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1. 发明申请

WO2008121324A3 RECOMBINANT EXPRESSION VECTOR ELEMENTS (REVES) FOR ENHANCING EXPRESSION OF RECOMBINANT PROTEINS IN HOST CELLS 审中-公开
标题翻译：重组表达载体元件（改良）增强重组蛋白在宿主细胞中的表达
公开(公告)号：WO2008121324A3
公开(公告)日：2008-12-11
申请号：PCT/US2008004063
申请日：2008-03-28
申请人： ABBOTT LAB , GION WENDY R , CARSON GERALD R , GAO HONG , KUNES YUNE Z
发明人： GION WENDY R , CARSON GERALD R , GAO HONG , KUNES YUNE Z
IPC分类号： C07H21/04
CPC分类号： C07K16/00 , C07K16/241 , C07K16/244 , C07K16/2854 , C12N15/79 , C12N15/85 , C12N2510/02 , C12N2830/46 , C12P21/02
摘要： Compositions and methods comprising recombinant expression vector elements (rEVEs) to enhance the level of expression of recombinant proteins are described. Other compositions and methods for lowering, substantially suppressing, or essentially silencing expression of a recombinant protein are also described.
摘要翻译：描述了包含重组表达载体元件（rEVEs）以增强重组蛋白表达水平的组合物和方法。还描述了用于降低，基本抑制或基本沉默重组蛋白表达的其他组合物和方法。

2. 发明公开

EP2142560A4 RECOMBINANT EXPRESSION VECTOR ELEMENTS (REVES) FOR ENHANCING EXPRESSION OF RECOMBINANT PROTEINS IN HOST CELLS 审中-公开
标题翻译：重组表达载体ELEMENTS（雷沃）改善重组蛋白在宿主细胞中表达
公开(公告)号：EP2142560A4
公开(公告)日：2010-12-01
申请号：EP08727191
申请日：2008-03-28
申请人： ABBOTT LAB
发明人： GION WENDY R , CARSON GERALD R , GAO HONG , KUNES YUNE Z
IPC分类号： C12N15/85
CPC分类号： C07K16/00 , C07K16/241 , C07K16/244 , C07K16/2854 , C12N15/79 , C12N15/85 , C12N2510/02 , C12N2830/46 , C12P21/02

3. 发明专利

MX2012005117A CONSTRUCCIONES DE SORF Y EXPRESION DE GEN MULTIPLE. 未知
公开(公告)号：MX2012005117A
公开(公告)日：2012-06-14
申请号：MX2012005117
申请日：2010-10-28
申请人： ABBOTT LAB
发明人： FUNG EMMA , CARSON GERALD R , GION WENDY R , KUNES YUNE Z , LEISE WALTER F III , DAVIS-TABER RACHEL A
IPC分类号： C07K16/00 , C12P21/02 , C12P21/06
摘要： Las modalidades de la invención se refieren a construcciones de vector y a métodos para expresión de polipéptidos incluyendo productos multiméricos tales como anticuerpos terapéuticos. Las construcciones particulares permiten la generación de productos de expresión a partir de un marco de lectura abierto individual (sORF). Una modalidad provee un vector de expresión aislado o purificado para generar uno o más productos de proteína recombinante que comprenden un inserto de marco de lectura abierto individual; dicho inserto comprende una secuencia de ácido nucleico de péptido de señal que codifica para un péptido de señal; una primera secuencia de ácido nucleico que codifica para un primer polipéptido; una primera secuencia de ácido nucleico de intercalado que codifica para un primer sitio de corte de proteína, en la cual dicho primer sitio de corte de proteína es provisto por un segmento de inteína de un gen de proteasa Ion de Pyrococcus o un gen klbA de Pyrococcus o Methanococcus, o un segmento de inteína modificada derivado a partir de los mismos; y una segunda secuencia de ácido nucleico que codifica para un segundo polipéptido. Ciertas modalidades de construcciones y métodos emplean un segmento de inteína de un gen de proteasa Ion de Pyrococcus abyssi, Pyrococcus furiosus, o Pyrococcus horikoshii 0T3; o un segmento de inteína de un gen klbA de Pyrococcus abyssi, Pyrococcus furiosus, o Methanococcus jannaschii; u otro segmento de inteína.

