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1. 发明申请

WO2006017759A2 TUMOR ENDOTHELIAL MARKER-1 (TEM1) BINDING ANTIBODIES AND USES THEREOF 审中-公开
标题翻译：肿瘤内皮标记-1（TEM1）结合抗体及其应用
公开(公告)号：WO2006017759A2
公开(公告)日：2006-02-16
申请号：PCT/US2005/027938
申请日：2005-08-05
申请人： KIRIN BREWERY CO., LTD. , GENZYME CORPORATION , TEICHER, Beverly , ROBERTS, Bruce , KATAOKA, Shiro , TAHARA, Tomoyuki , HONMA, Nakayuki
发明人： TEICHER, Beverly , ROBERTS, Bruce , KATAOKA, Shiro , TAHARA, Tomoyuki , HONMA, Nakayuki
IPC分类号： A61K39/395
CPC分类号： C07K16/2851 , A61K2039/505 , C07K2317/21 , C07K2317/732 , C07K2317/734
摘要： The present invention relates to antibodies that bind tumor endothelial marker 1 (TEM1) and effectively inhibit angiogenesis, tumor growth, or both. Pharmaceutical compositions and uses thereof for the treatment of angiogenesis-associated diseases including cancer, polycystic kidney disease, diabetic retinopathy, age-related macular degenerations, rheumatoid arthritis, and psoriasis are also disclosed. Also disclosed are methods of identifying such antibodies by assessing (1) the inhibitory activity of candidate antibodies in proliferation and tube formation assays using endothelial cells, endothelial precursor cells and pericytes, and (2) the antibody-dependent cellular cytotoxic, phagocytosis, and complement-dependent cytotoxic activities of candidate antibodies.
摘要翻译：本发明涉及结合肿瘤内皮标志物1（TEM1）并有效抑制血管生成，肿瘤生长或两者的抗体。还公开了用于治疗血管生成相关疾病（包括癌症，多囊肾病，糖尿病性视网膜病，年龄相关性黄斑变性，类风湿性关节炎和牛皮癣）的药物组合物及其用途。还公开了通过评估（1）候选抗体在使用内皮细胞，内皮前体细胞和周细胞的增殖和管形成分析中的抑制活性和（2）抗体依赖性细胞毒性，吞噬作用和补体候选抗体的细胞毒活性。

2. 发明申请

WO2005086713A2 ROLE OF HUMAN ENDOTHELIAL PRECURSOR CELLS AND VASCULAR PERICYTES TUMOR IN ANGIOGENESIS 审中-公开
标题翻译：人类内皮祖细胞和血管炎患者血管生成的作用
公开(公告)号：WO2005086713A2
公开(公告)日：2005-09-22
申请号：PCT/US2005/007154
申请日：2005-03-04
申请人： KIRIN BREWERY CO., LTD. , GENZYME CORPORATION , TEICHER, Beverly , ROBERTS, Bruce , KATAOKA, Shiro , TAHARA, Tomoyuki , HONMA, Nakayuki
发明人： TEICHER, Beverly , ROBERTS, Bruce , KATAOKA, Shiro , TAHARA, Tomoyuki , HONMA, Nakayuki
IPC分类号： G01N33/50 , G01N33/53 , G01N33/574
CPC分类号： G01N33/5011 , C07K2317/732 , G01N33/5064
摘要： The present invention relates to methods of identifying such antibodies by assessing (1) the inhibitory activity of candidate antibodies in proliferation and tube formation assays using endothelial cells, endothelial precursor cells and pericytes, and (2) the antibody-dependent cellular cytotoxic, phagocytosis, and complement-dependent cytotoxic activities of candidate antibodies.
摘要翻译：本发明涉及通过评估（1）候选抗体在使用内皮细胞，内皮前体细胞和周细胞的增殖和管形成测定中的抑制活性，以及（2）抗体依赖性细胞毒性，吞噬作用，和候选抗体的补体依赖性细胞毒活性。

