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1. 发明申请

WO2010110754A1 APPARATUS FOR CELL OR TISSUE CULTURE 审中-公开
标题翻译：细胞或组织培养装置
公开(公告)号：WO2010110754A1
公开(公告)日：2010-09-30
申请号：PCT/SG2010/000120
申请日：2010-03-26
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , YU, Hanry , ZHANG, Shufang , LEO, Hwa Liang
发明人： YU, Hanry , ZHANG, Shufang , LEO, Hwa Liang
IPC分类号： C12M1/00 , B01L3/00 , C12M3/00
CPC分类号： C12M25/04 , B01L3/50255 , C12M29/10
摘要： The apparatus for cell or tissue culture comprises a base plate (1), an intermediate face (2) and a top plate (3). The intermediate face (2) is removably sandwiched between the base plate (1) and the top plate (3). The base plate (1) has a circumferential wall (13), a base (14) and a top wall (16). The top wall (16) of the base plate (1) comprises a plurality of recesses (12) arranged in n lines, wherein n is an integer from 1 to about 25. Each line of recesses (12) ranges from a first recess to a last recess. Each recess has a circumferential recess wall (15), which has one recess inlet and one recess outlet (40, 41). The circumferential wall (13) comprises a number of 2 n ports (11). Each port (11) is coupled to a single line of recesses (12). The recesses (12) of each line of recesses are in fluid communication with (i) each other via the recess inlets and a recess outlets (40, 41) and (ii) with a first and a second port (11) of the 2 n ports, such that the first recess of each line of recesses is coupled to a first port and the last recess of each line of recesses is coupled to a second port. The intermediate face (2) has a plurality of recesses (21) arranged in m lines, fitted into the plurality of recesses (12) of the top wall (16) of the base plate (13). m is an integer from 1 to about 25 equal to or smaller than n. The recesses (21) of the intermediate face (2) have water permeability. The top plate (3) is reversibly sealed to the intermediate face (2) and the intermediate face (2) is reversibly sealed to the base plate (1). Thus the recesses (12) of the top wall (16) of the base plate (1) define culture chambers. Each culture chamber has a circumferential wall defined by the recess wall (15) and a removable top, which is defined by a portion of the top plate (3).
摘要翻译：用于细胞或组织培养的装置包括基板（1），中间面（2）和顶板（3）。中间面（2）可拆卸地夹在基板（1）和顶板（3）之间。基板（1）具有圆周壁（13），基座（14）和顶壁（16）。基板（1）的顶壁（16）包括布置成n条线的多个凹槽（12），其中n是从1到大约25的整数。每条凹槽（12）的范围从第一凹槽到最后一个休息每个凹槽具有圆周凹陷壁（15），其具有一个凹进入口和一个凹槽出口（40,41）。圆周壁（13）包括多个2n个端口（11）。每个端口（11）联接到单个凹槽（12）。每一排凹槽的凹槽（12）通过凹口进入第一和第二端口（11）与第一和第二端口（11）流体连通（i）和凹口（40,41）和（ii） n个端口，使得每一排凹槽的第一凹部联接到第一端口，并且每一个凹槽线的最后一个凹部联接到第二端口。中间面（2）具有多个配置在基板（13）的顶壁（16）的多个凹部（12）中的m行的凹部（21）。 m是等于或小于n的从1到约25的整数。中间面（2）的凹部（21）具有透水性。顶板（3）可逆地密封到中间面（2），中间面（2）可逆地密封到基板（1）上。因此，底板（1）的顶壁（16）的凹部（12）限定培养室。每个培养室具有由凹陷壁（15）限定的圆周壁和由顶板（3）的一部分限定的可移除顶部。

