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1. 发明授权

US6393320B2 Method for treating cardiac arrest 有权
标题翻译：心脏停搏的治疗方法
公开(公告)号：US6393320B2
公开(公告)日：2002-05-21
申请号：US91137101
申请日：2001-07-24
申请人： ALSIUS CORP
发明人： LASERSOHN JACK W , WORTHEN WILLIAM J , EVANS SCOTT M , WINTER SUZANNE C , BALDING DAVID
IPC分类号： A61B18/00 , A61F7/00 , A61F7/12 , A61H31/00 , A61M1/36 , A61M5/44 , A61N1/39
CPC分类号： A61F7/12 , A61B2018/00011 , A61F7/123 , A61F2007/0056 , A61F2007/0076 , A61F2007/126 , A61H31/006 , A61H2201/0214 , A61M1/369 , A61M5/44 , A61M16/0465 , A61M16/10 , A61N1/39 , A61N1/3962
摘要： A method for treating cardiac arrest includes defibrillating the patient and/or ventilating the patient and/or administering a cardiac arrest drug such as epinephrine to resuscitate the patient, and then cooling the patient's body temperature using one or more cooling catheters positioned in the central venous system of the patient and/or particularly cooling the patient's brain temperature using a catheter advanced into the aortic arch or into the carotid artery whereby a bolus of cold saline solution is introduced into the blood supplied to the brain to lower the brain temperature quickly, and further cooling or maintaining the brain temperature at a desired level by pumping coolant in a closed circuit formation between the catheter and the coolant source to remove heat from the blood supplied to the patient's brain.
摘要翻译：用于治疗心脏骤停的方法包括使患者去纤维化和/或使患者通风和/或施用心脏骤停药物如肾上腺素来复苏患者，然后使用位于中心静脉中的一个或多个冷却导管来冷却患者的体温系统和/或特别是使用进入主动脉弓或进入颈动脉的导管特别冷却患者的脑温度，由此将大量冷盐水溶液引入供应给脑的血液中以迅速降低脑温度，并且通过在导管和冷却剂源之间的封闭回路形成中泵送冷却剂以便从供应给患者的大脑的血液中除去热量来进一步冷却或保持脑温度达到所需水平。

2. 发明专利

JP2009018210A Central venous line catheter 有权
标题翻译：中央通风线吸管
公开(公告)号：JP2009018210A
公开(公告)日：2009-01-29
申请号：JP2008279870
申请日：2008-10-30
申请人： Alsius Corp , オルシウス・コーポレイションAlsius Corporation
发明人： EVANS SCOTT M , ALIBERTO ANTHONY C , WORTHEN WILLIAM J
IPC分类号： A61B17/00 , A61M25/00 , A61B18/00 , A61F2/958 , A61F7/12 , A61M1/36 , A61M5/44
CPC分类号： A61F7/123 , A61B2018/00011 , A61M1/369 , A61M5/44
摘要： PROBLEM TO BE SOLVED: To provide a central venous line catheter adapted to actively perform heat exchange with a patient's body and can thereby raise or lower the body temperature at need. SOLUTION: A heat exchange element arranged to have a heat exchange relation with the blood of a patient is supplied to the central venous line. The heat exchange element houses in its inside a circulating fluid and the fluid is automatically cooled or warmed outside the patient' body in compliance with the patient's body temperature feedback mechanism. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供适于主动地与患者身体进行热交换的中心静脉导管导管，从而能够提高或降低需要时的体温。解决方案：将布置成与患者的血液具有热交换关系的热交换元件供应到中心静脉线。热交换元件在其内部容纳循环流体，并且流体在患者身体外部被自动冷却或加热，以符合患者体温反馈机制。版权所有（C）2009，JPO＆INPIT

3. 发明申请

WO2006023056A3 SYSTEM AND METHOD FOR TREATING CARDIAC ARREST AND MYOCARDIAL INFARCTION 审中-公开
标题翻译：治疗心脏病和心肌梗塞的系统和方法
公开(公告)号：WO2006023056A3
公开(公告)日：2007-05-31
申请号：PCT/US2005022478
申请日：2005-06-23
申请人： ALSIUS CORP , WORTHEN WILLIAM J , COLLINS KENNETH A
发明人： WORTHEN WILLIAM J , COLLINS KENNETH A
IPC分类号： A61F7/12
CPC分类号： A61F7/12 , A61F2007/126
摘要： A closed loop heat exchange catheter (18, 100, 200) can be placed in a patient (11) suffering from cardiac arrest or myocardial infarction to cool the patient. Oxygen is infused into the patient to provide extra oxygen to the heart. Both modalities reduce infarct volume.
摘要翻译：可以将闭合的热交换导管（18,100,200）放置在患有心脏骤停或心肌梗死的患者（11）中以冷却患者。氧气注入患者体内，为心脏提供额外的氧气。两种方式都可以减少梗死体积。

