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1. 发明申请

WO2006052566A3 GPR41 AND MODULATORS THEREOF FOR THE TREATMENT OF INSULIN-RELATED DISORDERS 审中-公开
标题翻译： GPR41及其与胰岛素相关性疾病治疗的调节剂
公开(公告)号：WO2006052566A3
公开(公告)日：2006-10-12
申请号：PCT/US2005039551
申请日：2005-11-01
申请人： ARENA PHARM INC , LEONARD JAMES N , CHU ZHI LIANG , BRUCE MARC A , BOATMAN P DOUGLAS
发明人： LEONARD JAMES N , CHU ZHI LIANG , BRUCE MARC A , BOATMAN P DOUGLAS
IPC分类号： A61K49/00 , G01N33/50
CPC分类号： G01N33/66 , G01N2500/04
摘要： The present invention relates to a method for identifying a glycemic stabilizing compound by: a) contacting a candidate compound with GPR41, and b) determining whether GPR41 functionality is modulated, where a modulation in GPR41 functionality is indicative of the candidate compound being a glycemic stabilizing compound. In addition, the invention relates to a method for identifying a glycemic stabilizing compound, comprising: a) contacting a candidate compound with GPR41, and b) determining whether GPR41 functionality is increased, wherein an increase in GPR41 functionality is indicative of the candidate compound being a glycemic stabilizing compound. Further, the invention relates to a method for identifying a glycemic stabilizing compound, comprising: a) contacting a candidate compound with GPR41, and b) determining whether GPR41 functionality is decreased, wherein a decrease in GPR41 functionality is indicative of the candidate compound being a glycemic stabilizing compound.
摘要翻译：本发明涉及通过以下方式鉴定血糖稳定化合物的方法：a）使候选化合物与GPR41接触，以及b）确定是否调节GPR41功能性，其中GPR41官能度的调节指示候选化合物是血糖稳定剂复合。此外，本发明涉及一种鉴定血糖稳定化合物的方法，包括：a）使候选化合物与GPR41接触，和b）确定GPR41的功能是否增加，其中GPR41功能的增加指示候选化合物为血糖稳定化合物。此外，本发明涉及用于鉴定血糖稳定化合物的方法，其包括：a）使候选化合物与GPR41接触，和b）确定GPR41的功能性是否降低，其中GPR41官能度的降低指示候选化合物为血糖稳定化合物。

2. 发明申请

WO2005119252A3 MODULATORS OF GPR35 FOR THE TREATMENT OF METABOLIC-RELATED DISORDERS 审中-公开
标题翻译： GPR35的调节剂用于治疗与代谢相关的疾病
公开(公告)号：WO2005119252A3
公开(公告)日：2006-01-12
申请号：PCT/US2005018082
申请日：2005-05-23
申请人： ARENA PHARM INC , LEONARD JAMES N , CHU ZHI LIANG , UNETT DAVID J , GATLIN JOEL E , GAIDAROV IBRAGIM , QIU JUN , SKINNER PHILIP J , BOATMAN P DOUGLAS
发明人： LEONARD JAMES N , CHU ZHI LIANG , UNETT DAVID J , GATLIN JOEL E , GAIDAROV IBRAGIM , QIU JUN , SKINNER PHILIP J , BOATMAN P DOUGLAS
IPC分类号： A61K31/425 , G01N33/50 , A61P3/06 , A61P3/10
CPC分类号： G01N33/6893 , A61K31/425 , G01N2333/726 , G01N2500/00
摘要： The present invention relates to a method for identifying a metabolic stabilizing compound, comprising: a) contacting a candidate compound with GPR35, and b) determining whether GPR35 functionality is increased, wherein an increase in GPR35 functionality is indicative of the candidate compound being a metabolic stabilizing compound. The invention further relates to use of a GPR35 modulator for the manufacture of a medicament for use as a metabolic stabilizing agent. In addition, the invention relates to a method for increasing GPR35 function, comprising contacting GPR35 with an effective amount of a compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein X is O or S; and R1, R2, R3, R4, and R5 are each independently selected from the group consisting of H, C1-4 alkoxy, C1-4 alkyl, halogen, hydroxyl, and nitro; wherein said C1-4 alkoxy is optionally substituted with carbo-C1-4-alkoxy or carboxy.
摘要翻译：本发明涉及用于鉴定代谢稳定化合物的方法，包括：a）使候选化合物与GPR35接触，和b）确定GPR35的功能是否增加，其中GPR35功能的增加指示候选化合物是代谢稳定化合物。本发明还涉及GPR35调节剂在制备用作代谢稳定剂的药物中的用途。另外，本发明涉及增加GPR35功能的方法，其包括使GPR35与有效量的式（I）化合物或其药学上可接受的盐接触，其中X为O或S; 并且R 1，R 2，R 3，R 4和R 5各自独立地选自H，C 1-4烷氧基，C 1-4烷基，卤素，羟基和硝基; 其中所述C 1-4烷氧基任选被碳-C 1-4 - 烷氧基或羧基取代。

