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1. 实用新型

TWM595138U 鍍膜布結構有权
简体标题：镀膜布结构
公开(公告)号：TWM595138U
公开(公告)日：2020-05-11
申请号：TW109201400
申请日：2020-02-07
申请人：馳顏國際有限公司 , CHI YAN GUO JI LTD
发明人：林文鴻 , 徐薪閎
IPC分类号： D06M11/77 , D06M13/148

2. 发明申请

WO9950427A3 NOVEL BASAL ENDOSPERM TRANSFER CELL LAYER (BETL) SPECIFIC GENES 审中-公开
标题翻译：新型基本内转移细胞层（BETL）特异性基因
公开(公告)号：WO9950427A3
公开(公告)日：1999-12-09
申请号：PCT/EP9902063
申请日：1999-03-26
申请人： MAX PLACK GES ZUR FOERDERUNG D , THOMPSON RICHARD D , YAN GUO , SALAMINI FRANCESCO , HUEROS GREGORIO
发明人： THOMPSON RICHARD D , YAN GUO , SALAMINI FRANCESCO , HUEROS GREGORIO
IPC分类号： A01H5/00 , C07K14/415 , C07K16/16 , C12N5/10 , C12N15/29 , C12N15/82 , G01N33/50
CPC分类号： C12N15/8222 , C07K14/415 , C12N15/8234 , C12N15/8279
摘要： Described are nucleic acid molecules encoding basal endosperm transfer cell layer (BETL) specific proteins as well as regulatory sequences which naturally regulate the expression of such nucleic acid molecules. Vectors comprising said nucleic acid molecules, wherein the nucleic acid molecules are operatively linked to regulatory elements allowing expression in prokaryotic and/or eukaryotic host cells as well as proteins encoded by said nucleic acid molecules, antibodies to said proteins and methods for their production are provided. Described are also recombinant DNA molecules and vectors comprising said regulatory sequences as well as host cells transformed therewith. Furthermore, kits and diagnostic compositions comprising the aforementioned nucleic acid molecules, proteins, antibodies, regulatory sequences, recombinant DNA molecules and vectors as well as antibodies are provided. Also provided are methods for the identification of compounds being capable of activating or inhibiting the expression of BETL specific genes. Furthermore, transgenic plant cells, plant tissue and plants containing the above-described nucleic acid molecules, regulatory sequences, recombinant DNA molecules and vectors as well as the use of the aforementioned nucleic acid molecules, regulatory sequences, recombinant DNA molecules, vectors, proteins, antibodies, peptides and/or compounds identified by a method of the invention in plant cell and tissue culture, plant breeding and/or agriculture are described.
摘要翻译：描述了编码基础胚乳转移细胞层（BETL）特异性蛋白质的核酸分子以及天然调节这种核酸分子表达的调节序列。提供了包含所述核酸分子的载体，其中所述核酸分子可操作地连接到允许在原核和/或真核宿主细胞中表达的调节元件以及由所述核酸分子编码的蛋白质，对所述蛋白质的抗体及其生产方法。还描述了重组DNA分子和包含所述调节序列的载体以及用其转化的宿主细胞。此外，提供了包含上述核酸分子，蛋白质，抗体，调节序列，重组DNA分子和载体以及抗体的试剂盒和诊断组合物。还提供了用于鉴定能够激活或抑制BETL特异性基因表达的化合物的方法。此外，含有上述核酸分子，调节序列，重组DNA分子和载体的转基因植物细胞，植物组织和植物以及上述核酸分子，调节序列，重组DNA分子，载体，蛋白质，描述了通过本发明的方法在植物细胞和组织培养，植物育种和/或农业中鉴定的抗体，肽和/或化合物。