3. 发明申请

WO2004044156A2 TRANSGENIC UNGULATES HAVING REDUCED PRION PROTEIN ACTIVITY AND USES THEREOF 审中-公开
标题翻译：具有降低的朊蛋白活性的转基因组合物及其用途
公开(公告)号：WO2004044156A2
公开(公告)日：2004-05-27
申请号：PCT/US2003/035720
申请日：2003-11-10
申请人： HEMATECH, LLC , KIRIN BREWERY CO., LTD. , ROBL, James , KUROIWA, Yoshimi , COLLAS, Philippe , SULLIVAN, Eddie , KASINATHAN, Poothappillai , TOMIZUKA, Kazuma , ISHIDA, Isao
发明人： ROBL, James , KUROIWA, Yoshimi , COLLAS, Philippe , SULLIVAN, Eddie , KASINATHAN, Poothappillai , TOMIZUKA, Kazuma , ISHIDA, Isao
IPC分类号： C12N
CPC分类号： C12N15/8509 , A01K67/0271 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/072 , A01K2227/101 , A01K2267/01 , A01K2267/02 , C07K16/00 , C07K2317/12 , C07K2317/21 , C12N2800/30
摘要： The invention provides cloned transgenic ungulates (e.g., bovines) in which prion protein activity is reduced by one or more genetically engineered mutations. Desirably, these transgenic bovines are also genetically modified to express xenogenous (e.g., human) antibodies. Because of their resistance to prion-related diseases such as bovine spongiform encephalopy (also known as mad cow disease), these bovines are a safer source of human antibodies for pharmaceutical uses and safer source of agricultural products.
摘要翻译：本发明提供了克隆的转基因有蹄类动物（例如牛），其中朊病毒蛋白质活性被一种或多种基因工程突变降低。理想地，这些转基因牛也被遗传修饰以表达异种（例如人）抗体。由于它们对朊病毒相关疾病如牛海绵状脑病（也称为疯牛病）的抵抗力，这些牛是用于制药用途和更安全的农产品来源的更安全的人抗体来源。

4. 发明申请

WO1998029564A1 METHOD FOR JUDGING EARLY FLOCCULATION 审中-公开
标题翻译：评估早期絮凝的方法
公开(公告)号：WO1998029564A1
公开(公告)日：1998-07-09
申请号：PCT/JP1997004654
申请日：1997-12-17
申请人： KIRIN BREWERY CO., LTD. , NAKAMURA, Takashi , CHIBA, Kazuhiro
发明人： KIRIN BREWERY CO., LTD.
IPC分类号： C12Q01/40
CPC分类号： C12C1/00
摘要： A method by which the ability of untreated barley to cause early flocculation, i.e., whether or not a factor causing the early flocculation of yeast is present in untreated barley, can be judged much more easily in a shortened period as compared with the methods of the prior art. Specifically, a method for judging the ability of untreated barley to cause early flocculation by the fermentation test using yeast, which comprises adding an enzyme to the barley to conduct the enzymatic treatment of the barley, adding the product of the enzymatic treatment or a high-molecular fraction separated from the product to a synthetic wort to prepare a sample for the fermentation test, subjecting the sample to the fermentation test, and determining the turbidity of the sample after 48 hours for judging whether or not such a factor is present in the barley.
摘要翻译：未经处理的大麦能够引起早期絮凝的能力，即，在未处理的大麦中是否存在引起酵母早期絮凝的因素的方法，在缩短的时间内可以更容易地判断，与现有技术具体地说，一种判断未经处理的大麦通过使用酵母的发酵试验引起早期絮凝能力的方法，其包括向大麦中加入酶进行大麦的酶处理，加入酶处理的产物或高效液相色谱法，从产物分离成合成麦芽汁以制备用于发酵试验的样品，对样品进行发酵试验，并在48小时后测定样品的浊度，以判断这种因素是否存在于大麦中。