3. 发明申请

WO0242461A2 ENDOGENOUS AND NON-ENDOGENOUS VERSIONS OF HUMAN G PROTEIN-COUPLED RECEPTORS 审中-公开
标题翻译：人G蛋白偶联受体的内源性和非内源性版本
公开(公告)号：WO0242461A2
公开(公告)日：2002-05-30
申请号：PCT/US0144386
申请日：2001-11-26
申请人： ARENA PHARM INC , CHEN RUOPING , CHU ZHI LIANG , DANG HUONG T , LOWITZ KEVIN P , PRIDE CAMERON
发明人： CHEN RUOPING , CHU ZHI LIANG , DANG HUONG T , LOWITZ KEVIN P , PRIDE CAMERON
IPC分类号： C12N15/09 , C07K14/705 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12
CPC分类号： C07K14/705
摘要： The invention disclosed in this patent document relates to transmembrane receptors, more particularly to a human G protein-coupled receptor for which the endogenous ligand is unknown, and to mutated (non-endogenous) versions of the human GPCRs for evidence of constitutive activity.
摘要翻译：本专利文献中公开的发明涉及跨膜受体，更具体地涉及内源性配体未知的人G蛋白偶联受体，以及用于组成型活性证据的人GPCR的突变（非内源）版本。

4. 发明专利

AU1989002A Endogenous and non-endogenous versions of human g protein-coupled receptors 未知
公开(公告)号：AU1989002A
公开(公告)日：2002-06-03
申请号：AU1989002
申请日：2001-11-26
申请人： ARENA PHARM INC
发明人： CHEN RUOPING , CHU ZHI LIANG , DANG HUONG T , LOWITZ KEVIN P , PRIDE CAMERON
IPC分类号： C12N15/09 , C07K14/705 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12

5. 发明专利

AU2007216752A8 Endogenous and non-endogenous versions of human G protein-coupled receptor hRUP35 未知
公开(公告)号：AU2007216752A8
公开(公告)日：2007-10-18
申请号：AU2007216752
申请日：2007-09-12
申请人： ARENA PHARM INC
发明人： CHU ZHI LIANG , CHEN RUOPING , PRIDE CAMERON
IPC分类号： C12N15/09 , C07K14/705 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12

6. 发明专利

AU2007216752A1 Endogenous and non-endogenous versions of human G protein-coupled receptors 未知
公开(公告)号：AU2007216752A1
公开(公告)日：2007-10-04
申请号：AU2007216752
申请日：2007-09-12
申请人： ARENA PHARM INC
发明人： CHU ZHI LIANG , CHEN RUOPING , PRIDE CAMERON
IPC分类号： C12N15/09 , C07K14/705 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12

7. 发明专利

ES2498972T3 GPR41 y sus moduladores para el tratamiento de los trastornos relacionados con la insulina 未知
公开(公告)号：ES2498972T3
公开(公告)日：2014-09-26
申请号：ES05818064
申请日：2005-11-01
申请人： ARENA PHARM INC
发明人： LEONARD JAMES N , CHU ZHI LIANG , BRUCE MARC A , BOATMAN P DOUGLAS
IPC分类号： G01N33/66
摘要： Un procedimiento para identificar un compuesto estabilizador de la glucemia, que comprende: a) poner en contacto un compuesto candidato con GPR41, y b) determinar si la funcionalidad de GPR41 queda modulada, donde una modulación en la funcionalidad de GPR41 es indicativa de que el compuesto candidato es un compuesto estabilizador de la glucemia, dicho GPR41 tiene una secuencia de aminoácidos que se muestra en la SEC. ID Nº:2 o una de sus variantes u ortólogos, donde dicha variante es una variante alélica, variante de corte y empalme o variante de sustitución conservativa de aminoácidos de GPR41.

