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1. 发明申请

WO0149236A2 METHOD AND SYSTEM FOR TREATING CARDIAC ARREST 审中-公开
标题翻译：治疗心脏病的方法和系统
公开(公告)号：WO0149236A2
公开(公告)日：2001-07-12
申请号：PCT/US0100058
申请日：2001-01-03
申请人： ALSIUS CORP , LASERSOHN JACK W , WORTHEN WILLIAM J , EVANS SCOTT M , WINTER SUZANNE C , BALDING DAVID P
发明人： LASERSOHN JACK W , WORTHEN WILLIAM J , EVANS SCOTT M , WINTER SUZANNE C , BALDING DAVID P
IPC分类号： A61B18/00 , A61F7/00 , A61F7/12 , A61H31/00 , A61M1/36 , A61M5/44 , A61N1/39 , A61H
CPC分类号： A61F7/12 , A61B2018/00011 , A61F7/123 , A61F2007/0056 , A61F2007/0076 , A61F2007/126 , A61H31/006 , A61H2201/0214 , A61M1/369 , A61M5/44 , A61M16/0465 , A61M16/10 , A61N1/39 , A61N1/3962
摘要： A method for treating cardiac arrest includes defibrillating the patient and/or ventilating the patient and/or administering a cardiac arrest drug such as epinephrine to resuscitate the patient, and then cooling the patient's body temperature using one or more cooling catheters positioned in the central venous system of the patient and/or particularly cooling the patient's brain temperature using a catheter advanced into the aortic arch or into the carotid artery whereby a bolus of cold saline solution is introduced into the blood supplied to the brain to lower the brain temperature quickly, and further cooling or maintaining the brain temperature at a desired level by pumping coolant in a closed circuit formation between the catheter and the coolant source to remove heat from the blood supplied to the patient's brain.
摘要翻译：用于治疗心脏骤停的方法包括使患者去纤维化和/或使患者通风和/或施用心脏骤停药物如肾上腺素来复苏患者，然后使用位于中心静脉中的一个或多个冷却导管来冷却患者的体温系统和/或特别是使用进入主动脉弓或进入颈动脉的导管特别冷却患者的脑温度，由此将大量冷盐水溶液引入供应给脑的血液中以迅速降低脑温度，并且通过在导管和冷却剂源之间的封闭回路形成中泵送冷却剂以便从供应给患者的大脑的血液中除去热量来进一步冷却或保持脑温度达到所需水平。

2. 发明申请

WO0103606A9 OPERATIONAL ENHANCEMENTS FOR USING COOLING CATHETERS 审中-公开
标题翻译：使用冷却导管的操作增强
公开(公告)号：WO0103606A9
公开(公告)日：2002-09-12
申请号：PCT/US0018601
申请日：2000-07-07
申请人： ALSIUS CORP , BALDING DAVID P
发明人： BALDING DAVID P
IPC分类号： A61F7/12 , A61B18/18
CPC分类号： A61F7/12 , A61F2007/126
摘要： This invention is a cooling catheter (100) a continuous internal path extending from a supply opening (116) to the distal end of the catheter, and then back to a return operning (118); thus forming a sealed path, and preventing any contact between the coolant, and the patient. The catheter may have various structural features such as a multi-lumen coolant path, a heat exchange bundle of multiple thin hollow fibers, various shapes, etc. One operating technique includes the physician inserting the catheter into the patient's body, attaching the supply opening to a coolant source, and applying suction to the return opening, causing coolant to travel within the predefined coolant path. In another embodiment, which may operate under pressure, and/or suction, the coolant comprises a slushy medium of ice particles in a liquid coolant.
摘要翻译：本发明是冷却导管（100），从供给开口（116）延伸到导管的远端，然后返回到返回操作（118）的连续内部路径; 从而形成密封路径，并且防止冷却剂和患者之间的任何接触。导管可以具有各种结构特征，例如多腔冷却剂通道，多个中空纤维的热交换束，各种形状等。一种操作技术包括医师将导管插入患者体内，将供应开口连接到冷却剂源，并且向返回开口施加吸力，导致冷却剂在预定的冷却剂路径内行进。在可在压力和/或吸力下运行的另一实施例中，冷却剂包括液体冷却剂中的冰颗粒的泥浆介质。

