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1. 发明专利

IL281276D0 Crystalline (r)-5-carbamoylpyridin-3-yl-2-methyl-4-(3-(trifluoromethoxy)benzyl) piperazine-1-carboxylate, compositions and methods of use thereof 未知
公开(公告)号：IL281276D0
公开(公告)日：2021-04-29
申请号：IL28127621
申请日：2021-03-04
申请人： CELGENE CORP , ABIDE THERAPEUTICS INC , HUANG LIANFENG , TSOU NANCY , WHITE NICOLE SUZANNE , XU JUN , ZHANG QUN
发明人： HUANG LIANFENG , TSOU NANCY , WHITE NICOLE SUZANNE , XU JUN , ZHANG QUN
IPC分类号： A61P35/00
摘要： Provided herein are crystalline forms of (R)-5-carbamoylpyridin-3-yl-2-methyl-4-(3-(trifluoromethoxy)benzyl)piperazine-1-carboxylate. Pharmaceutical compositions comprising crystalline forms of (R)-5-carbamoylpyridin-3-yl-2-methyl-4-(3-(trifluoromethoxy)benzyl)piperazine-1-carboxylate are also disclosed.

2. 发明申请

WO2006031674A1 PROCESS FOR PREPARING N-(SUBSTITUTED ARYLMETHYL)-4-SUBSTITUTED-4- (DISUBSTITUTED METHYL) PIPERIDINES AND INTERMEDIATES 审中-公开
标题翻译：制备N-（取代的芳基甲基）-4-取代的4-（取代的甲基）哌嗪和中间体的方法
公开(公告)号：WO2006031674A1
公开(公告)日：2006-03-23
申请号：PCT/US2005/032279
申请日：2005-09-12
申请人： FMC CORPORATION , GOUDAR, Jaidev , ROSEN, David, S. , YEAGER, Walter, H. , WANG, Guozhi , ZHANG, Qun , PATERA, Russell
发明人： GOUDAR, Jaidev , ROSEN, David, S. , YEAGER, Walter, H. , WANG, Guozhi , ZHANG, Qun , PATERA, Russell
IPC分类号： C07D401/10 , C07D211/40 , A61K31/4747
CPC分类号： C07D211/46 , C07D401/12
摘要： An improved process is described for preparing a N-(substituted arylmethyl)4-substituted-4-(disubstituted methyl)piperidine of formula (I): wherein R l and R 2 are independently selected from the group consisting of halogen, CF 3 , OCF 3 , OCHF 2 , OCF 2 CHF 2 and SF 5 ; and Z and B are independently selected from the group consisting of CH and N; as well as processes for preparing intermediates useful in the overall process.
摘要翻译：描述了制备式（I）的N-（取代的芳基甲基）-4-取代的-4-（二取代的甲基）哌啶的改进方法：其中R

3. 发明申请

WO2009097270A3 METHOD OF DETERMINING BREAST CANCER RISK 审中-公开
标题翻译：确定乳腺癌风险的方法
公开(公告)号：WO2009097270A3
公开(公告)日：2009-10-15
申请号：PCT/US2009032113
申请日：2009-01-27
申请人： US HEALTH , SLOAN KETTERING INST CANCER , GOLD ALBERT MARK , OFFIT KENNETH , KIRCHHOFF TOMAS , CHEN ZHANG-QUN
发明人： GOLD ALBERT MARK , OFFIT KENNETH , KIRCHHOFF TOMAS , CHEN ZHANG-QUN
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/16 , C12Q2600/172
摘要： The invention provides methods and reagents related to a chromosomal loci associated with altered risk for developing breast cancer. The method includes screening genomic sequence information for the presence or absence of one or more polymorphism alleles in chromosome 6q22.33 that indicates a lower risk of developing breast cancer in the subject or an increased risk of developing breast cancer in the subject. The invention also provides related machine readable media and methods of screening for a candidate therapeutic compound for breast cancer. The invention also provides an oligonucleotide or set of oligonucleotides that selectively anneal to genomic DNA comprising one, but not both, of the rs2180341, rs6569479, rs6569480, or rs7776136 SNP alleles. The oligonucleotide or set of oligonucleotides can be provided in kits that also include reagents suitable for screening for the presence or absence of one or more polymorphism alleles in genomic sequence information.
摘要翻译：本发明提供了与改变发生乳腺癌风险相关的染色体基因座相关的方法和试剂。该方法包括筛选染色体6q22.33中存在或不存在一个或多个多态性等位基因的基因组序列信息，其指示在受试者中发展成乳腺癌的风险较低或受试者发生乳腺癌风险增加。本发明还提供相关的机器可读介质和筛选用于乳腺癌的候选治疗化合物的方法。本发明还提供与rs2180341，rs6569479，rs6569480或rs7776136 SNP等位基因中的一个但不同时选择性退火的寡核苷酸或寡核苷酸组。寡核苷酸或寡核苷酸组可以在试剂盒中提供，其还包括适合于筛选基因组序列信息中一个或多个多态性等位基因的存在或不存在的试剂。

