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1. 发明申请

WO2008033419A2 DROPLET-BASED ELECTROCHEMICAL DEVICES AND METHODS 审中-公开
标题翻译：基于DROPLET的电化学设备和方法
公开(公告)号：WO2008033419A2
公开(公告)日：2008-03-20
申请号：PCT/US2007/019848
申请日：2007-09-13
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , NEUZIL, Pavel , YU, Hsiao-Hua , YING, Jackie, Y.
发明人： NEUZIL, Pavel , YU, Hsiao-Hua , YING, Jackie, Y.
IPC分类号： G01N27/403
CPC分类号： H01L51/0006 , G01N27/403 , H01L51/0035 , H01L51/0036
摘要： The present invention generally relates to electronic devices and methods. In some cases, devices of the invention may be constructed to accommodate samples having small volumes (e.g., less than 50 microliters). Devices of the invention may also be configured to enhance performance by for example, facilitating symmetric diffusion of charge or formation of a uniform electric field. In some cases, devices of the invention may employ the use of organic materials in, for example, sensing devices and methods. Other methods of the invention relate to polymerization methods. One advantage of the present invention includes the ability to work with small amounts (e.g., volumes) of a sample using a simplified electronic device without the need to for more complex microfiuidic devices, for example.
摘要翻译：本发明一般涉及电子设备和方法。在一些情况下，可以构造本发明的装置以容纳具有小体积（例如，小于50微升）的样品。本发明的装置还可以被配置为通过例如促进电荷的对称扩散或形成均匀电场来增强性能。在一些情况下，本发明的装置可以在例如感测装置和方法中使用有机材料。本发明的其它方法涉及聚合方法。本发明的一个优点包括例如使用简化电子器件处理少量（例如，体积）样品的能力，而不需要更复杂的微流体装置。

2. 发明申请

WO2007078297A2 LUMINESCENT METAL OXIDE FILMS 审中-公开
标题翻译：发光金属氧化物薄膜
公开(公告)号：WO2007078297A2
公开(公告)日：2007-07-12
申请号：PCT/US2006/001941
申请日：2006-01-20
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , YING, Jackie, Y. , YU, Hsiao-hua , ALI, Amril, Mohamed
发明人： YING, Jackie, Y. , YU, Hsiao-hua , ALI, Amril, Mohamed
IPC分类号： G01N33/551 , G01N33/542 , G01N33/533 , C09K11/77
CPC分类号： G01N33/542 , B82Y5/00 , C09K11/54 , G01N33/533 , G01N33/551 , Y10T436/147777 , Y10T436/16 , Y10T436/173845 , Y10T436/18 , Y10T436/19 , Y10T436/20 , Y10T436/201666 , Y10T436/203332
摘要： The present invention relates to articles and methods involving luminescent films which may be useful in various applications. Luminescent films of the present invention may comprise a layer of metal oxide nanoparticles and, in some cases, may interact with an analyte to generate a detectable signal, whereby the presence and/or amount of analyte can be determined. In some embodiments, fluorescence resonance energy transfer (FRET) may occur between the luminescent film and the analyte. Such articles and methods may be useful in, for example, biological assays or in sensors.
摘要翻译：本发明涉及涉及可用于各种应用的发光膜的制品和方法。本发明的发光膜可以包含金属氧化物纳米颗粒层，并且在一些情况下可以与分析物相互作用以产生可检测信号，从而可以确定分析物的存在和/或量。在一些实施例中，荧光共振能量转移（FRET）可以发生在发光膜和分析物之间。这样的制品和方法可用于例如生物测定或传感器中。

3. 发明申请

WO2007075495A2 DETECTION VIA SWITCHABLE EMISSION OF NANOCRYSTALS 审中-公开
标题翻译：通过纳米晶体的切换发射检测
公开(公告)号：WO2007075495A2
公开(公告)日：2007-07-05
申请号：PCT/US2006/048087
申请日：2006-12-15
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , YING, Jackie, Y. , YU, Hsiao-Hua , ALI, Emril, Mohammed , JANA, Nikhil, R.
发明人： YING, Jackie, Y. , YU, Hsiao-Hua , ALI, Emril, Mohammed , JANA, Nikhil, R.
IPC分类号： G01N31/22 , G01N21/78 , G01N21/76
CPC分类号： G01N21/6489 , B82Y15/00 , B82Y20/00 , B82Y30/00 , G01N21/6408 , G01N21/77 , G01N2021/7786
摘要： The present invention relates to methods for determination of an analyte. The invention provides various methods involving exposure of a luminescent material to an analyte wherein, upon interaction with the analyte., a change in luminescence may be observed as a function of the duration of exposure to electromagnetic radiation, thereby determining the analyte. Some embodiments of the invention include the use of highly emissive semiconductor nanocrystals.
摘要翻译：本发明涉及测定分析物的方法。本发明提供了涉及将一种发光材料暴露于分析物的各种方法，其中在与分析物相互作用时，作为暴露于电磁辐射的持续时间的函数可观察到发光变化，由此确定分析物。本发明的一些实施方案包括使用高发射半导体纳米晶体。

