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1. 发明专利

JP2012235782A Multiple gene expression including sorf construct and method with polyprotein, pro-protein, and proteolysis 审中-公开
标题翻译：多基因表达包括SORF结构和方法与聚丙烯，蛋白质和蛋白质和蛋白质
公开(公告)号：JP2012235782A
公开(公告)日：2012-12-06
申请号：JP2012148624
申请日：2012-07-02
申请人： Abbott Lab , アボット・ラボラトリーズAbbott Laboratories
发明人： CARSON GERALD R , GION WENDY , SALFELD JOCHEN G , GU JIJIE , REGIER DEAN A , KUNES YUNE
IPC分类号： C12N15/09 , C12N15/63 , C07H21/04 , C07K16/18 , C12N1/18 , C12N5/07 , C12N5/071 , C12P21/08
CPC分类号： C12N15/67 , C07K16/00 , C07K2319/50 , C07K2319/92 , C12N15/1055 , C12P21/02 , C12P21/06
摘要： PROBLEM TO BE SOLVED: To provide useful constructs and methods for the expression of proteins using primary translation products that are processed within a recombinant host cell.SOLUTION: Multiple vectors for protein expressions comprising a single open reading frame (sORF) insert are described. The expression vector includes polypeptides such as inteins or hedgehog family auto-processing domains, or variants thereof, inserted in frame between multiple protein subunits of interest contained in the primary translation product (a pro-protein or a polyprotein).
摘要翻译：要解决的问题：提供用于使用在重组宿主细胞内处理的初级翻译产物来表达蛋白质的有用构建体和方法。描述了包含单个开放阅读框（sORF）插入物的蛋白质表达的多个载体。表达载体包括插入到主要翻译产物（前蛋白质或多蛋白）中包含的感兴趣的多个蛋白质亚基之间的多肽，例如内含肽或刺猬蛋白家族自身处理结构域或其变体。版权所有（C）2013，JPO＆INPIT

2. 发明专利

JP2012228248A Dual variable domain immunoglobulin and use thereof 审中-公开
标题翻译：双变量免疫球蛋白及其用途
公开(公告)号：JP2012228248A
公开(公告)日：2012-11-22
申请号：JP2012116896
申请日：2012-05-22
申请人： Abbott Lab , アボット・ラボラトリーズAbbott Laboratories
发明人： WU CHENGBIN , GHAYUR TARIQ , DIXON RICHARD W , SALFELD JOCHEN G
IPC分类号： C12N15/09 , A61K39/395 , A61K45/00 , A61P1/04 , A61P1/16 , A61P1/18 , A61P3/06 , A61P3/08 , A61P3/10 , A61P3/14 , A61P5/14 , A61P5/18 , A61P7/00 , A61P7/04 , A61P7/06 , A61P9/04 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/12 , A61P15/08 , A61P17/00 , A61P17/02 , A61P17/06 , A61P17/14 , A61P19/02 , A61P19/10 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/06 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P25/32 , A61P27/02 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/18 , A61P33/00 , A61P33/02 , A61P33/06 , A61P33/08 , A61P35/00 , A61P35/02 , A61P37/06 , A61P37/08 , C07K16/24 , C07K16/28 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/08
CPC分类号： Y02A50/386 , Y02A50/401 , Y02A50/41 , Y02A50/412 , Y02A50/478 , Y02A50/58
摘要： PROBLEM TO BE SOLVED: To provide engineered multivalent and multispecific binding proteins, methods for making the proteins, and methods for using the proteins in the prevention and/or treatment of acute and chronic inflammatory and other diseases.SOLUTION: The binding protein comprises a polypeptide chain, wherein the polypeptide chain comprises VD1-(X1)-VD2-C-(X2), wherein VD1 is a first variable domain, VD2 is a second variable domain, C is a constant domain, X1 represents an amino acid or polypeptide, X2 represents an Fc region and n is 0 or 1.
摘要翻译：要解决的问题：提供工程化的多价和多特异性结合蛋白，制备蛋白质的方法，以及使用蛋白质预防和/或治疗急性和慢性炎症和其他疾病的方法。解决方案：结合蛋白包含多肽链，其中多肽链包含VD1-（X1）-VD2-C-（X2）版权所有（C）2013，JPO＆INPIT

3. 发明申请

WO2008024188A3 DUAL VARIABLE DOMAIN IMMUNOGLOBULIN AND USES THEREOF 审中-公开
标题翻译：双变量免疫球蛋白及其用途
公开(公告)号：WO2008024188A3
公开(公告)日：2008-09-04
申请号：PCT/US2007017340
申请日：2007-08-03
申请人： ABBOTT LAB , WU CHENGBIN , GHAYUR TARIQ , DIXON RICHARD W , SALFELD JOCHEN G
发明人： WU CHENGBIN , GHAYUR TARIQ , DIXON RICHARD W , SALFELD JOCHEN G
IPC分类号： A61K39/00
CPC分类号： C07K16/468 , A61K39/3955 , A61K45/06 , A61K47/42 , A61K47/48384 , A61K47/6803 , A61K51/1093 , A61K2039/505 , C07K16/22 , C07K16/24 , C07K16/241 , C07K16/244 , C07K16/245 , C07K16/2809 , C07K16/2887 , C07K16/2896 , C07K16/40 , C07K16/46 , C07K16/467 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/522 , C07K2317/56 , C07K2317/64 , C07K2317/76
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.
摘要翻译：本发明涉及工程化的多价和多特异性结合蛋白，制备方法，特别涉及其用于预防和/或治疗急性和慢性炎症和其它疾病的用途。

