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1. 发明申请

WO0157063A8 ETO1 AND RELATED PROTEINS, AND METHODS OF REGULATING ETHYLENE BIOSYNTHESIS 审中-公开
标题翻译： ETO1和相关蛋白质，以及调控乙烯生物合成的方法
公开(公告)号：WO0157063A8
公开(公告)日：2002-02-07
申请号：PCT/US0103994
申请日：2001-02-07
申请人： UNIV PENNSYLVANIA , ECKER JOSEPH R , YOSHIDA HITOSHI , WANG LONG CHI , LURIN CLAIRE
发明人： ECKER JOSEPH R , YOSHIDA HITOSHI , WANG LONG-CHI , LURIN CLAIRE
IPC分类号： C07K14/415 , C12N15/29 , C12N15/82 , C07H21/04 , C07K14/00 , C07K16/16
CPC分类号： C07K14/415 , C12N15/8249 , C12N15/8291
摘要： The invention provides a negative regulator of ethylene biosynthesis in plants, which is embodied by ETHYLENE-OVERPRODUCER1 (ETO1) , a recessive gene, which controls the expression of the synthesis of the plant hormone ethylene. ETO1 is a member of a novel gene family, which is highly conserved in the plant kingdom, and which is unique in that it comprises both BTB and TPR domains. Two-hybrid experiments, together with in vitro binding experiments and double mutant analyses in planta revealed direct interaction of ETO1 with 1-aminocyclopropane-1-carboxylate synthase (ACS), a key enzyme of ethylene biosynthesis. Furthermore, functional assay in E. coli showed that members of the related ETO1-LIKE (EOL) proteins also significantly inhibit ethylene biosynthesis. Thus, the invention further provides methods of controlling, regulating and modulating ethylene biosynthesis in plants, plant cells, and the like.
摘要翻译：本发明提供了植物中乙烯生物合成的负调节剂，其由ETHYLENE-OVERPRODUCER1（ETO1），即控制植物激素乙烯合成表达的隐性基因体现。 ETO1是新型基因家族的成员，其在植物界是高度保守的，其特征在于它包含BTB和TPR结构域。双杂交实验与植物体内的体外结合实验和双重突变分析结合显示ETO1与1-氨基环丙烷-1-羧酸合酶（ACS）的直接相互作用乙烯生物合成的关键酶。此外，E中的功能测定。大肠杆菌显示相关ETO1-LIKE（EOL）蛋白的成员也显着抑制乙烯生物合成。因此，本发明还提供了控制，调节和调节植物，植物细胞等中乙烯生物合成的方法。

2. 发明申请

WO1997007671A1 CHIMERIC ANIMAL AND METHOD FOR CONSTRUCTING THE SAME 审中-公开
标题翻译：重要动物及其构建方法
公开(公告)号：WO1997007671A1
公开(公告)日：1997-03-06
申请号：PCT/JP1996002427
申请日：1996-08-29
申请人： KIRIN BEER KABUSHIKI KAISHA , TOMIZUKA, Kazuma , YOSHIDA, Hitoshi , HANAOKA, Kazunori , OSHIMURA, Mitsuo , ISHIDA, Isao
发明人： KIRIN BEER KABUSHIKI KAISHA
IPC分类号： A01K67/027
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K16/18 , C12N15/8509 , C12N15/90 , C12N2517/02
摘要： A method for constructing a chimeric nonhuman animal which comprises preparing microcells containing one or more foreign chromosomes or fragments of the same, and transferring the foreign chromosome(s) or fragments of the same into cells having differentiative pluripotency via the fusion with the microcells; a chimeric nonhuman animal which can be constructed by the above method and offsprings of the same; tissues and cells originating in the same; a method for utilizing the tissues and cells; cells which contain one or more foreign chromosomes or fragments of the same and sustain differentiative pluripotency; a method for constructing the cells; and a method for utilizing the cells.
摘要翻译：一种构建嵌合非人动物的方法，其包括制备含有一种或多种外来染色体或其片段的微细胞，并通过与所述微细胞融合将所述外源染色体或其片段转移到具有微分多能性的细胞中; 可以通过上述方法和其后代构建的嵌合非人动物; 起源于其的组织和细胞; 一种利用组织和细胞的方法; 含有一个或多个外来染色体或相同片段并维持差异多能性的细胞; 构建细胞的方法; 以及利用这些电池的方法。

