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1. 发明公开

EP3628006A1 COMPOSITIONS AND METHODS FOR TREATING RHEUMATOID ARTHRITIS 审中-实审
公开(公告)号：EP3628006A1
公开(公告)日：2020-04-01
申请号：EP18801432.8
申请日：2018-05-04
申请人： Generos Biopharma Ltd. , Fu, Xin-Yuan
发明人： FU, Xin-yuan
IPC分类号： A61K31/445 , A61K31/454 , A61P37/02

2. 发明专利

GB201907025D0 Device for drying out lawn clippings 未知
公开(公告)号：GB201907025D0
公开(公告)日：2019-07-03
申请号：GB201907025
申请日：2019-05-18
申请人： YANG YONG , YANG ANNA XIN YUAN

3. 发明申请

WO2021190641A1 METHODS FOR TREATING CYTOKINE STORM SYNDROME AND RELATED DISEASES 审中-公开
公开(公告)号：WO2021190641A1
公开(公告)日：2021-09-30
申请号：PCT/CN2021/083345
申请日：2021-03-26
申请人： FU, Xin-Yuan , LIU, Xinyu , ZHOU, Yi , LUFEI, Chengchen , GENEROS BIOPHARMA LTD.
发明人： FU, Xin-Yuan , LIU, Xinyu , ZHOU, Yi , LUFEI, Chengchen
IPC分类号： A61K31/454 , A61K31/357 , A61K31/366 , A61P29/00 , A61P31/12 , A61P11/00
摘要： Methods of treating cytokine storm syndrome and related diseases, including infectious diseases such as COVID-19 are provided. In particular, a method of treating cytokine storm syndrome (CSS) in a subject in need thereof comprising administering a therapeutically effective amount of a compound selected from the group consisting of pimozide, artemisinin and its derivatives, or a pharmaceutically acceptable salt, or a solvate thereof, to a subject in need thereof is provided.

4. 发明申请

WO2018213081A1 COMPOSITIONS AND METHODS FOR TREATING ALZHEIMER'S DISEASE 审中-公开
公开(公告)号：WO2018213081A1
公开(公告)日：2018-11-22
申请号：PCT/US2018/031901
申请日：2018-05-09
申请人： FU, Xin-Yuan , GENEROS BIOPHARMA LTD.
发明人： FU, Xin-Yuan
IPC分类号： A61K35/00 , A61K38/00 , A61K38/16 , A61K38/17 , A61K38/21 , A61K47/48 , C07K14/555 , C07K16/24
摘要： Disclosed are methods for treating or preventing or delaying outset of Alzheimer's disease (AD) in a subject by targeting the novel pathway STAT1-CH25H in AD pathogenesis, specifically by administering to the subject a pharmaceutically effective amount of a STAT1 inhibitor, a CH25H inhibitor, or a 25-OHC inhibitor, for example, a 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitor such as simvastatin.

5. 发明申请

WO2018213027A1 COMPOSITIONS AND METHODS FOR TREATING RHEUMATOID ARTHRITIS 审中-公开
公开(公告)号：WO2018213027A1
公开(公告)日：2018-11-22
申请号：PCT/US2018/031217
申请日：2018-05-04
申请人： FU, Xin-yuan , GENEROS BIOPHARMA LTD.
发明人： FU, Xin-yuan
IPC分类号： A61K31/445 , A61K31/454 , A61P37/02
摘要： Disclosed are methods and compositions for treating ore preventing a STAT5-mediated medical condition, e.g., rheumatoid arthritis, in a subject by administering to the subject a therapeutically effective amount of a compound, the compound being a STAT5 inhibitor, or a pharmaceutically acceptable salt of the STAT5 inhibitor, or a solvate of the STAT5 inhibitor, or a prodrug of the STAT5 inhibitor. In one example, the compound used in the methods and compositions is pimozide. In another example, the compound used in the methods and compositions is nicotinohydrazide.