5. 发明申请

WO2006029045A2 ENDOTHELIAL CELL SPECIFIC ANTIBODIES AND USES THEREOF 审中-公开
标题翻译：内皮细胞特异性抗体及其用途
公开(公告)号：WO2006029045A2
公开(公告)日：2006-03-16
申请号：PCT/US2005/031453
申请日：2005-09-02
申请人： KIRIN BREWERY CO., LTD. , GENZYME CORPORATION , TEICHER, Beverly , ROBERTS, Bruce , KATAOKA, Shiro , HONMA, Nakayuki , YOSHIDA, Hitoshi
发明人： TEICHER, Beverly , ROBERTS, Bruce , KATAOKA, Shiro , HONMA, Nakayuki , YOSHIDA, Hitoshi
IPC分类号： C07K16/30
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/2851 , C07K2317/21 , C07K2317/73
摘要： Methods and compositions provided herein relate to the inhibition of proliferation, migration, and tubule formation of endothelial cells and are thus useful in treating angiogenesis associated diseases, including cancer, polycystic kidney disease, diabetic retinopathy, rheumatoid arthritis, and psoriasis. Disclosed are methods of inhibiting endothelial cell proliferation, migration, and tubule formation by administering an antibody specific for Tumor EndothPelial Markers (TEMs). Also disclosed are methods of inhibiting angiogenesis and tumor growth by administering a TEM-specific antibody and antibody compositions useful in such methods.
摘要翻译：本文提供的方法和组合物涉及抑制内皮细胞的增殖，迁移和小管形成，因此可用于治疗血管生成相关疾病，包括癌症，多囊肾病，糖尿病性视网膜病，类风湿性关节炎和牛皮癣。公开了通过施用针对肿瘤内侧标记（TEM）特异的抗体来抑制内皮细胞增殖，迁移和小管形成的方法。还公开了通过施用在这些方法中有用的TEM特异性抗体和抗体组合物来抑制血管发生和肿瘤生长的方法。

6. 发明公开

EP1488818A1 PREFILLED SYRINGE WITH PLUNGER BACKWARD MOVEMENT LIMITING MECHANISM 有权转让
标题翻译： VORGEFÜLLTESPRITZE MIT机制ZUREINSCHRÄNKUNGDERRÜCKWÄRTSBEWEGUNGDES KOLBENS
公开(公告)号：EP1488818A1
公开(公告)日：2004-12-22
申请号：EP03744519.4
申请日：2003-03-11
申请人： NIPPON BECTON DICKINSON COMPANY, LTD. , Kirin Brewery Co., Ltd.
发明人： HATO, Seiichi, c/o Nippon Becton Dickinson Co.Ltd
IPC分类号： A61M5/315
CPC分类号： A61M5/31501 , A61M5/31505 , A61M2005/3117 , A61M2005/3139 , A61M2005/31506 , A61M2005/31508
摘要： A risk of injection liquid contamination due to contact of injection liquid in an injection-liquid filled area in a barrel with the surface in an injection-liquid unfilled area in the barrel by causing a plunger of a prefilled syringe to be inadvertently withdrawn by mishandling which may leads to medical malpractice, is eliminated by the Invention. Withdrawal of a plunger 14 is limited by engagement of a barrel 12 in which a withdrawal-limiting member 48 is provided and a the plunger 14 in which a withdrawal-limiting member 54 is provided. As a result of this, contact of the injection liquid L prefilled to a liquid-filled area 32 in the barrel 12 with the surface of a liquid-unfilled area 34 in the barrel by withdrawal of the plunger 14 is prevented.
摘要翻译：由于注射液体在桶中的注入液体填充区域中的注入液体污染的风险与筒中注射液体未填充区域中的表面通过使预充式注射器的柱塞不经意地通过误操作而被撤销可能导致医疗事故，被本发明消除。柱塞14的抽出通过其中设置有抽出限制构件48的筒体12和设置有抽出限制构件54的柱塞14的接合来限制。结果，防止了预先填充到筒体12中的液体填充区域32的注射液体L与柱塞14中的液体未填充区域34的表面的接触。

