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1. 发明申请

WO2005061475A3 ORNITHINE DERIVATIVES AS PROSTAGLANDIN E2 AGONISTS OR ANTAGONISTS 审中-公开
标题翻译：作为PROSTAGLANDIN E2激动剂或拮抗剂的异构体衍生物
公开(公告)号：WO2005061475A3
公开(公告)日：2006-05-04
申请号：PCT/JP2004019454
申请日：2004-12-17
申请人： ASTELLAS PHARMA INC , HATTORI KOUJI , FUJII NAOAKI , TANAKA AKIRA , WASHIZUKA KENICHI , SAKURAI MINORU , KURODA SATORU , TODA SUSUMU , NAKAJIMA YUTAKA
发明人： HATTORI KOUJI , FUJII NAOAKI , TANAKA AKIRA , WASHIZUKA KENICHI , SAKURAI MINORU , KURODA SATORU , TODA SUSUMU , NAKAJIMA YUTAKA
IPC分类号： C07D209/42 , C07D215/48 , C07D307/85 , C07D471/04
CPC分类号： C07D215/48 , C07D209/42 , C07D307/85 , C07D471/04
摘要： Ornithine derivatives of the formula (I): wherein X is -CO- or -(CH 2 ) k - (wherein k is 1, 2 or 3); Y is Z-(CH 2 ) n -, and the like; {wherein Z is R 1 -CO-NR 4 -, and the like, (wherein R 1 is aryl, and the like; and R 4 is hydrogen, or lower alkyl); and n is 1, 2, 3, 4, 5 or 6}; R 2 is aryl-(lower alkyl), and the like; R 3 is -Q-R 7 , [wherein Q is -CO- or -SO 2 -, R 7 is heterocyclyl], and the like; and R 5 and R 6 are independently hydrogen or lower alkyl; or a pharmaceutically acceptable salt thereof, which are useful as medicament.
摘要翻译：式（I）的鸟氨酸衍生物：其中X是-CO-或 - （CH 2 CH 2）n - （其中k是1,2或3）; Y是Z-（CH 2）n - 等等; {其中Z是R 1 -CO-NR 4 - 等，（其中R 1是芳基等）和 R 4是氢或低级烷基）; n为1,2,3,4,5或6}; R 2是芳基 - （低级烷基）等; R 3是-QR 7，[其中Q是-CO-或-SO 2 - ，R 7，是杂环基]等; R 5和R 6独立地是氢或低级烷基; 或其药学上可接受的盐，其可用作药物。

2. 发明申请

WO2007007919A3 HETEROCYCLIC JANUS KINASE 3 INHIBITORS 审中-公开
标题翻译：杂交种JANUS KINASE 3抑制剂
公开(公告)号：WO2007007919A3
公开(公告)日：2007-08-16
申请号：PCT/JP2006314326
申请日：2006-07-13
申请人： ASTELLAS PHARMA INC , INOUE TAKAYUKI , TOJO TAKASHI , MORITA MASATAKA , NAKAJIMA YUTAKA , HATANAKA KEIKO , SHIRAKAMI SHOHEI , SASAKI HIROSHI , TANAKA AKIRA , TAKAHASHI FUMIE , MUKOYOSHI KOICHIRO , HIGASHI YASUYUKI , OKIMOTO AKIRA , HONDO TAKESHI , SAWADA HITOSHI
发明人： INOUE TAKAYUKI , TOJO TAKASHI , MORITA MASATAKA , NAKAJIMA YUTAKA , HATANAKA KEIKO , SHIRAKAMI SHOHEI , SASAKI HIROSHI , TANAKA AKIRA , TAKAHASHI FUMIE , MUKOYOSHI KOICHIRO , HIGASHI YASUYUKI , OKIMOTO AKIRA , HONDO TAKESHI , SAWADA HITOSHI
IPC分类号： C07D471/04 , A61K31/437 , A61P11/06 , A61P17/00 , A61P25/28 , A61P35/00 , A61P35/02 , A61P37/06 , C07D471/14 , C07D498/04
CPC分类号： C07D471/14 , C07D519/00
摘要： The invention relates to compound of the formula (I) or its salt, wherein -R 1 , -R 2 , -R 3 , -R 4 , -R 5 , -M-, -X- and -Y= are as defined in the description, their use of as, medicament, the process for their preparation and use for the treatment of JAK3 mediated diseases.
摘要翻译：本发明涉及式（I）化合物或其盐，其中-R 1，R 2，R 3， R 4，-R 5，-M-，-X-和-Y =如说明书中所定义，它们作为药物的用途，其用途为制备和用于治疗JAK3介导的疾病。

