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1. 发明专利

AU5679201A Aids vaccines 未知
公开(公告)号：AU5679201A
公开(公告)日：2001-12-03
申请号：AU5679201
申请日：2001-05-22
申请人： JAPAN IMMUNO RES LAB , MASANORI BABA , MITSURU AKASHI
发明人： BABA MASANORI , AKASHI MITSURU , ADACHI MASAKAZU
IPC分类号： A61K9/16 , A61K39/12 , A61K39/21 , A61K39/385 , A61K47/30 , A61K47/42 , A61P31/18

2. 发明专利

JP2011067808A Capturing agent of fluorine-containing anionic surfactant included in water, and method for decreasing concentration of fluorine-containing anionic surfactant in water 审中-公开
标题翻译：包含水中含氟的阴离子表面活性剂的吸收剂，以及降低含氟的阴离子表面活性剂在水中的浓度的方法
公开(公告)号：JP2011067808A
公开(公告)日：2011-04-07
申请号：JP2009240861
申请日：2009-09-25
申请人： Mitsuru Akashi , Senka Kk , センカ株式会社 , 満明石
发明人： AKASHI MITSURU , KAGEYAMA TADASHI
IPC分类号： B01J20/26 , C02F1/28
摘要： PROBLEM TO BE SOLVED: To provide a capturing agent of a fluorine-containing anionic surfactant, by which the concentration of the fluorine-containing anionic surfactant in wastewater can be decreased easily and to provide a method for decreasing the concentration of the fluorine-containing anionic surfactant included in water, using the capturing agent.
SOLUTION: The capturing agent of the fluorine-containing anionic surfactant is a polymer fine particle which is obtained by radically polymerizing a hydrophobic monomer in the presence of a cationic polymer having a radically polymerizable group at the terminal end thereof, on the surface of which cationic polymer chains are accumulated, and the inside of which comprises a hydrophobic polymer compound. The method for decreasing the concentration of the fluorine-containing anionic surfactant included in water includes the steps of: adding the capturing agent of the fluorine-containing anionic surfactant to the water containing the fluorine-containing anionic surfactant; agitating/mixing the added capturing agent with the water containing the fluorine-containing anionic surfactant; and subjecting the obtained mixture to solid-liquid separation.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：解决的问题：为了提供含氟阴离子表面活性剂的捕获剂，能够容易地降低废水中含氟阴离子表面活性剂的浓度，并提供降低氟浓度的方法使用捕获剂包含在水中的阴离子表面活性剂。解决方案：含氟阴离子表面活性剂的捕获剂是聚合物细颗粒，其通过在其末端具有自由基聚合性基团的阳离子聚合物的存在下，在表面上自由基聚合疏水性单体而获得其中积聚阳离子聚合物链，其内部包含疏水性聚合物化合物。包含在水中的含氟阴离子表面活性剂浓度降低的方法包括以下步骤：将含氟阴离子表面活性剂的捕获剂加入到含有含氟阴离子表面活性剂的水中; 将添加的捕获剂与含有含氟阴离子表面活性剂的水搅拌/混合; 并将所得混合物进行固液分离。版权所有（C）2011，JPO＆INPIT

3. 发明专利

JP2010116373A Multi-layered coated particle, process of producing the same, and external preparation for skin 有权
标题翻译：多层涂层颗粒，其生产方法和皮肤外用制剂
公开(公告)号：JP2010116373A
公开(公告)日：2010-05-27
申请号：JP2008292283
申请日：2008-11-14
申请人： Mitsuru Akashi , Kose Corp , 満明石 , 株式会社コーセー
发明人： KOSUGI MASATERU , AKASHI MITSURU
IPC分类号： A61K8/81 , A61K8/25 , A61K8/67 , A61K8/73 , A61K9/18 , A61K9/32 , A61K9/36 , A61K9/52 , A61K31/015 , A61K31/122 , A61K47/02 , A61K47/32 , A61K47/36 , A61K47/38 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To provide a technique by which effective ingredients are formulated in a preparation to stay stable for a long time and the effective ingredients are slowly released with a controlled rate of release.
SOLUTION: The multi-layered coated particle comprises a porous particle which contains effective ingredients, has an average particle size of 50 nm-1 mm, and is covered with a polymer laminated film formed by adsorbing a positively charged polysaccharide polymer and a negatively charged acrylic polymer alternatively. The polymer laminated film functions as a shell to protect the porous particle. The time stability of the effective ingredients against hydrolysis and the like is improved by changing the thickness or the density of the laminated film.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种在制剂中配制有效成分长期保持稳定的技术，并且以有控制的释放速率缓慢释放有效成分。解决方案：多层涂覆颗粒包含含有有效成分的多孔颗粒，其平均粒径为50nm-1mm，并且被通过吸附带正电荷的多糖聚合物形成的聚合物层压膜覆盖，带负电荷的丙烯酸聚合物。聚合物层压膜起保护多孔颗粒的作用。通过改变层压膜的厚度或密度，有效成分对水解等的时间稳定性得到改善。版权所有（C）2010，JPO＆INPIT