6. 发明申请

US20180115766A1 3D IMAGE RECONSTRUCTION BASED ON LENSLESS COMPRESSIVE IMAGE ACQUISITION 审中-公开
公开(公告)号：US20180115766A1
公开(公告)日：2018-04-26
申请号：US15298580
申请日：2016-10-20
申请人： Xin Yuan , Hong Jiang , Gang Huang , Paul A. Wilford
发明人： Xin Yuan , Hong Jiang , Gang Huang , Paul A. Wilford
IPC分类号： H04N13/02 , G06T7/50 , G06K9/62 , H04N13/00
CPC分类号： H04N13/20 , G06T7/50 , H04N5/2226 , H04N5/2254 , H04N5/2258 , H04N13/128 , H04N13/243 , H04N13/254 , H04N13/271 , H04N2013/0081
摘要： The present disclosure generally discloses a three-dimensional (3D) image reconstruction capability. The 3D image reconstruction capability may be configured to support reconstruction of a 3D image of a scene. The 3D image reconstruction capability may be configured to support reconstruction of a 3D image of a scene based on lensless compressive image acquisition performed using a lensless compressive camera having a single aperture and a set of multiple sensors. The reconstructed 3D image of a scene may include (1) image data indicative of a set of multiple two-dimensional (2D) images reconstructed based on the set of multiple sensors of the lensless compressive camera (which may be represented as images) and (2) depth information indicative of depths at points or areas of an overlapping portion of the multiple images reconstructed based on the set of multiple sensors of the lensless compressive camera (which may be represented as a depth map).

7. 发明授权

US09064088B2 Computing device, storage medium and method for analyzing step formatted file of measurement graphics 有权
标题翻译：计算设备，存储介质和分析测量图形步骤格式化文件的方法
公开(公告)号：US09064088B2
公开(公告)日：2015-06-23
申请号：US13555085
申请日：2012-07-21
申请人： Chih-Kuang Chang , Xin-Yuan Wu , Bo Nie
发明人： Chih-Kuang Chang , Xin-Yuan Wu , Bo Nie
IPC分类号： G06F17/22 , G06F17/50
CPC分类号： G06F17/5086
摘要： A computing device performs a method to analyze a STEP (standardized exchange of product) formatted file of a measurement graphics, and to predefine one or more graphic keywords and graphics analysis modes in a storage device of the computing device. The method extracts a content keyword and a content character string from each line of the STEP formatted file, and analyzes the content keywords and the content character strings to obtain shell data of the graphic elements. The method further draws a geometrical shell of the measurement graphics according to the shell data using a curve meshing method, marks boundaries of the geometrical shell using an indication mark, and displays the measurement graphics with the indication mark on a display device of the computing device.
摘要翻译：计算设备执行分析测量图形的STEP（标准化交换产品）格式文件的方法，并且在计算设备的存储设备中预定义一个或多个图形关键字和图形分析模式。该方法从STEP格式化文件的每一行提取内容关键字和内容字符串，并分析内容关键字和内容字符串以获取图形元素的shell数据。该方法使用曲线网格划分法，根据壳数据绘制测量图形的几何外壳，使用指示标记标记几何外壳的边界，并在计算设备的显示设备上显示具有指示标记的测量图形。

8. 发明授权

US09030473B2 Computing device and method for determining distance between two curved surfaces 有权
标题翻译：用于确定两个曲面之间的距离的计算装置和方法
公开(公告)号：US09030473B2
公开(公告)日：2015-05-12
申请号：US13480481
申请日：2012-05-25
申请人： Chih-Kuang Chang , Xin-Yuan Wu , Min Wang
发明人： Chih-Kuang Chang , Xin-Yuan Wu , Min Wang
IPC分类号： G06T17/20 , G06T7/00 , G06F17/20 , G01B5/14 , G06F17/50
CPC分类号： G01B5/14 , G06F17/20 , G06F17/50 , G06T7/001 , G06T17/20 , G06T2207/30164
摘要： A computing device reads information in relation to a first curved surface and a second curved surface from a storage device, respectively meshes the first and second curved surfaces into a plurality of first and second triangles, and divides a parametric plane associated into a plurality of first grids, where each first grid corresponds to a small box in 3D space. The device determines associations between the first/second triangles of the two curved surfaces and the small boxes in the 3D space, determines a second triangle that is nearest to each first triangle of the first curved surface, and determines a distance between the first triangle and the second triangle as a minimum distance from the first triangle to the second curved surface. A minimum value from all of the minimum distances is determined as a minimum distance between the first curved surface and the second curved surface.
摘要翻译：计算设备从存储设备读取关于第一弯曲表面和第二弯曲表面的信息，分别将第一和第二曲面形成多个第一和第二三角形，并将与多个第一和第二三角形相关联的参数平面分割网格，其中每个第一个网格对应于3D空间中的一个小框。设备确定两个曲面的第一/第二三角形和3D空间中的小框之间的关联，确定最靠近第一曲面的每个第一三角形的第二个三角形，并确定第一个三角形和第二个三角形作为从第一个三角形到第二个曲面的最小距离。将所有最小距离的最小值确定为第一曲面和第二曲面之间的最小距离。

