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1. 发明专利

JPS6224305B2 JPS6224305B2 - 失效
公开(公告)号：JPS6224305B2
公开(公告)日：1987-05-27
申请号：JP11634778
申请日：1978-09-20
申请人： Yotaro Fujita
发明人： FUJITA YOTARO
IPC分类号： B61B9/00 , B61C11/02 , B62B3/00 , B62B19/04 , B66D1/00 , B66D1/74

2. 发明授权

US08222349B2 Bioabsorbable material and in-vivo indwelling device made thereof 有权
标题翻译：生物可吸收材料和由其制成的体内留置装置
公开(公告)号：US08222349B2
公开(公告)日：2012-07-17
申请号：US12886913
申请日：2010-09-21
申请人： Mitsuru Akashi , Michiya Matsusaki , Yotaro Fujita , Makoto Onishi
发明人： Mitsuru Akashi , Michiya Matsusaki , Yotaro Fujita , Makoto Onishi
IPC分类号： C08G63/64 , A61F2/02 , C08G63/06
CPC分类号： A61L31/148 , A61L31/06 , C08G63/64 , C08L69/00 , C08L101/16
摘要： A bioabsorbable material which is flexible and degradable at a controlled rate, and an in-vivo indwelling device made thereof. The bioabsorbable material is a copolymer composed of an aromatic compound having an α,β-unsaturated carboxylic group and at least one hydroxyl group as substituents on the aromatic ring, and a polycarbonate or a monomer constituting polycarbonate. Alternatively, it is a copolymer composed of, as the first component, an aromatic compound having an α,β-unsaturated carboxylic group and at least one hydroxyl group as substituents on the aromatic ring, as the second component, an aromatic compound having an α,β-unsaturated carboxylic group and at least two hydroxyl groups as substituents on the aromatic ring, and, as the third component, a polycarbonate or a monomer constituting polycarbonate.
摘要翻译：以可控制的速率灵活和可降解的生物可吸收材料，以及由其制成的体内留置装置。生物可吸收材料是由具有α，β-不饱和羧酸和至少一个羟基作为芳香环上的取代基的芳族化合物和聚碳酸酯或构成聚碳酸酯的单体组成的共聚物。或者，作为第一成分，具有作为第二成分的具有α，β-不饱和羧酸和至少一个羟基作为取代基的芳香族化合物作为第二成分的共聚物，具有 α，β-不饱和羧基和至少两个羟基作为芳环上的取代基，作为第三组分，聚碳酸酯或构成聚碳酸酯的单体。

3. 发明申请

US20110046309A1 BIOABSORBABLE MATERIAL AND IN-VIVO INDWELLING DEVICE MADE THEREOF 有权
标题翻译：可生物吸收材料及其内部制造装置
公开(公告)号：US20110046309A1
公开(公告)日：2011-02-24
申请号：US12886913
申请日：2010-09-21
申请人： Mitsuru Akashi , Michiya Matsusaki , Yotaro Fujita , Makoto Onishi
发明人： Mitsuru Akashi , Michiya Matsusaki , Yotaro Fujita , Makoto Onishi
IPC分类号： C08G63/64
CPC分类号： A61L31/148 , A61L31/06 , C08G63/64 , C08L69/00 , C08L101/16
摘要： A bioabsorbable material which is flexible and degradable at a controlled rate, and an in-vivo indwelling device made thereof. The bioabsorbable material is a copolymer composed of an aromatic compound having an α,β-unsaturated carboxylic group and at least one hydroxyl group as substituents on the aromatic ring, and a polycarbonate or a monomer constituting polycarbonate. Alternatively, it is a copolymer composed of, as the first component, an aromatic compound having an α,β-unsaturated carboxylic group and at least one hydroxyl group as substituents on the aromatic ring, as the second component, an aromatic compound having an α,β-unsaturated carboxylic group and at least two hydroxyl groups as substituents on the aromatic ring, and, as the third component, a polycarbonate or a monomer constituting polycarbonate.
摘要翻译：以可控制的速率灵活和可降解的生物可吸收材料，以及由其制成的体内留置装置。生物可吸收材料是由具有α，β-不饱和羧酸和至少一个羟基作为芳香环上的取代基的芳族化合物和聚碳酸酯或构成聚碳酸酯的单体组成的共聚物。或者，作为第一成分，具有作为第二成分的具有α，β-不饱和羧酸和至少一个羟基作为取代基的芳香族化合物作为第二成分的共聚物，具有 α，β-不饱和羧基和至少两个羟基作为芳环上的取代基，作为第三组分，聚碳酸酯或构成聚碳酸酯的单体。