7. 发明专利

JP2014162508A Multi chamber container 审中-公开
标题翻译：多室容器
公开(公告)号：JP2014162508A
公开(公告)日：2014-09-08
申请号：JP2013034716
申请日：2013-02-25
申请人： Kirin Brewery Co Ltd , 麒麟麦酒株式会社
发明人： ODA ASAMI , YANAGIDA NORIKO , NAGATANI AKIKO
IPC分类号： B65D81/32 , A61J1/05 , B65D30/22
摘要： PROBLEM TO BE SOLVED: To provide a multi chamber container in which contents in each of branched chambers are prevented from being accidentally mixed prior to use.SOLUTION: A multi chamber container 1 of the present invention comprises a storing chamber 5 formed by placing a strong seal part 4 around films 2 facing each other and a partition part 6 crossing the storing chamber 5 and separating the storing chamber 5 into a plurality of branched chambers 5a and 5b. In the multi chamber container, contents respectively filling the branched chambers 5a and 5b are mixed by opening of the partition part 6. The partition part 6 comprises at least two weak seal parts 6a arranged in parallel with an interval and a non sealed part 6b arranged between the weak seal parts 6a. There is at least one curved part 10 having a curve between the weak seal parts 6a.
摘要翻译：要解决的问题：提供一种多室容器，其中防止每个分支室中的内容物在使用前被意外混合。解决方案：本发明的多室容器1包括储存室5，其通过放置强力围绕彼此面对的膜2周围的密封部分4和与储存室5交叉并且将储存室5分离成多个分支室5a和5b的分隔部分6。在多室容器中，通过打开分隔部6，分别填充分支室5a和5b的内容物被混合。分隔部6包括至少两个与间隔平行布置的弱密封部6a和布置成不间断的非密封部6b 在弱密封部6a之间。至少有一个弯曲部分10在弱密封部分6a之间具有曲线。

8. 发明专利

JP2014125290A safety cover 有权
标题翻译：安全罩
公开(公告)号：JP2014125290A
公开(公告)日：2014-07-07
申请号：JP2012280892
申请日：2012-12-25
申请人： Kirin Brewery Co Ltd , 麒麟麦酒株式会社 , Kirin Engineering Co Ltd , キリンエンジニアリング株式会社
发明人： SASAZAKI HIROYUKI , ISHIBIKI MASAMI , MURAKAMI TOSHIHIRO , FUJIWARA YUICHIRO , KONDO TAKASHI , ISHII NAOTO
IPC分类号： B65G21/00
摘要： PROBLEM TO BE SOLVED: To provide a safety cover in which safety of an operator passing on a passage can be secured by covering the ceiling of the passage mounted as crossing a conveyor line installed in a plant below the conveyor line.SOLUTION: A safety cover, which is mounted at the ceiling part of a passage mounted below a conveyor line as crossing the conveyor line for passing of an operator, is mounted so as to cover both side surfaces of the conveyor frame 2 and the lower surface of the conveyor frame 2, and includes a cover body 11 constituted by a gutter-like thin plate comprising a plain plate part 11a and two side plate parts 11b, 11b bent upward from both side edges of the plain plate part 11a, and plural supporting members 12 which support the cover body 11 and are fixed to the conveyor frame 2. The plural support members 12 are made up of plate springs.
摘要翻译：要解决的问题：提供一种安全盖，其中可以通过覆盖安装在安装在输送线下方的工厂中的输送线安装的通道的天花板来确保通过通道的操作者的安全性。解决方案：安全盖安装在安装在输送线下方的通道的天花板部分上，以跨越输送线以使操作者通过，以便覆盖输送机框架2的两个侧表面和输送机框架2的下表面并且包括由平板部分11a和平板部分11a的两个侧边缘向上弯曲的两个侧板部分11b，11b的平滑板状薄板构成的盖体11，以及支撑该平板部分11a的多个支撑部件12，盖体11固定在输送机框架2上。多个支撑部件12由板簧构成。

