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1. 发明申请

WO2007081868A1 DETERMINATION OF CONCENTRATION OF FK778 BY COMPETITIVE IMMUNOASSAY 审中-公开
标题翻译：通过竞争性免疫测定法确定FK778的浓度
公开(公告)号：WO2007081868A1
公开(公告)日：2007-07-19
申请号：PCT/US2007/000389
申请日：2007-01-05
申请人： ABBOTT LABORATORIES , SPRING, Thomas, G. , BRATE, Elaine, M. , HOLETS-MCCORMACK, Shelley , REDDY, Rajarathnam, E. , JOHNSON, Donald, D. , CHEN, Yon-Yih , PAN, You
发明人： SPRING, Thomas, G. , BRATE, Elaine, M. , HOLETS-MCCORMACK, Shelley , REDDY, Rajarathnam, E. , JOHNSON, Donald, D. , CHEN, Yon-Yih , PAN, You
IPC分类号： G01N33/94
CPC分类号： G01N33/9493
摘要： Methods and kits for measurement of concentration of FK778 in a biological sample by means of an immunoassay, preferably a competitive immunoassay. In one aspect, the method and kit involve the use of (a) an antibody to FK778 conjugated to a label, e.g., an acridinium label, (b) an antibody to FK778 not conjugated to a label, (c) a solid phase containing an antibody to a first hapten, e.g., a fluorescein hapten, and (d) a bihapten comprising a first hapten and FK778 or an analogue of FK778, e.g., a bihapten comprising a fluorescein hapten and a FK778 hapten. In another aspect, the method and kit involve the use of (a) antibody to FK778, (b) a bihapten comprising FK778 or an analogue of FK778 and a first hapten, e.g., a bihapten comprising the fluorescein hapten and the hapten of FK778 or an analogue of FK778, and (c) a pretreatment reagent.
摘要翻译：通过免疫测定，优选竞争性免疫测定法测量生物样品中FK778的浓度的方法和试剂盒。一方面，该方法和试剂盒涉及使用（a）与标记缀合的FK778的抗体，例如吖啶标记，（b）与标记物不缀合的FK778的抗体，（c）含有第一半抗原的抗体，例如荧光素半抗原，和（d）包含第一半抗原和FK778或FK778的类似物的双突变体，例如包含荧光素半抗原和FK778半抗原的双突变体。另一方面，该方法和试剂盒涉及使用（a）FK778的抗体，（b）包含FK778或类似物FK778的双突变体和第一半抗原，例如包含荧光素半抗原的双突变体和FK778的半抗原或 FK778的类似物，（c）预处理试剂。

2. 发明申请

WO2008147982A1 IMMUNOASSAYS EXHIBITING REDUCED CROSS-REACTIVITY WITH HYDROPHOBIC DRUG ANALYTE METABOLITES 审中-公开
标题翻译：免疫力显着降低了与疏水性药物分析代谢物的交叉反应性
公开(公告)号：WO2008147982A1
公开(公告)日：2008-12-04
申请号：PCT/US2008/064688
申请日：2008-05-23
申请人： ABBOTT LABORATORIES , BRATE, Elaine, M. , FINLEY, David, M. , HOLETS-MCCORMACK, Shelley, R. , PACENTI, David, P. , PIKTEL, Ryan, E. , SHIELDS, Michelle , SPRING, Thomas, G. , WANG, Philip, P.
发明人： BRATE, Elaine, M. , FINLEY, David, M. , HOLETS-MCCORMACK, Shelley, R. , PACENTI, David, P. , PIKTEL, Ryan, E. , SHIELDS, Michelle , SPRING, Thomas, G. , WANG, Philip, P.
IPC分类号： G01N33/543 , G01N33/94
CPC分类号： G01N33/54393 , G01N33/9493
摘要： The present disclosure provides among other things immunoassays exhibiting reduced cross-reactivity with analyte metabolites. Additionally, the present disclosure provides diagnostic immunoassays to determine the concentration or level in a test sample of a hydrophobic drug that metabolizes in vivo or in vitro to form cross-reacting metabolites wherein cross-reactivity with such metabolites of the drug analyte is reduced. In particular, the disclosure provides such immunoassays where the hydrophobic drug is an immunosuppressant drug such as cyclosporine A.
摘要翻译：本公开提供了与分析物代谢物显示降低的交叉反应性的免疫测定法。此外，本公开提供诊断免疫测定以确定在体内或体外代谢形成交叉反应代谢物的疏水性药物的测试样品中的浓度或水平，其中与药物分析物的这种代谢物的交叉反应性降低。具体地，本公开提供了这样的免疫测定，其中疏水性药物是免疫抑制剂药物，例如环孢菌素A.

