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1. 发明申请

US20070292912A1 Diffusion-controlling sensor layer 审中-公开
标题翻译：扩散控制传感器层
公开(公告)号：US20070292912A1
公开(公告)日：2007-12-20
申请号：US11893800
申请日：2007-08-16
申请人： Wolfgang Kreiss , Gunther Eberz , Claus Weisemann , Klaus Burger
发明人： Wolfgang Kreiss , Gunther Eberz , Claus Weisemann , Klaus Burger
IPC分类号： C12Q1/68
CPC分类号： G01N33/5008 , C12Q1/18 , G01N21/76 , G01N33/558
摘要： The invention relates to a diffusion-controlling sensor layer for detecting the biological effect of substances consisting of a diffusion-controlling matrix and sensors suspended therein. The invention further comprises a method and an apparatus for the location-dependent detection of the biological effect of substances using the sensor layer according to the invention (“imaging” of the spatial distribution of biological activity). A further embodiment of the method according to the invention relates to the coupling of investigations of the biological activity of substances with chromatographic and electrophoretic separation techniques so that biologically active individual substances can be identified directly in mixtures. An additional embodiment of the method according to the invention comprises the direct combination of the detection of the effect via sensor layers with chromatographic and electrophoretic separation techniques which are in turn coupled to spectroscopic techniques. This close coupling of substance separation, detection of effect and spectroscopy directly provides results on the structure of the biologically active substances in a mixture of substances.
摘要翻译：本发明涉及一种扩散控制传感器层，用于检测由扩散控制基质和悬浮在其中的传感器组成的物质的生物学效应。本发明还包括用于使用根据本发明的传感器层（“成像”生物活性的空间分布）的物质的位置相关检测物质的生物学效应的方法和装置。根据本发明的方法的另一个实施方案涉及物质生物活性的研究与色谱和电泳分离技术的偶联，使得生物活性的个体物质可以直接在混合物中鉴定。根据本发明的方法的另外的实施例包括通过传感器层检测效应与色谱和电泳分离技术的直接组合，这些技术又耦合到光谱技术。物质分离的紧密耦合，效应和光谱的检测直接提供了物质混合物中生物活性物质结构的结果。

2. 发明申请

US20070154978A1 Method and device for detecting biologically active substances 失效
标题翻译：用于检测生物活性物质的方法和装置
公开(公告)号：US20070154978A1
公开(公告)日：2007-07-05
申请号：US11711560
申请日：2007-02-27
申请人： Wolfgang Kreiss , Gunther Eberz , Hans-Georg Rast , Claus Weisemann
发明人： Wolfgang Kreiss , Gunther Eberz , Hans-Georg Rast , Claus Weisemann
IPC分类号： C12Q1/18 , C12N1/20
CPC分类号： C12Q1/025 , C12Q1/04 , Y10S435/975
摘要： This application claims a method for detecting biologically active substances, comprising the following steps a) providing a support carrying substances to be tested b) providing a suspension containing luminescent microorganisms, c) coating the support with the suspension of microorganisms, d) detecting the biologically active substances on the support by detecting the change in luminescence of the suspension of microorganisms, and e) stimulating the luminescence of the microorganisms before or during detection, and/or f) extending the period of luminescence of the microorganisms by employing substances for regulating and extending the period of luminescence of the microorganisms.
摘要翻译：本申请要求一种用于检测生物活性物质的方法，包括以下步骤：a）提供携带待测物质的载体b）提供含有发光微生物的悬浮液，c）用微生物悬浮液涂覆载体，d）通过检测微生物悬浮液的发光变化，并且e）在检测前或检测期间刺激微生物的发光，和/或f）通过使用用于调节和调节微生物的物质来延长微生物的发光期延长微生物的发光时间。

3. 发明授权

US06238928B1 Analytical process for testing mixtures for toxic constituents 失效
标题翻译：用于测试有毒成分混合物的分析方法
公开(公告)号：US06238928B1
公开(公告)日：2001-05-29
申请号：US08116382
申请日：1993-09-02
申请人： Claus Weisemann , Wolfgang Kreiss , Hans-Georg Rast , Günther Eberz
发明人： Claus Weisemann , Wolfgang Kreiss , Hans-Georg Rast , Günther Eberz
IPC分类号： G01N3090
CPC分类号： C12Q1/025 , G01N2520/00 , Y10T436/255
摘要： The mixture to be tested for toxic components is first separated into fractions by chromatography. The separated fractions are then contacted with luminescent microorganisms in the chromatographic system itself and the toxicity of the fractions is determined by measurement of the bioluminescence. The chromatographic separation may be carried out either by thin layer chromatography or by column liquid chromatography.
摘要翻译：待测试有毒成分的混合物首先通过色谱法分离成级分。然后将分离的级分与色谱系统中的发光微生物本身接触，并通过测量生物发光来测定级分的毒性。色谱分离可以通过薄层色谱法或通过柱色谱法进行。