3. 发明专利

JP2012148977A 2,4-diaminopyrimidine compound having aminocyclohexylalkyl group 审中-公开
标题翻译：具有氨基环己基甲基的2,4-二氨基吡啶化合物
公开(公告)号：JP2012148977A
公开(公告)日：2012-08-09
申请号：JP2009121485
申请日：2009-05-20
申请人： Astellas Pharma Inc , アステラス製薬株式会社
发明人： TANAKA AKIRA , MUKAIYOSHI KOICHIRO , KUNIKAWA SHIGEKI , TAKASAGO YUJI , SENDA NOBORU
IPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , A61P37/06 , A61P43/00 , C07D401/12
CPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , C07D401/12
摘要： PROBLEM TO BE SOLVED: To provide a compound useful as an active ingredient of a pharmaceutical preparation having PKCθ inhibitory activity, especially of a pharmaceutical composition for inhibiting acute rejection in conducting transplant operations.SOLUTION: The present invention has been completed through such a process that: compounds having PKCθ inhibitory activity are studied; as a result, it has been confirmed that: a compound (or a salt thereof ) characterized by having a structure such as aralkyl on the 2-position amino group of 2,4-diaminopyrimidine and also having aminocyclohexylalkyl on the 4-position amino group thereof has excellent PKCθ inhibitory activity. The 2,4-diaminopyrimidine compound having the aminocyclohexyl alkyl group is usable as a PKCθ inhibitor, or an acute rejection inhibitor in conducting transplant operations.
摘要翻译：待解决的问题：提供可用作具有PKCθ抑制活性的药物制剂的活性成分的化合物，特别是用于在进行移植手术中抑制急性排斥反应的药物组合物。解决方案：本发明是通过以下方法完成的：研究了具有PKCθ抑制活性的化合物; 结果证实：其特征在于在2,4-二氨基嘧啶的2-位氨基上具有芳烷基结构并且在4-位氨基上具有氨基环己基烷基的化合物（或其盐）具有优异的PKCθ抑制活性。具有氨基环己基烷基的2,4-二氨基嘧啶化合物可用作PKCθ抑制剂或急性排斥抑制剂进行移植手术。版权所有（C）2012，JPO＆INPIT