9. 发明授权

US08982127B2 Computing device and method for establishing three dimensional coordinate system using graphics 有权
标题翻译：使用图形建立三维坐标系的计算装置和方法
公开(公告)号：US08982127B2
公开(公告)日：2015-03-17
申请号：US13598786
申请日：2012-08-30
申请人： Chih-Kuang Chang , Xin-Yuan Wu , Wei Wang
发明人： Chih-Kuang Chang , Xin-Yuan Wu , Wei Wang
IPC分类号： G06T15/10
CPC分类号： G06T15/10 , G06F17/50 , G06T19/20 , G06T2219/2016
摘要： In a method for establishing a three-dimensional coordinate system, the method establishes an original coordinate system in a design drawing of a product, and draws a hollow cube. Faces of the hollow cube are marked with different directions. Using the hollow cube, the method calculates a first matrix for correcting the original coordinate system according to a selected plane from the design drawing. The method also calculates a second matrix for correcting the original coordinate system according to a selected line, and calculates a third matrix for correcting the original coordinate system according to a selected point or a center of a selected circle. By multiplying the three matrixes, a new matrix is generated to establish a new coordinate system, which is displayed on a display screen.
摘要翻译：在建立三维坐标系的方法中，该方法在产品的设计图中建立原始坐标系，并绘制中空立方体。中空立方体的表面标有不同的方向。使用中空立方体，该方法根据来自设计图的选定平面计算用于校正原始坐标系的第一矩阵。该方法还根据所选择的线计算用于校正原始坐标系的第二矩阵，并且根据所选择的圆的选定点或中心来计算用于校正原始坐标系的第三矩阵。通过乘以三个矩阵，生成一个新的矩阵来建立一个新的坐标系，显示在显示屏上。

10. 发明授权

US08855407B2 Electronic device and method for adjusting orientation of product model in machine coordinate system 有权
标题翻译：用于调整机器坐标系中产品型号方向的电子设备和方法
公开(公告)号：US08855407B2
公开(公告)日：2014-10-07
申请号：US13245876
申请日：2011-09-27
申请人： Chih-Kuang Chang , Xin-Yuan Wu , Wei Wang
发明人： Chih-Kuang Chang , Xin-Yuan Wu , Wei Wang
IPC分类号： G06K9/00 , G06K9/36 , G06K9/32 , G01B7/008 , G01B5/008 , G06F17/50
CPC分类号： G06F17/50 , G01B5/008 , G01B7/008
摘要： An electronic device and method creates a part coordinate system of a three-dimensional (3D) product model based on dimensional information in a two-dimensional (2D) drawing of the product, determines transformation matrices of the part coordinate system relative to a machine coordinate system of the measuring machine, and automatically adjusts the orientation of the product model in the machine coordinate system, to align the part coordinate system with the machine coordinate system.
摘要翻译：电子设备和方法基于产品的二维（2D）图中的尺寸信息创建三维（3D）产品模型的零件坐标系，确定零件坐标系相对于机床坐标的变换矩阵测量机系统，自动调整机器坐标系中产品型号的方向，使零件坐标系与机床坐标系对齐。

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