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1. 发明申请

US20120201814A1 COMPOSITIONS MONOVALENT FOR CD28 BINDING AND METHODS OF USE 有权
标题翻译： CD28结合的组合物单一使用方法和使用方法
公开(公告)号：US20120201814A1
公开(公告)日：2012-08-09
申请号：US13416033
申请日：2012-03-09
申请人： Murray McKinnon , Steven G. Nadler , Suzanne J. Suchard , Brendan Classon , Steve Holmes , Olga Ignatovich , Christopher Plummer , Steve Grant
发明人： Murray McKinnon , Steven G. Nadler , Suzanne J. Suchard , Brendan Classon , Steve Holmes , Olga Ignatovich , Christopher Plummer , Steve Grant
IPC分类号： A61K39/395 , A61P29/00 , A61P37/02 , A61P37/00 , A61P37/06
CPC分类号： C07K16/2818 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/2896 , C07K2317/31 , C07K2317/569 , C07K2317/73
摘要： Disclosed are domain antibodies that monovalently bind CD28. Domain antibodies that are monovalent for binding of CD28 can inhibit CD28 activity. In one aspect, a domain antibody consists of or comprises a single immunoglobulin variable domain that specifically binds and antagonizes the activity of CD28, in an aspect, without substantially agonizing CD28 activity. In another aspect, the domain antibody is a human domain antibody. The disclosure further encompasses methods of antagonizing CD80 and/or CD86 interactions with CD28 in an individual and methods of treating diseases or disorders involving CD80 and/or CD86 interactions with CD28, the methods involving administering a domain antibody to the individual.
摘要翻译：公开了单价结合CD28的结构域抗体。对CD28结合而言是单价的域抗体可抑制CD28活性。在一个方面，结构域抗体由一个方面组成或包含单个免疫球蛋白可变区，其特异性结合并拮抗CD28的活性，一方面，没有实质上激动的CD28活性。另一方面，结构域抗体是人结构域抗体。本公开还包括在个体中拮抗CD80和/或CD86相互作用的方法以及涉及与CD28相互作用的CD80和/或CD86相互作用的疾病或病症的方法，所述方法涉及对个体施用结构域抗体。

2. 发明申请

US20110305696A1 ANTI-SERUM ALBUMIN BINDING VARIANTS 有权
标题翻译：抗血清白蛋白结合变体
公开(公告)号：US20110305696A1
公开(公告)日：2011-12-15
申请号：US13202353
申请日：2010-02-17
申请人： Elena De Angelis , Carolyn Enever , Haiqun Liu , Christopher Plummer , Oliver Schon
发明人： Elena De Angelis , Carolyn Enever , Haiqun Liu , Christopher Plummer , Oliver Schon
IPC分类号： A61K39/395 , C07K19/00 , C12N5/10 , C12N15/63 , C12N1/21 , C07K16/18 , C07H21/04
CPC分类号： C07K16/18 , C07K14/56 , C07K14/57563 , C07K16/2878 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/569 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/31
摘要： The invention relates to improved variants of the anti-serum albumin immunoglobulin single variable domain DOM7h-11, as well as ligands and drug conjugates comprising such variants, compositions, nucleic acids, vectors and hosts.
摘要翻译：本发明涉及抗血清白蛋白免疫球蛋白单可变结构域DOM7h-11的改进变体，以及包含这些变体，组合物，核酸，载体和宿主的配体和药物偶联物。

3. 发明申请

US20070234311A1 Fast patch-based method calls 有权
标题翻译：快速的基于补丁的方法调用
公开(公告)号：US20070234311A1
公开(公告)日：2007-10-04
申请号：US11365146
申请日：2006-02-28
申请人： Christopher Plummer
发明人： Christopher Plummer
IPC分类号： G06F9/45
CPC分类号： G06F9/449
摘要： A patch-based mechanism is disclosed for providing fast invocations of a target method from a compiled calling method. The code for the calling method is stored into a storage. The code for the calling method comprises an instruction for invoking the target method, where the instruction comprises a parameter. In response to a state change from a current state to a new state that is experienced by the target method, the parameter is modified from a first value to a second value, where the second value indicates the correct address for facilitating the execution of the target method in its new state. Thus, the parameter in the instruction for invoking the target method always reflects the correct state of the target method, which provides for a fast invocation of the target method when the instruction is executed.
摘要翻译：公开了一种基于补丁的机制，用于从编译的调用方法提供目标方法的快速调用。调用方法的代码存储在存储器中。调用方法的代码包括用于调用目标方法的指令，其中指令包括参数。响应于从目标方法经历的当前状态到新状态的状态改变，将参数从第一值修改为第二值，其中第二值指示用于促进目标的执行的正确地址方法在新的状态。因此，用于调用目标方法的指令中的参数总是反映目标方法的正确状态，其在执行指令时提供目标方法的快速调用。

