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1. 发明申请

WO2008147982A1 IMMUNOASSAYS EXHIBITING REDUCED CROSS-REACTIVITY WITH HYDROPHOBIC DRUG ANALYTE METABOLITES 审中-公开
标题翻译：免疫力显着降低了与疏水性药物分析代谢物的交叉反应性
公开(公告)号：WO2008147982A1
公开(公告)日：2008-12-04
申请号：PCT/US2008/064688
申请日：2008-05-23
申请人： ABBOTT LABORATORIES , BRATE, Elaine, M. , FINLEY, David, M. , HOLETS-MCCORMACK, Shelley, R. , PACENTI, David, P. , PIKTEL, Ryan, E. , SHIELDS, Michelle , SPRING, Thomas, G. , WANG, Philip, P.
发明人： BRATE, Elaine, M. , FINLEY, David, M. , HOLETS-MCCORMACK, Shelley, R. , PACENTI, David, P. , PIKTEL, Ryan, E. , SHIELDS, Michelle , SPRING, Thomas, G. , WANG, Philip, P.
IPC分类号： G01N33/543 , G01N33/94
CPC分类号： G01N33/54393 , G01N33/9493
摘要： The present disclosure provides among other things immunoassays exhibiting reduced cross-reactivity with analyte metabolites. Additionally, the present disclosure provides diagnostic immunoassays to determine the concentration or level in a test sample of a hydrophobic drug that metabolizes in vivo or in vitro to form cross-reacting metabolites wherein cross-reactivity with such metabolites of the drug analyte is reduced. In particular, the disclosure provides such immunoassays where the hydrophobic drug is an immunosuppressant drug such as cyclosporine A.
摘要翻译：本公开提供了与分析物代谢物显示降低的交叉反应性的免疫测定法。此外，本公开提供诊断免疫测定以确定在体内或体外代谢形成交叉反应代谢物的疏水性药物的测试样品中的浓度或水平，其中与药物分析物的这种代谢物的交叉反应性降低。具体地，本公开提供了这样的免疫测定，其中疏水性药物是免疫抑制剂药物，例如环孢菌素A.

2. 发明申请

WO2007081868A1 DETERMINATION OF CONCENTRATION OF FK778 BY COMPETITIVE IMMUNOASSAY 审中-公开
标题翻译：通过竞争性免疫测定法确定FK778的浓度
公开(公告)号：WO2007081868A1
公开(公告)日：2007-07-19
申请号：PCT/US2007/000389
申请日：2007-01-05
申请人： ABBOTT LABORATORIES , SPRING, Thomas, G. , BRATE, Elaine, M. , HOLETS-MCCORMACK, Shelley , REDDY, Rajarathnam, E. , JOHNSON, Donald, D. , CHEN, Yon-Yih , PAN, You
发明人： SPRING, Thomas, G. , BRATE, Elaine, M. , HOLETS-MCCORMACK, Shelley , REDDY, Rajarathnam, E. , JOHNSON, Donald, D. , CHEN, Yon-Yih , PAN, You
IPC分类号： G01N33/94
CPC分类号： G01N33/9493
摘要： Methods and kits for measurement of concentration of FK778 in a biological sample by means of an immunoassay, preferably a competitive immunoassay. In one aspect, the method and kit involve the use of (a) an antibody to FK778 conjugated to a label, e.g., an acridinium label, (b) an antibody to FK778 not conjugated to a label, (c) a solid phase containing an antibody to a first hapten, e.g., a fluorescein hapten, and (d) a bihapten comprising a first hapten and FK778 or an analogue of FK778, e.g., a bihapten comprising a fluorescein hapten and a FK778 hapten. In another aspect, the method and kit involve the use of (a) antibody to FK778, (b) a bihapten comprising FK778 or an analogue of FK778 and a first hapten, e.g., a bihapten comprising the fluorescein hapten and the hapten of FK778 or an analogue of FK778, and (c) a pretreatment reagent.
摘要翻译：通过免疫测定，优选竞争性免疫测定法测量生物样品中FK778的浓度的方法和试剂盒。一方面，该方法和试剂盒涉及使用（a）与标记缀合的FK778的抗体，例如吖啶标记，（b）与标记物不缀合的FK778的抗体，（c）含有第一半抗原的抗体，例如荧光素半抗原，和（d）包含第一半抗原和FK778或FK778的类似物的双突变体，例如包含荧光素半抗原和FK778半抗原的双突变体。另一方面，该方法和试剂盒涉及使用（a）FK778的抗体，（b）包含FK778或类似物FK778的双突变体和第一半抗原，例如包含荧光素半抗原的双突变体和FK778的半抗原或 FK778的类似物，（c）预处理试剂。