4. 发明专利

JP2011173853A 2,4-diaminopyrimidine compound having substituted aminoadamantylalkyl group 审中-公开
标题翻译：具有取代氨基亚氨基烷基的2,4-二氨基吡啶化合物
公开(公告)号：JP2011173853A
公开(公告)日：2011-09-08
申请号：JP2010041147
申请日：2010-02-26
申请人： Astellas Pharma Inc , アステラス製薬株式会社
发明人： TANAKA AKIRA , MUKAIYOSHI KOICHIRO , KUNIKAWA SHIGEKI , SENDA NOBORU
IPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , A61P37/06 , A61P43/00 , C07D401/12
摘要： PROBLEM TO BE SOLVED: To provide a compound useful as an active ingredient for medicines having PKCθ-inhibiting activity, especially for medicine compositions for inhibiting acute rejections in transplantation.
SOLUTION: A compound having a PKCθ-inhibiting activity has been examined. It has consequently been confirmed that a compound characterized by having a structure such as an aralkyl group on the 2-positioned amino group of 2,4-diaminopyrimidine and further having a substituted aminoadamantylalkyl group on the 4-positioned amino group or salt thereof has an excellent PKCθ-inhibiting activity, and the invention has been completed. The 2,4-diaminopyrimidine compound having a substituted aminoadamantylalkyl group can be used as a PKCθ-inhibitor, and an acute rejection inhibitor in transplantation.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供可用作具有PKCθ抑制活性的药物的活性成分的化合物，特别是用于抑制移植中急性排斥的药物组合物。已经研究了具有PKCθ抑制活性的化合物。因此已经证实，在4-位氨基或其盐上，在2,4-二氨基嘧啶的2-位氨基上还具有取代的氨基金刚烷基烷基的具有芳烷基结构的化合物具有优异的PKCθ抑制活性，本发明已经完成。具有取代的氨基金刚烷基烷基的2,4-二氨基嘧啶化合物可用作PKCθ抑制剂和移植中的急性排斥抑制剂。版权所有（C）2011，JPO＆INPIT

5. 发明专利

JP2011173854A 2,4-diaminopyrimidine compound having bicyclo ring-substituted alkyl group 审中-公开
标题翻译：具有双氰基取代的烷基的2,4-二氨基吡啶化合物
公开(公告)号：JP2011173854A
公开(公告)日：2011-09-08
申请号：JP2010041148
申请日：2010-02-26
申请人： Astellas Pharma Inc , アステラス製薬株式会社
发明人： TANAKA AKIRA , MUKAIYOSHI KOICHIRO , KUNIKAWA SHIGEKI , SENDA NOBORU
IPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , A61P37/06 , A61P43/00 , C07D401/12
摘要： PROBLEM TO BE SOLVED: To provide a compound useful as an active ingredient for medicines having PKCθ-inhibiting activity, especially for medicine compositions for inhibiting acute rejections in transplantation.
SOLUTION: A compound having a PKCθ-inhibiting activity has been examined. It has consequently been confirmed that a compound characterized by having a structure such as an aralkyl group on the 2-positioned amino group of 2,4-diaminopyrimidine and further having a bicyclo ring-substituted alkyl group on the 4-positioned amino group or salt thereof has an excellent PKCθ-inhibiting activity, and the invention has been completed. The 2,4-diaminopyrimidine compound having a bicyclo ring-substituted alkyl group can be used as a PKCθ-inhibitor, and an acute rejection inhibitor in transplantation.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供可用作具有PKCθ抑制活性的药物的活性成分的化合物，特别是用于抑制移植中急性排斥的药物组合物。已经研究了具有PKCθ抑制活性的化合物。因此已经证实，在4-位氨基或盐上，在2,4-二氨基嘧啶的2-位氨基上具有如芳烷基结构，还具有双环取代烷基的化合物其具有优异的PKCθ抑制活性，本发明已经完成。具有双环取代的烷基的2,4-二氨基嘧啶化合物可用作PKCθ抑制剂和移植中的急性排斥抑制剂。版权所有（C）2011，JPO＆INPIT