4. 发明申请

US20070160561A1 AMPHIPHILIC STAR BLOCK COPOLYMERS 审中-公开
标题翻译：大众星型嵌段共聚物
公开(公告)号：US20070160561A1
公开(公告)日：2007-07-12
申请号：US11690074
申请日：2007-03-22
申请人： Lahoussine Ouali , Andreas Herrmann , Celine Ternat , Christopher Plummer , Harm-Anton Klok , Georg Kreutzer , Jan-Anders Manson , Horst Sommer , Maria Ines Velazco
发明人： Lahoussine Ouali , Andreas Herrmann , Celine Ternat , Christopher Plummer , Harm-Anton Klok , Georg Kreutzer , Jan-Anders Manson , Horst Sommer , Maria Ines Velazco
IPC分类号： A61K8/81 , C08L61/00 , A01N25/00
CPC分类号： C08F293/00 , C08F293/005 , C08L53/00 , C08L2666/02
摘要： The present invention relates to a basically spherical hyperbranched block copolymer having an internal hydrophobic block and an external hydrophilic block. Within the spherical copolymer, the hydrophobic block constitutes a hydrophobic layer, suitable to associate or encapsulate hydrophobic bioactive agents, while the hydrophilic block provides an outer layer, which is suitable to render the copolymer soluble or dispersible in aqueous solutions. Also claimed is a method for preparing the copolymer, which is suitable to encapsulate fragrances, flavours, drugs, agrochemicals, for example.
摘要翻译：本发明涉及具有内部疏水嵌段和外部亲水嵌段的基本上球形的超支化嵌段共聚物。在球形共聚物内，疏水性嵌段构成适于缔合或包封疏水性生物活性剂的疏水层，而亲水嵌段提供外层，其适于使共聚物溶解或分散在水溶液中。还要求的是制备共聚物的方法，其适用于包封香料，香料，药物，农用化学品。

5. 发明申请

US20060048104A1 Mechanism for flowing local variables across a plurality of code blocks 审中-公开
标题翻译：在多个代码块中流动局部变量的机制
公开(公告)号：US20060048104A1
公开(公告)日：2006-03-02
申请号：US11215960
申请日：2005-08-30
申请人： Christopher Plummer
发明人： Christopher Plummer
IPC分类号： G06F9/44
CPC分类号： G06F8/441 , G06F9/45516
摘要： A compilation mechanism is disclosed for facilitating the keeping of local variables in hardware registers across multiple code blocks. In one implementation, the mechanism flows the local variables referenced in the code blocks to other code blocks. In a sense, the local variables are “merged”. A practical consequence of the flowing process is that some continuity of local variables is established between the code blocks. This continuity helps to keep the local variables referenced in the code blocks in registers, thereby, avoid the loading of the local variable into registers from memory.
摘要翻译：公开了一种汇编机制，以便于在多个代码块中保持硬件寄存器中的局部变量。在一个实现中，机制将代码块中引用的局部变量流入其他代码块。在某种意义上，局部变量“合并”。流程过程的实际结果是在代码块之间建立局部变量的一些连续性。这种连续性有助于保持寄存器中代码块中引用的局部变量，从而避免将本地变量加载到寄存器的寄存器中。

