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1. 发明申请

WO2009097270A3 METHOD OF DETERMINING BREAST CANCER RISK 审中-公开
标题翻译：确定乳腺癌风险的方法
公开(公告)号：WO2009097270A3
公开(公告)日：2009-10-15
申请号：PCT/US2009032113
申请日：2009-01-27
申请人： US HEALTH , SLOAN KETTERING INST CANCER , GOLD ALBERT MARK , OFFIT KENNETH , KIRCHHOFF TOMAS , CHEN ZHANG-QUN
发明人： GOLD ALBERT MARK , OFFIT KENNETH , KIRCHHOFF TOMAS , CHEN ZHANG-QUN
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/16 , C12Q2600/172
摘要： The invention provides methods and reagents related to a chromosomal loci associated with altered risk for developing breast cancer. The method includes screening genomic sequence information for the presence or absence of one or more polymorphism alleles in chromosome 6q22.33 that indicates a lower risk of developing breast cancer in the subject or an increased risk of developing breast cancer in the subject. The invention also provides related machine readable media and methods of screening for a candidate therapeutic compound for breast cancer. The invention also provides an oligonucleotide or set of oligonucleotides that selectively anneal to genomic DNA comprising one, but not both, of the rs2180341, rs6569479, rs6569480, or rs7776136 SNP alleles. The oligonucleotide or set of oligonucleotides can be provided in kits that also include reagents suitable for screening for the presence or absence of one or more polymorphism alleles in genomic sequence information.
摘要翻译：本发明提供了与改变发生乳腺癌风险相关的染色体基因座相关的方法和试剂。该方法包括筛选染色体6q22.33中存在或不存在一个或多个多态性等位基因的基因组序列信息，其指示在受试者中发展成乳腺癌的风险较低或受试者发生乳腺癌风险增加。本发明还提供相关的机器可读介质和筛选用于乳腺癌的候选治疗化合物的方法。本发明还提供与rs2180341，rs6569479，rs6569480或rs7776136 SNP等位基因中的一个但不同时选择性退火的寡核苷酸或寡核苷酸组。寡核苷酸或寡核苷酸组可以在试剂盒中提供，其还包括适合于筛选基因组序列信息中一个或多个多态性等位基因的存在或不存在的试剂。

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