3. 发明申请

WO2006029045A2 ENDOTHELIAL CELL SPECIFIC ANTIBODIES AND USES THEREOF 审中-公开
标题翻译：内皮细胞特异性抗体及其用途
公开(公告)号：WO2006029045A2
公开(公告)日：2006-03-16
申请号：PCT/US2005/031453
申请日：2005-09-02
申请人： KIRIN BREWERY CO., LTD. , GENZYME CORPORATION , TEICHER, Beverly , ROBERTS, Bruce , KATAOKA, Shiro , HONMA, Nakayuki , YOSHIDA, Hitoshi
发明人： TEICHER, Beverly , ROBERTS, Bruce , KATAOKA, Shiro , HONMA, Nakayuki , YOSHIDA, Hitoshi
IPC分类号： C07K16/30
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/2851 , C07K2317/21 , C07K2317/73
摘要： Methods and compositions provided herein relate to the inhibition of proliferation, migration, and tubule formation of endothelial cells and are thus useful in treating angiogenesis associated diseases, including cancer, polycystic kidney disease, diabetic retinopathy, rheumatoid arthritis, and psoriasis. Disclosed are methods of inhibiting endothelial cell proliferation, migration, and tubule formation by administering an antibody specific for Tumor EndothPelial Markers (TEMs). Also disclosed are methods of inhibiting angiogenesis and tumor growth by administering a TEM-specific antibody and antibody compositions useful in such methods.
摘要翻译：本文提供的方法和组合物涉及抑制内皮细胞的增殖，迁移和小管形成，因此可用于治疗血管生成相关疾病，包括癌症，多囊肾病，糖尿病性视网膜病，类风湿性关节炎和牛皮癣。公开了通过施用针对肿瘤内侧标记（TEM）特异的抗体来抑制内皮细胞增殖，迁移和小管形成的方法。还公开了通过施用在这些方法中有用的TEM特异性抗体和抗体组合物来抑制血管发生和肿瘤生长的方法。

4. 发明申请

WO2005026416A1 METHOD OF FORMING A CATIONIC ELECTRODEPOSITION FILM FORMING AN ELECTRIC THROUGH HOLE AND AN ELECTRIC THROUGH HOLE-FORMING CATIONIC ELECTROCOATING COMPOSITION 审中-公开
标题翻译：形成形成电穿孔的阳极电沉积膜和通过孔形成的阳极电解质组合物的方法
公开(公告)号：WO2005026416A1
公开(公告)日：2005-03-24
申请号：PCT/JP2004/013696
申请日：2004-09-13
申请人： NIPPON PAINT CO., LTD. , KOJIMA, Yoshio , YOSHIDA, Hitoshi
发明人： KOJIMA, Yoshio , YOSHIDA, Hitoshi
IPC分类号： C25D13/06
CPC分类号： C09D5/4488
摘要： It is an object of the present invention to provide a method of forming a cationic electrodeposition film, which has no detrimental effect on basic performances of electrodeposition that a curing property in low temperature and the stability of pigment dispersion are good and basic performances such as corrosion resistance and a rust-preventive property are maintained while maintaining both surface smoothness and economical advantage and exhibits the extremely precise throwing power and can attain an excellent ability of preventing a pinhole due to-gas. A method of forming a cationic electrodeposition film, comprising immersing an article to be coated, composed of a galvanized steel sheet, into a bath tank filled with a cationic electrocoating liquid containing a base resin and forming an electrodeposition film on the surface of the above galvanized steel sheet by current-carrying, wherein an electric through hole is formed within the above film to secure the conductivity of the above film in order to wipe out a spark discharge phenomenon arising due to the presence of a hydrogen bubble produced through cohesion of hydrogen gas, with the passage of time, generated by the above current-carrying at a gap of the film, which develops in depositing/forming the film by the above current-carrying and increasing its thickness with the passage of time, on the surface of the above galvanized steel sheet, and thereby an increase in an electric resistance value (k&•cm 2 ) per unit weight (mg) of the above film is inhibited.
摘要翻译：本发明的目的是提供一种形成阳离子电沉积膜的方法，其对电沉积的基本性能没有不利影响，即低温下的固化性能和颜料分散体的稳定性良好，腐蚀性等基本性能保持电阻和防锈性，同时保持表面平滑性和经济性，并且具有极其精确的抛光力，并且可以获得防止由于气体引起的针孔的优异的能力。一种形成阳离子电沉积膜的方法，包括将由镀锌钢板构成的待涂覆制品浸入填充有含有基础树脂的阳离子电泳涂料的浴槽中，并在上述镀锌层的表面上形成电沉积膜钢板，其中在上述膜内形成电气通孔以确保上述膜的导电性，以便消除由于氢气的内聚产生的氢气泡的存在而产生的火花放电现象随着时间的推移，由上述载流子在膜的间隙产生的上述电流产生，该膜的间隙通过上述载流子沉积/形成膜而随着时间的推移而增加其厚度，因此，上述膜的单位重量（mg）的电阻值（k＆lt; cm 2）的增加被抑制。