4. 发明申请

WO2006104464A1 CDTE/GSH CORE-SHELL QUANTUM DOTS 审中-公开
标题翻译： CDTE / GSH CORE-SHELL QUANTUM DOTS
公开(公告)号：WO2006104464A1
公开(公告)日：2006-10-05
申请号：PCT/SG2006/000003
申请日：2006-01-11
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , YING, Jackie, Y. , ZHENG, Yuangang , GAO, Shujun
发明人： YING, Jackie, Y. , ZHENG, Yuangang , GAO, Shujun
IPC分类号： B82B3/00 , B82B1/00 , H01L31/0296
CPC分类号： C09K11/883 , B82Y10/00 , B82Y30/00
摘要： Quantum dots, each having a core comprising CdTe and a shell comprising GSH covering the core, are provided. The Quantum dots can be formed in a solution comprising a telluride (Te) precursor and a cadmium (Cd) precursor for forming the cores, and glutathione (GSH) for forming shells covering the cores. The cores can comprise CdTe nanocrystals grown in the solution. The growth of the nanocrystals can be limited. The quantum dots can have high fluorescence emission quantum yield such as up to about 45%, and small sizes such as from about 3.8 nm to about 6 nm.
摘要翻译：提供了每个具有包括CdTe的核心和包含覆盖核心的GSH的外壳的量子点。量子点可以形成在包含用于形成芯的碲化物（Te）前体和镉（Cd）前体的溶液中，并且形成覆盖芯的壳的谷胱甘肽（GSH）。芯可以包含在溶液中生长的CdTe纳米晶体。纳米晶体的生长可能受到限制。量子点可以具有高的荧光发射量子产率，例如高达约45％，小尺寸例如约3.8nm至约6nm。

5. 发明申请

WO2006096131A1 CHIRAL BISOXAZOLINE CATALYSTS 审中-公开
公开(公告)号：WO2006096131A1
公开(公告)日：2006-09-14
申请号：PCT/SG2005/000072
申请日：2005-03-08
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , YING, Jackie, Y. , LEE, Su, Seong , HADINOTO, Sukandar
发明人： YING, Jackie, Y. , LEE, Su, Seong , HADINOTO, Sukandar
IPC分类号： C07D413/06 , C07G17/00 , B01J32/00 , B01J35/00 , C07F7/08 , C07F7/10
CPC分类号： C07D263/62 , B01J31/1625 , B01J31/1815 , B01J31/183 , B01J2231/325 , B01J2531/0241 , C07B2200/07 , C07B2200/11 , C07C67/347 , C07D263/14 , C07F1/005 , Y02P20/588 , C07C69/743
摘要： The present invention describes a heterogeneous chiral catalyst comprising a heterogeneous chiral catalyst precursor complexed with a metal species. The precursor comprises a chiral bisoxazoline group coupled to an inorganic substrate. The heterogeneous chiral catalyst may be capable of catalysing a chemical reaction, for example cyclopropanation, and the chemical reaction may be capable of generating a chiral product.
摘要翻译：本发明描述了异构手性催化剂，其包含与金属物质复合的多相手性催化剂前体。前体包含与无机基质偶联的手性双恶唑啉基团。异相手性催化剂可能能够催化化学反应，例如环丙烷化，化学反应可以产生手性产物。

6. 发明申请

WO2009108125A1 GOLD NANOPARTICLES 审中-公开
标题翻译：黄金纳米粒子
公开(公告)号：WO2009108125A1
公开(公告)日：2009-09-03
申请号：PCT/SG2009/000063
申请日：2009-02-23
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , ZHANG, Yugen , YING, Jackie, Y. , ZHAO, Lan
发明人： ZHANG, Yugen , YING, Jackie, Y. , ZHAO, Lan
IPC分类号： B82B3/00 , B22F9/16 , C01G7/00 , C22B11/00
CPC分类号： C22B5/00 , B22F1/0022 , B22F9/24 , B22F2009/245 , B82Y30/00 , B82Y40/00 , C22B11/04 , C30B7/14 , C30B29/02 , C30B29/60
摘要： Gold nanoparticles are prepared by combining a gold salt, an N,N'-disubstituted imidazolium salt and a thiol.
摘要翻译：通过组合金盐，N，N'-二取代咪唑鎓盐和硫醇制备金纳米颗粒。