4. 发明专利

JP2005255967A Surface-reactive crenellated macromolecular microparticle and method for producing the same 审中-公开
标题翻译：表面活性断裂大分子微球及其生产方法
公开(公告)号：JP2005255967A
公开(公告)日：2005-09-22
申请号：JP2004111596
申请日：2004-03-09
申请人： Mitsuru Akashi , Kaneko Denki Bosai:Kk , Tatsuo Kaneko , 満明石 , 有限会社金子電気防災 , 達雄金子
发明人： KANEKO TATSUO , HAMADA KAZUHIRO , AKASHI MITSURU
IPC分类号： C08F2/00 , C08F299/02
摘要： PROBLEM TO BE SOLVED: To provide surface-reactive crenellated macromolecular microparticles higher in performance than conventional macromolecular microparticles, having such a shape as to have numerous projections on the surface in order to enlarge its specific surface area while keeping its size intact for the purpose of creating macromolecular microparticles usable in such wide-range fields as drug transport and sustained-releasing carriers, morbid state-catching carriers, gene-transferring carriers and carriers for diagnostic use, and to provide a method for producing the surface-reactive crenated macromolecular microparticles in a single step.
SOLUTION: The surface-reactive crenellated macromolecular microparticles are characterized by each having at least one kind of chemically reactive functional group, electrically chargeable functional group or functional group having physically interactive tendency such as hydrogen bond and also having numerous projections on the surface. The method for producing the surface-reactive crenellated macromolecular microparticles in a single step comprises carrying out a copolymerization between a plurality of monomers significantly differing in polymerization rate and solubility to a polymerization solvent and autoorganizing the resultant copolymer.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：为了提供比常规的大分子微粒性能更高的表面反应性色谱分离的大分子微粒，具有在表面上具有许多突起的形状，以便在保持其尺寸完整的同时扩大其比表面积制备可用于药物输送和持续释放载体，病态捕捉载体，基因转移载体和用于诊断用途的载体等广泛领域的大分子微粒的目的，并且提供一种生产表面活性淋巴细胞的方法大分子微粒在一个步骤。表面活性炭黑大分子微粒的特征在于具有至少一种化学反应性官能团，可带电荷官能团或具有物理相互作用倾向的官能团，例如氢键，并且在表面上具有许多突起。在一个步骤中制备表面反应性色谱分离的大分子微粒的方法包括在聚合溶剂中聚合速率和溶解度显着不同的多种单体之间进行共聚合，并对所得共聚物进行自组织。版权所有（C）2005，JPO＆NCIPI

5. 发明专利

JP2004081739A Composition for hemostasis of hydroxy apatite polymer composite material 审中-公开
公开(公告)号：JP2004081739A
公开(公告)日：2004-03-18
申请号：JP2002250288
申请日：2002-08-29
申请人： Mitsuru Akashi , Biomedical Technology Hybrid Ltd , Masashi Tabata , 明石満 , 株式会社ビーエムティーハイブリッド , 田畑雅士
发明人： AKASHI MITSURU , TABATA MASASHI , SHIMODA TORU , SUGIHARA KAZUMASA , OGOMI DAISUKE , SERIZAWA TAKESHI
IPC分类号： A61L15/16 , A61K31/661 , A61K31/729 , A61K33/10 , A61K33/42 , A61P1/02 , A61P17/02 , A61P19/00 , A61P27/16 , A61P35/00 , A61P41/00 , A61P43/00
CPC分类号： A61L2400/04
摘要： PROBLEM TO BE SOLVED: To provide a composition for a hemostasis effective at a wound site.
SOLUTION: The composition for the hemostasis contains a composite material which carries a hydroxy apatite or a calcium carbonate having a mean particle size of 50 μm or less in a biocompatible polymer matrix as an effective component.
COPYRIGHT: (C)2004,JPO

