专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2004110984A1 PHARMACEUTICALLY USEFUL SALTS OF CARBOXYLIC ACID DERIVATES 审中-公开
标题翻译：羧甲酸衍生物的药用有效的盐
公开(公告)号：WO2004110984A1
公开(公告)日：2004-12-23
申请号：PCT/SE2004/000964
申请日：2004-06-16
申请人： ASTRAZENECA AB , AURELL, Carl-Johan , DAHLSTRÖM, Mikael , LINDSTEDT-ALSTERMARK, Eva-Lotte , MINIDIS, Anna , OHLSSON, Bengt , STÅHLE, Erica
发明人： AURELL, Carl-Johan , DAHLSTRÖM, Mikael , LINDSTEDT-ALSTERMARK, Eva-Lotte , MINIDIS, Anna , OHLSSON, Bengt , STÅHLE, Erica
IPC分类号： C07C235/20
CPC分类号： C07C235/20 , C07B2200/07
摘要： A compound selected from one or more of the following: a ( 1 R ,2 S )-2-hydroxyindan-1-amine salt of (2 S )-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid; an L-arginine salt of (2 S )-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino-2-oxoethoxyphenyl)propanoic acid; a tert -butylamine salt of (2 S )-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino-2-oxoethoxyphenyl)propanoic acid; a choline salt of (2 S )-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid; an adamantylamine salt of (2 S )-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid; a N -benzyl-2-phenylethanaminium salt of (2 S )-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid; a N -benzyl-2-(benzylamino) ethanaminium salt of (2 S )-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid; or a tris(hydroxymethyl)methylamine salt of (2 S )-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid.
摘要翻译：选自下列一种或多种的化合物：（2S）-2-乙氧基-3-（4- {2- [己基（2-苯基乙基）氨基] -2-氧代乙氧基}苯基）丙酸; （2S）-2-乙氧基-3-（4- {2- [己基（2-苯基乙基）氨基-2-氧代乙氧基苯基）丙酸的L-精氨酸盐; （2S）-2-乙氧基-3-（4- {2- [己基（2-苯基乙基）氨基-2-氧代乙氧基苯基）丙酸的叔丁基胺盐; （2S）-2-乙氧基-3-（4- {2- [己基（2-苯基乙基）氨基] -2-氧代乙氧基}苯基）丙酸的胆碱盐; （2S）-2-乙氧基-3-（4- {2- [己基（2-苯基乙基）氨基] -2-氧代乙氧基}苯基）丙酸的金刚烷基胺盐; （2S）-2-乙氧基-3-（4- {2- [己基（2-苯基乙基）氨基] -2-氧代乙氧基}苯基）丙酸的N-苄基-2-苯基乙胺盐; （2S）-2-乙氧基-3-（4- {2- [己基（2-苯基乙基）氨基] -2-氧代乙氧基}苯基）丙酸的N-苄基-2-（苄基氨基）乙胺盐; 或（2S）-2-乙氧基-3-（4- {2- [己基（2-苯基乙基）氨基] -2-氧代乙氧基}苯基）丙酸的三（羟甲基）甲胺盐。

2. 发明申请

WO2004056748A1 THERAPEUTIC AGENTS 审中-公开
标题翻译：治疗药剂
公开(公告)号：WO2004056748A1
公开(公告)日：2004-07-08
申请号：PCT/GB2003/005602
申请日：2003-12-19
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , LINDSTEDT ALSTERMARK, Eva-Lotte , OLSSON, Anna, Christina , LI, Lanna , AURELL, Carl-Johan , MINIDIS, Anna , YOUSEFI-SALAKDEH, Esmail , DAHLSTROM, Mikael, Ulf, Johan
发明人： LINDSTEDT ALSTERMARK, Eva-Lotte , OLSSON, Anna, Christina , LI, Lanna , AURELL, Carl-Johan , MINIDIS, Anna , YOUSEFI-SALAKDEH, Esmail , DAHLSTROM, Mikael, Ulf, Johan
IPC分类号： C07C235/20
CPC分类号： A61K31/16 , C07C235/20
摘要： The present invention provides the S enantiomer of a compound of formula (I) wherein R 1 represents chloro, trifluoromethyl or trifluoromethoxy, R 2 represents H or fluoro and R 3 represents a C 2-4 alkyl group as well as pharmaceutically acceptable salts, solvates and prodrugs thereof, to processes for preparing such compounds, to their the utility in treating clinical conditions including lipid disorders (dyslipidemias) whether or not associated with insulin resistance, to methods for their therapeutic use and to pharmaceutical compositions containing them.
摘要翻译：本发明提供式（I）化合物的S对映异构体，其中R 1表示氯，三氟甲基或三氟甲氧基，R 2表示H或氟，R 3表示C 2-4烷基，用于制备此类化合物的方法，用于治疗临床状况，包括不论是否与胰岛素抵抗相关的脂质紊乱（血脂异常），其治疗用途的方法和含有它们的药物组合物。

