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1. 发明专利

DE1243619B 未知
公开(公告)号：DE1243619B
公开(公告)日：1967-07-06
申请号：DEA0037261
申请日：1961-04-24
申请人： AJINOMOTO KK , SANRAKU OCEAN KABUSHIKI KAISHA
发明人： MOTOZAKI SHINICHI , TSUNODA TOSHINAO , OKUMURA SHINJI , TSUGAWA RYUICHIRO
IPC分类号： C12P13/14 , C12P13/18
摘要： L-Glutamic acid is prepared by aerobic culture of a micro-organism of the genus Brevibacterium in a culture medium including one or more carbohydrates, one or more amino acids, a nitrogen source other than an amino acid, one or more inorganic salts and one or more of the nutrients desthiobiotin, biotin-d-sulphoxide and biocytin. Suitable micro-organisms are B. roseum, B. flavum, B. immariophirium, B. Saccharolyticum, and B. lactofermentum. Suitable nitrogen sources are inorganic and organic ammonium salts, urea, nitrates, nitrites, aqueous ammonia and ammonia gas. Specifications 873,448, 876,943 and 889,187 are referred to.

2. 发明授权

US3551292A Process of producing l-glutamic acid by fermentation 失效
标题翻译：通过发酵生产L-谷氨酸的方法
公开(公告)号：US3551292A
公开(公告)日：1970-12-29
申请号：US3551292D
申请日：1968-02-20
申请人： AJINOMOTO KK , SANRAKU OCEAN CO
发明人： KAMIMURA AKIRA , TSUGAWA RYUICHIRO , OKUMURA SHINJI
IPC分类号： C12P13/14 , C12B1/00
CPC分类号： C12P13/14 , Y10S435/84 , Y10S435/843 , Y10S435/861

3. 发明授权

US3616213A Production of alpha-ketoglutaric acid by fermentation of hydrocarbons 失效
标题翻译：通过发酵生产α-氨基丁酸
公开(公告)号：US3616213A
公开(公告)日：1971-10-26
申请号：US3616213D
申请日：1969-01-15
申请人： AJINOMOTO KK
发明人： TSUGAWA RYUICHIRO , NAKASE TAKASHI , KOBAYSHI TADAO , YAMASHITA KOICHI , OKUMURA SHINJI
IPC分类号： C12P7/50 , C12B1/00
CPC分类号： C12P7/50 , Y10S435/921 , Y10S435/923 , Y10S435/924 , Y10S435/94 , Y10S435/943
摘要： Alpha -KETOGLUTARIC ACID IS OBTAINED IN GOOD YIELDS BY AEROBIC CULTURING OF CERTAIN STRAINS OF Candida and Saccharomyces on culture media containing hydrocarbons as principal carbon source. The yield is enhanced by the presence of trace amounts of vitamin B1, Zn , Cu , and/or Fe .

4. 发明授权

US3533914A Method of producing l-glutamic acid by fermentation 失效
标题翻译：通过发酵生产L-谷氨酸的方法
公开(公告)号：US3533914A
公开(公告)日：1970-10-13
申请号：US3533914D
申请日：1967-11-21
申请人： AJINOMOTO KK , SANRAKU OCEAN CO
发明人： OKUMURA SHINJI , TSUGAWA RYUICHIRO , KURONUMA HIDEO
IPC分类号： C12P13/14 , C12B1/00 , C12D3/00
CPC分类号： C12P13/14 , Y10S435/813 , Y10S435/83 , Y10S435/84 , Y10S435/843 , Y10S435/859

5. 发明专利

DE1417585A1 未知
公开(公告)号：DE1417585A1
公开(公告)日：1968-10-10
申请号：DE1417585
申请日：1961-09-29
申请人： AJINOMOTO KK , SANRAKU CO INC
发明人： OKUMURA SHINJI , TSUGAWA RYUICHIRO , TSUNODA TOSHINAO , MOTOZAKI SHINICHI , SUYAMA TADASHI , KANAO SEIZO
IPC分类号： C12P13/14

6. 发明专利

DE1417584A1 未知
公开(公告)号：DE1417584A1
公开(公告)日：1968-10-10
申请号：DE1417584
申请日：1961-07-06
申请人： AJINOMOTO KK , SANRAKU CO INC
发明人： OKUMURA SHINJI , TSUGAWA RYUICHIRO , TSUNODA TOSHINAO , MOTOZAKI SHINICHI , SUYAMA TADASHI , KANAO SEIZO
IPC分类号： C12P13/14