4. 发明申请

WO2009097270A2 METHOD OF DETERMINING BREAST CANCER RISK 审中-公开
标题翻译：确定乳腺癌风险的方法
公开(公告)号：WO2009097270A2
公开(公告)日：2009-08-06
申请号：PCT/US2009/032113
申请日：2009-01-27
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , MEMORIAL SLOAN-KETTERING CANCER CENTER , GOLD, Albert Mark , OFFIT, Kenneth , KIRCHHOFF, Tomas , CHEN, Zhang-Qun
发明人： GOLD, Albert Mark , OFFIT, Kenneth , KIRCHHOFF, Tomas , CHEN, Zhang-Qun
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/16 , C12Q2600/172
摘要： The invention provides methods and reagents related to a chromosomal loci associated with altered risk for developing breast cancer. The method includes screening genomic sequence information for the presence or absence of one or more polymorphism alleles in chromosome 6q22.33 that indicates a lower risk of developing breast cancer in the subject or an increased risk of developing breast cancer in the subject. The invention also provides related machine readable media and methods of screening for a candidate therapeutic compound for breast cancer. The invention also provides an oligonucleotide or set of oligonucleotides that selectively anneal to genomic DNA comprising one, but not both, of the rs2180341, rs6569479, rs6569480, or rs7776136 SNP alleles. The oligonucleotide or set of oligonucleotides can be provided in kits that also include reagents suitable for screening for the presence or absence of one or more polymorphism alleles in genomic sequence information.
摘要翻译：本发明提供了与改变患乳腺癌风险相关的染色体基因座相关的方法和试剂。该方法包括筛选染色体6q22.33中存在或不存在一个或多个多态性等位基因的基因组序列信息，其指示受试者中发生乳腺癌的风险较低或患者中患乳腺癌的风险增加。本发明还提供了相关的机器可读介质和筛选用于乳腺癌的候选治疗性化合物的方法。本发明还提供选择性退火至包含rs2180341，rs6569479，rs6569480或rs7776136 SNP等位基因之一但不是两者的基因组DNA的寡核苷酸或一组寡核苷酸。寡核苷酸或一组寡核苷酸可以以试剂盒提供，所述试剂盒还包括适合于筛选基因组序列信息中一种或多种多态性等位基因的存在或不存在的试剂。

5. 发明申请

WO2006031764A3 PROCESSES FOR PREPATING N-(SUBSTITUTED ARYLMETHYL)-4-(DISUBSTITUTED METHYL)PIPERIDINES AND INTERMEDIATES 审中-公开
公开(公告)号：WO2006031764A3
公开(公告)日：2006-03-23
申请号：PCT/US2005/032473
申请日：2005-09-12
申请人： FMC CORPORATION , GOUDAR, Jaidev , ROSEN, David, S. , WANG, Guozhi , ZHANG, Qun , PATERA, Russell
发明人： GOUDAR, Jaidev , ROSEN, David, S. , WANG, Guozhi , ZHANG, Qun , PATERA, Russell
IPC分类号： C07D401/00 , C07D211/00 , C07D211/68
摘要： Improved processes are described for preparing compounds of formulae: (B, C, F, H) wherein R 1 , R 2 , B and Z are defined herein. These compounds are useful in the preparation of N-(substituted arylmethyl)-4(disubstituted methyl)piperidines.

