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1. 发明申请

US20060010513A1 Oligonucleotide arrays to monitor gene expression and methods for making and using same 审中-公开
标题翻译：用于监测基因表达的寡核苷酸阵列及其制备和使用方法
公开(公告)号：US20060010513A1
公开(公告)日：2006-01-12
申请号：US11128049
申请日：2005-05-11
申请人： Mark Melville , Timothy Charlebois , William Mounts , Louane Hann , Martin Sinacore , Mark Leonard , Eugene Brown , Christopher Miller , Gene Lee
发明人： Mark Melville , Timothy Charlebois , William Mounts , Louane Hann , Martin Sinacore , Mark Leonard , Eugene Brown , Christopher Miller , Gene Lee
IPC分类号： A01H1/00 , C12N15/82
CPC分类号： C07K14/47 , C12Q1/6837 , C12Q1/6876 , C12Q2600/158
摘要： The present invention provides an oligonucleotide array capable of identifying genes and related pathways involved with the induction of a particular phenotype by a cell line, e.g., the genes and related pathways involved with the induction of transgene expression by the cell line. The invention is particularly useful when there is little or no information about the genome of the cell line being studied, because it provides methods for identifying consensus sequences for known and previously undiscovered genes, and for designing oligonucleotide probes to the identified consensus sequences. Additionally, when the array is to be used to determine optimal conditions for expression of a transgene by the cell line, the invention teaches methods of including oligonucleotide probes to transgene sequences in the array. The invention also provides methods of using the array to identify genes and related pathways involved with the induction of a particular cell line phenotype. The invention also provides novel polynucleotides of undiscovered genes (i.e., a gene that had not been sequenced and/or shown to be expressed by CHO cells) and novel polynucleotides involved with the induction of a particular cell phenotype, e.g., increased survival when grown under stressful culture conditions, increased transgene expression, decreased production of an antigen, etc. These novel polynucleotides are termed novel CHO sequences and differential CHO sequences, respectively. The invention also provides genetically engineered expression vectors, host cells, and transgenic animals comprising the novel nucleic acid molecules of the invention. The invention additionally provides antisense and RNAi molecules to the nucleic acid molecules of the invention. The invention further provides methods of using the polynucleotides of the invention.
摘要翻译：本发明提供了能够鉴定涉及通过细胞系诱导特定表型的基因和相关途径的寡核苷酸阵列，例如涉及通过细胞系诱导转基因表达的基因和相关途径。当关于正在研究的细胞系的基因组的信息很少或没有信息时，本发明是特别有用的，因为它提供了用于鉴定已知和先前未被发现的基因的共有序列的方法，以及为所识别的共有序列设计寡核苷酸探针。另外，当该阵列用于确定由细胞系表达转基因的最佳条件时，本发明教导了将阵列中的转基因序列包含寡核苷酸探针的方法。本发明还提供了使用该阵列鉴定涉及诱导特定细胞系表型的基因和相关途径的方法。本发明还提供未被发现的基因的新型多核苷酸（即，未被测序和/或显示由CHO细胞表达的基因）和参与特定细胞表型诱导的新型多核苷酸，例如当在下面生长时增加的存活压力培养条件，转基因表达增加，抗原产生减少等。这些新型多核苷酸分别被称为新的CHO序列和差异CHO序列。本发明还提供了遗传工程改造的表达载体，宿主细胞和包含本发明的新型核酸分子的转基因动物。本发明还向本发明的核酸分子提供反义和RNAi分子。本发明还提供使用本发明的多核苷酸的方法。