5. 发明申请

WO1998037425A1 ACCELERATION SENSOR ELEMENT AND METHOD OF ITS MANUFACTURE 审中-公开
标题翻译：加速传感器元件及其制造方法
公开(公告)号：WO1998037425A1
公开(公告)日：1998-08-27
申请号：PCT/JP1997003811
申请日：1997-10-22
申请人： MATSUSHITA ELECTRIC WORKS, LTD. , YOSHIDA, Hitoshi , TOMONARI, Shigeaki , OKA, Naomasa , NAKAMURA, Takuro , ISHIDA, Takuro , KAMAKURA, Masanao , KASANO, Fumihiro
发明人： MATSUSHITA ELECTRIC WORKS, LTD.
IPC分类号： G01P15/08
CPC分类号： G01P15/123 , G01P15/0802 , G01P15/125 , G01P15/18 , G01P2015/084 , G01P2015/0842
摘要： A flexure transducer which is used for the detection of an applied acceleration comprising (1) a frame having an upper surface and a lower surface, (2) a sheet member which has a plurality of flexible parts and a center part and whose flexible parts are extended between at least a part of the inner edge of the frame and the center part and are integrally continuous with them, (3) a weight which has a neck part integrally connected to the center part of the sheet member and is hung from the sheet member through the neck part and (4) a support member which supports the lower surface of the frame and whose inner surface faces the side surface of the weight with a first gap therebetween, a second gap being continuous with the first gap, and defined between the flexible parts of the sheet member and the weight, a third gap being defined between the frame and the sheet member and/or inside the sheet member, the frame and the sheet member being joined to each other and the sheet member and the weight being joined to each other in such a manner that, when an acceleration is applied to the transducer, at least two flexible parts are elastically deformed and, as a result, the weight is displaced relatively to the frame, the weight and the support member being formed of a semiconductor substrate, the 2nd gap being formed by removing a sacrifice layer which is provided in the semiconductor substrate and the frame and the sheet member comprising epitaxial layers provided on the semiconductor substrate.
摘要翻译：一种用于检测施加加速度的弯曲换能器，包括：（1）具有上表面和下表面的框架，（2）片材，其具有多个柔性部分和中心部分，并且其柔性部分是在框架的内边缘的至少一部分与中心部分之间延伸并且与它们一体连续，（3）重物，该重物具有与片状构件的中心部分一体地连接并从该片材悬挂的颈部构件通过颈部和（4）支撑构件，其支撑框架的下表面并且其内表面面对重物的侧表面，其间具有第一间隙，第二间隙与第一间隙连续，并且定义在片状部件的柔性部分和重物，第三间隙限定在框架和片状部件之间和/或片材部件的内部，框架和片状部件彼此接合并且片状部件和第 e重物彼此接合，使得当对换能器施加加速度时，至少两个柔性部分弹性变形，结果，重量相对于框架移动，重量和支撑件构件由半导体衬底形成，所述第二间隙通过去除设置在所述半导体衬底中的牺牲层和所述框架以及所述片构件包括设置在所述半导体衬底上的外延层而形成。