7. 发明申请

WO2008005035A1 POROUS POLYMERIC ARTICLES 审中-公开
标题翻译：多孔聚合物
公开(公告)号：WO2008005035A1
公开(公告)日：2008-01-10
申请号：PCT/US2006/035610
申请日：2006-09-12
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , YING, Jackie, Y. , CHOW, Edwin Pei Yong , LOH, Jeremy Ming Hok , SCHUMACHER, Karl
发明人： YING, Jackie, Y. , CHOW, Edwin Pei Yong , LOH, Jeremy Ming Hok , SCHUMACHER, Karl
IPC分类号： C08J9/00 , A61P27/00
CPC分类号： A61L27/56 , B33Y80/00
摘要： Porous polymeric articles, and more specifically, porous polymeric articles for tissue engineering and organ replacement, are described. In some embodiments, methods described herein include use of a polymer-solvent system (e.g., phase inversion) to generate porosity in a structure. The process may include formation of a structure precursor material including a first crosslinkable component and a second component that can be precipitated in a precipitation medium. The structure precursor material may be shaped into a three-dimensional shape by a suitable technique such as three- dimensional printing. Upon shaping of the structure precursor material, at least a portion of the first component may be crosslinked. The structure may then be contacted with a precipitation medium to remove the precursor solvent from the structure, which can cause the second polymer component to precipitate and form a porous structure containing a network of uniform pores. In some embodiments, the porous structure is constructed and arranged for use as a template for ultrafiltration, cell growth, and/or for forming complex, biomimetic, porous biohybrid organs, where living cells can be immobilized and perform their normal physiological functions.
摘要翻译：描述了多孔聚合物制品，更具体地说，用于组织工程和器官置换的多孔聚合物制品。在一些实施方案中，本文所述的方法包括使用聚合物 - 溶剂体系（例如相转化）以在结构中产生孔隙。该方法可以包括形成包含可在沉淀介质中沉淀的第一可交联组分和第二组分的结构前体材料。结构前体材料可以通过诸如三维印刷的合适技术成形为三维形状。在结构前体材料成型时，第一组分的至少一部分可以是交联的。然后可以将结构与沉淀介质接触以从结构中除去前体溶剂，这可使第二聚合物组分沉淀并形成含有均匀孔网络的多孔结构。在一些实施方案中，多孔结构被构造和布置用作超滤，细胞生长和/或形成复合物，仿生性，多孔生物杂交器官的模板，其中活细胞可以被固定并执行其正常的生理功能。

8. 发明申请

WO2007106497A2 THREE-DIMENSIONAL FABRICATION OF BIOCOMPATIBLE STRUCTURES IN ANATOMICAL SHAPES AND DIMENSIONS FOR TISSUE ENGINEERING AND ORGAN REPLACEMENT 审中-公开
标题翻译：用于组织工程和组织替代的解剖形状和尺寸的生物化学结构的三维制造
公开(公告)号：WO2007106497A2
公开(公告)日：2007-09-20
申请号：PCT/US2007/006346
申请日：2007-03-13
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , YING, Jackie, Y. , KAN, Shyi-herng , LOH, Jeremy Ming Hock , SCHUMACHER, Karl , HSIEH, James, Tseng-ming
发明人： YING, Jackie, Y. , KAN, Shyi-herng , LOH, Jeremy Ming Hock , SCHUMACHER, Karl , HSIEH, James, Tseng-ming
IPC分类号： A61L27/38 , A61L27/56 , C12N5/00
CPC分类号： A61L27/38 , A61L27/56 , B33Y80/00 , C12N5/0068 , C12N2533/30
摘要： The present invention relates to methods and apparatuses involving biocompatible structures for tissue engineering and organ replacement and, more specifically, to methods and apparatuses involving biocompatible structures formed by three-dimensional fabrication for tissue engineering and organ replacement. In some embodiments, the biocompatible structures are scaffolds for cells that can be used as tissue engineering templates and/or as artificial organs. The structures may be three- dimensional and can mimic the shapes and dimensions of tissues and/or organs, including the microarchitecture and porosities of the tissues and organs. In some cases, a structure formed by three-dimensional fabrication comprises a wall defining a cavity and a plurality of pores in at least a portion of the wall. The pores may permeate the wall and enable exchange of a component (e.g., a molecule and/or a cell) between a portion interior to the cavity and a portion exterior to the cavity. For instance, pores may allow delivery of molecules, cell migration, and/or generation of connective tissue between the structure and its host environment. Structures of the invention can be implanted into a mammal, or alternatively and/or additionally, can be used ex vivo as bioartificial assist devices.
摘要翻译：本发明涉及包括用于组织工程和器官置换的生物相容结构的方法和装置，更具体地涉及涉及通过用于组织工程和器官置换的三维制造形成的生物相容性结构的方法和装置。在一些实施方案中，生物相容性结构是可用作组织工程模板和/或作为人造器官的细胞的支架。结构可以是三维的并且可以模拟组织和/或器官的形状和尺寸，包括组织和器官的微结构和孔隙率。在一些情况下，通过三维制造形成的结构包括在壁的至少一部分中限定空腔和多个孔的壁。孔可以渗透到壁上并且使得能够在空腔内部的部分和腔外部的部分（例如，分子和/或细胞）之间进行交换。例如，孔可以允许在结构和其宿主环境之间传递分子，细胞迁移和/或结缔组织的产生。本发明的结构可以植入哺乳动物，或者另外地和/或另外可以作为生物人造辅助装置离体使用。