6. 发明专利

JP2010214356A Nitrite/nitrate-nitrogen lowering agent and method of lowering nitrite/nitrate-nitrogen concentration in water 审中-公开
标题翻译：硝酸盐/硝酸盐 - 硝态氮降解剂和降低硝酸/硝酸浓度的方法
公开(公告)号：JP2010214356A
公开(公告)日：2010-09-30
申请号：JP2009095287
申请日：2009-03-17
申请人： Mitsuru Akashi , Senka Kk , センカ株式会社 , 満明石
发明人： AKASHI MITSURU , KAGEYAMA TADASHI
IPC分类号： C02F1/28 , B01J20/26 , B01J41/14 , C02F1/42
摘要： PROBLEM TO BE SOLVED: To provide nitrite/nitrate-nitrogen lowering agent which is capable of easily lowering the nitrite/nitrate-nitrogen concentration in wastewater, and a method of lowering nitrate/nitrate-nitrogen concentration in water using the same. SOLUTION: The nitrite/nitrate-nitrogen lowering agent can be obtained by a method of radical-polymerizing of hydrophobic monomer in the presence of cationic polymer having a radical polymerizable group at the end, it has cationic polymer chains cumulated on the surface, and inside of it is polymer fine grains consisting of hydrophobic polymer compound. In the method of lowering nitrite/nitrate-nitrogen concentration in water, the nitrite/nitrate-nitrogen lowering agent is added in the water containing nitrite/nitrate-nitrogen, and solid/liquid separation is carried out after stirring/mixing. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供能够容易地降低废水中的亚硝酸盐/硝酸盐 - 氮浓度的亚硝酸盐/硝酸盐 - 氮降低剂，以及使用该方法降低水中的硝酸盐/硝酸盐 - 氮浓度的方法。解决方案：亚硝酸盐/硝酸盐 - 氮降低剂可以通过在末端具有自由基聚合性基团的阳离子聚合物存在下通过自由基聚合疏水性单体的方法获得，其中阳离子聚合物链在表面上累积其内部是由疏水性高分子化合物组成的聚合物细粒。在降低水中的亚硝酸盐/硝酸盐 - 氮浓度的方法中，将亚硝酸盐/硝酸盐 - 氮降低剂加入到含有亚硝酸盐/硝酸盐 - 氮的水中，搅拌/混合后进行固/液分离。版权所有（C）2010，JPO＆INPIT

7. 发明专利

JP2006271839A Auxiliary appliance for medical column for extracorporeal circulation 有权
标题翻译：医用柱辅助器械用于超声波循环
公开(公告)号：JP2006271839A
公开(公告)日：2006-10-12
申请号：JP2005098639
申请日：2005-03-30
申请人： Mitsuru Akashi , Biomedical Technology Hybrid Ltd , Yukiro Maruyama , Toray Ind Inc , 征郎丸山 , 満明石 , 東レ株式会社 , 株式会社ビーエムティーハイブリッド
发明人： UENO YOSHIYUKI , SUGAYA HIROYUKI , FUNAKI TAKAFUMI , KATO MASAYA , AKASHI MITSURU , MARUYAMA YUKIRO
IPC分类号： A61M1/36 , A61M1/02 , A61M1/14
摘要： PROBLEM TO BE SOLVED: To improve a therapeutic effect of a medical column for extracorporeal circulation by providing an auxiliary appliance for the medical column for the extracorporeal circulation which plays an auxiliary role for the medical column for the extracorporeal circulation used for an original purpose and to reduce an anxiety of side-effects of medial agent by non-use or reduction of anticoagulant.
SOLUTION: This auxiliary appliance for the medical column for the extracorporeal circulation is an auxiliary appliance for use in a pretreatment and/or posttreatment of the medical column for the extracorporeal circulation and is characterized in that a physiologically active substance is immobilized to the auxiliary appliance for the medical column for the extracorporeal circulation.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：通过提供用于体外循环的医用柱的辅助器具来提高医用柱体外循环的治疗效果，其对于用于原始体外的体外循环的医用柱起辅助作用目的，并通过不使用或减少抗凝血剂减少内侧药物副作用的焦虑。解决方案：用于体外循环的用于医疗柱的辅助装置是用于体外循环的医用柱的预处理和/或后处理的辅助装置，其特征在于将生理活性物质固定在用于体外循环医用柱的辅助器具。版权所有（C）2007，JPO＆INPIT

