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1. 发明申请

WO2011025964A3 THERAPEUTIC DLL4 BINDING PROTEINS 审中-公开
标题翻译：治疗DLL4结合蛋白
公开(公告)号：WO2011025964A3
公开(公告)日：2011-04-21
申请号：PCT/US2010047006
申请日：2010-08-27
申请人： ABBOTT LAB , BENATUIL LORENZO , BOGHAERT ERWIN R , GU JIJIE , HARRIS MARIA , HICKSON JONATHAN A , HSIEH CHUNG-MING , KUTSKOVA YULIYA , LI YINGCHUN , LIU ZHIHONG , MORGAN-LAPPE SUSAN
发明人： BENATUIL LORENZO , BOGHAERT ERWIN R , GU JIJIE , HARRIS MARIA , HICKSON JONATHAN A , HSIEH CHUNG-MING , KUTSKOVA YULIYA , LI YINGCHUN , LIU ZHIHONG , MORGAN-LAPPE SUSAN
IPC分类号： C07K16/28
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K7/06 , C07K7/08 , C07K14/47 , C07K16/18 , C07K2317/21 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： Improved DLL4 binding proteins are described, including antibodies, CDR-grafted antibodies, human antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis, and/or other angiogenesis-dependent diseases such as ocular neovascularization, or angiogenesis-independent diseases characterized by aberrant DLL4 expression or activity such as autoimmune disorders including multiple sclerosis.
摘要翻译：描述了改进的DLL4结合蛋白，包括抗体，CDR-移植抗体，人抗体和DLL4结合片段，以高亲和力结合DLL4的蛋白质，以及中和DLL4活性的DLL4结合蛋白。 DLL4结合蛋白可用于治疗或预防癌症和肿瘤，特别是用于治疗或预防肿瘤血管生成和/或其它血管发生依赖性疾病，例如眼新生血管形成或以异常DLL4表达或活性为特征的血管发生非依赖性疾病，例如自身免疫包括多发性硬化的疾病。

2. 发明申请

WO2010006059A8 PROSTAGLANDIN E2 BINDING PROTEINS AND USES THEREOF 审中-公开
标题翻译：前列腺素E2结合蛋白及其用途
公开(公告)号：WO2010006059A8
公开(公告)日：2010-09-02
申请号：PCT/US2009049953
申请日：2009-07-08
申请人： ABBOTT LAB , GU JIJIE , HUTCHINS CHARLES W , ZHU RONG-RONG , SHEN JIANWEI , HARRIS MARIA C , BELANGER EILEEN , MURTAZA ANWAR , TARCSA EDIT , STINE WILLIAM B , HSIEH CHUNG-MING
发明人： GU JIJIE , HUTCHINS CHARLES W , ZHU RONG-RONG , SHEN JIANWEI , HARRIS MARIA C , BELANGER EILEEN , MURTAZA ANWAR , TARCSA EDIT , STINE WILLIAM B , HSIEH CHUNG-MING
IPC分类号： A61K39/395
CPC分类号： C07K16/18 , A61K31/405 , A61K31/573 , A61K39/39533 , A61K2039/505 , C07K16/26 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76
摘要： The present invention encompasses prostaglandin E2 (PGE2) binding proteins. The invention relates to antibodies that are wild-type, chimeric, CDR grafted and humanized. Preferred antibodies have high affinity for prostaglandin E2 and neutralize prostaglandin E2 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody, or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antigen-binding portions, of the invention are useful for detecting prostaglandin E2 and for inhibiting prostaglandin E2 activity, e.g., in a human subject suffering from a disorder in which prostaglandin E2 activity is detrimental.
摘要翻译：本发明包括前列腺素E2（PGE2）结合蛋白。本发明涉及野生型，嵌合，CDR移植和人源化的抗体。优选的抗体对前列腺素E2具有高亲和力并且在体外和体内中和前列腺素E2的活性。本发明的抗体可以是全长抗体或其抗原结合部分。还提供了制备方法和使用本发明抗体的方法。本发明的抗体或抗原结合部分可用于检测前列腺素E2和用于抑制前列腺素E2活性，例如，在患有前列腺素E2活性是有害的病症的人类受试者中。