2. 发明申请

WO2009078819A1 FORMING POROUS SCAFFOLD FROM CELLULOSE DERIVATIVES 审中-公开
标题翻译：从纤维素衍生物形成多孔的SCAFF
公开(公告)号：WO2009078819A1
公开(公告)日：2009-06-25
申请号：PCT/SG2008/000491
申请日：2008-12-18
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , YUE, Zhilian , WEN, Feng , YU, Hanry
发明人： YUE, Zhilian , WEN, Feng , YU, Hanry
IPC分类号： A61L27/20 , A61L27/56 , C08F6/14 , C08L1/08
CPC分类号： B32B3/26 , A61L27/20 , A61L27/56 , C08B11/20 , C08J9/28 , C08J2201/024 , C08J2201/026 , C08J2201/0484 , C08J2201/0524 , C08J2205/044 , C08J2207/10 , C08J2301/28 , C08L1/14 , Y10T428/249921 , Y10T428/249978 , Y10T428/249979 , C08L1/28
摘要： Scaffold comprises a polymer defining macropores and comprising hydroxypropylcellulose partially substituted by a substituent comprising a self-crosslinkable group, which is crosslinked through the self-crosslinkable group. The macropores have an average pore size larger than 50 microns and are at least partially interconnected. In one method, bicontinuous emulsion comprising a continuous aqueous phase and a continuous polymer phase is formed. The polymer phase comprises hydroxypropylcellulose partially substituted by a substituent comprising a self-crosslinkable group, and is crosslinked through the self-crosslinkable group to form a polymer defining at least partially interconnected pores. In another method, phase separation is induced in a solution comprising a polymer precursor and water to form a bicontinuous emulsion comprising a continuous polymer phase and a continuous aqueous phase. The polymer precursor comprises a self-crosslinkable group and is crosslinked through the self-crosslinkable group in the emulsion to form a polymer defining at least partially interconnected macropores.
摘要翻译：脚手架包含限定大孔的聚合物，并且包含部分被包含通过自交联基团交联的自交联基团的取代基取代的羟丙基纤维素。大孔具有大于50微米的平均孔径并且至少部分互连。在一种方法中，形成包含连续水相和连续聚合物相的双连续乳液。聚合物相包含部分由包含自交联基团的取代基取代的羟丙基纤维素，并且通过自交联基团交联以形成限定至少部分互连的孔的聚合物。在另一种方法中，在包含聚合物前体和水的溶液中诱导相分离以形成包含连续聚合物相和连续水相的双连续乳液。聚合物前体包含自交联基团，并且通过乳液中的自交联基团交联以形成限定至少部分互连的大孔的聚合物。

3. 发明申请

WO2009048435A1 FORMING CELL STRUCTURE WITH TRANSIENT LINKER IN CAGE 审中-公开
标题翻译：在笼中形成具有瞬态连接器的细胞结构
公开(公告)号：WO2009048435A1
公开(公告)日：2009-04-16
申请号：PCT/SG2008/000395
申请日：2008-10-13
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , YU, Hanry , ONG, Siew Min
发明人： YU, Hanry , ONG, Siew Min
IPC分类号： C12M3/00 , C12N5/06
CPC分类号： C12M25/06 , C12M21/08 , C12M23/16 , C12M23/34
摘要： In a method of forming a cellular structure, cells and a transient linker are supplied to a volume partially enclosed by a cage. The linker facilitates initial attachment of adjacent cells to form a cell aggregate. The cage defines distributed openings that are sized to retain the cell aggregate. A fluid comprising a cell culture medium is supplied to the volume. The fluid is withdrawn from the volume through the openings. Aggregated cells retained in the volume are cultured to form a cell structure. A cell culturing device is provided which comprises a conduit and a cage in the conduit. A fluid flows in the conduit. The fluid comprises the cells, the transient linker and the cell culture medium. The cage retains aggregated cells formed in the fluid, and defines distributed openings that allow the fluid to flow through.
摘要翻译：在形成细胞结构的方法中，将细胞和瞬时接头提供给由笼子部分包围的体积。接头有助于相邻细胞的初始附着以形成细胞聚集体。笼子定义了分布开口，其大小用于保持细胞聚集体。包含细胞培养基的流体被供应到体积。流体通过开口从容积中取出。将保留在体积中的聚集细胞进行培养以形成细胞结构。提供了一种细胞培养装置，其包括管道中的导管和笼。流体在管道中流动。流体包含细胞，瞬时接头和细胞培养基。保持架保持形成在流体中的聚集细胞，并且限定允许流体流过的分布开口。