3. 发明申请

WO1997022715A1 INTERFERENCE FREE BIOSENSOR 审中-公开
标题翻译：干扰免费生物传感器
公开(公告)号：WO1997022715A1
公开(公告)日：1997-06-26
申请号：PCT/US1996018889
申请日：1996-11-25
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , HENNING, Timothy, P. , SPRING, Thomas, G.
IPC分类号： C12Q01/28
CPC分类号： C12Q1/002 , Y10S435/817
摘要： Provided are microparticle forms of carbon, carbon catalysts and carbon-containing electrically conductive materials which are covalently linked to peroxidase. The carbon:peroxidase conjugates are suitable for use as substrates in conventional electrodes. Surprisingly, the conjugates display very little sensitivity to known interfering substances and thus are suitable for use as interference free electrodes.
摘要翻译：提供了与过氧化物酶共价连接的碳，碳催化剂和含碳导电材料的微粒形式。碳：过氧化物酶缀合物适用于常规电极中的底物。令人惊奇的是，缀合物对已知的干扰物质的灵敏度非常小，因此适合用作无干扰电极。

4. 发明申请

WO1995022057A1 BIOREAGENT IMMOBILIZATION MEDIUM 审中-公开
标题翻译：生物维生素中间体
公开(公告)号：WO1995022057A1
公开(公告)日：1995-08-17
申请号：PCT/US1995001605
申请日：1995-02-06
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , SPRING, Thomas, G. , BRACKETT, John, M. , VOGDES, Sheila, A. , SCHULTZ, Steven, G.
IPC分类号： G01N33/543
CPC分类号： G01N33/545 , G01N33/543 , G01N33/5436 , Y10S435/817 , Y10S436/806
摘要： The present invention provides an immobilization medium which can immobilize bioreagents to support materials and which dries to a water resistant layer or film. The immobilization medium comprises (i) a liquid or fluid binding reagent and (ii) complexes of a bioreagent immobilized to a solid phase which are evenly dispersed within the binding reagent. The suspension can further include supplemental ingredients evenly dispersed throughout the medium which can provide the medium with electrochemical properties, enhance the stability of the immobilized bioreagent and/or improve the medium's capability of drying to a substantially water resistant or insoluble layer. The immobilization medium provided by the instant invention is in the form of a homogeneous liquid suspension. The immobilizing medium of the present invention can be employed in essentially any assay format which utilizes an immobilized bioreagent. For example, using the immobilization medium, an enzyme electrode can be manufactured and used in conjunction with a counter and reference electrode to electrochemically detect the bioconversion of the enzyme's substrate; a biosensor can be manufactured which is capable, via non-electrochemical means, of detecting the bioconversion of the enzyme's substrate; and a solid phase can be manufactured which can be used in heterogeneous immunoassay formats known in the art.
摘要翻译：本发明提供一种固定培养基，其可以将生物试剂固定在支撑材料上并干燥到防水层或膜上。固定培养基包括（i）液体或流体结合试剂和（ii）固定在固相上的生物试剂的复合物，其均匀分散在结合试剂中。悬浮液可以进一步包括均匀分散在整个培养基中的补充成分，其可以为培养基提供电化学性质，增强固定化生物试剂的稳定性和/或提高培养基对基本上防水或不溶性层的干燥能力。由本发明提供的固定介质是均匀的液体悬浮液的形式。本发明的固定培养基可以基本上使用利用固定的生物试剂的任何测定形式来使用。例如，使用固定培养基，可以制造酶电极并与对照和参比电极结合使用以电化学检测酶底物的生物转化; 可以制造能够通过非电化学手段检测酶底物的生物转化的生物传感器; 并且可以制造可用于本领域已知的异种免疫测定形式的固相。

