会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 3. 发明申请
    • HETEROCYCLIC SULFONAMIDE DERIVATIVES AS INHIBITORS OF FACTOR XA
    • 异烟肼衍生物作为因子XA的抑制剂
    • WO2007008146A1
    • 2007-01-18
    • PCT/SE2006/000840
    • 2006-07-05
    • ASTRAZENECA ABALSTERMARK, ChristerAMIN, KosratANDERSSON, KjellFAHLANDER, UlfGRANBERG, KennethHOVDAL, Daniel
    • ALSTERMARK, ChristerAMIN, KosratANDERSSON, KjellFAHLANDER, UlfGRANBERG, KennethHOVDAL, Daniel
    • C07D401/14A61K31/501A61P7/02
    • C07D401/14
    • The invention relates to compounds of formula (I), Chemical formula should be inserted here. Please see paper copy wherein R 1 , R 2 , R 3 and R 4 are independently selected from carbon and nitrogen, and where at least one of R 1 , R 2 , R 3 and R 4 is nitrogen; A 1 is a single bond or a double bond; n is 0, 1, 2 or 3; each R 5 is independently selected from hydrogen, halogen, C 1-3 alkyl, oxo, oxy, oxido and thioxo; R 6 is hydrogen or oxo; m is 0, 1, 2 or 3; A 2 is a single bond or a double bond; each R 7 is independently selected from hydrogen, hydroxy, oxo, C 1-5 alkyl, carboxy, cyano, tetrazolyl, N -C 1-5 alkyltetrazolyl, oxazolyl, C 1-5 oxazolyl, isoxazolyl, C 1-5 isoxazolyl, hydroxyC 1-5 alkyl, carboxy C 1-5 alkyl, C 1-5 alkoxyoxo C 1-5 alkyl, carbamoyl, C 1-5 alkylcarbamoyl, di(C 1-5 alkyl)carbamoyl, carbamoyl C 1-4 alkyl, C 1-5 alkylcarbamoyl C 1-4 alkyl, di(C 1-5 alkyl)carbamoyl C 1-4 alkyl, hydroxy C 1-5 alkylcarbamoyl, C 1-5 alkoxy C 1-5 alkylcarbamoyl, hydroxy C 1-5 alkylcarbamoyl C 1-4 alkyl, C 1-5 alkoxy C 1-5 alkylcarbamoyl C 1-4 alkyl, -CONR 8 (CH 2 ) x S(O) p R 9 , -CONH(CH 2 ) q NR 10 R 11 , -C 1-5 alkyl-Y 1 , -COOCHR 17 R 18 and -CON R 17 R 18 ; and R 30 is hydrogen, amino, methyl or halogen; or a pharmaceutically acceptable salt thereof, said compounds possess antithrombotic and anticoagulant properties and are accordingly useful in methods of treatment of humans or animals. The invention also relates to processes for the preparation of the compounds, to their use, to pharmaceutical compositions comprising them, to their use in the manufacture of medicaments for use in the production of an antithrombotic or anticoagulant effect, and to combinations comprising them.
    • 本发明涉及式(I)化合物,其中应插入化学式。 请参见其中R 1,R 2,R 3和R 4中的R 8独立地选自碳和 氮,其中R 1,R 2,R 3和R 4中的至少一个为氮; A <1>是单键或双键; n为0,1,2或3; 每个R 5独立地选自氢,卤素,C 1-3烷基,氧代,氧基,氧代和硫代; R 6是氢或氧代; m为0,1,2或3; A <2>是单键或双键; 每个R 7独立地选自氢,羟基,氧代,C 1-5烷基,羧基,氰基,四唑基,NC 1-5 - 烷基四唑基,恶唑基,C 1-5 - 恶唑基,异恶唑基,C 1-5 - 异恶唑基,羟基C 1-5 - 烷基,羧基C 1-4烷基, C 1-5烷基,C 1-5烷氧基氧基C 1-5烷基,氨基甲酰基,C 1-5烷基氨基甲酰基,二 (C 1-5烷基)氨基甲酰基,氨基甲酰基C 1-4烷基,C 1-5烷基氨基甲酰基C 1-4, (C 1-5烷基)氨基甲酰基C 1-4烷基,羟基C 1-5烷基氨基甲酰基,C 1 -C 6烷基氨基甲酰基, 烷基氨基甲酰基,羟基C 1-5烷基氨基甲酰基C 1-4烷基,C 1-5烷氧基C 1-5烷基氨基甲酰基C 1-4烷基,-CONR 8(CH
    • 4. 发明申请
    • HETEROCYCLIC SULFONAMIDE DERIVATIVES AS INHIBITORS OF FACTOR XA
    • 异烟肼衍生物作为因子XA的抑制剂
    • WO2007008142A1
    • 2007-01-18
    • PCT/SE2006/000836