3. 发明申请

WO2004110982A1 PROCESSES FOR PREPARING (2S)-3-(4-{2-[AMINO]-2-OXOETHOXY}PHENYL)-2-ETHOXYPROPANOIC ACID DERIVATIVES 审中-公开
标题翻译：制备（2S）-3-（4- {2- [氨基] -2-氧代乙基}苯基）-2-乙氧基丙酸衍生物的方法
公开(公告)号：WO2004110982A1
公开(公告)日：2004-12-23
申请号：PCT/SE2004/000966
申请日：2004-06-16
申请人： ASTRAZENECA AB , AURELL, Carl-Johan , MACEDO, Emmanuel , MINIDIS, Anna , YOUSEFI-SALAKDEH, Esmail
发明人： AURELL, Carl-Johan , MACEDO, Emmanuel , MINIDIS, Anna , YOUSEFI-SALAKDEH, Esmail
IPC分类号： C07C231/08
CPC分类号： C07C235/20 , C07C231/08 , Y02P20/55
摘要： The present invention provides a process for the preparation of a compound of formula I [Chemical formula should be inserted here. Please see paper copy] in which a compound of formula II [Chemical formula should be inserted here. Please see paper copy] in which R is H or OR represents a protecting group for a carboxylic hydroxy group is reacted with a compound of formula III C 6 H 13 X wherein X is a leaving group, in the presence of a base in the presence of an inert solvent at a temperature in the range -25°C to 150°C and optionally, when OR represents a protecting group, removal of the protecting group.
摘要翻译：本发明提供了制备式I化合物的方法[化学式应在此插入。请参见纸质文件]，其中应将式Ⅱ化合物[化学式在此插入。请参见纸张文件]，其中R为H或OR表示羧基羟基的保护基团与式III的化合物C6H13X（其中X为离去基团）在碱存在下，在惰性溶剂在-25℃至150℃的温度范围内，任选地，当OR表示保护基时，除去保护基。

4. 发明申请

WO2011142716A1 NOVEL HEMIFUMARATE SALT OF ISOINDOLE COMPOUND ACTING AS BACE INHIBITOR 审中-公开
标题翻译：新型化合物作为化合物抑制剂的盐酸盐
公开(公告)号：WO2011142716A1
公开(公告)日：2011-11-17
申请号：PCT/SE2011/050592
申请日：2011-05-11
申请人： ASTRAZENECA AB , BERGSTRÖM, Per-Olov , MINIDIS, Anna , STRANNE, Robert, Ulf, Johan , WERNERSSON, Mikael
发明人： BERGSTRÖM, Per-Olov , MINIDIS, Anna , STRANNE, Robert, Ulf, Johan , WERNERSSON, Mikael
IPC分类号： C07D401/14 , A61K31/506 , A61P25/28
CPC分类号： C07D401/14 , C07D213/50 , C07D401/04
摘要： The present invention relates to a hemifumarate salt of the compound (1 S )-1-(2- (difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1 H -isoindol-3-amine, Form A thereof and its pharmaceutical compositions. In addition, the present invention relates to therapeutic methods for the treatment and/or prevention of Αβ-related pathologies such as Downs syndrome, β-amyloid angiopathy such as but not limited to cerebral amyloid angiopathy or hereditary cerebral hemorrhage, disorders associated with cognitive impairment such as but not limited to MCI ("mild cognitive impairment"), Alzheimer Disease, memory loss, attention deficit symptoms associated with Alzheimer disease, neurodegeneration associated with diseases such as Alzheimer disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration.
摘要翻译：本发明涉及化合物（1S）-1-（2-（二氟甲基）吡啶-4-基）-4-氟-1-（3-（嘧啶-5-基）苯基）-1H的半富马酸盐 - 异吲哚-3-胺，其A型及其药物组合物。此外，本发明涉及用于治疗和/或预防ß相关病理学的治疗方法，例如唐氏综合征，β-淀粉样变性血管病，例如但不限于脑淀粉样血管病或遗传性脑出血，与认知相关的疾病损伤例如但不限于MCI（“轻度认知障碍”），阿尔茨海默病，记忆丧失，与阿尔茨海默病相关的注意力缺陷症状，与疾病如阿尔茨海默病或痴呆相关的神经变性，包括混合血管和退行性来源的痴呆老年性痴呆，老年性痴呆和与帕金森病相关的痴呆，进行性核上性麻痹或皮质基底变性。