3. 发明申请

WO2009136382A2 ANTIBODIES TO RECEPTOR OF ADVANCED GLYCATION END PRODUCTS (RAGE) AND USES THEREOF 审中-公开
标题翻译：高级糖果终产品（RAGE）及其用途的受体抗体
公开(公告)号：WO2009136382A2
公开(公告)日：2009-11-12
申请号：PCT/IB2009051915
申请日：2009-05-08
申请人： ABBOTT GMBH & CO KG , ABBOTT LAB , GU JIJIE , HSIEH CHUNG-MING , WU ZHEN , DIGIAMMARINO ENRICO L , LUO FENG , FOX GERARD B , HARLAN JOHN E , SCHMIDT MARTIN , LOEBBERT RALF , MUELLER REINHOLD , EBERT ULRICH , NIMMRICH VOLKER
发明人： GU JIJIE , HSIEH CHUNG-MING , WU ZHEN , DIGIAMMARINO ENRICO L , LUO FENG , FOX GERARD B , HARLAN JOHN E , SCHMIDT MARTIN , LOEBBERT RALF , MUELLER REINHOLD , EBERT ULRICH , NIMMRICH VOLKER
IPC分类号： C12N15/12 , C12N5/00 , C12N7/00
CPC分类号： C07K16/2803 , A61K2039/505 , C07K16/28 , C07K16/464 , C07K2317/14 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C12P21/005
摘要： The present application relates to isolated proteins, particularly monoclonal antibodies, in particular CDR-grafted, humanized antibodies which bind to RAGE protein. Specifically, these antibodies have the ability to inhibit the binding of RAGE to its various ligands. The antibodies or portions thereof of described in the present application are useful for treating a disease or disorder characterized by or induced by pathophysiological ligands of RAGE, for example missfolded proteins like amyloid ß and advanced glycation-end-products.
摘要翻译：本申请涉及分离的蛋白质，特别是单克隆抗体，特别是结合RAGE蛋白质的CDR-移植的人源化抗体。具体地说，这些抗体具有抑制RAGE与其各种配体结合的能力。本申请中描述的抗体或其部分可用于治疗由RAGE的病理生理学配体表征或诱导的疾病或病症，例如错折叠蛋白，如淀粉样蛋白β和晚期糖基化终产物。

4. 发明申请

WO2012061374A3 DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF 审中-公开
标题翻译：双变量域免疫球蛋白及其用途
公开(公告)号：WO2012061374A3
公开(公告)日：2012-11-01
申请号：PCT/US2011058769
申请日：2011-11-01
申请人： ABBOTT LAB , GHAYUR TARIQ , LIU JUNJIAN , GU JIJIE , HARRIS MARIA C
发明人： GHAYUR TARIQ , LIU JUNJIAN , GU JIJIE , HARRIS MARIA C
IPC分类号： C12P21/08 , A61K39/395 , C07K16/00
CPC分类号： C07K16/468 , A61K2039/505 , C07K16/22 , C07K16/241 , C07K16/26 , C07K16/2863 , C07K16/2875 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/567 , C07K2317/60 , C07K2317/64 , C07K2317/71 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.
摘要翻译：提供了工程化的多价和多特异性结合蛋白，制备方法以及它们在疾病的预防，诊断和/或治疗中的用途。

5. 发明申请

WO2011059755A3 DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF 审中-公开
公开(公告)号：WO2011059755A3
公开(公告)日：2011-07-28
申请号：PCT/US2010054521
申请日：2010-10-28
申请人： ABBOTT LAB , GHAYUR TARIQ , SALFELD JOCHEN G , MCPHERSON MICHAEL J , HARRIS MARIA C , LIU JUNJIAN , ISAKSON PETER C , GU JIJIE
发明人： GHAYUR TARIQ , SALFELD JOCHEN G , MCPHERSON MICHAEL J , HARRIS MARIA C , LIU JUNJIAN , ISAKSON PETER C , GU JIJIE
IPC分类号： C07K16/00 , A61K39/395
CPC分类号： C07K16/241 , C07K16/22 , C07K16/2803 , C07K16/2875 , C07K16/44 , C07K16/468 , C07K2317/31 , C07K2317/73
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

