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1. 发明申请

WO2021190641A1 METHODS FOR TREATING CYTOKINE STORM SYNDROME AND RELATED DISEASES 审中-公开
公开(公告)号：WO2021190641A1
公开(公告)日：2021-09-30
申请号：PCT/CN2021/083345
申请日：2021-03-26
申请人： FU, Xin-Yuan , LIU, Xinyu , ZHOU, Yi , LUFEI, Chengchen , GENEROS BIOPHARMA LTD.
发明人： FU, Xin-Yuan , LIU, Xinyu , ZHOU, Yi , LUFEI, Chengchen
IPC分类号： A61K31/454 , A61K31/357 , A61K31/366 , A61P29/00 , A61P31/12 , A61P11/00
摘要： Methods of treating cytokine storm syndrome and related diseases, including infectious diseases such as COVID-19 are provided. In particular, a method of treating cytokine storm syndrome (CSS) in a subject in need thereof comprising administering a therapeutically effective amount of a compound selected from the group consisting of pimozide, artemisinin and its derivatives, or a pharmaceutically acceptable salt, or a solvate thereof, to a subject in need thereof is provided.

2. 发明公开

EP3960175A1 USE OF COMPOUND IN PREPARATION OF DRUG FOR TREATING ATHEROSCLEROSIS 审中-实审
公开(公告)号：EP3960175A1
公开(公告)日：2022-03-02
申请号：EP20796243.2
申请日：2020-04-24
申请人： Generos Biopharma Ltd.
发明人： FU, Xin-Yuan , LIU, Xinyu , ZHOU, Yi , LUFEI, Chengchen , LU, Cenbin
IPC分类号： A61K31/445 , A61K31/454 , A61P9/10
摘要： Disclosed is use of a compound in the preparation of a medicament for treating atherosclerosis. The compound is selected from a group consisting of a compound of formula I, Nib2 and a pharmaceutically acceptable salt thereof. Based on the mechanism of atherogenesis, the invention started with the inhibition of inflammatory reaction. The research results showed that the compounds disclosed herein can significantly inhibit the macrophage foaming, reduce the deposition of lipidic necrotic substances, and reduce the formation of plaques, thus to some extent delaying or inhibiting atherosclerosis.

3. 发明公开

EP3954374A1 PHARMACEUTICAL COMBINATION OF PIMOZIDE AND METHOTREXATE AND USE THEREOF 审中-公开
公开(公告)号：EP3954374A1
公开(公告)日：2022-02-16
申请号：EP20788031.1
申请日：2020-04-03
申请人： Generos Biopharma Ltd.
发明人： FU, Xin-Yuan , LUFEI, Chengchen , LIU, Xinyu , ZHOU, Yi
IPC分类号： A61K31/519 , A61K31/454 , A61P19/02 , A61P29/00
摘要： Disclosed are a pharmaceutical combination of pimozide and methotrexate and use thereof. The pharmaceutical combination comprises methotrexate, a pharmaceutically acceptable salt thereof, a solvate thereof, or a solvate of pharmaceutically acceptable salt thereof, and pimozide, a pharmaceutically acceptable salt thereof, a solvate thereof, or a solvate of pharmaceutically acceptable salt thereof. The pharmaceutical combination can be used for the treatment of rheumatoid arthritis.

4. 发明公开

EP4234544A1 FUSED RING-CONTAINING COMPOUND, APPLICATION THEREOF, AND COMPOSITION CONTAINING SAME 审中-实审
公开(公告)号：EP4234544A1
公开(公告)日：2023-08-30
申请号：EP21882143.7
申请日：2021-10-22
申请人： Generos Biopharma Ltd.
发明人： LU, Cenbin , XU, Xiao , CAI, Zehong , FU, Xinyuan , LUFEI, Chengchen , LIU, Xinyu , MA, Zhongnan , RONG, Frank , ZHOU, Yi
IPC分类号： C07D401/02 , C07D401/14 , A61K31/445 , A61K31/454 , A61P19/04 , A61P9/10
摘要： A fused ring-containing compound, an application thereof, and a composition containing same, and specifically, a fused ring-containing compound represented by formula II, a pharmaceutically acceptable salt or solvate thereof, or a solvate of said pharmaceutically acceptable salt. The compound has good STATS inhibitory activity.