2. 发明申请

US20050287570A1 Probe arrays for expression profiling of rat genes 审中-公开
标题翻译：用于大鼠基因表达谱的探针阵列
公开(公告)号：US20050287570A1
公开(公告)日：2005-12-29
申请号：US11136527
申请日：2005-05-25
申请人： William Mounts
发明人： William Mounts
IPC分类号： C07H21/04 , C12Q1/68 , G01N33/68
CPC分类号： G01N33/6803 , C12Q1/6837 , C12Q1/6876 , C12Q2600/158
摘要： The present invention provides probe arrays for expression profiling of rat genes. Each probe array comprises a plurality of probes, each of which is directed to a rat gene that encodes a sequence selected from SEQ ID NOs: 1-8,192. Suitable probes for the present invention include polynucleotides that can hybridize under stringent or nucleic acid array hybridization conditions to the RNA transcripts, or the complements thereof, of the corresponding rat genes. Suitable probes also include antibodies or other protein-binding molecules that can bind to the protein products of the corresponding rat genes. In one embodiment, a probe array of the present invention includes one or more probes, each of which is directed to a rat gene that encodes a sequence selected from SEQ ID NOs: 7622 and 8084-8124.
摘要翻译：本发明提供了用于大鼠基因表达谱的探针阵列。每个探针阵列包括多个探针，每个探针指向编码选自SEQ ID NO：1-8,192的序列的大鼠基因。用于本发明的合适的探针包括可以在严格或核酸阵列杂交条件下与相应大鼠基因的RNA转录物或其补体杂交的多核苷酸。合适的探针还包括能结合相应大鼠基因的蛋白质产物的抗体或其它蛋白结合分子。在一个实施方案中，本发明的探针阵列包括一个或多个探针，每个探针针对编码选自SEQ ID NO：7622和8084-8124的序列的大鼠基因。

3. 发明申请

US20080070797A1 Nucleic acid arrays for detecting gene expression associated with human osteoarthritis and human proteases 审中-公开
标题翻译：用于检测与人类骨关节炎和人类蛋白酶相关的基因表达的核酸阵列
公开(公告)号：US20080070797A1
公开(公告)日：2008-03-20
申请号：US11891302
申请日：2007-08-08
申请人： William Mounts
发明人： William Mounts
IPC分类号： C40B30/04 , C40B40/08
CPC分类号： C12Q1/6883 , B01J2219/00378 , B01J2219/005 , B01J2219/00518 , B01J2219/00675 , B01J2219/00677 , B01J2219/00722 , B82Y30/00 , C12Q1/6837 , C12Q2600/158 , C12Q2600/166 , C12Q2565/501
摘要： The present invention provides nucleic acid arrays and methods of using the same for expression profiling of human protease and/or osteoarthritis genes. The nucleic acid arrays of the present invention include one or more substrate supports. A substantial portion of all polynucleotide probes that are stably attached to the substrate support(s) can hybridize under stringent or nucleic acid array hybridization conditions to human protease or osteoarthritis genes. In one embodiment, the nucleic acid arrays of the present invention include a plurality of probe sets, each of which can hybridize under stringent or nucleic acid array hybridization conditions to a different respective tiling sequence selected from Attachment C, or the complement thereof.
摘要翻译：本发明提供核酸阵列及其用于人类蛋白酶和/或骨关节炎基因表达谱的方法。本发明的核酸阵列包括一种或多种底物载体。稳定连接到底物载体上的所有多核苷酸探针的大部分可以在严格或核酸阵列杂交条件下与人类蛋白酶或骨关节炎基因杂交。在一个实施方案中，本发明的核酸阵列包括多个探针组，每个探针组可以在严格或核酸阵列杂交条件下与选自附件C或其补体的不同的相应拼接序列杂交。