5. 发明授权

EP0876506B1 INTERFERENCE FREE BIOSENSOR 失效
标题翻译：无故障的生物传感器
公开(公告)号：EP0876506B1
公开(公告)日：2003-07-09
申请号：EP96940610.7
申请日：1996-11-25
申请人： Abbott Laboratories
发明人： HENNING, Timothy, P. , SPRING, Thomas, G.
IPC分类号： C12Q1/28 , C12Q1/54 , G01N27/327
CPC分类号： C12Q1/002 , Y10S435/817
摘要： Provided are microparticle forms of carbon, carbon catalysts and carbon-containing electrically conductive materials which are covalently linked to peroxidase. The carbon:peroxidase conjugates are suitable for use as substrates in conventional electrodes. Surprisingly, the conjugates display very little sensitivity to known interfering substances and thus are suitable for use as interference free electrodes.

6. 发明公开

EP1969378A1 DETERMINATION OF CONCENTRATION OF FK778 BY COMPETITIVE IMMUNOASSAY 审中-公开
标题翻译：浓度FK778的由竞争性免疫测定
公开(公告)号：EP1969378A1
公开(公告)日：2008-09-17
申请号：EP07716431.7
申请日：2007-01-05
申请人： ABBOTT LABORATORIES
发明人： SPRING, Thomas, G. , BRATE, Elaine, M. , HOLETS-MCCORMACK, Shelley , REDDY, Rajarathnam, E. , JOHNSON, Donald, D. , CHEN, Yon-Yih , PAN, You
IPC分类号： G01N33/94
CPC分类号： G01N33/9493
摘要： Methods and kits for measurement of concentration of FK778 in a biological sample by means of an immunoassay, preferably a competitive immunoassay. In one aspect, the method and kit involve the use of (a) an antibody to FK778 conjugated to a label, e.g., an acridinium label, (b) an antibody to FK778 not conjugated to a label, (c) a solid phase containing an antibody to a first hapten, e.g., a fluorescein hapten, and (d) a bihapten comprising a first hapten and FK778 or an analogue of FK778, e.g., a bihapten comprising a fluorescein hapten and a FK778 hapten. In another aspect, the method and kit involve the use of (a) antibody to FK778, (b) a bihapten comprising FK778 or an analogue of FK778 and a first hapten, e.g., a bihapten comprising the fluorescein hapten and the hapten of FK778 or an analogue of FK778, and (c) a pretreatment reagent.

7. 发明公开

EP1015569A1 INTERFERENCE FREE BIOSENSOR 审中-公开
标题翻译： TROUBLE生物传感器减量
公开(公告)号：EP1015569A1
公开(公告)日：2000-07-05
申请号：EP98944679.4
申请日：1998-09-01
申请人： Abbott Laboratories
发明人： HENNING, Timothy, P. , SPRING, Thomas, G.
IPC分类号： C12N11/00 , C12Q1/00 , G01N27/327 , C12Q1/28
CPC分类号： C12Q1/005 , C12Q1/002 , Y10S435/817
摘要： Provided are microparticle forms of carbon, carbon catalysts and carbon-containing electrically conductive materials which are covalently linked to peroxidase. The carbon:peroxidase conjugates are suitable for use as substrates in conventional electrodes. Surprisingly, the conjugates display very little sensitivity to known interfering substances and thus are suitable for use as interference free electrodes.

8. 发明授权

EP2174137B1 IMMUNOASSAYS EXHIBITING REDUCED CROSS-REACTIVITY WITH HYDROPHOBIC DRUG ANALYTE METABOLITES 失效
标题翻译：疏水ARZNEISTOFFANALYT，代谢产物指着免疫试验方法还原的交叉反应
公开(公告)号：EP2174137B1
公开(公告)日：2011-11-30
申请号：EP08769692.8
申请日：2008-05-23
申请人： Abbott Laboratories
发明人： BRATE, Elaine, M. , FINLEY, David, M. , HOLETS-MCCORMACK, Shelley, R. , PACENTI, David, P. , PIKTEL, Ryan, E. , SHIELDS, Michelle , SPRING, Thomas, G. , WANG, Philip, P.
IPC分类号： G01N33/543 , G01N33/94
CPC分类号： G01N33/54393 , G01N33/9493
摘要： The present disclosure provides among other things immunoassays exhibiting reduced cross-reactivity with analyte metabolites. Additionally, the present disclosure provides diagnostic immunoassays to determine the concentration or level in a test sample of a hydrophobic drug that metabolizes in vivo or in vitro to form cross-reacting metabolites wherein cross-reactivity with such metabolites of the drug analyte is reduced. In particular, the disclosure provides such immunoassays where the hydrophobic drug is an immunosuppressant drug such as cyclosporine A.