3. 发明申请

WO1996031780A1 REAGENTS AND METHODS FOR THE DETECTION AND QUANTIFICATION OF VANCOMYCIN IN BIOLOGICAL FLUIDS 审中-公开
标题翻译： VANCOMYCIN在生物流体中检测和定量的试剂和方法
公开(公告)号：WO1996031780A1
公开(公告)日：1996-10-10
申请号：PCT/US1996004469
申请日：1996-04-01
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , ADAMCZYK, Maciej , BRATE, Elaine, M. , PERKOWITZ, Mary, M. , REGE, Sushil, D.
IPC分类号： G01N33/94
CPC分类号： C07K16/44 , G01N33/533 , G01N33/9446 , Y10T436/10
摘要： Immunoassay reagents, methods and test kits for the specific quantification of vancomycin in a test sample are disclosed. The reagent comprises antibodies prepared with immunogens of Figure 6 wherein P is an immunogenic carrier material and X is a linking moiety. Also described is the synthesis of labeled reagents of Figure 8 wherein Q is a detectable moiety, preferably fluorescein or a fluorescein derivative, and X is a linking moiety.
摘要翻译：公开了用于测试样品中万古霉素的特异性定量的免疫测定试剂，方法和测试试剂盒。试剂包含用图6的免疫原制备的抗体，其中P是免疫原性载体材料，X是连接部分。还描述了图8的标记试剂的合成，其中Q是可检测部分，优选荧光素或荧光素衍生物，X是连接部分。

4. 发明申请

WO1994020636A1 GENETICALLY ENGINEERED ENZYMES AND THEIR CONJUGATES FOR DIAGNOSTIC ASSAYS 审中-公开
标题翻译：基因工程酶及其与诊断学结合的诊断
公开(公告)号：WO1994020636A1
公开(公告)日：1994-09-15
申请号：PCT/US1994002539
申请日：1994-03-09
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , BRATE, Elaine, M. , BRENNAN, Catherine, A. , BRIDON, Dominique, P. , JAFFE, Keeve, D. , KRAFFT, Grant, A. , MANDECKI, Wlodzimierz , MARCH, Steven, C. , RUSSELL, John, C. , YUE, Vincent, T.
IPC分类号： C12Q01/00
CPC分类号： C07K14/59 , C07K2319/40 , C12N9/16 , C12Q1/42
摘要： This invention relates to genetically engineered enzymes, their ligand conjugates, their manufacture, and their use in qualitative or quantitative assays. A hybrid enzyme, such as an AP-epitope, has a foreign amino acid moiety (an epitope) inserted near the active site of the starting AP enzyme. The foreign amino acid moiety binds with an analyte, and, as a consequence of this binding, the enzymatic activity of the hybrid enzyme, AP-epitope, is modified. The changes in the enzymatic activity are dependent upon the presence, or the amount, of the analyte. In another embodiment, the hybrid enzyme consists of a cysteine introduced near the active site of an AP to give a hybrid enzyme. The cysteine on the hybrid enzyme serves as a point of conjugation of a ligand, such as theophylline, ferritin, thyroxine, or digoxigenin, to form the hybrid enzyme-ligand conjugate. The ligand binds with an antibody, an analyte or a binding molecule to an analyte and as a result of this binding, the enzymatic activity of the hybrid enzyme-ligand conjugate is modified or modulated.
摘要翻译：本发明涉及基因工程改造的酶，其配体缀合物，其制备及其在定性或定量测定中的用途。诸如AP-表位的杂交酶在起始AP酶的活性位点附近插入外源氨基酸部分（表位）。外来氨基酸部分与分析物结合，并且作为该结合的结果，修饰了杂合酶AP-表位的酶活性。酶活性的变化取决于分析物的存在或数量。在另一个实施方案中，杂交酶由在AP的活性位点附近引入的半胱氨酸组成以产生杂交酶。杂交酶上的半胱氨酸用作配体如茶碱，铁蛋白，甲状腺素或地高辛的缀合点，以形成杂交酶 - 配体缀合物。配体与分析物结合抗体，分析物或结合分子，作为该结合的结果，修饰或调节杂交酶 - 配体结合物的酶活性。