6. 发明申请

WO2012088302A3 HALF IMMUNOGLOBULIN BINDING PROTEINS AND USES THEREOF 审中-公开
标题翻译：半免疫球蛋白结合蛋白及其用途
公开(公告)号：WO2012088302A3
公开(公告)日：2012-10-11
申请号：PCT/US2011066557
申请日：2011-12-21
申请人： ABBOTT LAB , GHAYUR TARIQ , GU JIJIE , LIU JUNJIAN , HUTCHINS CHARLES W
发明人： GHAYUR TARIQ , GU JIJIE , LIU JUNJIAN , HUTCHINS CHARLES W
IPC分类号： A61K39/395 , C12P21/08
CPC分类号： C07K16/2863 , C07K16/00 , C07K16/2803 , C07K16/2809 , C07K16/2818 , C07K16/468 , C07K2317/31 , C07K2317/52 , C07K2317/55 , C07K2317/60 , C07K2317/64 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： The invention provides compositions, methods, and kits related to half-Ig binding proteins that include a functional antibody binding site and a CH3 domain wherein the CH3 domain includes at least one mutation to inhibit CH3-CH3 dimerization.
摘要翻译：本发明提供了与包含功能性抗体结合位点和CH3结构域的半-Ig结合蛋白有关的组合物，方法和试剂盒，其中CH3结构域包含至少一个抑制CH3-CH3二聚化的突变。

7. 发明申请

WO2008064116A2 METHOD OF PREVENTING OR TREATING ORGAN, HEMATOPOIETIC STEM CELL OR BONE MARROW TRANSPLANT REJECTION 审中-公开
标题翻译：预防或治疗器官，HEMATOPOIETIC干细胞或骨髓移植物移植的方法
公开(公告)号：WO2008064116A2
公开(公告)日：2008-05-29
申请号：PCT/US2007084959
申请日：2007-11-16
申请人： ABBOTT LAB , BARDWELL PHILIP , GHAYUR TARIQ , GU JIJIE
发明人： BARDWELL PHILIP , GHAYUR TARIQ , GU JIJIE
IPC分类号： A61K31/44
CPC分类号： A61K31/44
摘要： Methods of preventing or treating organ, hematopoietic stem cell or bone marrow transplant rejection are disclosed.
摘要翻译：公开了预防或治疗器官，造血干细胞或骨髓移植排斥的方法。

8. 发明申请

WO2007014162A3 MULTIPLE GENE EXPRESSION INCLUDING SORF CONSTRUCTS AND METHODS WITH POLYPROTEINS, PRO-PROTEINS, AND PROTEOLYSIS 审中-公开
标题翻译：多种基因表达，包括SORF构建体和方法与聚丙烯酸，蛋白质和蛋白质和蛋白质
公开(公告)号：WO2007014162A3
公开(公告)日：2009-05-07
申请号：PCT/US2006028691
申请日：2006-07-21
申请人： ABBOTT LAB , CARSON GERALD R , GION WENDY , SALFELD JOCHEN G , GU JIJIE , REGIER DEAN A , KUNES YUNE
发明人： CARSON GERALD R , GION WENDY , SALFELD JOCHEN G , GU JIJIE , REGIER DEAN A , KUNES YUNE
IPC分类号： C12N15/63 , C12P21/06 , C07H21/02 , C07H21/04 , C07K16/18 , C12N1/18 , C12N5/07 , C12N5/071 , C12N15/00 , C12P21/04 , C12P21/08
CPC分类号： C12N15/67 , C07K16/00 , C07K2319/50 , C07K2319/92 , C12N15/1055 , C12P21/02 , C12P21/06
摘要： Disclosed are useful constructs and methods for the expression of proteins using primary translation products that are processed within a recombinant host cell. Constructs comprising a single open reading frame (sORF) are described for protein expression including expression of multiple polypeptides. A primary translation product (a pro-protein or a polyprotein) contains polypeptides such as inteins or hedgehog family auto-processing domains, or variants thereof, inserted in frame between multiple protein subunits of interest. The primary product can also contain cleavage sequences such as other proteolytic cleavage or protease recognition sites, or signal peptides which contain recognition sequences for signal peptidases, separating at least two of the multiple protein subunits. The sequences of the inserted auto-processing polypeptides or cleavage sites can be manipulated to enhance the efficiency of expression of the separate multiple protein subunits. Also disclosed are independent aspects of conducting efficient expression, secretion, and/or multimeric assembly of proteins such as immunoglobulins. Where the polyprotein contains immunoglobulin heavy and light chain segments or fragments capable of antigen recognition, in an embodiment a selectable stoichiometric ratio is at least two copies of a light chain segment per heavy chain segment, with the result that the production of properly folded and assembled functional antibody is made. Modified signal peptides, including such from immunoglobulin light chains, are described.
摘要翻译：公开了使用在重组宿主细胞内处理的主要翻译产物来表达蛋白质的有用构建体和方法。描述了包含单个开放阅读框（sORF）的构建体用于蛋白质表达，包括多个多肽的表达。初级翻译产品（前蛋白质或多蛋白质）含有多肽，例如内含肽或刺猬蛋白家族自身处理结构域或其变体，其插入到感兴趣的多个蛋白质亚基之间。初级产物还可以含有裂解序列，如其他蛋白水解切割或蛋白酶识别位点，或含有信号肽酶识别序列的信号肽，分离多个蛋白质亚基中的至少两个。可以操纵插入的自动处理多肽或切割位点的序列，以提高分离的多个蛋白质亚基的表达效率。还公开了进行蛋白质例如免疫球蛋白的有效表达，分泌和/或多聚体装配的独立方面。当多蛋白含有免疫球蛋白重链和轻链片段或能够进行抗原识别的片段时，在一个实施方案中，可选择的化学计量比为每个重链段的轻链片段的至少两个拷贝，结果是适当地折叠和组装制备功能性抗体。描述了包含免疫球蛋白轻链的修饰的信号肽。