5. 发明公开

EP3960736A1 HETEROCYCLIC COMPOUND, APPLICATION THEREOF, AND COMPOSITION CONTAINING SAME 审中-公开
公开(公告)号：EP3960736A1
公开(公告)日：2022-03-02
申请号：EP20794013.1
申请日：2020-04-26
申请人： Generos Biopharma Ltd.
发明人： FU, Xin-Yuan , LU, Cenbin , LIU, Xinyu , LUFEI, Chengchen , ZHOU, Yi
IPC分类号： C07D403/02 , C07D413/02 , A61K31/445 , A61K31/454 , A61P37/02 , A61P29/00 , A61P19/02
摘要： A heterocyclic compound represented by formula XI, a pharmaceutically acceptable salt, a solvate, or a solvate of a pharmaceutically acceptable salt thereof, use thereof, and a composition containing the same. The compound is novel in structure and has good STAT5 inhibitory activity.

6. 发明公开

EP4125894A1 METHODS FOR TREATING CYTOKINE STORM SYNDROME AND RELATED DISEASES 审中-实审
公开(公告)号：EP4125894A1
公开(公告)日：2023-02-08
申请号：EP21775162.7
申请日：2021-03-26
申请人： Generos Biopharma Ltd.
发明人： ZHOU, Yi , FU, Xin-Yuan , LIU, Xinyu , LUFEI, Chengchen
IPC分类号： A61K31/454 , A61K31/357 , A61K31/366 , A61P29/00 , A61P31/12 , A61P11/00

7. 发明公开

EP3964212A1 COMPOUND FOR TREATING AUTOIMMUNE SKIN DISEASES CAUSED BY INFLAMMATION, AND USE THEREOF 审中-公开
公开(公告)号：EP3964212A1
公开(公告)日：2022-03-09
申请号：EP20799197.7
申请日：2020-04-30
申请人： Generos Biopharma Ltd.
发明人： FU, Xin-Yuan , LUFEI, Chengchen , LIU, Xinyu , ZHOU, Yi
IPC分类号： A61K31/454 , A61P37/00 , A61P17/00 , A61P17/06
摘要： Disclosed is a compound, a medicament, and a pharmaceutical composition for treating inflammation induced autoimmune skin diseases, for example psoriasis. The compound is Nib1, a pharmaceutically acceptable salt thereof, a solvate thereof, a solvate of a pharmaceutically acceptable salt thereof, or a crystal form thereof. The compound Nib1 has a chemical formula of C 28 H 29 F 2 N 3 O. It represents a new treatment mechanism and can effectively treat inflammation induced autoimmune skin diseases, for example, non-specific dermatitis such as psoriasis, with less side effects and convenient route of administration, achieving a balance between safety and effectiveness. The compounds can be used for a long time and improve the quality of life of patients. The compounds, medicament, and pharmaceutical compositions can significantly improve clinical symptoms of inflammation induced autoimmune skin diseases, such as non-specific dermatitis such as psoriasis, such as skin rash, skin peeling, skin thickening, and epidermal hyperplasia, improve blood vessel dilation, reduce immune cell infiltration, and etc.

8. 发明公开

EP2389452A2 METHODS FOR AMPLIFYING HEPATITIS C VIRUS NUCLEIC ACIDS 审中-公开
标题翻译：丙型肝炎病毒NUCLEIC的方法扩增
公开(公告)号：EP2389452A2
公开(公告)日：2011-11-30
申请号：EP10703544.6
申请日：2010-01-21
申请人： Vertex Pharmaceuticals Incorporated , Kwong, Ann D. , Frantz, James Daniel , Bartels, Douglas J. , Lin, Chao , Shames, Benjamin , Seepersaud, Sheila , Lippke, Judith A. , Kieffer, Tara L. , Zhou, Yi , Zhang, Eileen Z. , Sullivan, James C.
发明人： KWONG, Ann, D. , FRANTZ, James, Daniel , BARTELS, Douglas, J. , LIN, Chao , SHAMES, Benjamin , SEEPERSAUD, Sheila , LIPPKE, Judith, A. , KIEFFER, Tara, L. , ZHOU, Yi , ZHANG, Eileen, Z. , SULLIVAN, James, C.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/707 , C12Q1/6883
摘要： A method of amplifying an HCV nucleic acid in an HCV infected sample comprises amplifying a segment of a DNA template that is complementary to a genome of HCV RNA from the sample by a two-stage PCR, wherein a first stage PCR employs a first outer primer and a second outer primer, and a second stage PCR employs a first inner primer and a second inner primer. The nucleotide sequence of the first outer primer comprises a nucleotide sequence as set forth in SEQ ID NO: 2; or SEQ ID NO:9, wherein optionally 1, 2 or 3 nucleotides are other nucleotides than those of SEQ ID NO: 9. The nucleotide sequence of the second outer primer comprises a nucleotide sequence set forth in SEQ ID NO: 3 or 4; or a nucleotide sequence as set forth in SEQ ID NO: 10 or 11, wherein optionally 1, 2 or 3 nucleotides are other nucleotides than those of SEQ ID NO: 10 and 11. The nucleotide sequence of the first inner primer comprises a nucleotide sequence as set forth in SEQ ID NO: 5; or SEQ ID NO: 12, wherein optionally 1, 2 or 3 nucleotides are other nucleotides than those of SEQ ID NO: 12. The nucleotide sequence of the second inner primer comprises a nucleotide sequence as set forth in SEQ ID NO: 6 or 7; or a nucleotide sequence as set forth in SEQ ID NO: 13 or 14, wherein optionally 1, 2 or 3 nucleotides are other nucleotides than those of SEQ ID NO: 13 and 14.