4. 发明申请

US20080009008A1 Composition and method for treating lupus nephritis 失效
标题翻译：用于治疗狼疮性肾炎的组合物和方法
公开(公告)号：US20080009008A1
公开(公告)日：2008-01-10
申请号：US11787715
申请日：2007-04-17
申请人： Margot O'Toole , William Mounts , Negin Shojaee
发明人： Margot O'Toole , William Mounts , Negin Shojaee
IPC分类号： C12Q1/68 , C12N15/00 , C12N15/11 , C12N5/06 , C12P21/04
CPC分类号： C07K14/705
摘要： The present invention provides novel isolated BFLP1698 polynucleotides and polypeptides encoded by the BFLP1698 polynucleotides. Also provided are the antibodies that immunospecifically bind to a BFLP1698 polypeptide or any derivative (including fusion derivative), variant, mutant or fragment of the BFLP1698 polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the BFLP1698 polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.
摘要翻译：本发明提供新的分离的BFLP1698多核苷酸和由BFLP1698多核苷酸编码的多肽。还提供免疫特异性结合BFLP1698多肽或BFLP1698多肽，多核苷酸或抗体的任何衍生物（包括融合衍生物），变体，突变体或片段的抗体。本发明另外提供了BFLP1698多肽，多核苷酸和抗体用于检测和治疗广泛的病理状态以及其它用途的方法。

5. 发明申请

US20060160121A1 Probe arrays for detecting multiple strains of different species 审中-公开
标题翻译：用于检测不同物种的多种菌株的探针阵列
公开(公告)号：US20060160121A1
公开(公告)日：2006-07-20
申请号：US11348413
申请日：2006-02-07
申请人： William Mounts , Ellen Murphy , Stephen Olmsted
发明人： William Mounts , Ellen Murphy , Stephen Olmsted
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： C12Q1/6837 , C12Q1/689 , C12Q2600/158
摘要： The present invention provides probe arrays and methods of using the same for concurrent and discriminable detection of multiple strains of different species. In one aspect, the probe arrays of the present invention are nucleic acid arrays comprising (1) a first group of probes, each of which is specific to a different respective strain of a first species; and (2) a second group of probes, each of which is specific to a different respective strain of a second species. In many embodiments, the nucleic acid arrays of the present invention further include a third group of probes, each of which is specific to a different strain of a third species. In one example, a nucleic acid array of the present invention includes probes for sequences selected from SEQ ID NOs: 1 to 18,598, and can discriminably detect different strains of Streptococcus pyogenes, Streptococcus agalactiae and Staphylococcus epidermidis.
摘要翻译：本发明提供了探针阵列和使用该探针阵列的方法，用于同时和可区分检测不同物种的多种菌株。在一个方面，本发明的探针阵列是核酸阵列，其包含（1）第一组探针，其各自特异于第一种不同的相应菌株; 和（2）第二组探针，其中每个探针对于第二物种的不同的相应菌株是特异性的。在许多实施方案中，本发明的核酸阵列进一步包括第三组探针，其中每个探针对于第三物种的不同菌株是特异性的。在一个实例中，本发明的核酸阵列包括选自SEQ ID NO：1至18,598的序列的探针，并且可以区分地检测化脓性链球菌（Streptococcus pyogenes），无乳链球菌（Streptococcus agactactiae）和表皮葡萄球菌（Staphylococcus epidermidis）的不同菌株。

6. 发明申请

US20060228356A1 Composition and method for treating lupus nephritis 失效
公开(公告)号：US20060228356A1
公开(公告)日：2006-10-12
申请号：US11355297
申请日：2006-02-15
申请人： Margot O'Toole , William Mounts , Negin Shojaee
发明人： Margot O'Toole , William Mounts , Negin Shojaee
IPC分类号： C12Q1/68 , G01N33/53 , C07H21/04 , C12P21/06 , A61K39/395 , C07K14/705 , C07K16/28
CPC分类号： C07K14/4713
摘要： The present invention provides novel isolated BFLP0169 polynucleotides and polypeptides encoded by the BFLP0169 polynucleotides. Also provided are the antibodies that immunospecifically bind to a BFLP0169 polypeptide or any derivative (including fusion derivative), variant, mutant or fragment of the BFLP0169 polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the BFLP0169 polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.