4. 发明授权

US4772635A Bead-shaped crosslinked copolymers containing epoxide groups and basic amino groups, a process for their preparation and their use 失效
标题翻译：包含环氧基团和碱性氨基的珠状交联共聚物，其制备方法及其应用
公开(公告)号：US4772635A
公开(公告)日：1988-09-20
申请号：US934877
申请日：1986-11-25
申请人： Alfred Mitschker , Peter M. Lange , Wolfgang Kreiss
发明人： Alfred Mitschker , Peter M. Lange , Wolfgang Kreiss
IPC分类号： B01J20/281 , B01J20/26 , B01J20/285 , B01J41/14 , C07K1/16 , C07K16/00 , C08F2/16 , C08F2/22 , C08F2/44 , C08F16/14 , C08F16/26 , C08F20/32 , C08F20/34 , C08F20/36 , C08F216/14 , C08F220/32 , C08F220/36 , C08G59/50 , C08L101/00 , C08L101/06 , C12N11/08 , G01N30/88 , C08C19/22 , C08F24/00
CPC分类号： B01J20/261 , B01J20/26 , B01J20/267 , B01J41/14 , C08F216/1416 , C08F220/32 , C12N11/08
摘要： The invention relates to new bead-shaped crosslinked macroporous copolymers containing epoxide groups and basic amino groups, which are obtainable by reacting polymerizable glycidyl compounds, before or during free radical bead polymerization, which is carried out in the presence of agents which impart porosity and, if appropriate, with the addition of polyvinyl compounds which can be polymerized by free radical polymerization, with amines which are capable of reacting with at least two epoxide groups, a process for their preparation and their use, for example, for binding biologically active substances, for the preparation of strongly basic anion exchangers and hydrophilic chromatography resins for biomaterials.
摘要翻译：本发明涉及包含环氧基团和碱性氨基的新的珠状交联的大孔共聚物，其可通过可聚合的缩水甘油基化合物在自由基珠子聚合之前或期间获得，其在赋予孔隙率的试剂存在下进行，如果合适，加入可以通过自由基聚合聚合的聚乙烯基化合物与能够与至少两个环氧基团反应的胺，其制备方法及其用途，例如结合生物活性物质，用于制备用于生物材料的强碱性阴离子交换剂和亲水层析树脂。

5. 发明授权

US4524205A Process for the preparation of 1-amino-1,3,5-triazine-2,4(1H,3H)-diones 失效
标题翻译： 1-氨基-1,3,5-三嗪-2,4（1H，3H） - 二酮的制备方法
公开(公告)号：US4524205A
公开(公告)日：1985-06-18
申请号：US544334
申请日：1983-10-21
申请人： Gerhard Bonse , Reinhard Lantzsch , Henning Dorr , Wolfgang Kreiss , Karlfried Dickore , Klaus Ditgens , Eckart Kranz
发明人： Gerhard Bonse , Reinhard Lantzsch , Henning Dorr , Wolfgang Kreiss , Karlfried Dickore , Klaus Ditgens , Eckart Kranz
IPC分类号： A01N43/64 , C07D213/20 , C07D251/38 , C07D251/26
CPC分类号： C07D213/20 , A01N43/64 , C07D251/38
摘要： A process for the preparation of a herbicidally active 1-amino-1,3,5-triazone-2,4 (1H,3H)-dione of the formula ##STR1## comprising in a first stage at a temperature from about 0.degree. to 100.degree. C. reacting an isocyanate of the formulaR.sup.1 - NCO (II)with an isothio semicarbazone of the tautomeric formulas ##STR2## in which R.sup.3 and R.sup.4 each independently is hydrogen, alkyl, cycloalkyl, aralkyl o alkyl, cycloalkyl, aralkyl or aryl,thereby to form a urea derivative of the tautomeric formulas ##STR3## in a second stage at a temperature between about -50.degree. and 0.degree. C. reacting the urea derivative with phosgene (COCl.sub.2) in the presence of an auxiliary organic base and in the presence of a diluent, at least about 2 mols of phosgene and at least about 2 mols of the auxiliary base being used per mol of urea derivative, thereby to form a 1-alkylideneamino-1,3,5-triazine-2,4(1H,3H)-dione of the formula V ##STR4## and in a third stage converting the 1-alkylideneamino group to a 1-amino group.
摘要翻译：制备式（I）的除草活性1-氨基-1,3,5-三嗪-2,4（1H，3H） - 二酮的方法，其包含在第一阶段中在约使式R 1 -NCO（II）的异氰酸酯与互变异构结构式（III）的异噻唑烷酮反应，其中R 3和R 4各自独立地为氢，烷基，环烷基，芳烷基烷基，环烷基，芳烷基或芳基，从而在约-50℃至0℃的温度下在第二阶段中形成互变异构体式（IV）的脲衍生物。将脲衍生物与光气（COCl 2）在辅助有机碱的存在和在稀释剂存在下，每摩尔脲衍生物使用至少约2摩尔的光气和至少约2摩尔的辅助碱，从而形成1-亚烷基氨基-1，（V）的3,5-三嗪-2,4（1H，3H） - 二酮，在第一阶段将1-亚烷基氨基转化为1-氨基没有组。