4. 发明申请

WO2012027570A4 DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF 审中-公开
公开(公告)号：WO2012027570A4
公开(公告)日：2012-07-19
申请号：PCT/US2011049147
申请日：2011-08-25
申请人： ABBOTT LAB , GHAYUR TARIQ , SALFELD JOCHEN G , MCPHERSON MICHAEL J
发明人： GHAYUR TARIQ , SALFELD JOCHEN G , MCPHERSON MICHAEL J
IPC分类号： A61K39/00 , C07K16/00
CPC分类号： G01N33/53 , A61K2039/505 , C07K16/18 , C07K16/22 , C07K16/241 , C07K2317/24 , C07K2317/626 , C07K2317/64 , C07K2317/76
摘要： Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.

5. 发明申请

WO2007024715A3 DUAL VARIABLE DOMAIN IMMUNOGLOBIN AND USES THEREOF 审中-公开
标题翻译：双变量域免疫球蛋白及其用途
公开(公告)号：WO2007024715A3
公开(公告)日：2008-10-30
申请号：PCT/US2006032398
申请日：2006-08-18
申请人： ABBOTT LAB , WU CHENGBIN , GHAYUR TARIQ , DIXON RICHARD W , SALFELD JOCHEN G
发明人： WU CHENGBIN , GHAYUR TARIQ , DIXON RICHARD W , SALFELD JOCHEN G
IPC分类号： A61K51/00 , A61M36/14 , C12Q1/68
CPC分类号： C07K16/241 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/244 , C07K16/28 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/64 , C07K2317/94
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.
摘要翻译：本发明涉及工程化的多价和多特异性结合蛋白，制备方法，特别涉及它们在预防和/或治疗急性和慢性炎症和其他疾病中的用途。

6. 发明申请

WO2008024188A8 DUAL VARIABLE DOMAIN IMMUNOGLOBULIN AND USES THEREOF 审中-公开
标题翻译：双变异域免疫球蛋白及其用途
公开(公告)号：WO2008024188A8
公开(公告)日：2008-07-03
申请号：PCT/US2007017340
申请日：2007-08-03
申请人： ABBOTT LAB , WU CHENGBIN , GHAYUR TARIQ , DIXON RICHARD W , SALFELD JOCHEN G
发明人： WU CHENGBIN , GHAYUR TARIQ , DIXON RICHARD W , SALFELD JOCHEN G
IPC分类号： A61K51/00 , C07H21/04 , C12N1/18 , C12N1/21 , C12N5/06 , C12P21/06
CPC分类号： C07K16/468 , A61K39/3955 , A61K45/06 , A61K47/42 , A61K47/48384 , A61K47/6803 , A61K51/1093 , A61K2039/505 , C07K16/22 , C07K16/24 , C07K16/241 , C07K16/244 , C07K16/245 , C07K16/2809 , C07K16/2887 , C07K16/2896 , C07K16/40 , C07K16/46 , C07K16/467 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/522 , C07K2317/56 , C07K2317/64 , C07K2317/76
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.
摘要翻译：本发明涉及工程化的多价和多特异性结合蛋白，制备方法，特别涉及它们在预防和/或治疗急性和慢性炎症和其他疾病中的用途。

7. 发明申请

WO2011059755A3 DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF 审中-公开
公开(公告)号：WO2011059755A3
公开(公告)日：2011-07-28
申请号：PCT/US2010054521
申请日：2010-10-28
申请人： ABBOTT LAB , GHAYUR TARIQ , SALFELD JOCHEN G , MCPHERSON MICHAEL J , HARRIS MARIA C , LIU JUNJIAN , ISAKSON PETER C , GU JIJIE
发明人： GHAYUR TARIQ , SALFELD JOCHEN G , MCPHERSON MICHAEL J , HARRIS MARIA C , LIU JUNJIAN , ISAKSON PETER C , GU JIJIE
IPC分类号： C07K16/00 , A61K39/395
CPC分类号： C07K16/241 , C07K16/22 , C07K16/2803 , C07K16/2875 , C07K16/44 , C07K16/468 , C07K2317/31 , C07K2317/73
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