9. 发明公开

EP0744029A1 BIOREAGENT IMMOBILIZATION MEDIUM 失效
标题翻译：双组份固定介质
公开(公告)号：EP0744029A1
公开(公告)日：1996-11-27
申请号：EP95910943.0
申请日：1995-02-06
申请人： Abbott Laboratories
发明人： SPRING, Thomas, G. , BRACKETT, John, M. , VOGDES, Sheila, A. , SCHULTZ, Steven, G.
IPC分类号： C12N11 , C12Q1 , G01N27 , G01N33
CPC分类号： G01N33/545 , G01N33/543 , G01N33/5436 , Y10S435/817 , Y10S436/806
摘要： The present invention provides an immobilization medium which can immobilize bioreagents to support materials and which dries to a water resistant layer or film. The immobilization medium comprises (i) a liquid or fluid binding reagent and (ii) complexes of a bioreagent immobilized to a solid phase which are evenly dispersed within the binding reagent. The suspension can further include supplemental ingredients evenly dispersed throughout the medium which can provide the medium with electrochemical properties, enhance the stability of the immobilized bioreagent and/or improve the medium's capability of drying to a substantially water resistant or insoluble layer. The immobilization medium provided by the instant invention is in the form of a homogeneous liquid suspension. The immobilizing medium of the present invention can be employed in essentially any assay format which utilizes an immobilized bioreagent. For example, using the immobilization medium, an enzyme electrode can be manufactured and used in conjunction with a counter and reference electrode to electrochemically detect the bioconversion of the enzyme's substrate; a biosensor can be manufactured which is capable, via non-electrochemical means, of detecting the bioconversion of the enzyme's substrate; and a solid phase can be manufactured which can be used in heterogeneous immunoassay formats known in the art.
摘要翻译：本发明提供了一种固定化培养基，其可将生物试剂固定到支持材料上并干燥成防水层或膜。固定介质包含（i）液体或流体结合试剂和（ii）固定于固相的生物试剂的复合物，所述生物试剂均匀分散于结合试剂中。悬浮液可以进一步包括均匀分散在整个介质中的补充成分，其可以为介质提供电化学性质，增强固定化生物试剂的稳定性和/或改善介质干燥至基本上防水或不溶解层的能力。本发明提供的固定介质是均匀液体悬浮液的形式。本发明的固定化介质可以以基本上任何利用固定化生物试剂的测定形式使用。例如，使用固定介质，可以制造酶电极，并与反电极和参比电极结合使用，以电化学方式检测酶底物的生物转化; 可以制造生物传感器，其能够通过非电化学方式检测酶底物的生物转化; 并且可以制造可以以本领域已知的非均相免疫测定形式使用的固相。

10. 发明公开

EP2174137A1 IMMUNOASSAYS EXHIBITING REDUCED CROSS-REACTIVITY WITH HYDROPHOBIC DRUG ANALYTE METABOLITES 失效
标题翻译：疏水ARZNEISTOFFANALYT，代谢产物指着免疫试验方法还原的交叉反应
公开(公告)号：EP2174137A1
公开(公告)日：2010-04-14
申请号：EP08769692.8
申请日：2008-05-23
申请人： Abbott Laboratories
发明人： BRATE, Elaine, M. , FINLEY, David, M. , HOLETS-MCCORMACK, Shelley, R. , PACENTI, David, P. , PIKTEL, Ryan, E. , SHIELDS, Michelle , SPRING, Thomas, G. , WANG, Philip, P.
IPC分类号： G01N33/543 , G01N33/94
CPC分类号： G01N33/54393 , G01N33/9493
摘要： The present disclosure provides among other things immunoassays exhibiting reduced cross-reactivity with analyte metabolites. Additionally, the present disclosure provides diagnostic immunoassays to determine the concentration or level in a test sample of a hydrophobic drug that metabolizes in vivo or in vitro to form cross-reacting metabolites wherein cross-reactivity with such metabolites of the drug analyte is reduced. In particular, the disclosure provides such immunoassays where the hydrophobic drug is an immunosuppressant drug such as cyclosporine A.

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