4. 发明申请

WO2008002278A1 SHG QUANTIFICATION OF MATRIX-RELATED TISSUE DYNAMIC AND DISEASE 审中-公开
标题翻译：基质相关组织动态和疾病的SHG量化
公开(公告)号：WO2008002278A1
公开(公告)日：2008-01-03
申请号：PCT/SG2007/000194
申请日：2007-06-29
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , SUN, Wanxin , YU, Hanry
发明人： SUN, Wanxin , YU, Hanry
IPC分类号： G02F1/37 , G02B21/00
CPC分类号： G02B21/0024 , G01N21/6458 , G01N21/6486 , G02B21/086
摘要： A microscope (200) for optical imaging of high optical scattering coefficient biological tissue, comprising an optical excitation source (201) for irradiating a scan area of the sample (205) and generating optical emissions, wherein the sample has a first face facing away from the source and a second face facing the source. A two dimensional element (207) for scanning the light over the sample; a focussing element (209) having a numerical aperture NAi to focus the light onto the sample; a first optical condenser (213) to collect light from the first face, the collected light comprising source transmitted light and first optical emission generated in the sample, the condenser having a NA2 larger than NAi; an optical filter(215) to block the transmitted source light; an aperture with a size corresponding to the irradiated area of the sample, the aperture at the conjugate image position of the sample generated by the condenser; and an optical detector (217) collecting light from the first face for detecting the first optical emission from the scan area.
摘要翻译：一种用于高光学散射系数生物组织的光学成像的显微镜（200），包括用于照射样品（205）的扫描区域并产生光学发射的光学激发源（201），其中所述样品具有面向远离来源和面向源的第二面。用于扫描样品上的光的二维元件（207）; 具有数值孔径NAi以将光聚焦到样品上的聚焦元件（209）; 收集来自第一面的光的第一光学冷凝器（213），所收集的光包括源透射光和在样品中产生的第一光发射，冷凝器具有大于NAi的NA2; 滤光器（215），用于阻挡所发射的光源; 具有对应于样品的照射面积的尺寸的孔，由冷凝器产生的样品的共轭图像位置处的孔; 以及收集来自第一面的光的光学检测器（217），用于检测来自扫描区域的第一光发射。

5. 发明申请

WO2010042072A1 APPARATUS FOR CULTURING ANCHORAGE DEPENDENT CELLS 审中-公开
标题翻译：培养锚固依赖细胞的装置
公开(公告)号：WO2010042072A1
公开(公告)日：2010-04-15
申请号：PCT/SG2009/000369
申请日：2009-10-08
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , YU, Hanry , XIA, Lei , LEO, Hwa Liang
发明人： YU, Hanry , XIA, Lei , LEO, Hwa Liang
IPC分类号： C12M1/14 , C12N5/071 , C12M3/06
CPC分类号： C12M23/44 , C12M21/08 , C12M23/34 , C12M23/46 , C12M23/58 , C12M25/06 , C12M29/10
摘要： The invention relates to an apparatus (1) for culturing anchorage-dependent cells. The apparatus (1) comprises a housing (2) with an inlet (4) and an outlet (5), and a plurality of culture plates (6) removably stacked within the housing (2). The housing (2) has a circumferential wall (7), a base (8) and a top wall (9). The base (8) comprises the inlet (4) and the top wall (9) comprises the outlet (5). The circumferential wall (7) of the housing (2) defines a longitudinal axis thereof, as well as an inner cross section perpendicular to the longitudinal axis. Shape and dimensions of the inner cross section are essentially uniform along the longitudinal axis. The culture plates (6) are arranged at least essentially parallel to each other. Each plate (6) is mounted and sealed to the circumferential wall (7) of the housing (2). Plates (6) are arranged at a distance from each other. Each culture plate (6) has a through hole (14), so that inlet (4) and outlet (5) are in fluid communication. Each through hole (14) is positioned at an outer end of the respective culture plate (6), proximate the circumferential wall (7). Through holes (14) of adjacent culture plates (6) are distally positioned in the plane of the inner cross section of the housing (2).
摘要翻译：本发明涉及一种用于培养锚固依赖细胞的装置（1）。装置（1）包括具有入口（4）和出口（5）的壳体（2）和可移除地堆叠在壳体（2）内的多个培养板（6）。壳体（2）具有圆周壁（7），基部（8）和顶壁（9）。底座（8）包括入口（4），顶壁（9）包括出口（5）。壳体（2）的周向壁（7）限定其纵向轴线以及垂直于纵向轴线的内部横截面。内横截面的形状和尺寸沿纵向轴线基本均匀。培养板（6）至少基本上平行布置。每个板（6）被安装并密封到壳体（2）的周壁（7）。板（6）彼此间隔一定距离。每个培养板（6）具有通孔（14），使得入口（4）和出口（5）流体连通。每个通孔（14）位于相应的培养板（6）的外端处，靠近周壁（7）。相邻培养板（6）的通孔（14）远离定位在壳体（2）的内横截面的平面内。