6. 发明申请

US20060142359A1 Cyclopenta[c]isoxazole-3-amines used as protective agents for materials 审中-公开
标题翻译：环戊二烯[c]异恶唑-3-胺用作材料的保护剂
公开(公告)号：US20060142359A1
公开(公告)日：2006-06-29
申请号：US10537242
申请日：2003-11-22
申请人： Rainer Bruns , Gunther Eberz , Wolfgang Kreiss , Oliver Kretschik , Martin Kugler , Hermann Uhr , Erasmus Vogl , Peter Wachtler
发明人： Rainer Bruns , Gunther Eberz , Wolfgang Kreiss , Oliver Kretschik , Martin Kugler , Hermann Uhr , Erasmus Vogl , Peter Wachtler
IPC分类号： A01N43/80 , C09D5/16 , C07D261/20
CPC分类号： C07D261/20 , A01N43/80 , A01N47/36
摘要： The novel 2-oxyamino-1-cyclopentene-1-nitriles of the formula (I) in which the substituents R1 and R2 are as defined in the description are highly suitable for protecting industrial materials against infestation and destruction by microorganisms.
摘要翻译：其中取代基R 1和R 2的式（I）的新型2-羟基-1-环戊烯-1-腈如说明书中所定义是高度的适用于保护工业材料免受微生物的侵袭和破坏。

7. 发明授权

US07695900B2 Method and device for detecting biologically active substances 失效
标题翻译：用于检测生物活性物质的方法和装置
公开(公告)号：US07695900B2
公开(公告)日：2010-04-13
申请号：US11711560
申请日：2007-02-27
申请人： Wolfgang Kreiss , Guenther Eberz , Hans-Georg Rast , Claus Weisemann
发明人： Wolfgang Kreiss , Guenther Eberz , Hans-Georg Rast , Claus Weisemann
IPC分类号： C12Q1/00 , C12Q1/66
CPC分类号： C12Q1/025 , C12Q1/04 , Y10S435/975
摘要： This application claims a method for detecting biologically active substances, comprising the following steps a) providing a support carrying substances to be tested b) providing a suspension containing luminescent microorganisms, c) coating the support with the suspension of microorganisms, d) detecting the biologically active substances on the support by detecting the change in luminescence of the suspension of microorganisms, and e) stimulating the luminescence of the microorganisms before or during detection, and/or f) extending the period of luminescence of the microorganisms by employing substances for regulating and extending the period of luminescence of the microorganisms.
摘要翻译：本申请要求一种用于检测生物活性物质的方法，包括以下步骤：a）提供携带待测物质的载体b）提供含有发光微生物的悬浮液，c）用微生物悬浮液涂覆载体，d）通过检测微生物悬浮液的发光变化，并且e）在检测前或检测期间刺激微生物的发光，和/或f）通过使用用于调节和调节微生物的物质来延长微生物的发光期延长微生物的发光时间。