3. 发明申请

WO2013019817A1 N-ACETYL-D-GLUCOSAMINE FOR ENHANCED SPECIFICITY OF STREP A IMMUNOASSAY 审中-公开
标题翻译： N-乙酰-D-GLUCOSAMINE用于增强免疫功能的特异性
公开(公告)号：WO2013019817A1
公开(公告)日：2013-02-07
申请号：PCT/US2012/049072
申请日：2012-07-31
申请人： QUIDEL CORPORATION , REN, Peter, Yan-guo , MCCLURE, Jason , RICHARDSON, Kevin, S.
发明人： REN, Peter, Yan-guo , MCCLURE, Jason , RICHARDSON, Kevin, S.
IPC分类号： G01N33/543 , G01N33/558 , G01N33/569
CPC分类号： G01N33/56944 , G01N33/54393 , G01N33/558
摘要： Methods, compositions and kits for detecting Group A streptococcus in a biological sample are described. More particularly, the present disclosure provides an immunoassay in which the specificity of detection of Group A streptococcus is enhanced by addition of N-acetyl-D-glucosamine. These methods, compositions and kits are useful in convenient, reliable and early diagnosis of streptococcal infection in a human subject.
摘要翻译：描述了用于检测生物样品中的A组链球菌的方法，组合物和试剂盒。更具体地，本公开提供了其中通过加入N-乙酰基-D-葡糖胺来增强A组链球菌检测的特异性的免疫测定。这些方法，组合物和试剂盒在人类受试者的链球菌感染的方便，可靠和早期诊断中是有用的。

4. 发明公开

US20240209454A1 USE OF MUTATIONAL SIGNATURES FOR MULTIPLE CANCER TYPES 审中-公开
公开(公告)号：US20240209454A1
公开(公告)日：2024-06-27
申请号：US18556049
申请日：2022-04-19
申请人： Deirdre Hill , Eric R. Prossnitz , Yan Guo
发明人： Deirdre Hill , Eric R. Prossnitz , Yan Guo
IPC分类号： C12Q1/6886 , G16B20/20
CPC分类号： C12Q1/6886 , G16B20/20 , C12Q2600/106 , C12Q2600/156
摘要： A method to determine disease-specific survival, disease-free interval, progression-free interval, progression-free survival or overall survival in a cancer patient based on specific mutational signatures is provided.

5. 发明授权

US10059667B2 Antidiabetic compounds 有权
公开(公告)号：US10059667B2
公开(公告)日：2018-08-28
申请号：US15110894
申请日：2015-02-03
申请人： MERCK SHARP & DOHME CORP. , Harry Chobanian , Duane DeMong , Yan Guo , Zhiyong Hu , Michael Miller , Barbara Pio , Christopher W. Plummer , Dong Xiao , Cangming Yang , Rui Zhang
发明人： Harry Chobanian , Duane DeMong , Yan Guo , Zhiyong Hu , Michael Miller , Barbara Pio , Christopher W. Plummer , Dong Xiao , Cangming Yang
IPC分类号： C07D211/42 , A61K45/06 , A61K31/366 , A61K31/397 , A61K31/40 , A61K31/44 , C07D231/20 , A61K31/4985 , C07D401/04 , C07D239/52 , C07C217/52 , C07D205/04 , C07D491/056 , C07D265/30 , C07D207/08 , C07D207/10 , C07D207/12 , C07D209/52 , C07D209/54 , C07D211/22 , C07D213/30 , C07D213/64 , C07D213/65 , C07D213/69 , C07D307/86 , C07D307/88 , C07C59/72 , C07D205/12 , C07D213/647
CPC分类号： C07D211/42 , A61K31/366 , A61K31/397 , A61K31/40 , A61K31/44 , A61K31/4985 , A61K45/06 , C07C59/72 , C07C217/52 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07D205/04 , C07D205/12 , C07D207/08 , C07D207/10 , C07D207/12 , C07D209/52 , C07D209/54 , C07D211/22 , C07D213/30 , C07D213/64 , C07D213/647 , C07D213/65 , C07D213/69 , C07D231/20 , C07D239/52 , C07D265/30 , C07D307/86 , C07D307/88 , C07D401/04 , C07D491/056 , A61K2300/00
摘要： Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