3. 发明申请

WO0103606A3 OPERATIONAL ENHANCEMENTS FOR USING COOLING CATHETERS 审中-公开
标题翻译：使用冷却导管的操作增强
公开(公告)号：WO0103606A3
公开(公告)日：2001-11-15
申请号：PCT/US0018601
申请日：2000-07-07
申请人： ALSIUS CORP , BALDING DAVID P
发明人： BALDING DAVID P
IPC分类号： A61F7/12 , A61B18/18
CPC分类号： A61F7/12 , A61F2007/126
摘要： This invention is a cooling catheter (100) a continuous internal path extending from a supply opening (116) to the distal end of the catheter, and then back to a return operning (118); thus forming a sealed path, and preventing any contact between the coolant, and the patient. The catheter may have various structural features such as a multi-lumen coolant path, a heat exchange bundle of multiple thin hollow fibers, various shapes, etc. One operating technique includes the physician inserting the catheter into the patient's body, attaching the supply opening to a coolant source, and applying suction to the return opening, causing coolant to travel within the predefined coolant path. In another embodiment, which may operate under pressure, and/or suction, the coolant comprises a slushy medium of ice particles in a liquid coolant.
摘要翻译：本发明是冷却导管（100），从供应开口（116）延伸到导管的远端，然后返回到返回操作（118）的连续内部路径; 从而形成密封路径，并且防止冷却剂和患者之间的任何接触。导管可以具有各种结构特征，例如多腔冷却剂路径，多个中空纤维的热交换束，各种形状等。一种操作技术包括医师将导管插入患者体内，将供应开口连接到冷却剂源，并且将吸力施加到返回开口，使冷却剂在预定的冷却剂路径内行进。在可在压力和/或吸力下运行的另一实施例中，冷却剂包括液体冷却剂中的冰颗粒的泥浆介质。

4. 发明申请

WO0062837A2 CATHETER WITH MULTIPLE HEATING/COOLING FIBERS EMPLOYING FIBER SPREADING FEATURES 审中-公开
标题翻译：带多个加热/冷却纤维的导管采用纤维扩展功能
公开(公告)号：WO0062837A2
公开(公告)日：2000-10-26
申请号：PCT/US0010494
申请日：2000-04-19
申请人： ALSIUS CORP , WALKER BLAIR D , EVANS SCOTT M , BALDING DAVID P , HALLAM GREGG , SHIMADA LYNN M
发明人： WALKER BLAIR D , EVANS SCOTT M , BALDING DAVID P , HALLAM GREGG , SHIMADA LYNN M
IPC分类号： A61M25/00 , A61B18/00 , A61F7/00 , A61F7/12 , A61M1/36 , A61M5/44 , A61M
CPC分类号： A61F7/123 , A61B2018/00011 , A61F7/12 , A61F2007/0054 , A61F2007/126 , A61M1/369 , A61M5/44 , A61M25/00 , A61M25/0009 , A61M2205/36
摘要： This invention is a catheter (110) using multiple hollow fibers to carry a heating/cooling fluid employs fiber (108) spreading features to improve heat transfer, and prevent clotting of body fluids within which the catheter is immersed. The catheter includes an outer tube (102) surrounding an inner tube (104). The inner tube conveys fluids in one direction, a passageway between inner, and outer tubes conveying fluids in the opposite direction. The catheter's distal end is closed, but the proximal end is open to permit introduction of a heating or cooling fluid into the inner tube, and withdrawal of the fluid from the passageway between the inner, and outer tubes. At the tubes' distal end resides a proximal fluid transfer housing (106) coupled to multiple hollow heat exchange fibers. The distal ends of these fibers may be commonly connected to a distal fluid transfer housing (110), and optional reservoir (112). Actuating structure(s) may be included to spread the fibers.
摘要翻译：本发明是使用多个中空纤维承载加热/冷却流体的导管（110），该加热/冷却流体采用纤维（108）扩散特征以改善热传递，并且防止导管浸入其中的体液的凝结。导管包括围绕内管（104）的外管（102）。内管在一个方向上输送流体，内管和外管之间的通道沿相反方向输送流体。导管的远端是封闭的，但是近端是敞开的，以允许将加热或冷却流体引入内管，并且将流体从内管和外管之间的通道中取出。在管的远端存在耦合到多个中空热交换纤维的近端流体转移壳体（106）。这些纤维的远端可以共同连接到远端流体转移壳体（110）和任选的储存器（112）。可以包括致动结构以展开纤维。