8. 发明申请

US20080169431A1 METHOD AND DEVICE FOR DETECTING PHOTOSYNTHETIC INHIBITION 审中-公开
标题翻译：用于检测光合作用抑制的方法和装置
公开(公告)号：US20080169431A1
公开(公告)日：2008-07-17
申请号：US11962677
申请日：2007-12-21
申请人： Wolfgang Kreiss , Mark Wilhelm Drewes , Gunther Eberz , Norbert Caspers
发明人： Wolfgang Kreiss , Mark Wilhelm Drewes , Gunther Eberz , Norbert Caspers
IPC分类号： F21K2/00
CPC分类号： G01N33/5097 , C12Q1/025
摘要： This invention relates to systems and test strips for detecting the photosynthesis-inhibitory activity of substances by providing cells or cell parts with an intact photosystem, introducing the cells or cell parts into a planar layer, applying the test substance to the planar layer or into the planar layer, excitation of the luminescence of the cells or cell parts in the planar layer by an excitation light source, measuring the luminescence of the cells or the cell parts in the planar layer by means of a detector, and associating the detector signal with the degree of photosynthesis inhibition.
摘要翻译：本发明涉及用于通过向细胞或细胞部分提供完整的光系统来检测物质的光合作用抑制活性的系统和测试条，将细胞或细胞部分引入平面层，将测试物质施加到平面层或进入平面层，通过激发光源激发平面层中的单元或单元部分的发光，通过检测器测量平面层中的单元或单元部分的发光，以及将检测器信号与光合作用抑制程度。

9. 发明授权

US07183113B2 Method and device for detecting biologically active substances 失效
标题翻译：用于检测生物活性物质的方法和装置
公开(公告)号：US07183113B2
公开(公告)日：2007-02-27
申请号：US10424067
申请日：2003-04-25
申请人： Wolfgang Kreiss , Guenther Eberz , Hans-Georg Rast , Claus Weisemann
发明人： Wolfgang Kreiss , Guenther Eberz , Hans-Georg Rast , Claus Weisemann
IPC分类号： G01N33/53
CPC分类号： C12Q1/025 , C12Q1/04 , Y10S435/975
摘要： The invention claimed herein is a kit for detecting biologically active substances on a support, comprising the luminescent marine bacteria Vibria Fischeri in a form stabilized for transport and storage, one or more cultivation media or the individual components of cultivation media for the microorganism wherein the cultivation media contains 100 mg/l to 500 mg/l of aspartic acid, and optionally additives for extending the period of luminescence selected from N-acylhomoserine lactones, dipeptides, oligopeptides, or their biochemical precursors, and boron compounds.
摘要翻译：本文所要求的发明是用于检测载体上的生物活性物质的试剂盒，其包含以稳定运输和储存的形式的发光海洋细菌Vibria Fischeri，一种或多种培养基或微生物培养基的各组分，其中培养培养基含有100mg / l至500mg / l的天冬氨酸，以及任选的用于延长选自N-酰基高丝氨酸内酯，二肽，寡肽或其生化前体的发光期和硼化合物的添加剂。

10. 发明授权

US06723333B1 Moulded bodies made of thermoplastic polyurethane containing an active substance 失效
标题翻译：由含有活性物质的热塑性聚氨酯制成的模制体
公开(公告)号：US06723333B1
公开(公告)日：2004-04-20
申请号：US09646339
申请日：2000-09-15
申请人： Reinhard Albers , Ralf Dujardin , Heinz Pudleiner , Joachim Simon , Günther Eberz , Wolfgang Kreiss , Christina Krasemann-Sharma
发明人： Reinhard Albers , Ralf Dujardin , Heinz Pudleiner , Joachim Simon , Günther Eberz , Wolfgang Kreiss , Christina Krasemann-Sharma
IPC分类号： A61L2900
CPC分类号： C08G18/12 , A61L29/06 , A61L29/16 , A61L2300/406 , C08G18/6674 , C08K5/0058 , C08L75/04 , C08G18/3234
摘要： The invention provides moulded items made from thermoplastic polyurethanes (TPUs), in particular medical articles such as central venous catheters which contain a homogeneous distribution of antibiotic substances, a process for the preparation thereof and preparation of the active substance-containing TPUs.
摘要翻译：本发明提供由热塑性聚氨酯（TPU）制成的模制品，特别是包含抗生素物质的均匀分布的中心静脉导管的医疗制品，其制备方法和含活性物质的TPU的制备。

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