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    • 7. 发明公开
    • 신규한 페닐피로펜 디, 이의 생산방법 및 이를 포함하는 약학적 조성물
    • 新型苯乙烯D,其制备方法及其包含的药物组合物
    • KR1020130100618A
    • 2013-09-11
    • KR1020120022012
    • 2012-03-02
    • 한국생명공학연구원
    • 김영국김중수김형진배경숙김지연문옥성윤원기이성윤
    • C07D493/04A61K31/35A61P9/00A61P25/28
    • PURPOSE: Phenylpyropene D and a pharmaceutical composition containing the same are provided to effectively suppress the activity of acyl coA:acyl cholesterol transferase, thereby preventing or treating cardiovascular diseases or Alzheimer's disease. CONSTITUTION: Phenylpyropene D of chemical formula 1 is provided. A method for preparing phenylpyropene D or pyripyropene comprises the steps of: culturing Penicillium griseofulvum; and isolating and purifying phenylpyropene D of chemical formula 1 or pyripyropene A of chemical formula 2 from the cultured liquid. A compound (C_30H_36O_9) is isolated from C_30H_36O_9 (deposit number : KCTC 11759BP). A pharmaceutical composition for preventing or treating cardiovascular diseases or Alzheimer's disease contains phenylpyropene D of chemical formula 1 and/or a pharmaceutically acceptable salt thereof.
    • 目的:提供苯基丙苯D和含有它们的药物组合物以有效抑制酰基辅酶A酰基胆固醇转移酶的活性,从而预防或治疗心血管疾病或阿尔茨海默氏病。 构成:提供化学式1的苯基丙苯D。 制备苯基丙醚D或吡柔比苯的方法包括以下步骤:培养青霉青霉; 并从培养液中分离和纯化化学式1的苯基丙醚D或化学式2的吡啶并芘A. 化合物(C_30H_36O_9)与C_30H_36O_9(保藏号:KCTC 11759BP)分离。 用于预防或治疗心血管疾病或阿尔茨海默氏病的药物组合物含有化学式1的苯基丙醚D和/或其药学上可接受的盐。