘要翻译：本发明涉及2-（取代的硫，砜或亚砜）-3-（取代的苯基）丙酸衍生物，2-（取代的氧）-3-（取代的苯基）丙酸衍生物，苯甲酸衍生物及其衍生物 2-（苯氧基或苯硫基）丙酸和2-（甲基 - 乙基）-2-（苯氧基或苯硫基）丁酸制备此类化合物的方法，用于治疗炎性病症，以及含有它们的药物组合物。

9. 发明申请

WO2016087338A1 1-[2-(AMINOMETHYL)BENZYL]-2-THIOXO-1,2,3,5-TETRAHYDRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONES AS INHIBITORS OF MYELOPEROXIDASE 审中-公开
标题翻译： 1- [2-（氨基甲酰基）苄基] -2-硫代-1,2,3,5-四氢-2H-吡喃并[3,2-D]嘧啶-4-酮，作为麦芽酮糖苷酶的抑制剂
公开(公告)号：WO2016087338A1
公开(公告)日：2016-06-09
申请号：PCT/EP2015/077998
申请日：2015-11-30
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED
发明人： INGHARDT, Tord, Bertil , TOMKINSON, Nicholas , GAN, Li-Ming , STONEHOUSE, Jeffrey, Paul , JOHANNESSON, Petra , JURVA, Ulrik , MICHAËLSSON, Erik , LINDSTEDT-ALSTERMARK, Eva-Lotte
IPC分类号： C07D487/04 , A61K31/519 , A61P9/10
CPC分类号： A61K31/519 , C07D487/04
摘要： There are disclosed certain 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H- pyrrolo[3,2-d]pyrimidin-4-one compounds of formula (I), and pharmaceutically acceptable salts thereof, together with compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme MPO and are thereby particularly useful in the treatment or prophylaxis of cardiovascular disorders such as heart failure and coronary artery disease related conditions.
摘要翻译：公开了式（I）的某些1- [2-（氨基甲基）苄基] -2-硫代-1,2,3,5-四氢-4H-吡咯并[3,2-d]嘧啶-4-酮化合物，及其药学上可接受的盐，以及含有它们的组合物及其在治疗中的用途。这些化合物是MPO酶的抑制剂，因此特别可用于治疗或预防心血管疾病如心力衰竭和冠状动脉疾病相关病症。

10. 发明公开

EP1638927A1 THERAPEUTIC AGENTS 审中-公开
标题翻译：治疗物质
公开(公告)号：EP1638927A1
公开(公告)日：2006-03-29
申请号：EP04736926.9
申请日：2004-06-16
申请人： AstraZeneca AB
发明人： LINDSTEDT-ALSTERMARK, Eva-Lotte , BOIJE, Anna, Maria, Persdotter , HOLM, Patrik
IPC分类号： C07C317/46 , C07C323/56 , A61P5/48 , A61K31/192
CPC分类号： C07C323/56 , C07C317/46 , C07C323/60 , C07D333/18
摘要： Substituted 3-phenylpropionic acid derivatives, processes for preparing such compounds, their utility in treating clinical conditions including lipid disorders (dyslipidemias) whether or not associated with insulin resistance, methods for their therapeutic use and pharmaceutical compositions containing them.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式