4. 发明申请

WO0149236A2 METHOD AND SYSTEM FOR TREATING CARDIAC ARREST 审中-公开
标题翻译：治疗心脏病的方法和系统
公开(公告)号：WO0149236A2
公开(公告)日：2001-07-12
申请号：PCT/US0100058
申请日：2001-01-03
申请人： ALSIUS CORP , LASERSOHN JACK W , WORTHEN WILLIAM J , EVANS SCOTT M , WINTER SUZANNE C , BALDING DAVID P
发明人： LASERSOHN JACK W , WORTHEN WILLIAM J , EVANS SCOTT M , WINTER SUZANNE C , BALDING DAVID P
IPC分类号： A61B18/00 , A61F7/00 , A61F7/12 , A61H31/00 , A61M1/36 , A61M5/44 , A61N1/39 , A61H
CPC分类号： A61F7/12 , A61B2018/00011 , A61F7/123 , A61F2007/0056 , A61F2007/0076 , A61F2007/126 , A61H31/006 , A61H2201/0214 , A61M1/369 , A61M5/44 , A61M16/0465 , A61M16/10 , A61N1/39 , A61N1/3962
摘要： A method for treating cardiac arrest includes defibrillating the patient and/or ventilating the patient and/or administering a cardiac arrest drug such as epinephrine to resuscitate the patient, and then cooling the patient's body temperature using one or more cooling catheters positioned in the central venous system of the patient and/or particularly cooling the patient's brain temperature using a catheter advanced into the aortic arch or into the carotid artery whereby a bolus of cold saline solution is introduced into the blood supplied to the brain to lower the brain temperature quickly, and further cooling or maintaining the brain temperature at a desired level by pumping coolant in a closed circuit formation between the catheter and the coolant source to remove heat from the blood supplied to the patient's brain.
摘要翻译：用于治疗心脏骤停的方法包括使患者去纤维化和/或使患者通风和/或施用心脏骤停药物如肾上腺素来复苏患者，然后使用位于中心静脉中的一个或多个冷却导管来冷却患者的体温系统和/或特别是使用进入主动脉弓或进入颈动脉的导管特别冷却患者的脑温度，由此将大量冷盐水溶液引入供应给脑的血液中以迅速降低脑温度，并且通过在导管和冷却剂源之间的封闭回路形成中泵送冷却剂以便从供应给患者的大脑的血液中除去热量来进一步冷却或保持脑温度达到所需水平。

5. 发明申请

WO0141708A9 METHOD AND SYSTEM FOR TREATING STROKE USING HYPOTHERMIA 审中-公开
标题翻译：使用。FOR FOR FOR。。。。。。。。。。。。。。。
公开(公告)号：WO0141708A9
公开(公告)日：2002-05-10
申请号：PCT/US0042676
申请日：2000-12-07
申请人： ALSIUS CORP , LUO XIA , EVANS SCOTT M , WORTHEN WILLIAM J
发明人： LUO XIA , EVANS SCOTT M , WORTHEN WILLIAM J
IPC分类号： A61F7/12 , A61M1/36
CPC分类号： A61F7/12 , A61F2007/126 , A61M1/369 , A61M2205/3606 , A61M2205/366
摘要： A method for treating stroke patients includes inducing mild or moderate hypothermia in a patient using one or more closed loop heat exchange catheters positioned either in the patient's central venous system, carotid artery or both when the patient's body temperature and/or brain temperature are above predetermined thresholds. Additional steps for treating and managing a stroke patient can also be undertaken, e.g., infusing paralytics, infusing neuro-protectants, infusing anti-clot and/or clot lysis medications, performing neuro-protection procedures, performing non-catheter-based hypothermia, performing angioplasty, deploying stent, removing clot(s), maintaining a predetermined ICP level such as draining CSF, and/or ventilating the patient.
摘要翻译：一种治疗中风患者的方法包括：当患者的体温和/或脑温度高于预定值时，使用位于患者的中心静脉系统，颈动脉或两者中的一个或多个闭环热交换导管在患者中诱导轻度或中度体温过低阈值。还可以进行用于治疗和管理中风患者的附加步骤，例如，输注麻醉剂，输注神经保护剂，输注抗凝块和/或凝块溶解药物，进行神经保护程序，执行基于非导管的低温，执行血管成形术，部署支架，去除血块，保持预定的ICP水平，例如排出CSF，和/或使患者通气。