9. 发明申请

WO2010006060A3 PROSTAGLANDIN E2 DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF 审中-公开
标题翻译： PROSTAGLANDIN E2双变量域免疫球蛋白及其用途
公开(公告)号：WO2010006060A3
公开(公告)日：2010-06-03
申请号：PCT/US2009049954
申请日：2009-07-08
申请人： ABBOTT LAB , GHAYUR TARIQ , GU JIJIE , ISAKSON PETER C
发明人： GHAYUR TARIQ , GU JIJIE , ISAKSON PETER C
IPC分类号： C12P21/08 , A61K39/00 , C07K16/00
CPC分类号： C07K16/468 , A61K38/00 , A61K45/06 , A61K47/6879 , A61K51/109 , C07K16/22 , C07K16/24 , C07K16/26 , C07K16/2863 , C07K16/2866 , C07K16/44 , C07K2317/31 , C07K2317/64 , C07K2317/73 , C07K2317/732 , C07K2317/734 , G01N33/6869 , G01N33/74 , G01N33/88 , G01N2333/4709 , G01N2333/48 , G01N2333/525 , G01N2333/5443 , G01N2333/545 , G01N2333/7155
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
摘要翻译：本发明涉及工程化的多价和多特异性结合蛋白，制备方法，具体涉及用于预防，诊断和/或治疗疾病的用途。

10. 发明专利

JP2012235782A Multiple gene expression including sorf construct and method with polyprotein, pro-protein, and proteolysis 审中-公开
标题翻译：多基因表达包括SORF结构和方法与聚丙烯，蛋白质和蛋白质和蛋白质
公开(公告)号：JP2012235782A
公开(公告)日：2012-12-06
申请号：JP2012148624
申请日：2012-07-02
申请人： Abbott Lab , アボット・ラボラトリーズAbbott Laboratories
发明人： CARSON GERALD R , GION WENDY , SALFELD JOCHEN G , GU JIJIE , REGIER DEAN A , KUNES YUNE
IPC分类号： C12N15/09 , C12N15/63 , C07H21/04 , C07K16/18 , C12N1/18 , C12N5/07 , C12N5/071 , C12P21/08
CPC分类号： C12N15/67 , C07K16/00 , C07K2319/50 , C07K2319/92 , C12N15/1055 , C12P21/02 , C12P21/06
摘要： PROBLEM TO BE SOLVED: To provide useful constructs and methods for the expression of proteins using primary translation products that are processed within a recombinant host cell.SOLUTION: Multiple vectors for protein expressions comprising a single open reading frame (sORF) insert are described. The expression vector includes polypeptides such as inteins or hedgehog family auto-processing domains, or variants thereof, inserted in frame between multiple protein subunits of interest contained in the primary translation product (a pro-protein or a polyprotein).

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