4. 发明申请

US20080275547A1 INTRAVASCULAR, INDWELLING INSTRUMENT 审中-公开
标题翻译：血管内窥镜检查仪
公开(公告)号：US20080275547A1
公开(公告)日：2008-11-06
申请号：US12167286
申请日：2008-07-03
申请人： Takeshi KANAMARU , Yotaro Fujita
发明人： Takeshi KANAMARU , Yotaro Fujita
IPC分类号： A61F2/06
CPC分类号： A61L31/047 , A61L2430/36
摘要： An intravascular, indwelling instrument for placement in a blood vessel includes a body having a face in contact with a maintained blood flow to be maintained and a face in contact with a non-maintained blood flow not to be maintained, and a peptide fixed to all or part of the maintained blood flow contact face or the non-maintained blood flow contact face of the body. The peptide has specific interaction with vascular endothelial precursor cells, with the peptide permitting selective adsorption and adhesion of the vascular endothelial precursor cells to cover all or part of the maintained blood flow contact face or the non-maintained blood flow contact face of the body with the vascular endothelial precursor cells thereby reducing or inhibiting the blood flow not to be maintained.
摘要翻译：用于放置在血管中的血管内留置器械包括：身体，其具有与要维持的保持的血流接触的面和与不保持的未保持的血流接触的面，以及固定到所有的血液的肽或身体的维持的血液流动接触面或未维持的血液流动接触面的一部分。肽与血管内皮前体细胞具有特异性相互作用，其中肽允许血管内皮前体细胞的选择性吸附和粘附以覆盖身体的所有或部分维持的血液接触面或未维持的血液流动接触面，血管内皮前体细胞由此减少或抑制血流不被维持。

5. 发明申请

US20060052862A1 Intravascular, indwelling instrument 审中-公开
标题翻译：血管内，留置仪器
公开(公告)号：US20060052862A1
公开(公告)日：2006-03-09
申请号：US11217452
申请日：2005-09-02
申请人： Takeshi Kanamaru , Yotaro Fujita
发明人： Takeshi Kanamaru , Yotaro Fujita
IPC分类号： A61F2/82
CPC分类号： A61L31/047 , A61L2430/36
摘要： An intravascular, indwelling instrument for placement in a blood vessel includes a body having a face in contact with a maintained blood flow to be maintained and a face in contact with a non-maintained blood flow not to be maintained, and a peptide fixed to all or part of the maintained blood flow contact face or the non-maintained blood flow contact face of the body. The peptide has specific interaction with vascular endothelial precursor cells, with the peptide permitting selective adsorption and adhesion of the vascular endothelial precursor cells to cover all or part of the maintained blood flow contact face or the non-maintained blood flow contact face of the body with the vascular endothelial precursor cells thereby reducing or inhibiting the blood flow not to be maintained.
摘要翻译：用于放置在血管中的血管内留置器械包括：身体，其具有与要维持的保持的血流接触的面和与不保持的未保持的血流接触的面，以及固定到所有的血液的肽或身体的维持的血液流动接触面或未维持的血液流动接触面的一部分。肽与血管内皮前体细胞具有特异性相互作用，其中肽允许血管内皮前体细胞的选择性吸附和粘附以覆盖身体的所有或部分维持的血液接触面或未维持的血液流动接触面，血管内皮前体细胞由此减少或抑制血流不被维持。

6. 发明申请

US20120296415A1 BIOABSORBABLE STENT 审中-公开
标题翻译：生物耐药性
公开(公告)号：US20120296415A1
公开(公告)日：2012-11-22
申请号：US13563199
申请日：2012-07-31
申请人： Yotaro Fujita , Makoto Onishi
发明人： Yotaro Fujita , Makoto Onishi
IPC分类号： A61F2/82
CPC分类号： A61L31/148 , A61F2/91 , A61F2/915 , A61F2002/91566 , A61F2210/0004 , A61F2210/0076 , A61F2230/0013 , A61L31/06 , C08L67/04 , C08L69/00
摘要： A bioabsorbable stent has a relatively high radial force and can be placed directly at the lesion without the possibility or reducing the possibility of occluding the lesion again after placement. The bioabsorbable stent is formed from a mixture composed of a bioabsorbable aliphatic polyester and an aromatic compound having one or more aromatic rings.
摘要翻译：生物吸收性支架具有相当高的径向力，并且可以直接放置在病变处，而没有放置之后可能再次闭合病变的可能性。生物可吸收性支架由由生物可吸收的脂族聚酯和具有一个或多个芳环的芳族化合物组成的混合物形成。