6. 发明申请

WO0247139A3 METHODE OF FORMING A COPPER FILM ON A SUBSTRATE 审中-公开
标题翻译：在基材上形成铜膜的方法
公开(公告)号：WO0247139A3
公开(公告)日：2004-01-15
申请号：PCT/JP0110590
申请日：2001-12-04
申请人： EBARA CORP , KONDO FUMIO , MISHIMA KOJI , TANAKA AKIRA , SUZUKI YOKO , TOGAWA TETSUJI , INOUE HIROAKI
发明人： KONDO FUMIO , MISHIMA KOJI , TANAKA AKIRA , SUZUKI YOKO , TOGAWA TETSUJI , INOUE HIROAKI
IPC分类号： B65G49/07 , B24B37/04 , B24B49/16 , C23C18/16 , C25D5/00 , C25D5/50 , C25D7/12 , H01L21/00 , H01L21/02 , H01L21/288 , H01L21/304 , H01L21/3205 , H01L21/321 , H01L21/673 , H01L21/677 , H01L21/768 , H01L23/52 , B24B7/22
CPC分类号： H01L21/67161 , B24B37/005 , B24B37/042 , B24B37/245 , B24B37/345 , B24B41/061 , B24B49/16 , C23C18/1632 , C23C18/1653 , C25D7/123 , H01L21/02074 , H01L21/02087 , H01L21/0209 , H01L21/288 , H01L21/2885 , H01L21/3212 , H01L21/67167 , H01L21/67173 , H01L21/67184 , H01L21/67219 , H01L21/6723 , H01L21/67393 , H01L21/67396 , H01L21/67772 , H01L21/7684 , H01L21/76843 , H01L21/76849 , H01L21/76864 , H01L21/76873 , H01L21/76874 , H01L21/76877
摘要： A substrate processing method comprising steps for forming a copper film on a surface of a substrate. These steps includes the step of filling a first metal in the trenches so as to form a plated film of the first metal on an entire surface of the substrate by electroplating, wherein the electromagnetic field is adjusted by the virtual anode so that differences of thickness of the plated film between the central portion and the peripheral portion of the substrate being minimized, and polishing and removing the plated film by pressing the substrate to the polishing surface, wherein the pressures pressing the substrate to the polishing surface at a central portion and a peripheral portion are adjusted.
摘要翻译：一种基板处理方法，包括在基板的表面上形成铜膜的步骤。这些步骤包括在沟槽中填充第一金属以便通过电镀在基板的整个表面上形成第一金属的镀膜的步骤，其中电磁场由虚拟阳极调节，使得厚度差异基板的中心部分和周边部分之间的镀膜最小化，并且通过将基板压在研磨表面上来研磨和去除镀膜，其中将基板压在抛光表面的压力在中心部分和周边部分进行调整。

7. 发明申请

WO2006082887A3 MULTILAYER FILM, LAMINATE USING SAME, AND METHOD FOR PRODUCING LAMINATE 审中-公开
标题翻译：多层膜，使用它的层压板以及生产层压板的方法
公开(公告)号：WO2006082887A3
公开(公告)日：2007-01-18
申请号：PCT/JP2006301758
申请日：2006-02-02
申请人： ZEON CORP , TANAKA AKIRA
发明人： TANAKA AKIRA
IPC分类号： B32B27/00 , B32B27/24 , C09J7/02 , C09J201/02
CPC分类号： G02B1/10 , B32B17/10018 , B32B37/12 , B32B2315/08 , B32B2398/20 , B32B2457/00 , C09J7/22 , C09J163/00 , C09J2201/622 , Y10T156/1089 , Y10T156/1092 , Y10T428/266 , Y10T428/269 , Y10T428/28 , Y10T428/2813 , Y10T428/287 , Y10T428/2891 , Y10T428/31504 , Y10T428/31507 , Y10T428/31616 , Y10T428/31645 , Y10T428/31649 , Y10T428/31667 , Y10T428/31678 , Y10T428/31681 , Y10T428/31692 , Y10T428/31786 , Y10T428/31855
摘要： Disclosed is a multilayer film for a strain-free laminate which is used for flexible TFT substrates or the like. Also disclosed are a laminate obtained by arranging such a multilayer film on a substrate made of an inorganic material, and a method for producing such a laminate. Specifically disclosed is a multilayer film wherein an adhesive resin layer which can be adhered to inorganic materials is arranged on a film base made of a resin. This multilayer film is characterized in that the average thermal expansion coefficient between 60°C and 80°C measured while heating the multilayer film from 30°C to 130°C is larger by 30-400 ppm/°C than the average thermal expansion coefficient between 60°C and 80°C measured while reheating the multilayer film, which is once heated to 130°C and then cooled to 30°C or less, from 30°C to 130°C. Also specifically disclosed is a laminate obtained by bonding such a multilayer film on at least one surface of a substrate which is made of an inorganic material. Further specifically disclosed is a method for producing such a laminate wherein the multilayer film and the substrate of inorganic material are bonded at a temperature not less than 40°C but not more than the glass transition temperature of a resin constituting the adhesive resin layer of the multilayer film.
摘要翻译：公开了用于柔性TFT基板等的无应变层叠体的多层膜。还公开了通过将这种多层膜设置在由无机材料制成的基板上获得的层压体以及这种层压体的制造方法。具体公开了一种多层膜，其中可粘附到无机材料上的粘合树脂层布置在由树脂制成的膜基底上。该多层膜的特征在于，将多层膜从30℃加热至130℃时测定的60℃〜80℃的平均热膨胀系数比平均热膨胀系数大30〜400ppm /℃ 在将多次膜再加热一次加热至130℃，然后冷却至30℃以下的同时，在30℃〜130℃下测定60℃〜80℃。还具体公开了通过在由无机材料制成的基板的至少一个表面上接合这样的多层膜获得的层压体。进一步具体公开的是这样的层压体的制造方法，其中，多层膜和无机材料的基材在不低于40℃但不高于构成粘合树脂层的树脂的玻璃化转变温度的温度下接合多层膜。