4. 发明专利

AU2008233196A1 Recombinant expression vector elements (rEVEs) for enhancing expression of recombinant proteins in host cells 未知
公开(公告)号：AU2008233196A1
公开(公告)日：2008-10-09
申请号：AU2008233196
申请日：2008-03-28
申请人： ABBOTT LAB
发明人： GAO HONG , CARSON GERALD R , GION WENDY R , KUNES YUNE Z
IPC分类号： C07H21/04 , C12N5/00 , C12N5/02 , C12N15/00
摘要： Compositions and methods comprising recombinant expression vector elements (rEVEs) to enhance the level of expression of recombinant proteins are described. Other compositions and methods for lowering, substantially suppressing, or essentially silencing expression of a recombinant protein are also described.

5. 发明专利

IN3281DEN2012A "SORF CONSTRUCTS AND MULTIPLE GENE EXPRESSION" 未知
公开(公告)号：IN3281DEN2012A
公开(公告)日：2015-10-23
申请号：IN3281DEN2012
申请日：2012-04-16
申请人： ABBOTT LAB
发明人： CARSON GERALD R , GION WENDY R , KUNES YUNE Z , LEISE III WALTER F , DAVIS-TABER RACHEL A , FUNG EMMA
IPC分类号： C07K16/00
摘要： Embodiments of the invention relate to vector constructs and methods for expression of polypeptides including multimeric products such as therapeutic antibodies. Particular constructs allow for the generation of expression products from a single open reading frame (sORF). An embodiment provides an isolated or purified expression vector for generating one or more recombinant protein products comprising a single open reading frame insert; said insert comprising a signal peptide nucleic acid sequence encoding a signal peptide; a first nucleic acid sequence encoding a first polypeptide; a first intervening nucleic acid sequence encoding a first protein cleavage site, wherein said first protein cleavage site is provided by an intein segment of a Ion protease gene of Pyrococcus or a klbA gene of Pyrococcus or Methanococcus, or a modified intein segment derived therefrom; and a second nucleic acid sequence encoding a second polypeptide. Certain embodiments of constructs and methods employ an intein segment of a Ion protease gene of Pyrococcus abyssi, Pyrococcus furiosus, or Pyrococcus horikoshii OT3; or an intein segment of a klbA gene of Pyrococcus abyssi, Pyrococcus furiosus, or Methanococcus jannaschir, or other intein segment.

6. 发明专利

NZ580378A RECOMBINANT EXPRESSION VECTOR ELEMENTS (REVES) FOR ENHANCING EXPRESSION OF RECOMBINANT PROTEINS IN HOST CELLS 未知
公开(公告)号：NZ580378A
公开(公告)日：2012-11-30
申请号：NZ58037808
申请日：2008-03-28
申请人： ABBOTT LAB
发明人： GION WENDY R , CARSON GERALD R , GAO HONG , KUNES YUNE Z
IPC分类号： C07H21/04
摘要： Disclosed is an isolated recombinant expression vector element (rEVE) polynucleotide molecule comprising a nucleotide base sequence selected from the group consisting of the nucleotide base sequence of SEQ ID NO: 1, the nucleotide base sequence of SEQ ID NO:2, a sequence complementary to any foregoing sequence, an expression-enhancing portion of any foregoing sequence, and combinations thereof.

