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1. 发明申请

US20130145777A1 CLEAR ICE MAKING MACHINE 审中-公开
标题翻译：清洁制冰机
公开(公告)号：US20130145777A1
公开(公告)日：2013-06-13
申请号：US13675476
申请日：2012-11-13
申请人： William G. Nelson
发明人： William G. Nelson
IPC分类号： F25C1/00
CPC分类号： F25C1/00 , F25C1/18 , F25C1/24 , F25C5/22 , F25D11/02 , F25D23/00 , F28D15/0275 , F28F3/02 , Y10T29/4935
摘要： An ice making machine includes a heat pipe that extends between a freezer compartment and a refrigerator compartment. The heat pipe has a first end in the freezer compartment and a second end in the refrigerator compartment. A heat exchanger is located in the freezer compartment and is in contact with the first end of the heat pipe. A heat block is located in the refrigerator compartment and is in contact with the second end of the heat pipe. A removable ice cube tray is mounted on the heat block with a surface in contact with the heat block such that when the removable ice cube tray is filled with water, ice forms from the surface of the removable ice cube tray in contact with the block.
摘要翻译：制冰机包括在冷冻室和冷藏室之间延伸的热管。热管具有冷冻室中的第一端和冷藏室中的第二端。热交换器位于冷冻室中并与热管的第一端接触。热块位于冷藏室中并与热管的第二端接触。可拆卸的冰块托盘安装在加热块上，其表面与加热块接触，使得当可移除的冰块托盘充满水时，冰从与块接触的可移除冰块托盘的表面形成。

2. 发明授权

US5962237A Method of enriching rare cells 失效
标题翻译：丰富稀有细胞的方法
公开(公告)号：US5962237A
公开(公告)日：1999-10-05
申请号：US832468
申请日：1997-04-02
申请人： Paul O. P. Ts'o , Zheng-Pin Wang , Stephen A. Lesko , William G. Nelson , Alan W. Partin
发明人： Paul O. P. Ts'o , Zheng-Pin Wang , Stephen A. Lesko , William G. Nelson , Alan W. Partin
IPC分类号： C12N15/09 , C12N5/06 , C12N5/08 , C12N5/10 , C12Q1/68 , G01N33/48 , G01N33/569 , G01N33/574 , B01D33/15 , G01N9/30 , G01N33/53
CPC分类号： G01N33/57407 , G01N33/56966 , G01N33/57434 , G01N33/57438 , G01N33/57488
摘要： A method for enriching cancer cells such as prostate cancer cells in a bodily fluid sample is disclosed comprising (a) obtaining the sample comprising cancer cells and non-rare cells; (b) subjecting the sample to multiple density gradient separation comprising a first density gradient and a second density gradient, wherein the second density gradient is greater than the first density gradient, and producing a first fluid comprising an increased concentration of cancer cells of a first density, and a second fluid comprising an increased concentration of cancer cells of a second density, wherein the second density is greater than the first density; wherein subjecting the sample to multiple density gradient separation includes producing a plasma layer, a first interface layer, a first gradient layer, a second interface layer, a second gradient layer, and a cell pellet; wherein producing the first fluid includes combining the first interface layer and the first gradient layer and forming a first suspension; and wherein producing the second fluid includes combining the second interface layer and the second gradient layer and forming a second suspension; (c) subjecting said second fluid comprising the second suspension to a binding agent that binds non-rare cells; and (d) removing the bound non-rare cells from the second fluid to provide a second fluid enriched with the greater density cancer cells.
摘要翻译：公开了一种在体液样品中富集癌细胞如前列腺癌细胞的方法，其包括（a）获得包含癌细胞和非罕见细胞的样品; （b）对样品进行多密度梯度分离，其包括第一密度梯度和第二密度梯度，其中所述第二密度梯度大于所述第一密度梯度，并且产生第一流体，所述第一流体包含增加浓度的第一并且包括第二密度增加的癌细胞浓度的第二流体，其中所述第二密度大于所述第一密度; 其中对样品进行多重密度梯度分离包括产生等离子体层，第一界面层，第一梯度层，第二界面层，第二梯度层和细胞沉淀物; 其中制备所述第一流体包括组合所述第一界面层和所述第一梯度层并形成第一悬浮液; 并且其中制备所述第二流体包括组合所述第二界面层和所述第二梯度层并形成第二悬浮液; （c）使包含第二悬浮液的所述第二流体接合结合非稀有细胞的结合剂; 和（d）从第二流体中除去结合的非稀有细胞以提供富含更大密度的癌细胞的第二种液体。