6. 发明申请

WO0066053A9 CENTRAL VENOUS CATHETER WITH HEAT EXCHANGE MEMBRANE 审中-公开
标题翻译：具有热交换膜的中央通风管
公开(公告)号：WO0066053A9
公开(公告)日：2002-05-02
申请号：PCT/US0012137
申请日：2000-05-04
申请人： ALSIUS CORP , ALIBERTO ANTHONY C , EVANS SCOTT M , WORTHEN WILLIAM J
发明人： ALIBERTO ANTHONY C , EVANS SCOTT M , WORTHEN WILLIAM J
IPC分类号： A61B17/00 , A61B18/00 , A61F2/958 , A61F7/12 , A61M1/36 , A61M5/44 , A61M25/00 , A61M25/14 , A61M39/00 , A61M25/16 , A61M25/18 , A61M39/10
CPC分类号： A61F7/12 , A61B2018/00011 , A61F7/123 , A61F2007/126 , A61M1/369 , A61M5/44 , A61M25/00 , A61M25/0029 , A61M25/003 , A61M25/0032 , A61M25/1011 , A61M2205/36
摘要： A central venous catheter (18) includes coolant supply and returnlumens (54, 56) which communicate coolant to and from first and second heat exchange membranes (66, 68) arranged along the distal segment of the catheter. The coolant in the heat exchange membranes removes heat from the patient. Additional lumens (58, 60) are provided for conventional central venous catheter uses.
摘要翻译：中心静脉导管（18）包括冷却剂供应和回流腔（54,56），其将冷却剂连通到沿着导管的远端段布置的第一和第二热交换膜（66,68）。热交换膜中的冷却剂从患者中除去热量。为常规中心静脉导管使用提供额外的腔（58,60）。

7. 发明申请

WO0112122A3 METHOD AND SYSTEM FOR TREATING CARDIAC ARREST USING HYPOTHERMIA 审中-公开
标题翻译：使用血压治疗心脏病的方法和系统
公开(公告)号：WO0112122A3
公开(公告)日：2008-03-13
申请号：PCT/US0022198
申请日：2000-08-14
申请人： ALSIUS CORP , WORTHEN WILLIAM J , EVANS SCOTT M , WINTER SUZANNE C , BALDING DAVID P
发明人： WORTHEN WILLIAM J , EVANS SCOTT M , WINTER SUZANNE C , BALDING DAVID P
IPC分类号： A61B17/00 , A61F7/12 , A61B18/00 , A61F7/00 , A61M1/36 , A61M5/44 , A61N1/39
CPC分类号： A61F7/123 , A61B2018/00011 , A61F7/12 , A61F2007/0056 , A61F2007/126 , A61M1/369 , A61M5/44 , A61N1/39
摘要： A method for treating cardiac arrest includes defibrillating (38) the patient, and/or ventilating (42) the patient, administering a cardiac arrest drug such as epinephrine to resuscitate the patient, then cooling the patient using one or more cooling catheters (18) positioned in the central venous system of the patient.
摘要翻译：用于治疗心脏骤停的方法包括使患者去除纤维化（38）和/或通气（42）患者，施用心脏骤停药物例如肾上腺素以复苏患者，然后使用一个或多个冷却导管（18）冷却患者，位于患者的中心静脉系统中。

8. 发明申请

WO0226285A3 KIT OF PARTS INCLUDING A CENTRAL VENOUS LINE CATHETER HAVING A TEMPERATURE CONTROL SYSTEM 审中-公开
标题翻译：部件包括包括温度控制系统的中央通风管道
公开(公告)号：WO0226285A3
公开(公告)日：2002-08-29
申请号：PCT/US0130250
申请日：2001-09-27
申请人： ALSIUS CORP , EVANS SCOTT M , ALIBERTO ANTHONY C , WORTHEN WILLIAM J
发明人： EVANS SCOTT M , ALIBERTO ANTHONY C , WORTHEN WILLIAM J
IPC分类号： A61B17/00 , A61F2/958 , A61F7/00 , A61F7/12 , A61M25/00
CPC分类号： A61M25/002 , A61F7/123 , A61M2205/36 , A61M2205/366 , A61M2209/06
摘要： A kit (92) of parts comprises a system and instructions for use (90) for controlling patient temperature which uses a central venous line catheter (20) having a heat exchange element (58). The central venous line catheter (20) is provided with one or more lumens (66) for providing access to the central blood supply of the patient, and with additional lumens (32, 34) for communicating heat exchange fluid to the heat exchange element (58). Heat exchange fluid temperature is controlled through a feedback loop in which patient temperature is sensed and used to control a temperature control unit (50) comprising a heating device (57) and/or a cooling device (57) in heat exchange relationship with the heat exchange fluid. A tubing set (52) transports the heat exchange fluid between the central venous line (20) and the temperature control unit (50), with a pump (not shown) serving to circulate the fluid in a closed fluid circuit in the system.
摘要翻译：部件的套件（92）包括使用（90）用于控制患者体温的系统和使用具有热交换元件（58）的中心静脉导管（20）的使用说明书。中心静脉导管（20）设置有一个或多个腔（66），用于提供对患者的中心血液供应的通路，以及用于将热交换流体连通到热交换元件（32,34） 58）。通过感测患者体温的反馈回路来控制热交换液体温度，并用于控制温度控制单元（50），所述温度控制单元（50）包括与热量的热交换关系的加热装置（57）和/或冷却装置（57）交换液体管组（52）通过用于将流体循环在系统中的封闭流体回路中的泵（未示出）在中心静脉管路（20）和温度控制单元（50）之间输送热交换流体。