8. 发明申请

WO2007014162A3 MULTIPLE GENE EXPRESSION INCLUDING SORF CONSTRUCTS AND METHODS WITH POLYPROTEINS, PRO-PROTEINS, AND PROTEOLYSIS 审中-公开
标题翻译：多种基因表达，包括SORF构建体和方法与聚丙烯酸，蛋白质和蛋白质和蛋白质
公开(公告)号：WO2007014162A3
公开(公告)日：2009-05-07
申请号：PCT/US2006028691
申请日：2006-07-21
申请人： ABBOTT LAB , CARSON GERALD R , GION WENDY , SALFELD JOCHEN G , GU JIJIE , REGIER DEAN A , KUNES YUNE
发明人： CARSON GERALD R , GION WENDY , SALFELD JOCHEN G , GU JIJIE , REGIER DEAN A , KUNES YUNE
IPC分类号： C12N15/63 , C12P21/06 , C07H21/02 , C07H21/04 , C07K16/18 , C12N1/18 , C12N5/07 , C12N5/071 , C12N15/00 , C12P21/04 , C12P21/08
CPC分类号： C12N15/67 , C07K16/00 , C07K2319/50 , C07K2319/92 , C12N15/1055 , C12P21/02 , C12P21/06
摘要： Disclosed are useful constructs and methods for the expression of proteins using primary translation products that are processed within a recombinant host cell. Constructs comprising a single open reading frame (sORF) are described for protein expression including expression of multiple polypeptides. A primary translation product (a pro-protein or a polyprotein) contains polypeptides such as inteins or hedgehog family auto-processing domains, or variants thereof, inserted in frame between multiple protein subunits of interest. The primary product can also contain cleavage sequences such as other proteolytic cleavage or protease recognition sites, or signal peptides which contain recognition sequences for signal peptidases, separating at least two of the multiple protein subunits. The sequences of the inserted auto-processing polypeptides or cleavage sites can be manipulated to enhance the efficiency of expression of the separate multiple protein subunits. Also disclosed are independent aspects of conducting efficient expression, secretion, and/or multimeric assembly of proteins such as immunoglobulins. Where the polyprotein contains immunoglobulin heavy and light chain segments or fragments capable of antigen recognition, in an embodiment a selectable stoichiometric ratio is at least two copies of a light chain segment per heavy chain segment, with the result that the production of properly folded and assembled functional antibody is made. Modified signal peptides, including such from immunoglobulin light chains, are described.
摘要翻译：公开了使用在重组宿主细胞内处理的主要翻译产物来表达蛋白质的有用构建体和方法。描述了包含单个开放阅读框（sORF）的构建体用于蛋白质表达，包括多个多肽的表达。初级翻译产品（前蛋白质或多蛋白质）含有多肽，例如内含肽或刺猬蛋白家族自身处理结构域或其变体，其插入到感兴趣的多个蛋白质亚基之间。初级产物还可以含有裂解序列，如其他蛋白水解切割或蛋白酶识别位点，或含有信号肽酶识别序列的信号肽，分离多个蛋白质亚基中的至少两个。可以操纵插入的自动处理多肽或切割位点的序列，以提高分离的多个蛋白质亚基的表达效率。还公开了进行蛋白质例如免疫球蛋白的有效表达，分泌和/或多聚体装配的独立方面。当多蛋白含有免疫球蛋白重链和轻链片段或能够进行抗原识别的片段时，在一个实施方案中，可选择的化学计量比为每个重链段的轻链片段的至少两个拷贝，结果是适当地折叠和组装制备功能性抗体。描述了包含免疫球蛋白轻链的修饰的信号肽。

9. 发明申请

WO2007024715A2 DUAL VARIABLE DOMAIN IMMUNOGLOBIN AND USES THEREOF 审中-公开
标题翻译：双变量域免疫球蛋白及其用途
公开(公告)号：WO2007024715A2
公开(公告)日：2007-03-01
申请号：PCT/US2006032398
申请日：2006-08-18
申请人： ABBOTT LAB , WU CHENGBIN , GHAYUR TARIQ , DIXON RICHARD W , SALFELD JOCHEN G
发明人： WU CHENGBIN , GHAYUR TARIQ , DIXON RICHARD W , SALFELD JOCHEN G
IPC分类号： A61K49/00 , A61K31/192 , A61K31/343 , A61K31/365 , A61K31/4152 , A61K31/445 , A61K31/496 , A61K31/551 , A61K31/60 , A61K39/395
CPC分类号： C07K16/241 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/244 , C07K16/28 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/64 , C07K2317/94
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.
摘要翻译：本发明涉及工程化的多价和多特异性结合蛋白，制备方法，特别涉及其用于预防和/或治疗急性和慢性炎症和其它疾病的用途。

10. 发明公开

EP2493924A4 DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF 审中-公开
公开(公告)号：EP2493924A4
公开(公告)日：2013-05-29
申请号：EP10830460
申请日：2010-10-28
申请人： ABBOTT LAB
发明人： GHAYUR TARIQ , SALFELD JOCHEN G , MCPHERSON MICHAEL J , HARRIS MARIA C , LIU JUNJIAN , ISAKSON PETER C , GU JIJIE
IPC分类号： C07K16/46 , A61K39/395 , C07K16/22 , C07K16/28
CPC分类号： C07K16/241 , C07K16/22 , C07K16/2803 , C07K16/2875 , C07K16/44 , C07K16/468 , C07K2317/31 , C07K2317/73

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