    • 2006-07-05
    • ASTRAZENECA ABALSTERMARK, ChristerANDERSSON, KjellFAHLANDER, UlfGRANBERG, Kenneth
    • ALSTERMARK, ChristerANDERSSON, KjellFAHLANDER, UlfGRANBERG, Kenneth
    • C07D401/14A61K31/501A61P7/02
    • C07D401/14
    • The invention relates to heterocyclic derivatives of formula (I), Chemical formula should be inserted here. Please see paper copy wherein R 1 is hydrogen or C 1-3 alkyl; R 2 is selected from hydroxy, C 1-5 alkyl, carboxy, cyano, tetrazolyl, N -C 1-5 alkyltetrazolyl, oxazolyl, C 1-5 oxazolyl, isoxazolyl, C 1-5 isoxazolyl, hydroxyC 1-5 alkyl, carboxy C 1-5 alkyl, C 1-5 alkoxyoxo C 1-5 alkyl, carbamoyl, C 1-5 alkylcarbamoyl, di(C 1-5 alkyl)carbamoyl, C 1-5 alkylcarbamoyl C 1-4 alkyl, hydroxy C 1-5 alkylcarbamoyl, C 1-5 alkoxy C 1-5 alkylcarbamoyl; -C 1-5 alkyl-Y 1 , -COOCHR 17 R 18 and -CON R 17 R 18 ; and R 3 is hydrogen or halogen; or a pharmaceutically acceptable salt thereof, said compounds possess antithrombotic and anticoagulant properties and are accordingly useful in methods of treatment of humans or animals. The invention also relates to processes for the preparation of the compounds, to their use, to pharmaceutical compositions comprising them, to their use in the manufacture of medicaments for use in the production of an antithrombotic or anticoagulant effect, and to combinations comprising them.
    • 本发明涉及式(I)的杂环衍生物,此处应插入化学式。 请参见其中R 1是氢或C 1-3烷基的纸张; R 2选自羟基,C 1-5烷基,羧基,氰基,四唑基,NC 1-5烷基四唑基,恶唑基, C 1-5 - 恶唑基,异恶唑基,C 1-5 - 异恶唑基,羟基C 1-5 - 烷基,羧基C 1-5 - 烷基,C 1-5烷氧基氧基C 1-5烷基,氨基甲酰基,C 1-5烷基氨基甲酰基,二(C 1) -5个烷基)氨基甲酰基,C 1-5烷基氨基甲酰基C 1-4烷基,羟基C 1-5烷基氨基甲酰基,C 1-5个烷氧基C 1-5烷基氨基甲酰基; -C 1-6烷基-Y 1,-COOCHR 17 R 18和-CON R“ 17 R 3是氢或卤素; 或其药学上可接受的盐,所述化合物具有抗血栓形成和抗凝血性质,因此可用于治疗人或动物的方法。 本发明还涉及制备化合物,其用途,包含它们的药物组合物在制备用于产生抗血栓形成或抗凝血作用的药物中的用途以及包含它们的组合的方法。
    • 5. 发明申请
    • HETEROCYCLIC SULFONAMIDE DERIVATIVES AS INHIBITORS OF FACTOR XA
    • 作为因子XA的抑制剂的杂环磺酰胺衍生物
    • WO2007008143A1
    • 2007-01-18
    • PCT/SE2006/000837
    • 2006-07-05
    • ASTRAZENECA ABALSTERMARK, ChristerAMIN, KosratANDERSSON, KjellCHEN, YantaoFAHLANDER, UlfFOOTE, Kevin, MichaelGRANBERG, KennethHOVDAL, Daniel
    • ALSTERMARK, ChristerAMIN, KosratANDERSSON, KjellCHEN, YantaoFAHLANDER, UlfFOOTE, Kevin, MichaelGRANBERG, KennethHOVDAL, Daniel
    • C07D401/14A61K31/497A61K31/501A61P7/02C07D401/12C07D403/14C07D409/14C07D413/14
    • C07D409/14C07D401/04C07D401/14
    • The invention relates to compounds of formula (I), wherein R 1 and R 3 are independently selected from carbon and nitrogen; R 2 is oxo or thioxo; n is 0, 1 or 2; each R 10 is independently selected from hydrogen and C 1 - 3 alkyl; R 4 and R 5 are each selected from carbon and nitrogen, wherein at least one of R 4 and R 5 is nitrogen; R 6 is hydrogen or oxo; R 7 is an aliphatic, partially saturated or aromatic carbocyclic ring, said carbocyclic ring having 0, 1 or 2 hetero nitrogen; m is 0, 1 or 2; each R 11 