6. 发明申请

WO2006011855A8 ENCAPSULATION OF CELLS IN BIOLOGIC COMPATIBLE SCAFFOLDS BY COACERVATION OF CHARGED POLYMERS 审中-公开
标题翻译：通过带电聚合物凝胶封装生物相容性支架中的细胞
公开(公告)号：WO2006011855A8
公开(公告)日：2006-04-06
申请号：PCT/SG2005000249
申请日：2005-07-22
申请人： AGENCY SCIENCE TECH & RES , YU HANRY , TOH YI CHIN
发明人： YU HANRY , TOH YI CHIN
IPC分类号： A61L27/52 , A61L27/26 , C12N5/08
CPC分类号： C12N5/0068 , A61L27/165 , A61L27/24 , A61L27/38 , A61L27/44 , A61L27/56 , A61L27/58 , C12N11/04 , C12N2533/30 , C08L33/12
摘要： This invention relates to a method for the encapsulation of cells in biologic compatible three dimensional scaffolds and the use of such cells encapsulated in a scaffold. The cells are embedded in a charged polymer that is complex coacervating with an oppositely charged polymer within biologic compatible scaffolds. The polymer complex embedding the cells is forming an ultra thin membrane on the surface of the three dimensional scaffold.
摘要翻译：本发明涉及在生物相容的三维支架中包封细胞的方法以及包裹在支架中的这种细胞的用途。细胞嵌入带电的聚合物中，该聚合物与生物相容性支架内的带相反电荷的聚合物复合成凝聚物。嵌入细胞的聚合物复合物在三维支架的表面上形成超薄膜。

7. 发明申请

WO2005123240A1 APPARATUS FOR ENCAPSULATING CELLS 审中-公开
标题翻译：封装细胞的装置
公开(公告)号：WO2005123240A1
公开(公告)日：2005-12-29
申请号：PCT/SG2005/000175
申请日：2005-06-03
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH? , YU, Hanry , HO, Hai, Ting , ZHANG, Jing
发明人： YU, Hanry , HO, Hai, Ting , ZHANG, Jing
IPC分类号： B01J13/04
CPC分类号： C12N11/04 , B01J13/10 , Y10S530/817
摘要： An apparatus for encapsulating cells is disclosed. According to one embodiment, the apparatus includes an indirect-pumping dispenser (4) for dispensing a cell suspension into an encapsulation solution through an outlet of the dispenser (10). The apparatus also includes a dipping mechanism (8) that is attachable to the outlet (10) of the dispenser. The dipping mechanism is adapted to dip the dispenser outlet in the encapsulation solution to allow the cell suspension dispensed thereat to come into contact with the encapsulation solution (7).
摘要翻译：公开了一种封装电池的装置。根据一个实施例，该装置包括用于通过分配器（10）的出口将细胞悬浮液分配到包封溶液中的间接泵送分配器（4）。该装置还包括可附接到分配器的出口（10）的浸渍机构（8）。浸渍机构适于将分配器出口浸入包封溶液中以允许在其中分配的细胞悬浮液与封装溶液（7）接触。