7. 发明专利

GB1204635A A FERMANTATION PROCESS FOR THE PRODUCTION OF CITRIC ACID 未知
公开(公告)号：GB1204635A
公开(公告)日：1970-09-09
申请号：GB935469
申请日：1969-02-20
申请人： AJINOMOTO KK
发明人： OKUMURA SHINJI , TSUGAWA RYUICHIRO , KAMIJO HIROTAKA , KAMIMURA AKIRA , KOMAGATA KAZUO
IPC分类号： C12P7/48
摘要： 1,204,635. Citric acid. AJINOMOTO CO. Inc. 20 Feb., 1969 [4 March, 1968; 20 April, 1968], No. 9354/69. Heading C2C. Citric acid is prepared by a fermentation process which comprises aerobically culturing a strain of micro-organism of genus Candida on a culture medium containing a hydrocarbon, e.g. straight-chain paraffin 10-20 C or a mixture thereof, an assimilable nitrogen source and minor nutrients. Candida lipolytica, and Candida tropicalis are used in examples using biotin and a biotin derivative and thiamine respectively as growth promoting agents. The nitrogen source may be ammonium salts, gaseous ammonia or urea.

8. 发明专利

CA695064A PROCESS FOR PRODUCING L-GLUTAMIC ACID 未知
公开(公告)号：CA695064A
公开(公告)日：1964-09-29
申请号：CA695064D
申请人： AJINOMOTO KK , SANRAKU SHUZO KABUSHIKI KAISHA
发明人： MATSUI TOSHINORI , MOTOZAKI SHINICHI , TSUGAWA RYUICHIRO , OKUMURA SHINJI , KITAI ATSUO , MIYACHI NOBORU , TSUNODA TOSHINAO

9. 发明专利

GB1210770A IMPROVEMENTS IN OR RELATING TO THE PRODUCTION OF YEAST CELLS AND/OR OTHER FERMENTATION PRODUCTS 未知
公开(公告)号：GB1210770A
公开(公告)日：1970-10-28
申请号：GB1907769
申请日：1969-04-14
申请人： AJINOMOTO KK
发明人： OKUMURA SHINJI , YAMANOI AKIO , TSUGAWA RYUICHIRO , NAKASE TAKASHI
IPC分类号： C12N1/32 , C12P7/48
摘要： 1,210,770. Fermentation process. AJINOMOTO CO. Inc. 14 April, 1969 [15 April, 1968], No. 19077/69. Heading C2C. [Also in Division C6] The following yeasts are aerobically cultivated in a culture medium initially containing 0À8% or 1À5% of methanol as a main carbon source, to produce yeast cells and the specified chemical substances: (1) Pichia pastoris CBS 704 (L-glutamic acid, L-lysine and α-ketoglutaric acid); (2) Hansenula wickerhamii NRRL YB-4943 (L-glutamic acid, L-threonine, alanine, citric acid and trace amounts of fumaric acid); (3) Pichia haplophyla CBS 2028 (L-glutamic acid, L-valine and citric acid); and (4) Candida parapsilosis IFO 0585 (hypoxanthine). Alternatively, the methanol may be added gradually at the rate at which it is consumed.

10. 发明专利

GB1199068A Process for producing L-Glutamic Acid 未知
公开(公告)号：GB1199068A
公开(公告)日：1970-07-15
申请号：GB5395367
申请日：1967-11-27
申请人： AJINOMOTO KK , SANRAKU OCEAN CO
发明人： OKUMURA SHINJI , TSUGAWA RYUICHIRO , KURONUMA HIDEO
IPC分类号： C12P13/14
摘要： 1,199,068. L-Glutamic acid by fermentation. AJINOMOTO CO. Inc., and SANRAKU OCEAN CO. Ltd. 27 Nov., 1967 [1 Dec., 1966], No. 53953/67. Heading C2C. L-Glutamic acid is prepared by aerobically cultivating in a basal culture medium containing acetic acid or a salt thereof, microorganisms capable of producing L-glutamic acid from acetic acid, the cultivation being assisted by the addition of a sugar to the basal culture medium containing acetic acid and/or a salt thereof and by supplying further amounts of acetate ion during the fermentation. Specified sugars (normally present in a concentration of at least 0À3g/dl.) are glucose, sucrose, fructose, maltose, mixtures thereof, starch hydrolysate and molasses; specified salts of acetic acid are ammonium, sodium and potassium acetate, the medium is preferably maintained at pH 7À0- 9À0, and the acetic acid ions are preferably fed continuously to the medium after the half period of the logarithmic growth phase of the microorganisms. Examples detail the use of the following microorganisms: Brevibacterium flavum, B. saccharolyticum, B. immariophilium, B. roseum, B. lactofermentum, Micrococcus glutamicus, Corynebacterium lilium, C. acidophilum, C. callunae, C. herculis and Arthrobacter citreus.

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