6. 发明申请

US20130109846A1 COMPOSITIONS MONOVALENT FOR CD28 BINDING AND METHODS OF USE 有权
公开(公告)号：US20130109846A1
公开(公告)日：2013-05-02
申请号：US13415914
申请日：2012-03-09
申请人： Murray McKinnon , Steven G. Nadler , Suzanne J. Suchard , Brendan Classon , Steve Holmes , Olga Ignatovich , Christopher Plummer , Steve Grant
发明人： Murray McKinnon , Steven G. Nadler , Suzanne J. Suchard , Brendan Classon , Steve Holmes , Olga Ignatovich , Christopher Plummer , Steve Grant
IPC分类号： C07K16/28
CPC分类号： C07K16/2818 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/2896 , C07K2317/31 , C07K2317/569 , C07K2317/73
摘要： Disclosed are domain antibodies that monovalently bind CD28. Domain antibodies that are monovalent for binding of CD28 can inhibit CD28 activity. In one aspect, a domain antibody consists of or comprises a single immunoglobulin variable domain that specifically binds and antagonizes the activity of CD28, in an aspect, without substantially agonizing CD28 activity. In another aspect, the domain antibody is a human domain antibody. The disclosure further encompasses methods of antagonizing CD80 and/or CD86 interactions with CD28 in an individual and methods of treating diseases or disorders involving CD80 and/or CD86 interactions with CD28, the methods involving administering a domain antibody to the individual.

7. 发明申请

US20100028354A1 COMPOSITIONS MONOVALENT FOR CD28 BINDING AND METHODS OF USE 有权
标题翻译： CD28结合的组合物单一使用方法和使用方法
公开(公告)号：US20100028354A1
公开(公告)日：2010-02-04
申请号：US12505166
申请日：2009-07-17
申请人： Murray McKinnon , Steven G. Nadler , Suzanne J. Suchard , Brendan Classon , Steve Holmes , Olga Ignatovich , Christopher Plummer , Steve Grant
发明人： Murray McKinnon , Steven G. Nadler , Suzanne J. Suchard , Brendan Classon , Steve Holmes , Olga Ignatovich , Christopher Plummer , Steve Grant
IPC分类号： A61K39/395 , C07K16/00 , A61P37/00
CPC分类号： C07K16/2818 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/2896 , C07K2317/31 , C07K2317/569 , C07K2317/73
摘要： Disclosed are domain antibodies that monovalently bind CD28. Domain antibodies that are monovalent for binding of CD28 can inhibit CD28 activity. In one aspect, a domain antibody consists of or comprises a single immunoglobulin variable domain that specifically binds and antagonizes the activity of CD28, in an aspect, without substantially agonizing CD28 activity. In another aspect, the domain antibody is a human domain antibody. The disclosure further encompasses methods of antagonizing CD80 and/or CD86 interactions with CD28 in an individual and methods of treating diseases or disorders involving CD80 and/or CD86 interactions with CD28, the methods involving administering a domain antibody to the individual.
摘要翻译：公开了单价结合CD28的结构域抗体。对CD28结合而言是单价的域抗体可抑制CD28活性。在一个方面，结构域抗体由一个方面组成或包含单个免疫球蛋白可变区，其特异性结合并拮抗CD28的活性，一方面，没有实质上激动的CD28活性。另一方面，结构域抗体是人结构域抗体。本公开还包括在个体中拮抗CD80和/或CD86相互作用的方法以及涉及与CD28相互作用的CD80和/或CD86相互作用的疾病或病症的方法，所述方法涉及对个体施用结构域抗体。

8. 发明申请

US20090305436A1 DEVICE AND METHOD FOR DETECTION OF A PREGNANCY ASSOCIATED HORMONE 审中-公开
标题翻译：用于检测PREGNANCY相关霍尔姆的装置和方法
公开(公告)号：US20090305436A1
公开(公告)日：2009-12-10
申请号：US12297434
申请日：2007-04-20
申请人： Christopher Plummer , Jeffrey Bauer
发明人： Christopher Plummer , Jeffrey Bauer
IPC分类号： G01N33/76 , G01N33/53
CPC分类号： G01N33/558 , G01N33/76
摘要： The invention provides a device (10) for detection and providing an indication of the concentration of a single pregnancy associated hormone (especially hCG), comprising a matrix (16) defining an axial flow path, the matrix comprising: (i) a sample receiving zone (18) at the upstream end of the flow path, for receiving a fluid sample; (ii) a plurality of test zones (22) positioned within the flow path and downstream from the sample receiving zone (18), wherein each test zone is capable of detecting a different concentration of hormone compared with an adjacent test zone; and (iii) an indicator (26) for recording a previous hormone concentration recorded by the same or a previous device. The devices are especially useful to give an indication of a miscarriage or non-natural termination. Methods of using the assay devices are also provided.
摘要翻译：本发明提供一种用于检测并提供单个妊娠相关激素（特别是hCG）的浓度的指示的装置（10），其包括限定轴向流动路径的基质（16），所述基质包括：（i）样品接收在流路的上游端处的区域（18），用于接收流体样品; （ii）位于所述流动路径内并且位于所述样品接收区（18）下游的多个测试区（22），其中每个测试区能够检测与相邻测试区相比不同浓度的激素; 和（iii）用于记录由相同或先前装置记录的先前激素浓度的指示器（26）。这些装置对于给出流产或非自然终止的指示特别有用。还提供了使用测定装置的方法。