8. 发明申请

WO2002094324A1 INJECTABLE DRUG DELIVERY SYSTEMS WITH CYCLODEXTRIN-POLYMER BASED HYDROGELS 审中-公开
标题翻译：具有环糊精 - 聚合物水凝胶的注射药物输送系统
公开(公告)号：WO2002094324A1
公开(公告)日：2002-11-28
申请号：PCT/IB2002/001687
申请日：2002-05-17
申请人： INSTITUTE OF MATERIALS RESEARCH & ENGINEERING , LI, Jun , YU, Hanry , LEONG, Kam
发明人： LI, Jun , YU, Hanry , LEONG, Kam
IPC分类号： A61K47/40
CPC分类号： A61K9/0024 , A61K9/0019 , A61K47/10 , A61K47/40
摘要： A cyclodextrin polymer based injectable composition comprising cyclodextrin, a polymer which is capable of forming a hydrogel with the cyclodextrin and a pharmacologically effective amount of at least one drug. The polymer is selected from poly(ethylene glycol), derivatives thereof or a copolymer with a poly(ethylene glycol) segment. The copolymer with a poly(ethylene glycol) segment may include a polymer selected from the group consisting of polyesters, polyurethanes, polyamides, polyethers, polysaccharides, poly (amino acid)s, polypeptides, and proteins. The composition may be injected subcutaneously, intramuscularly, intradermally, or intracranially.
摘要翻译：一种基于环糊精聚合物的可注射组合物，其包含环糊精，能够与环糊精形成水凝胶的聚合物和药理学有效量的至少一种药物。聚合物选自聚（乙二醇），其衍生物或与聚（乙二醇）链段的共聚物。具有聚（乙二醇）链段的共聚物可以包括选自聚酯，聚氨酯，聚酰胺，聚醚，多糖，聚（氨基酸），多肽和蛋白质的聚合物。组合物可以皮下，肌肉内，皮内或颅内注射。

9. 发明申请

WO2010021601A1 MANUFACTURING AND USE OF COMPOSITE SCAFFOLDS 审中-公开
标题翻译：复合材料的制造和使用
公开(公告)号：WO2010021601A1
公开(公告)日：2010-02-25
申请号：PCT/SG2009/000296
申请日：2009-08-24
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , YU, Hanry , KHONG, Yuet Mei , WEN, Feng
发明人： YU, Hanry , KHONG, Yuet Mei , WEN, Feng
IPC分类号： A61L27/44 , A61L27/58 , A61L27/38 , A61L31/12
CPC分类号： A61L27/56 , A61L27/38 , A61L27/44
摘要： The present invention refers to a method of manufacturing a composite scaffold including the surface grafting of the scaffold using gamma-irradiation as well as gamma-irradiation of a polymer contacted with the surface of the scaffold. The present invention also directed to the use of the scaffold for tissue engineering and other applications. The present invention is further directed to a method of culturing cells in a composite scaffold of the present invention and to a three-dimensional porous composite scaffold.
摘要翻译：本发明涉及一种制造复合骨架的方法，该复合支架包括使用γ-照射的支架的表面接枝以及与支架表面接触的聚合物的γ-照射。本发明还涉及用于组织工程和其它应用的支架的用途。本发明还涉及在本发明的复合支架中培养细胞的方法和三维多孔复合支架。

10. 发明申请

WO2009002273A1 IMAGING CHAMBER WITH WINDOW AND MICRO-NEEDLE PLATFORM MAGNETICALLY BIASED TOWARD EACH OTHER 审中-公开
标题翻译：具有窗户和微针平台的成像室磁性自动化其他其他
公开(公告)号：WO2009002273A1
公开(公告)日：2008-12-31
申请号：PCT/SG2008/000224
申请日：2008-06-26
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , YU, Hanry , KHONG, Yuet Mei , LEO, Hwa Liang
发明人： YU, Hanry , KHONG, Yuet Mei , LEO, Hwa Liang
IPC分类号： C12M3/00 , G01N1/31 , G01N33/48
CPC分类号： G01N1/312 , B33Y80/00 , C12M33/04 , C12M35/00
摘要： A device for imaging a tissue culture comprises a chamber for housing a tissue to be cultured and imaged. The chamber comprises a transparent window. The device also includes a platform facing the window. Micro-needles are mounted on the platform and are connected for fluid communication with a fluid source. The platform and the window are magnetically biased toward each other to press the micro-needles into a tissue sandwiched between the window and platform for injecting a fluid into the tissue. One or more spacers are placed between the platform and the window for preventing over-compression of the tissue by the platform and the window. During use, a fluid is supplied to the tissue through the needles from the fluid source and the tissue is imaged through the window of the chamber.
摘要翻译：用于成像组织培养物的装置包括用于容纳待培养和成像的组织的室。该室包括透明窗。该装置还包括面向窗户的平台。微针安装在平台上并被连接以便与流体源流体连通。平台和窗口彼此磁偏置，将微针压入夹在窗户和平台之间的组织中，用于将流体注入组织。一个或多个间隔物放置在平台和窗户之间，用于防止平台和窗户对组织的过度压缩。在使用期间，流体通过来自流体源的针体向组织供应，并且组织通过腔室的窗口成像。

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