9. 发明申请

WO2007081543A2 HIGH-THROUGHPUT CELL-BASED ASSAYS FABRICATED WITH INTEGRATED SILICON AND CELL CULTURE TECHNOLOGIES 审中-公开
标题翻译：一体化硅和细胞培养技术的高通量细胞测定
公开(公告)号：WO2007081543A2
公开(公告)日：2007-07-19
申请号：PCT/US2006/049082
申请日：2006-12-20
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , KAN, Shyi-herng , YING, Jackie, Y. , YU, Hanry , SCHUMACHER, Karl , NG, Susanne, San San , SUN, Wanxin
发明人： KAN, Shyi-herng , YING, Jackie, Y. , YU, Hanry , SCHUMACHER, Karl , NG, Susanne, San San , SUN, Wanxin
IPC分类号： C12M3/00 , C12M3/04 , G01N33/50 , C12N5/06 , C12N5/08
CPC分类号： C12N5/0068 , B01L3/5085 , B01L2300/069 , B01L2300/0829 , B01L2300/0887 , C12M23/20 , C12M23/34 , C12M25/02 , C12N2533/10 , C12N2533/54 , C12N2535/10
摘要： The present invention relates to articles and methods involving porous materials (e.g., membranes) which may interact with species, such as biological molecules, cells, etc., whereby the species may adhere to or become immobilized with respect to a surface of the porous material or an adhesion layer coating the porous surface. The porous material may be capable of attaching species with control over the positioning and spatial distribution of the species across the surface of the material. Such articles and methods may be useful in, for example, biological assays, biological sensors, or in the culturing of biological cells.
摘要翻译：本发明涉及涉及可能与物种如生物分子，细胞等相互作用的多孔材料（例如膜）的制品和方法，由此物种可以相对于多孔材料的表面粘附或变得固定或涂覆多孔表面的粘附层。多孔材料可以能够连接物种，从而控制物种在材料表面上的定位和空间分布。这样的制品和方法可用于例如生物测定，生物传感器或生物细胞的培养。

10. 发明申请

WO2007067460A2 MANIPULATION OF CHEMICAL AND/OR BIOLOGICAL SPECIES USING MAGNETIC FIELD MODULATORS 审中-公开
标题翻译：使用磁场调制器操作化学和/或生物物种
公开(公告)号：WO2007067460A2
公开(公告)日：2007-06-14
申请号：PCT/US2006/046183
申请日：2006-12-01
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , YING, Jackie, Y. , LOH, Jeremy, Ming Hock , SCHUMACHER, Karl , KAN, Shi-Herng
发明人： YING, Jackie, Y. , LOH, Jeremy, Ming Hock , SCHUMACHER, Karl , KAN, Shi-Herng
IPC分类号： C12N5/00
CPC分类号： C12N5/0062 , C12N2535/10
摘要： Methods and apparatuses for manipulating chemical and/or biological species (e.g., cells) and using magnetic fields are provided. The methods may involve patterning magnetically-susceptible cells using a magnetic field modulator. For instance, when a fluid containing cells is brought in contact with a surface and the magnetic field modulator is positioned proximate the surface, the cells may form a pattern by aligning with portions of the modulated magnetic field. Advantageously, in certain embodiments, the magnetic field modulator is not integrally connected to the surface. Thus, patterns of cells can be formed on various types of surfaces and the magnetic field modulator may be repositioned without altering the surface. Patterns comprising multiple cell types on a single surface can also be formed. Such patterns may be useful for studying cell-cell interactions and for forming three-dimensional cellular structures (e.g., tissues).
摘要翻译：提供了用于操作化学和/或生物物种（例如细胞）和使用磁场的方法和装置。这些方法可以包括使用磁场调制器对磁敏感细胞进行图案化。例如，当含有细胞的流体与表面接触并且磁场调制器位于表面附近时，细胞可以通过与调制磁场的部分对准而形成图案。有利地，在某些实施例中，磁场调制器不一体地连接到表面。因此，可以在各种类型的表面上形成单元的图案，并且可以重新定位磁场调制器而不改变表面。也可以形成包括单个表面上的多种细胞类型的图案。这种图案可用于研究细胞 - 细胞相互作用和形成三维细胞结构（例如组织）。

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