8. 发明专利

CA1299718C SEMICONDUCTOR LASER DEVICE AND METHOD OF MANUFACTURING THE SAME 未知
公开(公告)号：CA1299718C
公开(公告)日：1992-04-28
申请号：CA585268
申请日：1988-12-07
申请人： TANAKA AKIRA
发明人： TANAKA AKIRA
IPC分类号： H01S5/227 , H01S3/19 , H01L33/00
摘要： A semiconductor laser device comprising a semiconductor substrate, a multi-layered mesa stripe having an active layer sandwitched between a semiconductor layer of the same conductivity type as that of the active layer and a semiconductor layer of the opposite conductivity type to that of the active layer, and formed on the substrate, a burying layer having a refractive index smaller than that of active layer and burying both sides of the mesa stripe, and a pair of electrodes for supplying a current to active layer. The mesa stripe is constructed such that both sides of active layer neighboring to the semiconductor layer of the opposite conductivity type substantially coinside with those of the semiconductor layer, and that active layer has a width decreasing toward the boundary between active layer and semiconductor layer of the same conductivity type, thereby to form a waist portion at the boundary, and in that a protective layer is formed to fill the waist portion, thus covering at least both sides of the active layer. A method for manufacturing the semiconductor laser device having above mentioned features, wherein etching of the multi-layer structure of semiconductor is so controlled to form a V-shaped waist portion at the boundary between active layer and semiconductor layer of the same conductivity type, and a protective layer is selectively formed to fill the waist portion.

9. 发明专利

BR9400219A 未知
公开(公告)号：BR9400219A
公开(公告)日：1995-03-21
申请号：BR9400219
申请日：1994-01-24
申请人： TANAKA AKIRA , TANAKA EMILIA
发明人： TANAKA AKIRA , TANAKA EMILIA
IPC分类号： A01G5/06 , A01G31/00

10. 发明公开

EP2325175A4 2,4-DIAMINOPYRIMIDINE COMPOUND 审中-公开
标题翻译： 2,4-DIAMINOPYRIMIDINVERBINDUNG
公开(公告)号：EP2325175A4
公开(公告)日：2012-03-21
申请号：EP09810074
申请日：2009-08-31
申请人： ASTELLAS PHARMA INC
发明人： TANAKA AKIRA , MUKOYOSHI KOICHIRO , KUNIKAWA SHIGEKI , TAKASUNA YUJI , MAEDA JUN , CHIDA NOBORU , NAGASHIMA SHINYA
IPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/5513 , A61P37/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D453/02 , C07D471/08
CPC分类号： C07D239/48

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