8. 发明专利

CA2584224A1 GPR41 AND MODULATORS THEREOF FOR THE TREATMENT OF INSULIN-RELATED DISORDERS 未知
公开(公告)号：CA2584224A1
公开(公告)日：2006-05-18
申请号：CA2584224
申请日：2005-11-01
申请人： ARENA PHARM INC
发明人： CHU ZHI LIANG , LEONARD JAMES N , BRUCE MARC A , BOATMAN P DOUGLAS
IPC分类号： A61K49/00 , G01N33/50
摘要： The present invention relates to a method for identifying a glycemic stabilizing compound by: a) contacting a candidate compound with GPR41, and b) determining whether GPR41 functionality is modulated, where a modulation in GPR41 functionality is indicative of the candidate compound being a glycemic stabilizing compound. In addition, the invention relates to a method for identifying a glycemic stabilizing compound, comprising: a) contacting a candidate compound with GPR41, and b) determining whether GPR41 functionality is increased, wherein an increase in GPR41 functionality is indicative of the candidate compound being a glycemic stabilizing compound. Further, the invention relates to a method for identifying a glycemic stabilizing compound, comprising: a) contacting a candidate compound with GPR41, and b) determining whether GPR41 functionality is decreased, wherein a decrease in GPR41 functionality is indicative of the candidate compound being a glycemic stabilizing compound.

9. 发明专利

AU2005305083A1 GPR41 and modulators thereof for the treatment of insulin-related disorders 未知
公开(公告)号：AU2005305083A1
公开(公告)日：2006-05-18
申请号：AU2005305083
申请日：2005-11-01
申请人： ARENA PHARM INC
发明人： CHU ZHI LIANG , BOATMAN P DOUGLAS , LEONARD JAMES N , BRUCE MARC A
IPC分类号： A61K49/00 , G01N33/50
摘要： The present invention relates to a method for identifying a glycemic stabilizing compound by: a) contacting a candidate compound with GPR41, and b) determining whether GPR41 functionality is modulated, where a modulation in GPR41 functionality is indicative of the candidate compound being a glycemic stabilizing compound. In addition, the invention relates to a method for identifying a glycemic stabilizing compound, comprising: a) contacting a candidate compound with GPR41, and b) determining whether GPR41 functionality is increased, wherein an increase in GPR41 functionality is indicative of the candidate compound being a glycemic stabilizing compound. Further, the invention relates to a method for identifying a glycemic stabilizing compound, comprising: a) contacting a candidate compound with GPR41, and b) determining whether GPR41 functionality is decreased, wherein a decrease in GPR41 functionality is indicative of the candidate compound being a glycemic stabilizing compound.

10. 发明专利

AU2005305083B2 GPR41 and modulators thereof for the treatment of insulin-related disorders 未知
公开(公告)号：AU2005305083B2
公开(公告)日：2012-02-02
申请号：AU2005305083
申请日：2005-11-01
申请人： ARENA PHARM INC
发明人： CHU ZHI LIANG , BOATMAN P DOUGLAS , LEONARD JAMES N , BRUCE MARC A
IPC分类号： A61K49/00 , G01N33/50
摘要： The present invention relates to a method for identifying a glycemic stabilizing compound by: a) contacting a candidate compound with GPR41, and b) determining whether GPR41 functionality is modulated, where a modulation in GPR41 functionality is indicative of the candidate compound being a glycemic stabilizing compound. In addition, the invention relates to a method for identifying a glycemic stabilizing compound, comprising: a) contacting a candidate compound with GPR41, and b) determining whether GPR41 functionality is increased, wherein an increase in GPR41 functionality is indicative of the candidate compound being a glycemic stabilizing compound. Further, the invention relates to a method for identifying a glycemic stabilizing compound, comprising: a) contacting a candidate compound with GPR41, and b) determining whether GPR41 functionality is decreased, wherein a decrease in GPR41 functionality is indicative of the candidate compound being a glycemic stabilizing compound.

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