5. 发明申请

WO2013054108A1 MONO-FLUORO BETA-SECRETASE INHIBITORS 审中-公开
标题翻译：单分子酶分子抑制剂
公开(公告)号：WO2013054108A1
公开(公告)日：2013-04-18
申请号：PCT/GB2012/052510
申请日：2012-10-10
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED
发明人： MINIDIS, Anna , RAHM, Fredrik , VIKLUND, Jenny
IPC分类号： C07D207/34 , C07D401/10 , C07D403/10 , C07D491/107 , A61K31/506 , A61K31/4439 , A61P25/00 , A61P25/28
CPC分类号： C07D209/54 , A61K31/403 , A61K31/407 , A61K31/4439 , A61K31/506 , A61K45/06 , C07D207/34 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D491/107
摘要： Beta-secretase inhibitors, of formula (I) as described in the specification, pharmaceutical compositions comprising them and therapeutic methods using them for the treatment and/or prevention of Αβ-related pathologies such as Down's syndrome, β-amyloid angiopathy such as but not limited to cerebral amyloid angiopathy or hereditary cerebral hemorrhage, disorders associated with cognitive impairment such as but not limited to MCI ("mild cognitive impairment"), Alzheimer's Disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration.
摘要翻译： β-分泌酶抑制剂，如说明书中所述的式（I），包含它们的药物组合物和使用它们用于治疗和/或预防与唐氏综合征，β-淀粉样血管病等不一致的阿尔茨海默氏症相关的病症的治疗方法限于脑淀粉样血管病或遗传性脑出血，与认知障碍相关的疾病，例如但不限于MCI（“轻度认知障碍”），阿尔茨海默病，记忆丧失，与阿尔茨海默病相关的注意力缺陷症状，与疾病相关的神经变性阿尔茨海默病或痴呆，包括混合血管和退行性痴呆，老年痴呆，老年痴呆和与帕金森病相关的痴呆，进行性核上性麻痹或皮层基底变性。

6. 发明公开

EP1292561A1 PROCESS FOR THE PREPARATION OF CYCLOPROPYL CARBOXYLIC ACID ESTERS AND DERIVATIVES 有权
标题翻译：维多利亚祖尔圣诞老人ON ON N N N N N N N N N N N N N N N N N
公开(公告)号：EP1292561A1
公开(公告)日：2003-03-19
申请号：EP01937110.3
申请日：2001-05-31
申请人： AstraZeneca AB
发明人： CLARK, Adrian , JONES, Elfyn , LARSSON, Ulf , MINIDIS, Anna
IPC分类号： C07C67/347 , C07C69/003 , C07C69/017 , C07C69/743 , C07C69/753 , C07C61/04 , C07C69/96 , C07C233/58
CPC分类号： C07C61/40 , C07B2200/07 , C07C51/09 , C07C51/38 , C07C51/60 , C07C57/60 , C07C57/66 , C07C67/347 , C07C69/753 , C07C211/40 , C07C247/22 , C07C2601/02 , C07C2601/14 , C07D487/04
摘要： The invention relates to a novel process for the preparation of certain cyclopropyl carboxylic acid esters and other cyclopropyl carboxylic acid derivatives; a novel process for the preparation of dimethylsulfoxonium methylide and dimethylsulfonium methylide; to the use of certain cyclopropyl carboxylic acid esters in a process for the preparation of intermediates that can be used in the synthesis of pharmaceutically active entities; and to certain intermediates provided by these processes.
摘要翻译：本发明涉及制备某些环丙基羧酸酯和其它环丙基羧酸衍生物的新方法; 制备二甲基锍甲基化物和二甲基锍甲基化物的新方法; 涉及在可用于合成药物活性物质的中间体的制备方法中使用某些环丙基羧酸酯; 以及由这些方法提供的某些中间体。

7. 发明授权

EP1292561B1 PROCESS FOR THE PREPARATION OF CYCLOPROPYL CARBOXYLIC ACID ESTERS AND DERIVATIVES 有权
标题翻译：用于生产CYCLOPROPYLCARBONSÄUREESTERN及其衍生物
公开(公告)号：EP1292561B1
公开(公告)日：2008-02-13
申请号：EP01937110.3
申请日：2001-05-31
申请人： AstraZeneca AB
发明人： CLARK, Adrian , JONES, Elfyn , LARSSON, Ulf , MINIDIS, Anna
IPC分类号： C07C67/347 , C07C69/003 , C07C69/017 , C07C69/743 , C07C69/753 , C07C61/04 , C07C69/96 , C07C233/58
CPC分类号： C07C61/40 , C07B2200/07 , C07C51/09 , C07C51/38 , C07C51/60 , C07C57/60 , C07C57/66 , C07C67/347 , C07C69/753 , C07C211/40 , C07C247/22 , C07C2601/02 , C07C2601/14 , C07D487/04
摘要： The invention relates to a novel process for the preparation of certain cyclopropyl carboxylic acid esters and other cyclopropyl carboxylic acid derivatives; a novel process for the preparation of dimethylsulfoxonium methylide and dimethylsulfonium methylide; to the use of certain cyclopropyl carboxylic acid esters in a process for the preparation of intermediates that can be used in the synthesis of pharmaceutically active entities; and to certain intermediates provided by these processes.