5. 发明申请

WO0112122A3 METHOD AND SYSTEM FOR TREATING CARDIAC ARREST USING HYPOTHERMIA 审中-公开
标题翻译：使用血压治疗心脏病的方法和系统
公开(公告)号：WO0112122A3
公开(公告)日：2008-03-13
申请号：PCT/US0022198
申请日：2000-08-14
申请人： ALSIUS CORP , WORTHEN WILLIAM J , EVANS SCOTT M , WINTER SUZANNE C , BALDING DAVID P
发明人： WORTHEN WILLIAM J , EVANS SCOTT M , WINTER SUZANNE C , BALDING DAVID P
IPC分类号： A61B17/00 , A61F7/12 , A61B18/00 , A61F7/00 , A61M1/36 , A61M5/44 , A61N1/39
CPC分类号： A61F7/123 , A61B2018/00011 , A61F7/12 , A61F2007/0056 , A61F2007/126 , A61M1/369 , A61M5/44 , A61N1/39
摘要： A method for treating cardiac arrest includes defibrillating (38) the patient, and/or ventilating (42) the patient, administering a cardiac arrest drug such as epinephrine to resuscitate the patient, then cooling the patient using one or more cooling catheters (18) positioned in the central venous system of the patient.
摘要翻译：用于治疗心脏骤停的方法包括使患者去除纤维化（38）和/或通气（42）患者，施用心脏骤停药物例如肾上腺素以复苏患者，然后使用一个或多个冷却导管（18）冷却患者，位于患者的中心静脉系统中。

6. 发明申请

WO0072787A9 METHOD OF SELECTIVELY SHAPING HOLLOW FIBERS OF HEAT EXCHANGE CATHETER 审中-公开
标题翻译：选择形成热交换器中空纤维的方法
公开(公告)号：WO0072787A9
公开(公告)日：2002-07-25
申请号：PCT/US0014480
申请日：2000-05-25
申请人： ALSIUS CORP , BALDING DAVID P , FOSTER STEVEN C
发明人： BALDING DAVID P , FOSTER STEVEN C
IPC分类号： A61F7/00 , A61F7/12 , F28F21/06
CPC分类号： A61F7/12 , A61F2007/0054 , F28F21/062 , Y10T428/2976
摘要： A group of multiple hollow fibers (600) are shaped to introduce angular divergence (608) among the fibers, or to introduce a selected oscillation into the fibers. In one case, the fibers (800) are held in parallel while upper, and lower crimping assemblies of parallel crimping bars (904) are drawn together on opposite sides of the parallel fibers, sandwiching the fibers between them causing each fiber to assume a shape that oscillates as the fiber repeatedly goes over, and under successive bars. Since the crimping bars are aligned at oblique angles to the fibers, the peaks, and valleys of the successive fibers are offset. In this position, the fibers are heated, and then cooled to permanently retain their shape. In another case, a shaping technique utilizes a lattice of criss-crossing tines (300) defining multiple apertures which results in the fibers having a prescribed outward divergence relative to each other.
摘要翻译：一组多个中空纤维（600）成形为在纤维之间引入角度发散（608），或将选定的振动引入纤维中。在一种情况下，纤维（800）保持平行，而平行卷边杆（904）的上部和下部压接组件被拉在一起在平行纤维的相对侧上，将纤维夹在它们之间，使得每个纤维呈现形状当光纤重复地过去时，并在连续的条形下振荡。由于压接杆与纤维成倾斜的角度对齐，所以连续纤维的峰和谷被抵消。在这个位置，纤维被加热，然后被冷却以永久保持其形状。在另一种情况下，成形技术利用限定多个孔的十字交叉尖（300）的格子，其导致纤维相对于彼此具有规定的向外发散。

7. 发明申请

WO0149236A9 METHOD AND SYSTEM FOR TREATING CARDIAC ARREST 审中-公开
标题翻译：治疗心脏病的方法和系统
公开(公告)号：WO0149236A9
公开(公告)日：2002-07-18
申请号：PCT/US0100058
申请日：2001-01-03
申请人： ALSIUS CORP , LASERSOHN JACK W , WORTHEN WILLIAM J , EVANS SCOTT M , WINTER SUZANNE C , BALDING DAVID P
发明人： LASERSOHN JACK W , WORTHEN WILLIAM J , EVANS SCOTT M , WINTER SUZANNE C , BALDING DAVID P
IPC分类号： A61B18/00 , A61F7/00 , A61F7/12 , A61H31/00 , A61M1/36 , A61M5/44 , A61N1/39
CPC分类号： A61F7/12 , A61B2018/00011 , A61F7/123 , A61F2007/0056 , A61F2007/0076 , A61F2007/126 , A61H31/006 , A61H2201/0214 , A61M1/369 , A61M5/44 , A61M16/0465 , A61M16/10 , A61N1/39 , A61N1/3962
摘要： A method for treating cardiac arrest includes defibrillating the patient and/or ventilating the patient and/or administering a cardiac arrest drug such as epinephrine to resuscitate the patient, and then cooling the patient's body temperature using one or more cooling catheters (51, 52) placed in the central venous system and/or particularly cooling the patient's brain temperature using a catheter in the aortic arch or carotid artery.
摘要翻译：用于治疗心脏骤停的方法包括使患者去纤维化和/或使患者通气和/或施用心脏骤停药物例如肾上腺素以使患者复苏，然后使用一个或多个冷却导管（51,52）冷却患者的体温，放置在中心静脉系统中和/或特别地使用主动脉弓或颈动脉中的导管来冷却患者的脑温度。