is independently selected from hydrogen, hydroxy, oxo, C 1-5 alkyl, carboxy, hydroxyC 1-5 alkyl, carboxyC 1-5 alkyl, C 1-5 alkoxyoxoC 1-5 alkyl, carbamoyl, C 1-5 alkylcarbamoyl, di (C 1-5 alkyl)carbamoyl, carbamoylC 1-4 alkyl,C 1-5 alkylcarbamoylC 1-4 alkyl, di(C 1-5 alkyl)carbamoylC 1-4 alkyl, hydroxyC 1-5 alkylcarbamoyl, C 1-5 alkoxyC 1-5 alkylcarbamoyl, hydroxyC 1-5 alkylcarbamoylC 1-4 alkyl, C 1-5 alkoxyC 1-5 alkylcarbamoylC 1-4 alkyl, CONR 80 (CH 2 ) x S(O) p R90, CONH(CH 2 ) q NR 100 R 100 , -C 1-5 alkyl-Y 1 , -COOCHR 170 R 180 and -CON R 170 R 180 ; R 8 is a bond, C 1-4 alkylene or C 2-6 alkenylene; R 9 is an aromatic ring system having 0, 1 or 2 hetero atoms; wherein R 9 is substituted by 0 or 1 halogen; or a pharmaceutically acceptable salt thereof, said compounds possess antithrombotic and anticoagulant properties and are accordingly useful in methods of treatment of humans or animals. The invention also relates to processes for the preparation of the compounds, to their use, to pharmaceutical compositions comprising them, to their use in the manufacture of medicaments for use in the production of an antithrombotic or anticoagulant effect, and to combinations comprising them.
    • 本发明涉及式(I)化合物,其中R 1和R 3独立地选自碳和氮; R 2是氧代或硫代; n为0,1或2; 每个R 10独立地选自氢和C 1 -C 3 - 烷基; R 4和R 5各自选自碳和氮,其中R 4和R 5中的至少一个 >是氮; R 6是氢或氧代; R 7是脂族,部分饱和或芳族碳环,所述碳环具有0,1或2个杂氮; m为0,1或2; 每个R 11独立地选自氢,羟基,氧代,C 1-5烷基,羧基,羟基C 1-5烷基,羧基C 1-4烷基, C 1-5烷基,C 1-5烷氧基氧基C 1-5烷基,氨基甲酰基,C 1-5烷基氨基甲酰基, 二(C 1-5烷基)氨基甲酰基,氨基甲酰基C 1-4烷基,C 1-5烷基氨基甲酰基C 1-4 - 烷基,二(C 1-5烷基)氨基甲酰基C 1-4烷基,羟基C 1-5烷基氨基甲酰基,C 1 -5烷氧基C 1-5烷基氨基甲酰基,羟基C 1-5烷基氨基甲酰基C 1-4烷基,C 1-5 烷基C 1-4烷基氨基甲酰基C 1-4烷基,CONR 80(CH 2)
    • 6. 发明申请
    • A PLANT FOR PRODUCTION OF HOT WATER
    • 一个生产热水的工厂
    • WO2006078215A1
    • 2006-07-27
    • PCT/SE2006/000088
    • 2006-01-20
    • MECMASTER ABANDERSSON, Kjell
    • ANDERSSON, Kjell
    • F25B30/02F24D11/02F25B27/00
    • F25B30/02F03B13/00F03D9/22F03D9/28F24D17/02F25B27/00Y02B10/70Y02E10/72Y02P70/523
    • The invention refers to a plant (1) for production of hot water, comprising means for evaporating a refrigerant, a compressor (3) for compressing the refrigerant whereupon the temperature thereof is increased, a condenser (4) for emitting the heat stored in said refrigerant to a water supply network (5) connectable to the plant, as well as means for operating the compressor (3). According to the invention is said operating means constituted by a mechanism (9) that is exposable to flowing energy and that is connected directly to the compressor (3) via a mechanical transmission (10), that the evaporation means is constituted by an evaporator (7) arranged to by means of energy, which is extracted from the geosphere, evaporate the refrigerant, and that the water supply network (5) is constituted by a regional district heating system, which is arranged to distribute hot water to a number of recipients.