5. 发明授权

EP2174137B1 IMMUNOASSAYS EXHIBITING REDUCED CROSS-REACTIVITY WITH HYDROPHOBIC DRUG ANALYTE METABOLITES 失效
标题翻译：疏水ARZNEISTOFFANALYT，代谢产物指着免疫试验方法还原的交叉反应
公开(公告)号：EP2174137B1
公开(公告)日：2011-11-30
申请号：EP08769692.8
申请日：2008-05-23
申请人： Abbott Laboratories
发明人： BRATE, Elaine, M. , FINLEY, David, M. , HOLETS-MCCORMACK, Shelley, R. , PACENTI, David, P. , PIKTEL, Ryan, E. , SHIELDS, Michelle , SPRING, Thomas, G. , WANG, Philip, P.
IPC分类号： G01N33/543 , G01N33/94
CPC分类号： G01N33/54393 , G01N33/9493
摘要： The present disclosure provides among other things immunoassays exhibiting reduced cross-reactivity with analyte metabolites. Additionally, the present disclosure provides diagnostic immunoassays to determine the concentration or level in a test sample of a hydrophobic drug that metabolizes in vivo or in vitro to form cross-reacting metabolites wherein cross-reactivity with such metabolites of the drug analyte is reduced. In particular, the disclosure provides such immunoassays where the hydrophobic drug is an immunosuppressant drug such as cyclosporine A.

6. 发明公开

EP1969378A1 DETERMINATION OF CONCENTRATION OF FK778 BY COMPETITIVE IMMUNOASSAY 审中-公开
标题翻译：浓度FK778的由竞争性免疫测定
公开(公告)号：EP1969378A1
公开(公告)日：2008-09-17
申请号：EP07716431.7
申请日：2007-01-05
申请人： ABBOTT LABORATORIES
发明人： SPRING, Thomas, G. , BRATE, Elaine, M. , HOLETS-MCCORMACK, Shelley , REDDY, Rajarathnam, E. , JOHNSON, Donald, D. , CHEN, Yon-Yih , PAN, You
IPC分类号： G01N33/94
CPC分类号： G01N33/9493
摘要： Methods and kits for measurement of concentration of FK778 in a biological sample by means of an immunoassay, preferably a competitive immunoassay. In one aspect, the method and kit involve the use of (a) an antibody to FK778 conjugated to a label, e.g., an acridinium label, (b) an antibody to FK778 not conjugated to a label, (c) a solid phase containing an antibody to a first hapten, e.g., a fluorescein hapten, and (d) a bihapten comprising a first hapten and FK778 or an analogue of FK778, e.g., a bihapten comprising a fluorescein hapten and a FK778 hapten. In another aspect, the method and kit involve the use of (a) antibody to FK778, (b) a bihapten comprising FK778 or an analogue of FK778 and a first hapten, e.g., a bihapten comprising the fluorescein hapten and the hapten of FK778 or an analogue of FK778, and (c) a pretreatment reagent.