9. 发明申请

WO0149236A9 METHOD AND SYSTEM FOR TREATING CARDIAC ARREST 审中-公开
标题翻译：治疗心脏病的方法和系统
公开(公告)号：WO0149236A9
公开(公告)日：2002-07-18
申请号：PCT/US0100058
申请日：2001-01-03
申请人： ALSIUS CORP , LASERSOHN JACK W , WORTHEN WILLIAM J , EVANS SCOTT M , WINTER SUZANNE C , BALDING DAVID P
发明人： LASERSOHN JACK W , WORTHEN WILLIAM J , EVANS SCOTT M , WINTER SUZANNE C , BALDING DAVID P
IPC分类号： A61B18/00 , A61F7/00 , A61F7/12 , A61H31/00 , A61M1/36 , A61M5/44 , A61N1/39
CPC分类号： A61F7/12 , A61B2018/00011 , A61F7/123 , A61F2007/0056 , A61F2007/0076 , A61F2007/126 , A61H31/006 , A61H2201/0214 , A61M1/369 , A61M5/44 , A61M16/0465 , A61M16/10 , A61N1/39 , A61N1/3962
摘要： A method for treating cardiac arrest includes defibrillating the patient and/or ventilating the patient and/or administering a cardiac arrest drug such as epinephrine to resuscitate the patient, and then cooling the patient's body temperature using one or more cooling catheters (51, 52) placed in the central venous system and/or particularly cooling the patient's brain temperature using a catheter in the aortic arch or carotid artery.
摘要翻译：用于治疗心脏骤停的方法包括使患者去纤维化和/或使患者通气和/或施用心脏骤停药物例如肾上腺素以使患者复苏，然后使用一个或多个冷却导管（51,52）冷却患者的体温，放置在中心静脉系统中和/或特别地使用主动脉弓或颈动脉中的导管来冷却患者的脑温度。

10. 发明申请

WO0156517A8 ESTABLISHING AND MAINTAINING THERAPEUTIC HYPOTHERMIA 审中-公开
标题翻译：建立和维护治疗性神经痛
公开(公告)号：WO0156517A8
公开(公告)日：2002-01-31
申请号：PCT/US0103576
申请日：2001-02-02
申请人： ALSIUS CORP , WORTHEN WILLIAM J
发明人： WORTHEN WILLIAM J
IPC分类号： A61B17/00 , A61B18/00 , A61F7/00 , A61F7/12 , A61M1/36 , A61M5/44
CPC分类号： A61F7/123 , A61B2018/00011 , A61F7/12 , A61F2007/0056 , A61F2007/126 , A61M1/369 , A61M5/44
摘要： A kit for establishing and maintaining hypothermia in a patient (12) for neurotherapeutic purposes includes a high cooling capacity catheter (18) that is advanced into the patient's central venous system to quickly cool the patient to, e.g., 32 degrees C (40) or so. Once hypothermia has been established, the high capacity catheter is removed and replaced with a lower cooling capacity catheter (28) which maintains a desired reduced temperature. The lower capacity catheter advantageously can be configured as a central venous catheter for permitting the catheter to be used for multiple functions. Alternatively, the high cooling capacity catheter can be used to attenuate a fever and lower the patients body temperature to normal, with the lower capacity catheter being used to maintain normal body temperature.
摘要翻译：用于在用于神经治疗目的的患者（12）中建立和维持体温低的试剂盒包括高冷却能力导管（18），其被推进到患者的中心静脉系统中，以将患者快速冷却至例如32摄氏度（40）或所以。一旦建立了低温，高容量的导管被去除，并被保持所需降低的温度的较低冷却能力的导管（28）代替。较低容量的导管有利地可以被配置为用于允许导管用于多种功能的中心静脉导管。或者，高冷却能力导管可用于减轻发烧，并将患者体温降低至正常水平，而较低容量的导管用于维持正常的体温。

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