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1. 发明申请

US20060160121A1 Probe arrays for detecting multiple strains of different species 审中-公开
标题翻译：用于检测不同物种的多种菌株的探针阵列
公开(公告)号：US20060160121A1
公开(公告)日：2006-07-20
申请号：US11348413
申请日：2006-02-07
申请人： William Mounts , Ellen Murphy , Stephen Olmsted
发明人： William Mounts , Ellen Murphy , Stephen Olmsted
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： C12Q1/6837 , C12Q1/689 , C12Q2600/158
摘要： The present invention provides probe arrays and methods of using the same for concurrent and discriminable detection of multiple strains of different species. In one aspect, the probe arrays of the present invention are nucleic acid arrays comprising (1) a first group of probes, each of which is specific to a different respective strain of a first species; and (2) a second group of probes, each of which is specific to a different respective strain of a second species. In many embodiments, the nucleic acid arrays of the present invention further include a third group of probes, each of which is specific to a different strain of a third species. In one example, a nucleic acid array of the present invention includes probes for sequences selected from SEQ ID NOs: 1 to 18,598, and can discriminably detect different strains of Streptococcus pyogenes, Streptococcus agalactiae and Staphylococcus epidermidis.
摘要翻译：本发明提供了探针阵列和使用该探针阵列的方法，用于同时和可区分检测不同物种的多种菌株。在一个方面，本发明的探针阵列是核酸阵列，其包含（1）第一组探针，其各自特异于第一种不同的相应菌株; 和（2）第二组探针，其中每个探针对于第二物种的不同的相应菌株是特异性的。在许多实施方案中，本发明的核酸阵列进一步包括第三组探针，其中每个探针对于第三物种的不同菌株是特异性的。在一个实例中，本发明的核酸阵列包括选自SEQ ID NO：1至18,598的序列的探针，并且可以区分地检测化脓性链球菌（Streptococcus pyogenes），无乳链球菌（Streptococcus agactactiae）和表皮葡萄球菌（Staphylococcus epidermidis）的不同菌株。

2. 发明申请

US20070128210A1 Surface proteins of Streptococcus pyogenes 审中-公开
公开(公告)号：US20070128210A1
公开(公告)日：2007-06-07
申请号：US11592128
申请日：2006-11-03
申请人： Stephen Olmsted , Robert Zagursky , Elliott Nickbarg , Laurie Winter
发明人： Stephen Olmsted , Robert Zagursky , Elliott Nickbarg , Laurie Winter
IPC分类号： C07K14/315 , A61K39/02 , C07H21/04 , C07K16/12 , C12N15/74 , C12N1/21
CPC分类号： C07K14/315
摘要： β-hemolytic streptococci polynucleotides, polypeptides, particularly Streptococcus pyogenes polypeptides and polynucleotides, and antibodies of these polypeptides are described. The polynucleotides, polypeptides, and antibodies of the invention can be formulated for use as immunogenic compositions. Also disclosed are methods for immunizing against and reducing β-hemolytic streptococcal infection, and for detecting β-hemolytic streptococci in a biological sample.

3. 发明申请

US20060189791A1 Recombinant expression of streptococcus pyogenes cysteine protease and immunogenic compositions thereof 审中-公开
标题翻译：化脓性链球菌半胱氨酸蛋白酶的重组表达及其免疫原性组成
公开(公告)号：US20060189791A1
公开(公告)日：2006-08-24
申请号：US10564264
申请日：2004-07-07
申请人： Laurie Winter , Yury Matsuka , Elzabeth Anderson , Stephen Olmsted
发明人： Laurie Winter , Yury Matsuka , Elzabeth Anderson , Stephen Olmsted
IPC分类号： C07K14/315 , C07H21/04 , C12P21/06 , C12N1/21 , C12N15/74
CPC分类号： C07K14/315 , A61K39/00 , C07K16/40 , C12N9/52
摘要： The present invention generally relates to the fields of molecular biology, clinical bacteriology and protein folding. More particularly, the invention relates to methods for recombinantly expressing a soluble mature Streptococcus pyogenesexotoxin B (SpeB) polypeptide in a host cell.
摘要翻译：本发明一般涉及分子生物学，临床细菌学和蛋白质折叠领域。更具体地说，本发明涉及在宿主细胞中重组表达可溶性成熟的脓性链球菌脓毒素B（SpeB）多肽的方法。

4. 发明申请

US20070128229A1 Surface proteins of Streptococcus pyogenes 审中-公开
标题翻译：化脓性链球菌的表面蛋白
公开(公告)号：US20070128229A1
公开(公告)日：2007-06-07
申请号：US11592200
申请日：2006-11-03
申请人： Stephen Olmsted , Robert Zagursky , Elliott Nickbarg , Laurie Winter
发明人： Stephen Olmsted , Robert Zagursky , Elliott Nickbarg , Laurie Winter
IPC分类号： A61K39/09 , C07H21/04 , C07K14/315 , C12N1/21
CPC分类号： C07K14/315 , A61K39/00 , A61K39/09
摘要： β-hemolytic streptococci polynucleotides, polypeptides, particularly Streptococcus pyogenes polypeptides and polynucleotides, and antibodies of these polypeptides are described. The polynucleotides, polypeptides, and antibodies of the invention can be formulated for use as immunogenic compositions. Also disclosed are methods for immunizing against and reducing β-hemolytic streptococcal infection, and for detecting β-hemolytic streptococci in a biological sample.
摘要翻译：描述了β-溶血性链球菌多核苷酸，多肽，特别是化脓性链球菌多肽和多核苷酸，以及这些多肽的抗体。本发明的多核苷酸，多肽和抗体可配制成用作免疫原性组合物。还公开了用于免疫抗原和减少β-溶血性链球菌感染以及用于检测生物样品中的β-溶血性链球菌的方法。

5. 发明申请

US20070128211A1 Surface proteins of Streptococcus pyogenes 审中-公开
公开(公告)号：US20070128211A1
公开(公告)日：2007-06-07
申请号：US11592153
申请日：2006-11-03
申请人： Stephen Olmsted , Robert Zagursky , Elliott Nickbarg , Laurie Winter
发明人： Stephen Olmsted , Robert Zagursky , Elliott Nickbarg , Laurie Winter
IPC分类号： A61K39/02 , C07H21/04 , C12P21/06 , C07K14/315 , C07K16/12 , C12N15/74
CPC分类号： C07K14/315
摘要： β-hemolytic streptococci polynucleotides, polypeptides, particularly Streptococcus pyogenes polypeptides and polynucleotides, and antibodies of these polypeptides are described. The polynucleotides, polypeptides, and antibodies of the invention can be formulated for use as immunogenic compositions. Also disclosed are methods for immunizing against and reducing β-hemolytic streptococcal infection, and for detecting β-hemolytic streptococci in a biological sample.

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