7. 发明公开

EP1121599A1 DETECTION AND QUANTIFICATION OF VANCOMYCIN IN BIOLOGICAL FLUIDS 有权
标题翻译：检测和定量万古霉素的生物体液
公开(公告)号：EP1121599A1
公开(公告)日：2001-08-08
申请号：EP99956580.7
申请日：1999-10-15
申请人： ABBOTT LABORATORIES
发明人： ADAMCZYK, Maciej , BRATE, Elaine, M. , PERKOWITZ, Mary, M. , REGE, Sushil, D.
IPC分类号： G01N33/58 , G01N33/531 , C07K16/14
CPC分类号： C07K16/44 , G01N33/533 , G01N33/9446
摘要： Immunoassay reagents, methods and test kits for the specific quantification of vancomycin in a test sample are disclosed. The reagent comprises antibodies prepared with immunogens of Figure 6 wherein P is an immunogenic carrier material and X is a linking moiety. Also described is the synthesis of labeled reagents of Figure 8 wherein Q is a detectable moiety, preferably fluorescein or a fluorescein derivative, and X is a linking moiety.

8. 发明公开

EP0819254A1 REAGENTS AND METHODS FOR THE DETECTION AND QUANTIFICATION OF VANCOMYCIN IN BIOLOGICAL FLUIDS 失效
标题翻译：试剂和方法检测和万古霉素的生物体液中定量测定方法
公开(公告)号：EP0819254A1
公开(公告)日：1998-01-21
申请号：EP96911523.0
申请日：1996-04-01
申请人： Abbott Laboratories
发明人： ADAMCZYK, Maciej , BRATE, Elaine, M. , PERKOWITZ, Mary, M. , REGE, Sushil, D.
IPC分类号： G01N33 , C07K16 , C12N5 , C12N15 , C12P21
CPC分类号： C07K16/44 , G01N33/533 , G01N33/9446 , Y10T436/10
摘要： Immunoassay reagents, methods and test kits for the specific quantification of vancomycin in a test sample are disclosed. The reagent comprises antibodies prepared with immunogens of Figure 6 wherein P is an immunogenic carrier material and X is a linking moiety. Also described is the synthesis of labeled reagents of Figure 8 wherein Q is a detectable moiety, preferably fluorescein or a fluorescein derivative, and X is a linking moiety.

9. 发明公开

EP2174137A1 IMMUNOASSAYS EXHIBITING REDUCED CROSS-REACTIVITY WITH HYDROPHOBIC DRUG ANALYTE METABOLITES 失效
标题翻译：疏水ARZNEISTOFFANALYT，代谢产物指着免疫试验方法还原的交叉反应
公开(公告)号：EP2174137A1
公开(公告)日：2010-04-14
申请号：EP08769692.8
申请日：2008-05-23
申请人： Abbott Laboratories
发明人： BRATE, Elaine, M. , FINLEY, David, M. , HOLETS-MCCORMACK, Shelley, R. , PACENTI, David, P. , PIKTEL, Ryan, E. , SHIELDS, Michelle , SPRING, Thomas, G. , WANG, Philip, P.
IPC分类号： G01N33/543 , G01N33/94
CPC分类号： G01N33/54393 , G01N33/9493
摘要： The present disclosure provides among other things immunoassays exhibiting reduced cross-reactivity with analyte metabolites. Additionally, the present disclosure provides diagnostic immunoassays to determine the concentration or level in a test sample of a hydrophobic drug that metabolizes in vivo or in vitro to form cross-reacting metabolites wherein cross-reactivity with such metabolites of the drug analyte is reduced. In particular, the disclosure provides such immunoassays where the hydrophobic drug is an immunosuppressant drug such as cyclosporine A.

10. 发明授权

EP1121599B1 DETECTION AND QUANTIFICATION OF VANCOMYCIN IN BIOLOGICAL FLUIDS 有权
标题翻译：检测和定量万古霉素的生物体液
公开(公告)号：EP1121599B1
公开(公告)日：2004-12-15
申请号：EP99956580.7
申请日：1999-10-15
申请人： ABBOTT LABORATORIES
发明人： ADAMCZYK, Maciej , BRATE, Elaine, M. , PERKOWITZ, Mary, M. , REGE, Sushil, D.
IPC分类号： G01N33/58 , G01N33/531 , C07K16/14
CPC分类号： C07K16/44 , G01N33/533 , G01N33/9446

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