7. 发明申请

US20060073496A1 Methods of identifying patients at risk of developing encephalitis following immunotherapy for Alzheimer's disease 审中-公开
标题翻译：鉴定患有阿尔茨海默病免疫治疗后发生脑炎风险的患者的方法
公开(公告)号：US20060073496A1
公开(公告)日：2006-04-06
申请号：US11186236
申请日：2005-07-20
申请人： Margot O'Toole , Andrew Dorner , Derek Janszen , Donna Slonim , William Mounts , Padmalatha Reddy , Andrew Hill
发明人： Margot O'Toole , Andrew Dorner , Derek Janszen , Donna Slonim , William Mounts , Padmalatha Reddy , Andrew Hill
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： G01N33/5023 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , G01N33/5008 , G01N33/5044 , G01N33/6896 , G06Q50/24 , G16B25/00 , G16B40/00 , G16B50/00 , Y02A90/22 , Y02A90/26
摘要： The present invention generally relates to a method for an improved treatment for Alzheimer's disease (AD) using immunotherapy, e.g., immunotherapy targeting β amyloid (Aβ), e.g., immunotherapy based on AN1792. In one embodiment, the method allows for predicting an adverse clinical response, and therefore allows for an improved safety profile of AN1792. In another embodiment, the method allows for predicting a favorable clinical response, and therefore allows for an improved efficacy profile of AN1792. The methods of the present invention may be combined to predict a favorable clinical response and the lack of an adverse clinical response.
摘要翻译：本发明总体上涉及使用免疫治疗（例如针对β淀粉样蛋白（Abeta）的免疫治疗），例如基于AN1792的免疫治疗来改善阿尔茨海默氏病（AD）治疗的方法。在一个实施方案中，该方法允许预测不利的临床反应，因此允许改进AN1792的安全性。在另一个实施方案中，该方法允许预测有利的临床反应，因此允许改进AN1792的功效特征。本发明的方法可以组合以预测良好的临床反应和缺乏不利的临床反应。

8. 发明授权

US4086620A Processor for increasing the run-length of facsimile data 失效
标题翻译：处理器，用于增加传真数据的运行时间
公开(公告)号：US4086620A
公开(公告)日：1978-04-25
申请号：US734387
申请日：1976-10-21
申请人： Edward George Bowen , Frank William Mounts , Arun Narayan Netravali
发明人： Edward George Bowen , Frank William Mounts , Arun Narayan Netravali
IPC分类号： H04N1/417 , H04N7/12
CPC分类号： H04N1/417
摘要： A facsimile scene typically includes a plurality of lines, each line having a plurality of picture elements (pels). Often, pel signals are adaptable for run-length coding, a run being one or more successive pels having the same brightness level. To increase the length of a run and hence to permit a more efficient use of a transmission link, a processor is disclosed for permuting a measure of the pel signals responsive to a reference signal. Illustratively, the reference signal is the pel signal from a previous line. In one exemplary bi-level pel signal embodiment, the measure is the current pel signal. Specifically, if the reference pel signal is a logic one, the current pel signal is loaded beginning at one end of a memory; if the reference pel signal is a logic zero, the current pel signal is loaded beginning at the other end of the memory. In a second embodiment, the measure is an error signal for indicating a difference between the reference signal and the current pel signal. But for loading the error signal rather than the current pel signal, the operations aforedescribed are again followed.
摘要翻译：传真场景通常包括多条线，每条线具有多个像素（像素）。通常，像素信号适用于游程长度编码，运行是具有相同亮度级的一个或多个连续的像素。为了增加运行的长度并且因此允许更有效地使用传输链路，公开了用于响应于参考信号来置换像素信号的度量的处理器。示例性地，参考信号是来自前一行的像素信号。在一个示例性双电平像素信号实施例中，测量是当前像素信号。具体地，如果参考像素信号是逻辑1，则从存储器的一端开始加载当前像素信号; 如果参考像素信号为逻辑0，则当前像素信号从存储器的另一端开始被加载。在第二实施例中，该测量是用于指示参考信号和当前像素信号之间的差的误差信号。但是，为了加载误差信号而不是当前的像素信号，再次遵循上述操作。