9. 发明申请

WO2015168857A1 CAPACITIVE TOUCH SENSOR AND METHOD 审中-公开
标题翻译：电容触摸传感器和方法
公开(公告)号：WO2015168857A1
公开(公告)日：2015-11-12
申请号：PCT/CN2014/076848
申请日：2014-05-06
申请人： TEXAS INSTRUMENTS INCORPORATED , ZHANG, Jun , SHEN, Ge , XU, Kangcheng , ZHOU, Yi , MENG, Hao , JI, Rujun
发明人： ZHANG, Jun , SHEN, Ge , XU, Kangcheng , ZHOU, Yi , MENG, Hao , JI, Rujun
IPC分类号： G06F3/044
CPC分类号： G06F3/044 , H03K17/9622 , H03K2017/9613 , H03K2217/96066
摘要： A capacitive touch sensor (600) is disclosed for use with input signal. The capacitive touch sensor (600) includes a number n of input/output lines (602, 604, 606, 608, 610, 612, 614, and 616). Each of the number n of input/output lines(602, 604, 606, 608, 610, 612, 614, and 616) is electrically disconnected from every other of the number n of input/output lines. Each of the number n of input/output lines (602, 604, 606, 608, 610, 612, 614, and 616) is arranged to cross every other of the number n of input/output lines. Each of a number β of positions (618), includes one of the number n of input/output lines crossing another of the number n of input/output lines.
摘要翻译：公开了与输入信号一起使用的电容式触摸传感器（600）。电容式触摸传感器（600）包括数量为n的输入/输出线（602,604,606,608,610,612,614和616）。 n个输入/输出线（602,604,606,608,610,612,614和616）中的每一个与n个输入/输出线中的每一个电气断开。 n个输入/输出线（602,604,606,608,610,612,614和616）中的每一个被布置成与n个输入/输出线中的每一个相交。位置（618）的数量β中的每一个包括与n个输入/输出线中的另一个的输入/输出线数量n中的一个。

10. 发明申请

WO2018002233A1 A VEHICLE RADAR FOR ENVIRONMENTAL DETECTION 审中-公开
标题翻译：用于环境检测的车载雷达
公开(公告)号：WO2018002233A1
公开(公告)日：2018-01-04
申请号：PCT/EP2017/066152
申请日：2017-06-29
申请人： AUTOLIV DEVELOPMENT AB , MARSCH, Sebastian , ZHOU, Yi
发明人： MARSCH, Sebastian , ZHOU, Yi
IPC分类号： G01S13/34 , G01S13/93 , G01S13/90 , G01S13/02 , G01S7/35
摘要： The present disclosure relates to a vehicle FMCW Doppler radar system (3) comprising a transmitter arrangement (4), a receiver arrangement (7) and at least one control unit (15). The radar system (3) is arranged to transmit signals (11), to receive reflected signals (12), and to obtain a plurality of measure results from the received reflected signals (12) along a main field of view (10) during at least two radar cycles where each radar cycle comprising a plurality of FMCW ramps. For each radar cycle, the control unit (15) is arranged to form a spectrum density map (30) from measuring points (14) along the main field of view (10), where each measure result results in a measuring point (14). The control unit (15) is arranged to combine at least two spectrum density maps to form a combined spectrum density map. The present disclosure also relates to a corresponding method.
摘要翻译：本公开涉及包括发射器装置（4），接收器装置（7）和至少一个控制单元（15）的车辆FMCW多普勒雷达系统（3）。雷达系统（3）被布置成发送信号（11），接收反射信号（12），并且在从上方在主视场（10）期间从接收到的反射信号（12）获得多个测量结果至少两个雷达循环，其中每个雷达循环包括多个FMCW斜坡。对于每个雷达循环，控制单元（15）被布置成沿着主视场（10）从测量点（14）形成谱密度图（30），其中每个测量结果导致测量点（14）。控制单元（15）被配置为组合至少两个频谱密度图以形成组合的频谱密度图。本公开还涉及相应的方法。

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