9. 发明申请

US20060037003A1 System and method for providing exceptional flow control in protected code through memory layers 有权
标题翻译：通过内存层在受保护的代码中提供卓越的流量控制的系统和方法
公开(公告)号：US20060037003A1
公开(公告)日：2006-02-16
申请号：US10918130
申请日：2004-08-13
申请人： Dean Long , Nedim Fresko , Christopher Plummer
发明人： Dean Long , Nedim Fresko , Christopher Plummer
IPC分类号： G06F9/44
CPC分类号： G06F9/45504 , G06F11/3624 , G06F12/0269
摘要： A system and method for providing exceptional flow control in protected code through memory layers. Code is generated. The generated code includes a sequence of normal operations and is subject to protection against copying during execution of the generated code. The generated code is instantiated as a master process into a master layer in a memory space. The master process is cloned by instantiating a copy of the master process as a child layer in the memory space. Execution points within the generated code are identified. A copy of at least a portion of the generated code containing each execution point as an exception layer is instantiated in the memory space. The generated code in the exception layer is patched at each identified execution point with operations exceptional to the normal operations sequence and which are performed upon a triggering of each execution point during execution of the generated code.
摘要翻译：一种用于通过存储器层在受保护代码中提供异常流控制的系统和方法。代码生成。生成的代码包括正常操作的顺序，并且在执行生成的代码期间受到保护以防止复制。将生成的代码作为主进程实例化为内存空间中的主层。通过将主进程的副本实例化为内存空间中的子层来克隆主进程。识别生成代码内的执行点。将包含每个执行点的生成代码的至少一部分的副本作为异常层在内存空间中被实例化。异常层中生成的代码在每个识别的执行点处被修补，其中操作与正常操作序列异常，并且在执行生成的代码期间触发每个执行点时执行。

10. 发明申请

US20050268273A1 Thread rendezvous for read-only code in an object-oriented computing environment 有权
标题翻译：面向对象计算环境中的只读代码的线程会合
公开(公告)号：US20050268273A1
公开(公告)日：2005-12-01
申请号：US10847779
申请日：2004-05-17
申请人： Nedim Fresko , Christopher Plummer , Dean Long
发明人： Nedim Fresko , Christopher Plummer , Dean Long
IPC分类号： G06F9/30 , G06F9/312 , G06F9/38 , G06F9/45 , G06F9/46 , G06F9/48 , G06F12/02 , G06F9/44
CPC分类号： G06F9/3009 , G06F8/458 , G06F9/30043 , G06F9/3851 , G06F9/52 , G06F9/522 , G06F12/0253
摘要： Techniques for assuring thread rendezvous for a plurality of threads executing in a computing system are disclosed. Techniques can be used to assure thread rendezvous for read-only code in a manner that is more efficient than polling techniques. A Light-weight, Yet Trappable On Demand (LYTOD) instruction can be generated for code that is executed by one or more threads. Typically, a LYTOD instruction is generated at critical points of the code in order to assure safe-point thread rendezvous. The LYTOD is a lightweight instruction that can change its behavior from a lightweight instruction to an instruction that causes a trap when executed. The LYTOD can, for example, be implemented as a read-from-memory instruction that operates to load a register with a content of a valid memory location.
摘要翻译：公开了用于确保在计算系统中执行的多个线程的线程会合的技术。技术可以用于以比轮询技术更有效的方式来确保只读代码的线程会合。可以为由一个或多个线程执行的代码生成轻量级，可追踪按需（LYTOD）指令。通常，在代码的关键点生成LYTOD指令，以确保安全点线程会合。 LYTOD是一个轻量级的指令，可以将其行为从轻量级指令更改为在执行时引发陷阱的指令。例如，LYTOD可以实现为从存储器读取指令，其操作用于加载具有有效存储器位置的内容的寄存器。

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