7. 发明申请

US20110257338A1 HYDROPHILIC MATERIAL, MEDICAL MATERIAL AND SUSTAINED DRUG RELEASE MATERIAL 有权
标题翻译：液体材料，医疗材料和持续的药物释放材料
公开(公告)号：US20110257338A1
公开(公告)日：2011-10-20
申请号：US13121604
申请日：2009-09-29
申请人： Mitsuru Akashi , Michiya Matsusaki , Dongjian Shi , Makoto Onishi , Yotaro Fujita
发明人： Mitsuru Akashi , Michiya Matsusaki , Dongjian Shi , Makoto Onishi , Yotaro Fujita
IPC分类号： C08F8/34 , B82Y30/00
CPC分类号： C08G63/912 , A61K9/5153 , C08G63/664 , G01N2203/00
摘要： A hydrophilic material having a hydrophilic nature and being biocompatible and processable into nanoparticles wherein a hydrophilic monomer such as threitol or a hydrophilic polymer such as polyethylene glycol is attached to the βposition of an α, β-unsaturated carboxyl group of a (co)polymer comprising an aromatic compound such as 4-hydroxycinnamic acid in which an aromatic ring is substituted by the α, β-unsaturated carboxyl group and one or more hydroxyl groups. In particular, a hydrophilic material having a nanoparticle size which is highly dispersible in water, can well migrate into the blood and is useful as a drug carrier, a medical material and a sustained drug release material.
摘要翻译：亲水性材料具有亲水性并且可生物相容并可加工成纳米颗粒，其中亲水性单体例如苏糖醇或亲水性聚合物例如聚乙二醇被连接到（共聚物）的α，β-不饱和羧基的基团上）聚合物，其包含芳族化合物如4-羟基肉桂酸，其中芳环被α，β-不饱和羧基和一个或多个羟基取代。具体而言，具有高度分散于水中的纳米粒子尺寸的亲水性材料能很好地迁移到血液中，可用作药物载体，医疗材料和持续的药物释放材料。

8. 发明授权

US08835570B2 Hydrophilic material, medical material and sustained drug release material 有权
标题翻译：亲水材料，医疗材料和持续的药物释放材料
公开(公告)号：US08835570B2
公开(公告)日：2014-09-16
申请号：US13121604
申请日：2009-09-29
申请人： Mitsuru Akashi , Michiya Matsusaki , Dongjian Shi , Makoto Onishi , Yotaro Fujita
发明人： Mitsuru Akashi , Michiya Matsusaki , Dongjian Shi , Makoto Onishi , Yotaro Fujita
IPC分类号： C08G63/664 , C08G63/91 , A61K9/51
CPC分类号： C08G63/912 , A61K9/5153 , C08G63/664 , G01N2203/00
摘要： A hydrophilic material having a hydrophilic nature and being biocompatible and processable into nanoparticles wherein a hydrophilic monomer such as threitol or a hydrophilic polymer such as polyethylene glycol is attached to the βposition of an α,β-unsaturated carboxyl group of a (co)polymer comprising an aromatic compound such as 4-hydroxycinnamic acid in which an aromatic ring is substituted by the α,β-unsaturated carboxyl group and one or more hydroxyl groups. In particular, a hydrophilic material having a nanoparticle size which is highly dispersible in water, can well migrate into the blood and is useful as a drug carrier, a medical material and a sustained drug release material.
摘要翻译：亲水性材料具有亲水性并且可生物相容并可加工成纳米颗粒，其中亲水性单体例如苏糖醇或亲水性聚合物例如聚乙二醇被连接到（共聚物）的α，β-不饱和羧基的基团上）聚合物，其包含芳族化合物如4-羟基肉桂酸，其中芳环被α，β-不饱和羧基和一个或多个羟基取代。具体而言，具有高度分散于水中的纳米粒子尺寸的亲水性材料能很好地迁移到血液中，可用作药物载体，医疗材料和持续的药物释放材料。

9. 发明授权

US1444870A Manufacture of adhesive metallic powder in the form of metallic scales 失效
标题翻译：以金属鳞片的形式制造粘合金属粉末
公开(公告)号：US1444870A
公开(公告)日：1923-02-13
申请号：US55718122
申请日：1922-04-28
申请人： YOTARO FUJITA
发明人： YOTARO FUJITA
IPC分类号： C09C1/62
CPC分类号： C09C1/62 , C01P2004/86 , C09C1/622

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