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1. 发明申请

WO2007106497A3 THREE-DIMENSIONAL FABRICATION OF BIOCOMPATIBLE STRUCTURES IN ANATOMICAL SHAPES AND DIMENSIONS FOR TISSUE ENGINEERING AND ORGAN REPLACEMENT 审中-公开
标题翻译：用于组织工程和组织替代的解剖形状和尺寸的生物化学结构的三维制造
公开(公告)号：WO2007106497A3
公开(公告)日：2008-07-17
申请号：PCT/US2007006346
申请日：2007-03-13
申请人： AGENCY SCIENCE TECH & RES , YING JACKIE Y , KAN SHYI-HERNG , LOH JEREMY MING HOCK , SCHUMACHER KARL , HSIEH JAMES TSENG-MING
发明人： YING JACKIE Y , KAN SHYI-HERNG , LOH JEREMY MING HOCK , SCHUMACHER KARL , HSIEH JAMES TSENG-MING
IPC分类号： A61L27/38 , A61L27/56 , C12N5/00
CPC分类号： A61L27/38 , A61L27/56 , B33Y80/00 , C12N5/0068 , C12N2533/30
摘要： The present invention relates to methods and apparatuses involving biocompatible structures for tissue engineering and organ replacement and, more specifically, to methods and apparatuses involving biocompatible structures formed by three-dimensional fabrication for tissue engineering and organ replacement. In some embodiments, the biocompatible structures are scaffolds for cells that can be used as tissue engineering templates and/or as artificial organs. The structures may be three- dimensional and can mimic the shapes and dimensions of tissues and/or organs, including the microarchitecture and porosities of the tissues and organs. In some cases, a structure formed by three-dimensional fabrication comprises a wall defining a cavity and a plurality of pores in at least a portion of the wall. The pores may permeate the wall and enable exchange of a component (e.g., a molecule and/or a cell) between a portion interior to the cavity and a portion exterior to the cavity. For instance, pores may allow delivery of molecules, cell migration, and/or generation of connective tissue between the structure and its host environment. Structures of the invention can be implanted into a mammal, or alternatively and/or additionally, can be used ex vivo as bioartificial assist devices.
摘要翻译：本发明涉及包括用于组织工程和器官置换的生物相容结构的方法和装置，更具体地涉及涉及通过用于组织工程和器官置换的三维制造形成的生物相容性结构的方法和装置。在一些实施方案中，生物相容性结构是可用作组织工程模板和/或作为人造器官的细胞的支架。结构可以是三维的并且可以模拟组织和/或器官的形状和尺寸，包括组织和器官的微结构和孔隙率。在一些情况下，通过三维制造形成的结构包括在壁的至少一部分中限定空腔和多个孔的壁。孔可以渗透到壁上并且使得能够在空腔内部的部分和腔外部的部分（例如，分子和/或细胞）之间进行交换。例如，孔可以允许在结构和其宿主环境之间传递分子，细胞迁移和/或结缔组织的产生。本发明的结构可以植入哺乳动物，或者另外地和/或另外可以作为生物人造辅助装置离体使用。