6. 发明申请

WO2007062245A2 HUMAN MONOCLONAL ANTIBODY HUMAN CD134 (OX40) AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译：人类单克隆抗体人CD134（OX40）及其制备和使用方法
公开(公告)号：WO2007062245A2
公开(公告)日：2007-05-31
申请号：PCT/US2006/045522
申请日：2006-11-27
申请人： KIRIN BEER KABUSHIKI KAISHA , LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY , KATO, Shinichiro , SOLOFF NUGENT, Rachel , YOSHIDA, Hitoshi , CROFT, Michael
发明人： KATO, Shinichiro , SOLOFF NUGENT, Rachel , YOSHIDA, Hitoshi , CROFT, Michael
IPC分类号： C07K16/00
CPC分类号： C07K16/2878 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/30 , C07K2317/565 , C07K2317/71 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C12N2799/026
摘要： The invention provides antibodies that specifically bind to OX40 (CD 134), referred to as OX40 antibodies, anti-OX40 or anti-OX40 antibodies. Invention antibodies that specifically bind to OX40 include mammalian (human, primate, etc.), humanized and chimeric anti-OX40 antibodies. Invention antibodies and antibody subsequences (fragments) that specifically bind to OX40 include purified and isolated antibodies, as well as pharmaceutical formulations thereof, are useful in various methods including treatment, screening and detection methods.
摘要翻译：本发明提供特异性结合OX40（CD134），称为OX40抗体，抗OX40或抗OX40抗体的抗体。特异性结合OX40的本发明抗体包括哺乳动物（人，灵长类动物等），人源化和嵌合抗OX40抗体。特异性结合OX40的本发明抗体和抗体子序列（片段）包括纯化和分离的抗体及其药物制剂，可用于各种方法，包括治疗，筛选和检测方法。

7. 发明申请

WO2007062245A3 HUMAN MONOCLONAL ANTIBODY HUMAN CD134 (OX40) AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译：人单克隆抗体人类CD134（OX40）及其制备和使用方法
公开(公告)号：WO2007062245A3
公开(公告)日：2007-12-06
申请号：PCT/US2006045522
申请日：2006-11-27
申请人： KIRIN BREWERY , JOLLA INST ALLERGY IMMUNOLOG , KATO SHINICHIRO , SOLOFF NUGENT RACHEL , YOSHIDA HITOSHI , CROFT MICHAEL
发明人： KATO SHINICHIRO , SOLOFF NUGENT RACHEL , YOSHIDA HITOSHI , CROFT MICHAEL
IPC分类号： C07K16/28 , A61K39/395 , A61P37/06 , C12N5/20 , C12N15/13
CPC分类号： C07K16/2878 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/30 , C07K2317/565 , C07K2317/71 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C12N2799/026
摘要： The invention provides antibodies that specifically bind to OX40 (CD 134), referred to as OX40 antibodies, anti-OX40 or anti-OX40 antibodies. Invention antibodies that specifically bind to OX40 include mammalian (human, primate, etc.), humanized and chimeric anti-OX40 antibodies. Invention antibodies and antibody subsequences (fragments) that specifically bind to OX40 include purified and isolated antibodies, as well as pharmaceutical formulations thereof, are useful in various methods including treatment, screening and detection methods.
摘要翻译：本发明提供了特异性结合OX40（CD134）的抗体，称为OX40抗体，抗OX40或抗OX40抗体。与OX40特异性结合的发明抗体包括哺乳动物（人，灵长类动物等），人源化和嵌合抗OX40抗体。与OX40特异性结合的发明抗体和抗体子序列（片段）包括纯化和分离的抗体及其药物制剂，可用于各种方法，包括治疗，筛选和检测方法。