9. 发明专利

JP2014110763A Brisk foam cereals decomposition product inclusion sparkling drink 有权
标题翻译： BRISK泡沫谷物分解产品包装SPARKLING DRINK
公开(公告)号：JP2014110763A
公开(公告)日：2014-06-19
申请号：JP2012026552
申请日：2012-02-09
申请人： Kirin Brewery Co Ltd , 麒麟麦酒株式会社
发明人： ENDO TOKUO , UENO SHINOBU , MIZUMOTO DAIKI , ASAKURA TAKASHI , SHIBATA HIROSHI
IPC分类号： C12G3/04 , A23L1/00 , C12H1/00
CPC分类号： A23G9/281 , A23G9/045 , A23G9/20 , A23L2/40 , A23P30/40 , C12C11/11
摘要： PROBLEM TO BE SOLVED: To provide a cereals decomposition product inclusion sparkling drink that is brisk texture and creamy, and forms a foam that is duration foam sustainability, and a new texture in which palatability is high when drinking; and a dispense method and a dispenser of the sparkling drink.SOLUTION: Provided is a dispensing method of a cereals decomposition product inclusion sparkling drink in which a cereals decomposition product inclusion sparkling drink is cooled, and provided being extracted in a container. The dispensing method is that a slurry that includes an extract freeze particle is formed by that a cereal decomposition product inclusion sparkling drink fluid is performed by cooling and agitation treatments, a freeze expanded material of the cereal decomposition product inclusion sparkling drink that includes an extract freeze particle and a fine air foam is prepared by that the slurry is performed by cooling, agitation and ambient air gas entrainment treatments, the prepared freeze expanded material of the cereal decomposition product inclusion sparkling drink is supplied to the cereal decomposition product inclusion sparkling drink that is extracted in the container as a foam component, thereby the cereal decomposition product inclusion sparkling drink that is brisk texture as snow and creamy, and forms a new texture foam that is duration foam sustainability is provided.
摘要翻译：要解决的问题：提供谷物分解产品包装起泡饮料，其质地柔软，乳脂状，并形成持续泡沫可持续性的泡沫，以及饮酒时适口性高的新质感; 以及喷射饮料的分配方法和分配器。解决方案：提供了一种谷物分解产品包装起泡饮料的分配方法，其中谷物分解产物包含起泡饮料被冷却并提供在容器中。分配方法是通过冷却和搅拌处理进行谷物分解产物包含起泡饮料的方法来形成包括提取物冻结颗粒的浆料，包括提取物冻结的谷物分解产物包含起泡饮料的冷冻膨胀材料通过冷却，搅拌和环境空气气体夹带处理进行浆料制备颗粒和细气泡沫，将制备的谷物分解产物夹杂物起泡饮料的冷冻膨胀材料供应到谷物分解产物夹杂物起泡饮料在容器中作为泡沫成分提取，由此提供谷物分解产物包含起泡饮料，其质地呈雪和奶油状，并且形成持续泡沫可持续性的新的质地泡沫。

10. 发明专利

JP2014108891A Transport device 审中-公开
标题翻译：运输设备
公开(公告)号：JP2014108891A
公开(公告)日：2014-06-12
申请号：JP2012265723
申请日：2012-12-04
申请人： Kirin Brewery Co Ltd , 麒麟麦酒株式会社
发明人： AKIYAMA CHIHIRO
IPC分类号： B65G47/28 , B65G21/20
摘要： PROBLEM TO BE SOLVED: To provide a transport device capable of saving the trouble to perform maintenance on a belt conveyor provided with arraying conveyors on both sides.SOLUTION: A transport device 1 including a transport conveyor 10 having a pair of belt conveyors 11 arranged in parallel and a pair of arraying conveyors 22 arranged on both sides of the transport conveyor 10 to be positioned by a can C includes a plurality of support members 3 supporting the respective arraying conveyors 22 so that the transport conveyor 10 has its sides made open so as to perform maintenance on the inside of the belt conveyor 11 and an opening part 4 for maintenance on the transport conveyor 10 is provided by the transport conveyor 10. The plurality of support members 3 support the pair of arraying conveyors 22 while leaving gaps 29 between the transport conveyor 10 and arraying conveyors 22.
摘要翻译：要解决的问题：提供一种能够节省对在两侧设置有排列输送机的带式输送机进行维护的运输装置。解决方案：一种运输装置1，其包括输送输送机10，输送机10具有布置在平行和布置在运输输送机10的两侧以由罐C定位的一对排列输送机22包括支撑各排列输送机22的多个支撑部件3，使得运输输送机10的侧面打开，以便为了在带式输送机11的内部进行维护，并且在运输输送机10上进行维护的开口部分4由输送输送机10提供。多个支撑部件3支撑一对排列输送机22，同时留下间隙29 运输输送机10和排列输送机22。

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