6. 发明申请

WO2004060865A2 N-(SUBSTITUTED ARYLMETHYL)-4-(DISUBSTITUTED METHYL)PIPERIDINES AND PIPERAZINES 审中-公开
标题翻译： N-（取代的芳基甲基）-4-（取代的甲基）哌嗪和哌嗪
公开(公告)号：WO2004060865A2
公开(公告)日：2004-07-22
申请号：PCT/US2003/039046
申请日：2003-12-08
申请人： FMC CORPORATION , DING, Ping , HENRIE, Robert, N., II , COHEN, Daniel, H. , LYGA, John, W. , ROSEN, David, S. , THEODORIDIS, George , ZHANG, Qun , YEAGER, Walter, H. , DONOVAN, Stephen, F. , ZHANG, Steven, Shunxiang , SHULMAN, Inna , YU, Seong, Jae , WNAG, Gouzhi , ZHANG, Y. Larry , GOPALSAMY, Ariamala , WARKENTIN, Dennis, L. , RENSNER, Paul, E. , SILVERMAN, Ian, R. , CULLEN, Thomas, G.
发明人： DING, Ping , HENRIE, Robert, N., II , COHEN, Daniel, H. , LYGA, John, W. , ROSEN, David, S. , THEODORIDIS, George , ZHANG, Qun , YEAGER, Walter, H. , DONOVAN, Stephen, F. , ZHANG, Steven, Shunxiang , SHULMAN, Inna , YU, Seong, Jae , WNAG, Gouzhi , ZHANG, Y. Larry , GOPALSAMY, Ariamala , WARKENTIN, Dennis, L. , RENSNER, Paul, E. , SILVERMAN, Ian, R. , CULLEN, Thomas, G.
IPC分类号： C07D
CPC分类号： C07D405/14 , A01N43/40 , A01N43/54 , A01N43/713 , C07D211/14 , C07D211/18 , C07D211/22 , C07D211/24 , C07D211/26 , C07D211/28 , C07D211/32 , C07D211/94 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D413/12 , C07D417/12 , C07D451/14 , C07D513/04
摘要： It has now been found that certain novel N-(substituted aryl)-4-(disubstituted methyl)piperidine and pyridine derivatives have provided unexpected insecticidal activity. These compounds are represented by formula (I): wherein m, n, q, r, and s are independently selected from 0 or 1; and p is 0, 1, 2, or 3; A is CH or N; and B, D, E, R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are fully described herein. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula I, and optionally, an effective amount of at least one of a second compound, with at least one insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.
摘要翻译：现在已经发现某些新的N-（取代的芳基）-4-（二取代的甲基）哌啶和吡啶衍生物提供了意想不到的杀虫活性。这些化合物由式（I）表示：其中m，n，q，r和s独立地选自0或1; 且p为0,1,2或3; A是CH或N; 和B，D，E，R，R 1，R 3，R 3，R 4，R 5，R 6，R 7和R 8，在此完全描述。此外，还公开了包含杀虫有效量的至少一种式I化合物和任选的有效量的至少一种第二化合物与至少一种与杀虫相容的载体的组合物; 以及控制昆虫的方法，包括将所述组合物施用于存在昆虫或预期存在的场所。

7. 发明申请

WO2004060371A1 N-(SUBSTITUTED ARYLMETHYL)-4-(DISUBSTITUTED METHYL) PIPERIDINES AND PYRIDINES 审中-公开
标题翻译： N-（取代的芳基甲基）-4-（取代的甲基）哌嗪和吡啶
公开(公告)号：WO2004060371A1
公开(公告)日：2004-07-22
申请号：PCT/US2003/038878
申请日：2003-12-08
申请人： FMC CORPORATION , DING, Ping , HENRIE II, Robert, H. , COHEN, Daniel, H. , LYGA, John, W. , ROSEN, David, S. , THEODORIDIS, George , ZHANG, Qun , YEAGER, Walter, H. , DONOVAN, Stephen, F. , ZHANG, Steven, Shunxiang , SHULMAN, Inna , YU, Seong, Jae , WANG, Guozhi , ZHANG, Y., Larry , GOPALSAMY, Ariamala , WARKENTIN, Dennis, L. , RENSNER, Paul, E. , SILVERMAN, Ian, R. , CULLEN, Thomas, G.
发明人： DING, Ping , HENRIE II, Robert, H. , COHEN, Daniel, H. , LYGA, John, W. , ROSEN, David, S. , THEODORIDIS, George , ZHANG, Qun , YEAGER, Walter, H. , DONOVAN, Stephen, F. , ZHANG, Steven, Shunxiang , SHULMAN, Inna , YU, Seong, Jae , WANG, Guozhi , ZHANG, Y., Larry , GOPALSAMY, Ariamala , WARKENTIN, Dennis, L. , RENSNER, Paul, E. , SILVERMAN, Ian, R. , CULLEN, Thomas, G.
IPC分类号： A61K31/44
CPC分类号： C07D405/14 , A01N43/40 , A01N43/54 , A01N43/713 , C07D211/14 , C07D211/18 , C07D211/22 , C07D211/24 , C07D211/26 , C07D211/28 , C07D211/32 , C07D211/94 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D413/12 , C07D417/12 , C07D451/14 , C07D513/04
摘要： It has now been found that certain novel N-(substituted aryl)-4(disubstituted methyl)piperidine and pyridine derivatives have provided unexpected insecticidal activity. These compounds are represented by formula (I): wherein m, n, q, r, and s are independently selected fronn 0 or 1 ; and p is 0, 1, 2, or 3; A is C or CH; and B, D, E, R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are fully described herein. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula I, and optionally, an effective amount of at least one of a second compound, with at least one insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.
摘要翻译：现在已经发现，某些新的N-（取代的芳基）-4（二取代的甲基）哌啶和吡啶衍生物已经提供了意想不到的杀虫活性。这些化合物由式（I）表示：其中m，n，q，r和s独立地选自0或1; 且p为0,1,2或3; A是C或CH; 和B，D，E，R，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8都是完全的在此描述。此外，还公开了包含杀虫有效量的至少一种式I化合物和任选的有效量的至少一种第二化合物与至少一种与杀虫相容的载体的组合物; 以及控制昆虫的方法，包括将所述组合物施用于存在昆虫或预期存在的场所。