9. 发明授权

US4060834A Processor for increasing the run-length of digital signals 失效
标题翻译：用于增加数字信号的运行长度的处理器
公开(公告)号：US4060834A
公开(公告)日：1977-11-29
申请号：US734384
申请日：1976-10-21
申请人： Frank William Mounts , Arun Narayan Netravali
发明人： Frank William Mounts , Arun Narayan Netravali
IPC分类号： H04N1/417 , H04N1/00
CPC分类号： H04N1/417
摘要： A facsimile scene typically includes a plurality of lines, each line having a plurality of picture elements (pels). Often, pel signals are adaptable for run-length coding, a run being one or more successive pels having the same brightness level. To increase the length of a run and hence to permit more efficient use of a transmission link between transmitter and receiver, a processor arrangement is disclosed for permuting a measure of the pel signals responsive to a reference signal. The reference signal is a calibration signal. The measure is an error signal for indicating a difference between the current pel signal and a prediction thereof. In an illustrative bi-level facsimile system embodiment, if the calibration signal is a logic one, the error signal is loaded beginning at one end of a memory; if the calibration pel signal is a logic zero, the error signal is loaded beginning at the other end of the memory. The loaded permuted error signal having an increased run length is then sequentially read from one end of the memory for extension to a state of the art run-length coder.
摘要翻译：传真场景通常包括多条线，每条线具有多个像素（像素）。通常，像素信号适用于游程长度编码，运行是具有相同亮度级的一个或多个连续的像素。为了增加运行的长度并且因此允许更有效地使用发射机和接收机之间的传输链路，公开了一种处理器装置，用于响应于参考信号来置换像素信号的测量。参考信号是校准信号。该度量是用于指示当前像素信号与其预测之间的差异的误差信号。在说明性双电平传真系统实施例中，如果校准信号是逻辑1，则误差信号从存储器的一端开始加载; 如果校准像素信号为逻辑0，则误差信号从存储器的另一端开始加载。然后从存储器的一端顺序地读取具有增加的游程长度的加载的置换错误信号，以扩展到现有的游程长度编码器的状态。

10. 发明申请

US20050221354A1 Nucleic acid arrays for monitoring expression profiles of drug target genes 审中-公开
标题翻译：用于监测药物靶基因表达谱的核酸阵列
公开(公告)号：US20050221354A1
公开(公告)日：2005-10-06
申请号：US11060756
申请日：2005-02-18
申请人： William Mounts
发明人： William Mounts
IPC分类号： C12M1/34 , C12Q1/68
CPC分类号： C12Q1/6876 , C12Q1/6837 , C12Q2600/158
摘要： The present invention provides nucleic acid arrays and methods of using the same for detecting or monitoring expression profiles of drug target genes. Non-limiting examples of drug target genes include kinase genes, phosphatase genes, protease genes, G-protein coupled receptor genes, nuclear hormone receptor genes, and ion channel genes. The present invention also provides methods of using nucleic acid arrays for the identification or validation of drugs or drug targets. In one embodiment, a nucleic acid array of the present invention is concentrated with probes for drug target genes. These probes constitute a substantial portion of all of the polynucleotide probes that are stably attached to the nucleic acid array, and can hybridize under stringent or nucleic acid array hybridization conditions to the tiling sequences selected from Attachment C, or the complements thereof.
摘要翻译：本发明提供核酸阵列及其用于检测或监测药物靶基因表达谱的方法。药物靶基因的非限制性实例包括激酶基因，磷酸酶基因，蛋白酶基因，G蛋白偶联受体基因，核激素受体基因和离子通道基因。本发明还提供了使用核酸阵列来鉴定或验证药物或药物靶标的方法。在一个实施方案中，本发明的核酸阵列用药物靶基因的探针浓缩。这些探针构成稳定连接于核酸阵列的所有多核苷酸探针的大部分，并且可以在严格或核酸阵列杂交条件下与选自附件C或其互补物的平铺序列杂交。

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