8. 发明申请

WO2006029045A3 ENDOTHELIAL CELL SPECIFIC ANTIBODIES AND USES THEREOF 审中-公开
标题翻译：内皮细胞特异性抗体及其用途
公开(公告)号：WO2006029045A3
公开(公告)日：2007-08-02
申请号：PCT/US2005031453
申请日：2005-09-02
申请人： KIRIN BREWERY , GENZYME CORP , TEICHER BEVERLY , ROBERTS BRUCE , KATAOKA SHIRO , HONMA NAKAYUKI , YOSHIDA HITOSHI
发明人： TEICHER BEVERLY , ROBERTS BRUCE , KATAOKA SHIRO , HONMA NAKAYUKI , YOSHIDA HITOSHI
IPC分类号： A61K39/395
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/2851 , C07K2317/21 , C07K2317/73
摘要： Methods and compositions provided herein relate to the inhibition of proliferation, migration, and tubule formation of endothelial cells and are thus useful in treating angiogenesis associated diseases, including cancer, polycystic kidney disease, diabetic retinopathy, rheumatoid arthritis, and psoriasis. Disclosed are methods of inhibiting endothelial cell proliferation, migration, and tubule formation by administering an antibody specific for Tumor EndothPelial Markers (TEMs). Also disclosed are methods of inhibiting angiogenesis and tumor growth by administering a TEM-specific antibody and antibody compositions useful in such methods.
摘要翻译：本文提供的方法和组合物涉及抑制内皮细胞的增殖，迁移和小管形成，因此可用于治疗血管生成相关疾病，包括癌症，多囊肾病，糖尿病性视网膜病，类风湿性关节炎和牛皮癣。公开了通过施用针对肿瘤内侧标记（TEM）特异的抗体来抑制内皮细胞增殖，迁移和小管形成的方法。还公开了通过施用在这些方法中有用的TEM特异性抗体和抗体组合物来抑制血管发生和肿瘤生长的方法。

9. 发明专利

JPH10311012A SNOW ELIMINATION METHOD AND DEVICE 失效
公开(公告)号：JPH10311012A
公开(公告)日：1998-11-24
申请号：JP13587597
申请日：1997-05-09
申请人： ISHIKAWA GIKEN RUBBER KK , YOSHIDA HITOSHI , SHIMO YUKIO , OSUMI KAKUJI
发明人： YAMADA HIROSHI , YOSHIDA HITOSHI , SHIMO YUKIO , OSUMI KAKUJI
IPC分类号： E01H5/00
摘要： PROBLEM TO BE SOLVED: To quickly thaw or sublimate snow, and easily eliminate snow by surrounding solid-phase water with an airtight enclosure and decompressing within the enclosure. SOLUTION: An open part of a rubber bag 15 is attached to the lower end of an annular frame 12, and an open/close cover 11 is fitted to the upper part of the annular frame 12, thereby forming a sealed vessel. The side wall of the annular frame 12 is fitted with a conduit tube 17 having one end open to the inside of the frame 12 and the other end connected to a vacuum pump 16. Snow or ice is supplied to the rubber bag 15 and the open/close cover is closed, thereby being sealed between the cover and the annular fame 12. Then, the vacuum pump 16 is operated to evacuate and keep the sealed vessel in a vacuum condition. As a result, when the sealed vessel is internally decompressed, the atmosphere pushes and compresses the flexible rubber bag 15, and crushes the snow inside. In this case, a solid-phase easily changes to a gaseous-phase or liquid-phase, due to decompression, and vapors are discharged through the vacuum pump 16. Also, water stagnating in the rubber bag 12 is discharged by opening a valve 18 after stopping the operation of the vacuum pump 16 and making the internal pressure of the rubber bag 15 equal to the atmospheric pressure. According to this construction, solid-phase water can be efficiently eliminated.

10. 发明专利

JPH0937188A TELEVISION WITH OUTLET FOR GAME MACHINE FOR HOUSEHOLD 失效
公开(公告)号：JPH0937188A
公开(公告)日：1997-02-07
申请号：JP21512895
申请日：1995-07-19
申请人： YOSHIDA HITOSHI
发明人： YOSHIDA HITOSHI
IPC分类号： H04N7/18 , H04N5/64 , A63F9/22
摘要： PROBLEM TO BE SOLVED: To easily set a television channel to the channel of a game machine by controlling an outlet for the game machine and a video input terminal by a switch. SOLUTION: The video/audio output cord 7 of the game machine is connected to the video/audio input terminal 2 of this television 4 and then, a cord 6 for the power source of the game machine is connected to the outlet 1 for the game machine of the television 4. Then, when the switch 3 attached to the television 4 is pressed, the power of the television 4 is supplied, a current is made to flow to the outlet 1 for the game machine and the power of the game machine for a household is turned on. Then, video signals and audio signals inputted from the video/ audio input terminal 2 are outputted respectively from the screen and the speaker of the television 4. When the power source cord 6 and the video/audio cord 7 of the game machine 5 for the household are connected to the television 4, since the game machine 5 for the household can be used just by pressing the switch 3 of the television 4, the handling time of switching the channel is reduced. Also, the switch can turn off the power and interrupt the input of signals.

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