6. 发明申请

US20170217918A1 ANTIDIABETIC BICYCLIC COMPOUNDS 审中-公开
公开(公告)号：US20170217918A1
公开(公告)日：2017-08-03
申请号：US15328735
申请日：2015-08-06
申请人： Helen CHEN , Steven L. COLLETTI , Duane MONG , Yan GUO , Michael MILLER , Anilkumar NAIR , Christopher W. PLUMMER , Dong XIAO , De-Yi YANG , Merck Sharp & Dohme Corp.
发明人： Helen Chen , Steven L. Colletti , Duane DeMong , Yan Guo , Michael Miller , Anilkumar Nair , Christopher W. Plummer , Dong Xiao , De-Yi Yang
IPC分类号： C07D311/60 , C07D405/14 , C07D471/08 , C07D487/08 , C07D487/04 , C07D491/107 , C07D413/12 , C07D491/08 , C07D405/10 , C07D491/048
CPC分类号： C07D311/60 , A61K31/366 , A61K31/397 , A61K31/4985 , A61K45/06 , C07D405/10 , C07D405/14 , C07D413/12 , C07D413/14 , C07D451/02 , C07D471/08 , C07D487/04 , C07D487/08 , C07D491/048 , C07D491/08 , C07D491/107 , A61K2300/00
摘要： Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

7. 发明申请

US20160332968A1 ANTIDIABETIC COMPOUNDS 审中-公开
标题翻译：抗菌化合物
公开(公告)号：US20160332968A1
公开(公告)日：2016-11-17
申请号：US15110894
申请日：2015-02-03
申请人： Harry CHOBANIAN , Duane DEMONG , Yan Guo , Zhiyong Hu , Barbara PIO , Christopher PLUMMER , Dong XIAO , Cangming YANG , Rui ZHANG , Merck Sharp & Dohme Corp. , Michael MILLER
发明人： Harry Chobanian , Duane DeMong , Yan Guo , Zhiyong Hu , Michael Miller , Barbara Pio , Christopher W. Plummer , Dong Xiao , Michael Yang
IPC分类号： C07D211/42 , C07D211/22 , C07D205/04 , C07D209/54 , C07D209/52 , C07D207/12 , C07D205/12 , C07C217/52 , C07D401/04 , C07D265/30 , C07C59/72 , C07D213/64 , C07D213/69 , C07D239/52 , C07D231/20 , C07D307/88 , C07D491/056 , C07D307/86 , C07D213/30 , C07D213/647 , C07D207/08
CPC分类号： C07D211/42 , A61K31/366 , A61K31/397 , A61K31/40 , A61K31/44 , A61K31/4985 , A61K45/06 , C07C59/72 , C07C217/52 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07D205/04 , C07D205/12 , C07D207/08 , C07D207/10 , C07D207/12 , C07D209/52 , C07D209/54 , C07D211/22 , C07D213/30 , C07D213/64 , C07D213/647 , C07D213/65 , C07D213/69 , C07D231/20 , C07D239/52 , C07D265/30 , C07D307/86 , C07D307/88 , C07D401/04 , C07D491/056 , A61K2300/00
摘要： Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
摘要翻译：结构式（I）的新型化合物及其药学上可接受的盐是G蛋白偶联受体40（GPR40）的激动剂，可用于治疗，预防和抑制G蛋白偶联受体受体40.本发明的化合物可用于治疗2型糖尿病，以及通常与该疾病相关的病症，包括肥胖症和脂质疾病，例如混合或糖尿病性血脂异常，高脂血症，高胆固醇血症和高甘油三酯血症

8. 发明申请

US20160304515A1 INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIM CHANNEL 有权
标题翻译：肾脏外侧药物通道的抑制剂
公开(公告)号：US20160304515A1
公开(公告)日：2016-10-20
申请号：US15101467
申请日：2014-12-16
申请人： Harry CHOBANIAN , Barbara PIO , Yan GUO , Fa-Xiang DING , Shuzhi DONG , Shawn P. WALSH , Jinlong JIANG , Dooseop KIM , MERCK SHARP & DOHME CORP.
发明人： Harry Chobanian , Barbara Pio , Yan Guo , Fa-Xiang Ding , Shuzhi Dong , Shawn P. Walsh , Jinlong Jiang , Dooseop Kim
IPC分类号： C07D471/04 , A61K45/06 , A61K31/55 , C07D487/04 , A61K31/4985 , C07D498/04 , A61K31/519 , A61K31/437
CPC分类号： C07D471/04 , A61K31/401 , A61K31/4178 , A61K31/424 , A61K31/437 , A61K31/4422 , A61K31/496 , A61K31/4965 , A61K31/4985 , A61K31/519 , A61K31/55 , A61K31/585 , A61K45/06 , C07D487/04 , C07D498/04 , A61K2300/00
摘要： The present invention provides compounds of Formula (I) (Formula (I)) including pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.