    • 本发明涉及一种用于生产热水的设备(1),包括用于蒸发制冷剂的装置,用于压缩制冷剂的压缩机(3),其中温度升高的冷凝器(4),用于发射存储在所述 制冷剂可连接到工厂的供水网络(5)以及用于操作压缩机(3)的装置。 根据本发明,所述操作装置由可暴露于流动能量的机构(9)构成,并经由机械传动装置(10)直接与压缩机3相连,蒸发装置由蒸发器 7)通过能量从地下环境中提取出来,使制冷剂蒸发,供水网络(5)由区域性区域供热系统构成,该区域供热系统被布置为将热水分配给多个接收者 。
    • 8. 发明申请
    • CORE DRILL WITH DETACHABLE END PORTION
    • 具有可拆卸端部的芯钻
    • WO2016080869A1
    • 2016-05-26
    • PCT/SE2014/000136
    • 2014-11-19
    • ANDERSSON, Kjell
    • ANDERSSON, Kjell
    • B28D1/04B23B51/04B23B51/05B28D1/14
    • B28D1/041B23B51/0473B23B2250/12B23B2260/124B23B2260/126
    • The invention relates to a core drill with an end portion (3) and a drill bit portion (1-2). The end portion and the drill bit portion are joinable in a watertight fashion with a sealing element (11). The sealing element (11) is provided in a space between the end portion and the drill bit portion, such that it is being compressed in a sealing fashion when the end portion and the drill bit portion are joined. The end portion and the drill bit portion are locked together with a joining element (8, 10) which achieves this locking effect when moves in the radial direction of the core drill. When the joining element moves in this direction, the end portion and the drill bit portion move towards each other. Thus the sealing element is being compressed while concurrently the end portion and the drill bit portion are joined together. This is further achieved without the joining element having to extend in the axial direction of the core drill. Typically, the joining element (8, 10) is constituted by a set screw.
    • 本发明涉及一种具有端部部分(3)和钻头部分(1-2)的芯钻。 端部和钻头部分以水密方式与密封元件(11)连接。 密封元件(11)设置在端部和钻头部分之间的空间中,使得当端部和钻头部分接合时,密封元件(11)以密封方式被压缩。 端部和钻头部分与在芯钻的径向方向上移动时实现该锁定效果的接合元件(8,10)锁定在一起。 当接合元件在该方向上移动时,端部和钻头部分朝向彼此移动。 因此,密封元件被压缩同时端部和钻头部分连接在一起。 这不需要连接元件必须在芯钻的轴向方向上延伸。 通常,接合元件(8,10)由固定螺钉构成。
    • 9. 发明申请
    • FILLER FOR PAPER MAKING PROCESS
    • 纸张制作过程填充
    • WO2005124021A1
    • 2005-12-29
    • PCT/SE2005/000862
    • 2005-06-08
    • AKZO NOBEL N.V.EKA CHEMICALS ABSANNE, ErikANDERSSON, KjellNYANDER, Johan
    • SANNE, ErikANDERSSON, KjellNYANDER, Johan
    • D21H17/74
    • D21H17/68D21H17/25D21H23/04
    • The present invention relates to a filler comprising clay and cellulose derivative having a degree of substitution of net ionic groups up to about 0.65. The invention also relates to a filler comprising clay and a cellulose derivative having a degree of substitution of carboxyalkyl groups up to about 0.65. The invention further relates to a method of producing a filler which comprises mixing clay with a cellulose derivative having a degree of substitution of net ionic groups up to about 0.65. The invention also relates to a method of producing a filler which comprises mixing clay with a cellulose derivative having a degree of substitution of carboxyalkyl groups up to about 0.65. The invention further relates to a filler obtainable by the methods. The invention further relates to a papermaking process which comprises providing an aqueous suspension containing cellulosic fibres, introducing into the suspension a filler comprising clay and cellulose derivative having a degree of substitution of net ionic groups up to about 0.65, and dewatering the suspension to form a web or sheet of paper. The invention also relates to a papermaking process which comprises providing an aqueous suspension containing cellulosic fibres, introducing into the suspension a filler clay and cellulose derivative having a degree of substitution of carboxyalkyl groups up to about 0.65, and dewatering the suspension to form a web or sheet of paper.
    • 本发明涉及包含粘土和纤维素衍生物的填料,其具有高达约0.65的净离子基团的取代度。 本发明还涉及包含粘土和纤维素衍生物的填料,所述纤维素衍生物具有至多约0.65的羧基烷基取代度。 本发明还涉及一种生产填料的方法,其包括将粘土与具有高达约0.65的净离子基团的取代度的纤维素衍生物混合。 本发明还涉及一种生产填料的方法,该方法包括将粘土与羧烷基取代度高达约0.65的纤维素衍生物混合。 本发明还涉及可通过该方法获得的填料。 本发明还涉及一种造纸方法,其包括提供含有纤维素纤维的水性悬浮液,将包含粘土和纤维素衍生物的填料包含在悬浮液中,所述填料具有至多约0.65的净离子基团的取代度,并将悬浮液脱水形成 网页或纸张。 本发明还涉及造纸方法,其包括提供含有纤维素纤维的水性悬浮液,将具有羧基烷基取代度的填料粘土和纤维素衍生物引入悬浮液中至多约0.65,并将悬浮液脱水以形成网或 一张纸。