2. 发明申请

WO2007106497A2 THREE-DIMENSIONAL FABRICATION OF BIOCOMPATIBLE STRUCTURES IN ANATOMICAL SHAPES AND DIMENSIONS FOR TISSUE ENGINEERING AND ORGAN REPLACEMENT 审中-公开
标题翻译：用于组织工程和组织替代的解剖形状和尺寸的生物化学结构的三维制造
公开(公告)号：WO2007106497A2
公开(公告)日：2007-09-20
申请号：PCT/US2007/006346
申请日：2007-03-13
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , YING, Jackie, Y. , KAN, Shyi-herng , LOH, Jeremy Ming Hock , SCHUMACHER, Karl , HSIEH, James, Tseng-ming
发明人： YING, Jackie, Y. , KAN, Shyi-herng , LOH, Jeremy Ming Hock , SCHUMACHER, Karl , HSIEH, James, Tseng-ming
IPC分类号： A61L27/38 , A61L27/56 , C12N5/00
CPC分类号： A61L27/38 , A61L27/56 , B33Y80/00 , C12N5/0068 , C12N2533/30
摘要： The present invention relates to methods and apparatuses involving biocompatible structures for tissue engineering and organ replacement and, more specifically, to methods and apparatuses involving biocompatible structures formed by three-dimensional fabrication for tissue engineering and organ replacement. In some embodiments, the biocompatible structures are scaffolds for cells that can be used as tissue engineering templates and/or as artificial organs. The structures may be three- dimensional and can mimic the shapes and dimensions of tissues and/or organs, including the microarchitecture and porosities of the tissues and organs. In some cases, a structure formed by three-dimensional fabrication comprises a wall defining a cavity and a plurality of pores in at least a portion of the wall. The pores may permeate the wall and enable exchange of a component (e.g., a molecule and/or a cell) between a portion interior to the cavity and a portion exterior to the cavity. For instance, pores may allow delivery of molecules, cell migration, and/or generation of connective tissue between the structure and its host environment. Structures of the invention can be implanted into a mammal, or alternatively and/or additionally, can be used ex vivo as bioartificial assist devices.
摘要翻译：本发明涉及包括用于组织工程和器官置换的生物相容结构的方法和装置，更具体地涉及涉及通过用于组织工程和器官置换的三维制造形成的生物相容性结构的方法和装置。在一些实施方案中，生物相容性结构是可用作组织工程模板和/或作为人造器官的细胞的支架。结构可以是三维的并且可以模拟组织和/或器官的形状和尺寸，包括组织和器官的微结构和孔隙率。在一些情况下，通过三维制造形成的结构包括在壁的至少一部分中限定空腔和多个孔的壁。孔可以渗透到壁上并且使得能够在空腔内部的部分和腔外部的部分（例如，分子和/或细胞）之间进行交换。例如，孔可以允许在结构和其宿主环境之间传递分子，细胞迁移和/或结缔组织的产生。本发明的结构可以植入哺乳动物，或者另外地和/或另外可以作为生物人造辅助装置离体使用。

3. 发明申请

WO2007106497A8 THREE-DIMENSIONAL FABRICATION OF BIOCOMPATIBLE STRUCTURES IN ANATOMICAL SHAPES AND DIMENSIONS FOR TISSUE ENGINEERING AND ORGAN REPLACEMENT 审中-公开
标题翻译：组织工程与器官组织解剖形态和尺寸中生物相容性结构的三维制作
公开(公告)号：WO2007106497A8
公开(公告)日：2008-01-03
申请号：PCT/US2007006346
申请日：2007-03-13
申请人： AGENCY SCIENCE TECH & RES , YING JACKIE Y , KAN SHYI-HERNG , LOH JEREMY MING HOCK , SCHUMACHER KARL , HSIEH JAMES TSENG-MING
发明人： YING JACKIE Y , KAN SHYI-HERNG , LOH JEREMY MING HOCK , SCHUMACHER KARL , HSIEH JAMES TSENG-MING
IPC分类号： A61L27/38 , A61L27/56 , C12N5/00
CPC分类号： A61L27/38 , A61L27/56 , B33Y80/00 , C12N5/0068 , C12N2533/30
摘要： The present invention relates to methods and apparatuses involving biocompatible structures for tissue engineering and organ replacement and, more specifically, to methods and apparatuses involving biocompatible structures formed by three-dimensional fabrication for tissue engineering and organ replacement. In some embodiments, the biocompatible structures are scaffolds for cells that can be used as tissue engineering templates and/or as artificial organs. The structures may be three- dimensional and can mimic the shapes and dimensions of tissues and/or organs, including the microarchitecture and porosities of the tissues and organs. In some cases, a structure formed by three-dimensional fabrication comprises a wall defining a cavity and a plurality of pores in at least a portion of the wall. The pores may permeate the wall and enable exchange of a component (e.g., a molecule and/or a cell) between a portion interior to the cavity and a portion exterior to the cavity. For instance, pores may allow delivery of molecules, cell migration, and/or generation of connective tissue between the structure and its host environment. Structures of the invention can be implanted into a mammal, or alternatively and/or additionally, can be used ex vivo as bioartificial assist devices.
摘要翻译：本发明涉及涉及用于组织工程学和器官替换的生物相容性结构的方法和装置，并且更具体地涉及涉及通过用于组织工程和器官替换的三维制造形成的生物相容性结构的方法和装置。在一些实施方案中，生物相容性结构是可用作组织工程模板和/或作为人造器官的细胞的支架。该结构可以是三维的并且可以模仿组织和/或器官的形状和尺寸，包括组织和器官的微构造和孔隙度。在一些情况下，由三维制造形成的结构包括在壁的至少一部分中限定腔体和多个孔的壁。孔可以渗透壁并且能够在空腔内部的部分和空腔外部的部分之间交换部件（例如，分子和/或细胞）。例如，孔可允许递送分子，细胞迁移和/或在结构与其宿主环境之间产生结缔组织。本发明的结构可以植入哺乳动物体内，或者可选地和/或另外地，可以作为生物人工辅助装置离体使用。

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