9. 发明授权

US08599168B2 Touch detection method and circuit for capacitive touch panels 有权
标题翻译：电容触摸屏的触摸检测方法和电路
公开(公告)号：US08599168B2
公开(公告)日：2013-12-03
申请号：US13066183
申请日：2011-04-07
申请人： Lianghua Mo , Yan Guo
发明人： Lianghua Mo , Yan Guo
IPC分类号： G06F3/045
CPC分类号： G06F3/044
摘要： A touch detection method for capacitive touch panels includes the steps of scanning the rows and columns of the capacitive matrix of a touch panel respectively; obtaining the capacitance differential value; processing the obtained capacitance differential value; and determining whether there is a touch on the touch panel in response to the processed capacitance differential value. The capacitance differential value is obtained by one of the steps of synchronously scanning two rows at the same time; synchronously scanning two columns at the same time; scanning one row to obtain the capacitance differential value between the row and a reference capacitance; and scanning one column to obtain the capacitance differential value between the column and a reference capacitance. The present invention creates conditions for the elimination of common code interferences and greatly improves the interference resistance of a capacitive touch panel.
摘要翻译：电容触摸面板的触摸检测方法包括以下步骤：分别扫描触摸面板的电容矩阵的行和列; 获得电容差分值; 处理所获得的电容差分值; 以及响应于所处理的电容差分值来确定触摸面板上是否存在触摸。通过同步同时扫描两行的步骤之一获得电容差分值; 同时同步扫描两列; 扫描一行以获得行与参考电容之间的电容差分值; 并扫描一列以获得列与参考电容之间的电容差分值。本发明创造了消除通用代码干扰的条件，并大大提高了电容式触摸面板的抗干扰能力。

10. 发明申请

US20130279642A1 BOTTOM NOZZLE FILTERING DEVICE AND DEBRIS-PREVENTIVE BOTTOM NOZZLE USING THE SAME 审中-公开
标题翻译： BOTTOM喷嘴过滤装置和防止底漆喷嘴使用它
公开(公告)号：US20130279642A1
公开(公告)日：2013-10-24
申请号：US13978686
申请日：2011-10-14
申请人： Wenchi Yu , Weicai Li , Yuemin Zhou , Xianfeng Lv , Yan Guo , Yuli Liu
发明人： Wenchi Yu , Weicai Li , Yuemin Zhou , Xianfeng Lv , Yan Guo , Yuli Liu
IPC分类号： G21C3/32 , B01D35/02
CPC分类号： G21C3/3206 , B01D29/03 , B01D35/02 , G21C3/322 , G21C3/3305 , Y02E30/38
摘要： The present invention provides a bottom nozzle filtering device and a debris-preventive bottom nozzle that can be used for a light water reactor (LWR) nuclear fuel assembly. The bottom nozzle filtering device includes a plurality of successively spliced unit plates; a through flow channel is formed between the spliced adjacent unit plates; the flow channel includes a plurality of spaced straight-section flow inlets and straight-section flow outlets, and a flow subchannel communicating; the outlet section of each straight-section flow inlet in the middle splits respectively into two flow subchannels, and the inlet section of each straight-section flow outlet in the middle communicates respectively with the two flow subchannels. The flow direction of the coolant is controlled by the straight-section flow inlet, the straight-section flow outlet, the flow subchannel to prevent unnecessary eddies forming, making the pressure loss effectively controlled and improving the filtering effect.
摘要翻译：本发明提供了可用于轻水反应堆（LWR）核燃料组件的底部喷嘴过滤装置和防碎底部喷嘴。底部喷嘴过滤装置包括多个连续拼接的单元板; 在接合的相邻单元板之间形成通流通道; 流动通道包括多个间隔开的直线部分流入口和直流部分流出口，以及流动通道。中间的每个直段流入口的出口部分别分成两个流通道，中间的每个直段流出口的入口部分分别与两个流动通道连通。冷却液的流动方向由直流流入口，直流流出口，流动通道进行控制，防止不必要的涡流成形，有效控制压力损失，提高过滤效果。

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