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    • 5. 发明授权
    • Aza-bridged-ring compound
    • 氮杂桥环化合物
    • US08367696B2
    • 2013-02-05
    • US12524758
    • 2008-02-08
    • Shinya NagashimaToru KontaniHiroshi NagataYuji MatsushimaHisao HamaguchiTadatsura Koshika
    • Shinya NagashimaToru KontaniHiroshi NagataYuji MatsushimaHisao HamaguchiTadatsura Koshika
    • A61K31/439C07D221/00C07D221/02
    • C07D453/02C07D471/18
    • [PROBLEMS] Provided is a compound which has an antagonistic action on a muscarinic M3 receptor and is useful as an active ingredient of a prophylactic and/or therapeutic agent for an inflammatory disease such as a chronic obstructive pulmonary disease (COPD), asthma and the like.[MEANS For SOLVING PROBLEMS] The present inventors have made studies on a compound having an antagonistic action on the binding of a muscarinic M3 receptor, and they have found that an aza-bridged-ring compound or a salt thereof has an antagonistic action on the binding of a muscarinic M3 receptor, thereby completing the present invention. The aza-bridged-ring compound of the present invention has an antagonistic action on the binding of a muscarinic M3 receptor, and can be used as a prophylactic and/or therapeutic agent for an inflammatory disease such as a chronic obstructive pulmonary disease (COPD), asthma and the like.
    • [问题]提供对毒蕈碱M3受体具有拮抗作用并可用作炎性疾病如慢性阻塞性肺疾病(COPD),哮喘的预防和/或治疗剂的活性成分的化合物 喜欢。 解决问题的手段本发明人研究了对毒蕈碱性M3受体的结合具有拮抗作用的化合物,并且已经发现氮杂桥环化合物或其盐对其具有拮抗作用 结合毒蕈碱M3受体,从而完成本发明。 本发明的氮杂桥环化合物对毒蕈碱性M3受体的结合具有拮抗作用,可用作炎性疾病如慢性阻塞性肺疾病(COPD)的预防和/或治疗剂, ,哮喘等。