8. 发明专利

JP2006271809A Irradiated modified base material 有权
标题翻译： IRRADIATED改性基材
公开(公告)号：JP2006271809A
公开(公告)日：2006-10-12
申请号：JP2005098154
申请日：2005-03-30
申请人： Mitsuru Akashi , Biomedical Technology Hybrid Ltd , Yukiro Maruyama , Toray Ind Inc , 征郎丸山 , 満明石 , 東レ株式会社 , 株式会社ビーエムティーハイブリッド
发明人： UENO YOSHIYUKI , SUGAYA HIROYUKI , FUNAKI TAKAFUMI , KATO MASAYA , AKASHI MITSURU , MARUYAMA YUKIRO
IPC分类号： A61L33/00 , A61F2/06 , A61M1/16
摘要： PROBLEM TO BE SOLVED: To provide an antithrombogenic modified base material which is sterilized by irradiation and is capable of activating protein C. SOLUTION: The modified base material is irradiated with radiation in the presence of a physiologically active substance to activate protein C therein and capable of activating protein C. The modified base material is sterilized by irradiation excellent in activating protein C and antithrombogenicity. The irradiation minimizes amount of physiologically active substance elution in spite of any induction method of the base material with the physiologically active substance is employed. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：提供通过照射灭菌并能够活化蛋白质C的抗血栓形成改性基础材料。解决方案：将改性的基材在生理活性物质的存在下用辐射照射至在其中活化蛋白质C并能够激活蛋白质C.经修饰的基材通过激活蛋白C和抗血栓形成性优异的照射而灭菌。尽管使用了具有生理活性物质的基材的任何诱导方法，照射使生理活性物质洗脱的量最小化。版权所有（C）2007，JPO＆INPIT

9. 发明专利

JP2005220326A Alternate adsorption layer-coated particle 有权
标题翻译：替代吸收层涂层颗粒
公开(公告)号：JP2005220326A
公开(公告)日：2005-08-18
申请号：JP2004032675
申请日：2004-02-09
申请人： Mitsuru Akashi , Nippon Shokubai Co Ltd , 満明石 , 株式会社日本触媒
发明人： AKASHI MITSURU , TOMITA TAKASHI
IPC分类号： C01B33/18 , C08G81/00 , C09C1/28 , C09C3/10
摘要： PROBLEM TO BE SOLVED: To provide a new alternate adsorption layer-coated particle, wherein the surface of which is laminated with polymers by an alternate adsorption method.
SOLUTION: This alternate adsorption layer-coated particle is a polyion complex layer-coated particle which is obtained by alternatively adsorbing a polymer A containing a carboxyl group and a polymer B that can form a polyion complex with the polymer A on a particle having a particle size in the range of 50 nm-1 mm, and is an alternate adsorption layer-coated particle which is obtained by alternately adsorbing a nonionic polymer C having at least an amide bond. The alternate adsorption layer-coated particle can be preferably used for a template polymerization, or the like, and the polymer obtained by the polymerization can be preferably used in a dispersing agent for an inorganic material.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供一种新的替代吸附层涂覆颗粒，其中表面通过交替吸附方法与聚合物层压。该替代的吸附层涂覆的颗粒是通过交替地吸附含有羧基的聚合物A和可以与聚合物A在颗粒上形成聚离子络合物的聚合物B而获得的聚离子复合层涂覆颗粒具有50nm-1mm范围内的粒度，并且是通过交替吸附具有至少一个酰胺键的非离子聚合物C而获得的交替的吸附层涂覆颗粒。替代的吸附层包覆的颗粒可以优选用于模板聚合等，并且通过聚合获得的聚合物可以优选用于无机材料的分散剂。版权所有（C）2005，JPO＆NCIPI

10. 发明专利

JP2003342367A Party hydrophilic and hydrophobic modified poly(gamma- glutamic acid) 有权
标题翻译：亲水亲水和疏水改性聚（甘氨酸）
公开(公告)号：JP2003342367A
公开(公告)日：2003-12-03
申请号：JP2002152198
申请日：2002-05-27
申请人： Mitsuru Akashi , Biomedical Technology Hybrid Ltd , 満明石 , 株式会社ビーエムティーハイブリッド
发明人： AKASHI MITSURU , HIWATARI KENICHIRO
IPC分类号： A61K47/34 , C08G69/48
摘要： PROBLEM TO BE SOLVED: To provide a modified poly(γ-glutamic acid) having new functions. SOLUTION: The modified poly(γ-glutamic acid) is derived by introducing hydrophlic graft parts into a poly(γ-glutamic acid) through part of its carboxy groups and introducing hydrophobic groups into it through another part of its carboxy groups. COPYRIGHT: (C)2004,JPO

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