8. 发明申请

WO2006031764A2 PROCESSES FOR PREPATING N-(SUBSTITUTED ARYLMETHYL)-4-(DISUBSTITUTED METHYL)PIPERIDINES AND INTERMEDIATES 审中-公开
标题翻译：用于制备N-（取代的芳基甲基）-4-（取代的甲基）哌嗪和中间体的方法
公开(公告)号：WO2006031764A2
公开(公告)日：2006-03-23
申请号：PCT/US2005032473
申请日：2005-09-12
申请人： FMC CORP , GOUDAR JAIDEV , ROSEN DAVID S , WANG GUOZHI , ZHANG QUN , PATERA RUSSELL
发明人： GOUDAR JAIDEV , ROSEN DAVID S , WANG GUOZHI , ZHANG QUN , PATERA RUSSELL
IPC分类号： C07D401/02
CPC分类号： C07D401/12
摘要： I Improved processes are described for preparing compounds of formulae: (B, C, F, H) wherein R
摘要翻译：描述了制备式（B，C，F，H）的化合物的改进方法，其中R

9. 发明申请

WO2004060865A3 N-(SUBSTITUTED ARYLMETHYL)-4-(DISUBSTITUTED METHYL)PIPERIDINES AND PIPERAZINES 审中-公开
标题翻译： N-（取代的芳基甲基）-4-（二取代甲基）哌啶和哌嗪
公开(公告)号：WO2004060865A3
公开(公告)日：2004-11-04
申请号：PCT/US0339046
申请日：2003-12-08
申请人： FMC CORP , DING PING , HENRIE ROBERT N II , COHEN DANIEL H , LYGA JOHN W , ROSEN DAVID S , THEODORIDIS GEORGE , ZHANG QUN , YEAGER WALTER H , DONOVAN STEPHEN F , ZHANG STEVEN SHUNXIANG , SHULMAN INNA , YU SEONG JAE , WNAG GOUZHI , ZHANG Y LARRY , GOPALSAMY ARIAMALA , WARKENTIN DENNIS L , RENSNER PAUL E , SILVERMAN IAN R , CULLEN THOMAS G
发明人： DING PING , HENRIE ROBERT N II , COHEN DANIEL H , LYGA JOHN W , ROSEN DAVID S , THEODORIDIS GEORGE , ZHANG QUN , YEAGER WALTER H , DONOVAN STEPHEN F , ZHANG STEVEN SHUNXIANG , SHULMAN INNA , YU SEONG JAE , WNAG GOUZHI , ZHANG Y LARRY , GOPALSAMY ARIAMALA , WARKENTIN DENNIS L , RENSNER PAUL E , SILVERMAN IAN R , CULLEN THOMAS G
IPC分类号： A01N43/40 , A01N43/54 , A01N43/713 , C07D211/14 , C07D211/18 , C07D211/22 , C07D211/24 , C07D211/26 , C07D211/28 , C07D211/32 , C07D211/94 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D451/14 , C07D513/04 , C07D241/02 , A61K31/445 , A61K31/495 , C07D211/06
CPC分类号： C07D405/14 , A01N43/40 , A01N43/54 , A01N43/713 , C07D211/14 , C07D211/18 , C07D211/22 , C07D211/24 , C07D211/26 , C07D211/28 , C07D211/32 , C07D211/94 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D413/12 , C07D417/12 , C07D451/14 , C07D513/04
摘要： It has now been found that certain novel N-(substituted aryl)-4-(disubstituted methyl)piperidine and pyridine derivatives have provided unexpected insecticidal activity. These compounds are represented by formula (I): wherein m, n, q, r, and s are independently selected from 0 or 1; and p is 0, 1, 2, or 3; A is CH or N; and B, D, E, R, R , R , R , R , R , R , R and R are fully described herein. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula I, and optionally, an effective amount of at least one of a second compound, with at least one insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.
摘要翻译：现已发现某些新的N-（取代的芳基）-4-（二取代的甲基）哌啶和吡啶衍生物提供了出乎意料的杀虫活性。这些化合物由式（I）表示：其中m，n，q，r和s独立地选自0或1; 并且p是0,1,2或3; A是CH或N; 和B，D，E，R，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8，在此完整描述。此外，还公开了包含杀虫有效量的至少一种式I化合物和任选地有效量的至少一种第二化合物与至少一种杀虫剂相容性载体的组合物; 以及控制昆虫的方法，包括将所述组合物施用于昆虫存在或预期存在的场所。

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