8. 发明授权

EP2780321B1 MONO-FLUORO BETA-SECRETASE INHIBITORS 有权
标题翻译： MONO-FLUOR-β分泌酶抑制剂
公开(公告)号：EP2780321B1
公开(公告)日：2015-12-30
申请号：EP12773365.7
申请日：2012-10-10
申请人： Astrazeneca AB
发明人： MINIDIS, Anna , RAHM, Fredrik , VIKLUND, Jenny
IPC分类号： C07D207/34 , C07D401/10 , C07D403/10 , C07D491/107 , A61K31/506 , A61K31/4439 , A61P25/00 , A61P25/28
CPC分类号： C07D209/54 , A61K31/403 , A61K31/407 , A61K31/4439 , A61K31/506 , A61K45/06 , C07D207/34 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D491/107

9. 发明公开

EP1638920A1 PROCESSES FOR PREPARING (2S)-3-(4-{2-[AMINO]-2-OXO ETHOXY}PHENYL)-2-ETHOXYPROPANOIC ACID DERIVATIVES 审中-公开
标题翻译：（2S）-3-（4- {2- [氨基] -2-氧代乙氧基}苯基）-2-乙氧基丙酸衍生物的制备方法
公开(公告)号：EP1638920A1
公开(公告)日：2006-03-29
申请号：EP04736958.2
申请日：2004-06-16
申请人： AstraZeneca AB
发明人： AURELL, Carl-Johan , MACEDO, Emmanuel , MINIDIS, Anna , YOUSEFI-SALAKDEH, Esmail
IPC分类号： C07C231/08 , C07C235/00
CPC分类号： C07C235/20 , C07C231/08 , Y02P20/55
摘要： The present invention provides a process for the preparation of a compound of formula I [Chemical formula should be inserted here. Please see paper copy] in which a compound of formula II [Chemical formula should be inserted here. Please see paper copy] in which R is H or OR represents a protecting group for a carboxylic hydroxy group is reacted with a compound of formula III C6H13X wherein X is a leaving group, in the presence of a base in the presence of an inert solvent at a temperature in the range -25°C to 150°C and optionally, when OR represents a protecting group, removal of the protecting group.
摘要翻译：本发明提供了制备式I化合物的方法[化学式应插入此处。请参阅纸质复印件]，其中应在此处插入式II化合物[化学式。其中R为H或OR代表羧基羟基的保护基的纸复制品在惰性溶剂存在下在碱的存在下与式III的化合物C6H13X（其中X为离去基团）反应在-25℃至150℃范围内的温度下，并且任选地，当OR表示保护基时，除去保护基。

10. 发明公开

EP2780321A1 MONO-FLUORO BETA-SECRETASE INHIBITORS 有权
标题翻译： MONO-FLUOR-β-SEKRETASE，缝边
公开(公告)号：EP2780321A1
公开(公告)日：2014-09-24
申请号：EP12773365.7
申请日：2012-10-10
申请人： Astrazeneca AB
发明人： MINIDIS, Anna , RAHM, Fredrik , VIKLUND, Jenny
IPC分类号： C07D207/34 , C07D401/10 , C07D403/10 , C07D491/107 , A61K31/506 , A61K31/4439 , A61P25/00 , A61P25/28
CPC分类号： C07D209/54 , A61K31/403 , A61K31/407 , A61K31/4439 , A61K31/506 , A61K45/06 , C07D207/34 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D491/107
摘要： Beta-secretase inhibitors, of formula (I) as described in the specification, pharmaceutical compositions comprising them and therapeutic methods using them for the treatment and/or prevention of Αβ-related pathologies such as Down's syndrome, β-amyloid angiopathy such as but not limited to cerebral amyloid angiopathy or hereditary cerebral hemorrhage, disorders associated with cognitive impairment such as but not limited to MCI ("mild cognitive impairment"), Alzheimer's Disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration.
摘要翻译：如本说明书所述的式（I）的β-分泌酶抑制剂，包含它们的药物组合物和使用它们用于治疗和/或预防与综合症状相关的病理学的治疗方法，例如唐氏综合征，淀粉样血管病但不限于脑淀粉样血管病或遗传性脑出血，与认知障碍相关的疾病，例如但不限于MCI（“轻度认知障碍”），阿尔茨海默病，记忆丧失，与阿尔茨海默病相关的注意力缺陷症状，与疾病相关的神经变性例如阿尔茨海默病或痴呆，包括混合血管和退行性起源的痴呆，老年痴呆，老年痴呆和与帕金森病相关的痴呆，进行性核上性麻痹或皮质基底变性。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式