8. 发明申请

WO0062837A9 CATHETER WITH MULTIPLE HEATING/COOLING FIBERS EMPLOYING FIBER SPREADING FEATURES 审中-公开
标题翻译：带多个加热/冷却纤维的导管采用纤维扩展功能
公开(公告)号：WO0062837A9
公开(公告)日：2002-03-14
申请号：PCT/US0010494
申请日：2000-04-19
申请人： ALSIUS CORP , WALKER BLAIR D , EVANS SCOTT M , BALDING DAVID P , HALLAM GREGG , SHIMADA LYNN M
发明人： WALKER BLAIR D , EVANS SCOTT M , BALDING DAVID P , HALLAM GREGG , SHIMADA LYNN M
IPC分类号： A61M25/00 , A61B18/00 , A61F7/00 , A61F7/12 , A61M1/36 , A61M5/44 , A61B18/04 , F28F1/00 , H05B7/12
CPC分类号： A61F7/123 , A61B2018/00011 , A61F7/12 , A61F2007/0054 , A61F2007/126 , A61M1/369 , A61M5/44 , A61M25/00 , A61M25/0009 , A61M2205/36
摘要： This invention is a catheter (110) using multiple hollow fibers to carry a heating/cooling fluid employs fiber (108) spreading features to improve heat transfer, and prevent clotting of body fluids within which the catheter is immersed. The catheter includes an outer tube (102) surrounding an inner tube (104). The inner tube conveys fluids in one direction, a passageway between inner, and outer tubes conveying fluids in the opposite direction. The catheter's distal end is closed, but the proximal end is open to permit introduction of a heating or cooling fluid into the inner tube, and withdrawal of the fluid from the passageway between the inner, and outer tubes. At the tubes' distal end resides a proximal fluid transfer housing (106) coupled to multiple hollow heat exchange fibers. The distal ends of these fibers may be commonly connected to a distal fluid transfer housing (110), and optional reservoir (112). Actuating structure(s) may be included to spread the fibers.
摘要翻译：本发明是使用多个中空纤维承载加热/冷却流体的导管（110），该加热/冷却流体采用纤维（108）扩散特征以改善热传递，并且防止导管浸入其中的体液的凝结。导管包括围绕内管（104）的外管（102）。内管在一个方向上输送流体，内管和外管之间的通道沿相反方向输送流体。导管的远端是封闭的，但是近端是敞开的，以允许将加热或冷却流体引入内管，并且将流体从内管和外管之间的通道中取出。在管的远端存在耦合到多个中空热交换纤维的近端流体转移壳体（106）。这些纤维的远端可以共同连接到远端流体转移壳体（110）和任选的储存器（112）。可以包括致动结构以展开纤维。

9. 发明专利

AU4446101A Venous line catheter and method of operating the same 未知
公开(公告)号：AU4446101A
公开(公告)日：2002-04-08
申请号：AU4446101
申请日：2001-04-09
申请人： ALSIUS CORP
发明人： WALKER BLAIR D , EVANS SCOTT M , BALDING DAVID P , BARKER PETER
IPC分类号： A61B17/00 , A61F2/958 , A61F7/00 , A61F7/12 , A61M25/00

10. 发明专利

AU6638700A Method and system for treating cardiac arrest using hypothermia 未知
公开(公告)号：AU6638700A
公开(公告)日：2001-03-13
申请号：AU6638700
申请日：2000-08-14
申请人： ALSIUS CORP
发明人： WORTHEN WILLIAM J , EVANS SCOTT M , WINTER SUZANNE C , BALDING DAVID P
IPC分类号： A61B17/00 , A61B18/00 , A61F7/00 , A61F7/12 , A61M1/36 , A61M5/44 , A61N1/39

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