7. 发明专利

MX2009010492A ELEMENTOS DE VECTOR DE EXPRESION RECOMBINANTE (REVES) PARA MEJORAR LA EXPRESION DE PROTEINAS RECOMBINANTES EN CELULAS HUESPED. 未知
公开(公告)号：MX2009010492A
公开(公告)日：2009-10-19
申请号：MX2009010492
申请日：2008-03-28
申请人： ABBOTT LAB
发明人： CARSON GERALD R , GION WENDY R , GAO HONG , KUNES YUNE Z
IPC分类号： C07H21/04
摘要： Se describen composiciones y métodos que comprenden elementos de vector de expresión recombinante (rEVEs) para mejorar el nivel de expresión de proteínas recombinantes. También se describen otras composiciones y métodos para reducir, suprimir substancialmente, o silenciar esencialmente la expresión de una proteína recombinante.

8. 发明专利

SG182953A1 RECOMBINANT EXPRESSION VECTOR ELEMENTS (REVES) FOR ENHANCING EXPRESSION OF RECOMBINANT PROTEINS IN HOST CELLS 未知
公开(公告)号：SG182953A1
公开(公告)日：2012-08-30
申请号：SG2012046504
申请日：2008-03-28
申请人： ABBOTT LAB
发明人： GION WENDY R , CARSON GERALD R , GAO HONG , KUNES YUNE Z
摘要： Compositions and methods comprising recombinant expression vector elements (rEVEs) to enhance the level of expression of recombinant proteins are described. Other compositions and methods for lowering, substantially suppressing, or essentially silencing expression of a recombinant protein are also described. Figure 4

9. 发明专利

AU2012200227A1 Recombinant expression vector elements (rEVEs) for enhancing expression of recombinant proteins in host cells 未知
公开(公告)号：AU2012200227A1
公开(公告)日：2012-02-02
申请号：AU2012200227
申请日：2012-01-13
申请人： ABBOTT LAB
发明人： CARSON GERALD R , KUNES YUNE Z , GION WENDY R , GAO HONG
IPC分类号： C07H21/04 , C12N5/00 , C12N5/02 , C12N15/00
摘要： Recombinant expression vector elements (rEVEs) for enhancing expression of recombinant proteins in host cells Abstract Compositions and methods comprising recombinant expression vector elements (rEVEs) to enhance the level of expression of recombinant proteins are described. Other compositions and methods for lowering, substantially suppressing, or essentially silencing expression of a recombinant protein are also described. (5885589_1):GGG

10. 发明专利

CA2776990A1 SORF CONSTRUCTS AND MULTIPLE GENE EXPRESSION 未知
公开(公告)号：CA2776990A1
公开(公告)日：2011-05-05
申请号：CA2776990
申请日：2010-10-28
申请人： ABBOTT LAB
发明人： CARSON GERALD R , GION WENDY R , KUNES YUNE Z , LEISE WALTER F III , DAVIS-TABER RACHEL A , FUNG EMMA
IPC分类号： C07K16/00 , C12P21/02 , C12P21/06
摘要： Embodiments of the invention relate to vector constructs and methods for expression of polypeptides including multimeric products such as therapeutic antibodies. Particular constructs allow for the generation of expression products from a single open reading frame (sORF). An embodiment provides an isolated or purified expression vector for generating one or more recombinant protein products comprising a single open reading frame insert; said insert comprising a signal peptide nucleic acid sequence encoding a signal peptide; a first nucleic acid sequence encoding a first polypeptide; a first intervening nucleic acid sequence encoding a first protein cleavage site, wherein said first protein cleavage site is provided by an intein segment of a Ion protease gene of Pyrococcus or a klbA gene of Pyrococcus or Methanococcus, or a modified intein segment derived therefrom; and a second nucleic acid sequence encoding a second polypeptide. Certain embodiments of constructs and methods employ an intein segment of a Ion protease gene of Pyrococcus abyssi, Pyrococcus furiosus, or Pyrococcus horikoshii OT3; or an intein segment of a klbA gene of Pyrococcus abyssi, Pyrococcus furiosus, or Methanococcus jannaschii; or other intein segment.

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