3. 外观设计

USD376396S Pitching training device 失效
公开(公告)号：USD376396S
公开(公告)日：1996-12-10
申请号：US39958
申请日：1995-06-07
申请人： William G. Nelson
设计人： William G. Nelson

4. 发明授权

US5552277A Genetic diagnosis of prostate cancer 失效
标题翻译：前列腺癌的遗传诊断
公开(公告)号：US5552277A
公开(公告)日：1996-09-03
申请号：US277202
申请日：1994-07-19
申请人： William G. Nelson , William B. Isaacs , Wen-Hsiang Lee
发明人： William G. Nelson , William B. Isaacs , Wen-Hsiang Lee
IPC分类号： A61K48/00 , C12N9/10 , C12N15/09 , C12Q1/48 , C12Q1/68 , G01N33/573 , G01N33/574 , C07H21/02 , C07H21/04
CPC分类号： C12N9/1088 , C12Q1/6886 , G01N33/573 , A61K48/00 , C12N2799/027 , C12Q2600/154
摘要： A method for detecting and a method for treating a cell proliferative disorder associated with glutathione-S-transferase (GSTP1) expression is provided. The method includes direct detection of a hypermethylated GSTP1 promoter, or indirect detection of decreased GSTP1 mRNA or GSTP1 protein in a suspect tissue sample.
摘要翻译：提供了一种检测方法和一种治疗与谷胱甘肽-S-转移酶（GSTP1）表达相关的细胞增殖性疾病的方法。该方法包括直接检测超甲基化GSTP1启动子，或间接检测可疑组织样品中GSTP1 mRNA或GSTP1蛋白的降低。

5. 发明申请

US20160201966A1 CLEAR ICE MAKING MACHINE 审中-公开
公开(公告)号：US20160201966A1
公开(公告)日：2016-07-14
申请号：US15076074
申请日：2016-03-21
申请人： William G. Nelson
发明人： William G. Nelson
IPC分类号： F25C1/18 , F25D23/00 , F25D11/02 , F28F3/02 , F28D15/02
CPC分类号： F25C1/00 , F25C1/18 , F25C1/24 , F25C5/22 , F25D11/02 , F25D23/00 , F28D15/0275 , F28F3/02 , Y10T29/4935
摘要： An ice making machine includes a heat pipe that extends between a freezer compartment and a refrigerator compartment. The heat pipe has a first end in the freezer compartment and a second end in the refrigerator compartment. A heat exchanger is located in the freezer compartment and is in contact with the first end of the heat pipe. A heat block is located in the refrigerator compartment and is in contact with the second end of the heat pipe. A removable ice cube tray is mounted on the heat block with a surface in contact with the heat block such that when the removable ice cube tray is filled with water, ice forms from the surface of the removable ice cube tray in contact with the block.

6. 发明授权

US09291381B2 Clear ice making machine 有权
标题翻译：清除制冰机
公开(公告)号：US09291381B2
公开(公告)日：2016-03-22
申请号：US13675476
申请日：2012-11-13
申请人： William G. Nelson
发明人： William G. Nelson
IPC分类号： F25C1/24 , F25C1/00 , F25C1/18 , F25C5/00
CPC分类号： F25C1/00 , F25C1/18 , F25C1/24 , F25C5/22 , F25D11/02 , F25D23/00 , F28D15/0275 , F28F3/02 , Y10T29/4935
摘要： An ice making machine includes a heat pipe that extends between a freezer compartment and a refrigerator compartment. The heat pipe has a first end in the freezer compartment and a second end in the refrigerator compartment. A heat exchanger is located in the freezer compartment and is in contact with the first end of the heat pipe. A heat block is located in the refrigerator compartment and is in contact with the second end of the heat pipe. A removable ice cube tray is mounted on the heat block with a surface in contact with the heat block such that when the removable ice cube tray is filled with water, ice forms from the surface of the removable ice cube tray in contact with the block.
摘要翻译：制冰机包括在冷冻室和冷藏室之间延伸的热管。热管具有冷冻室中的第一端和冷藏室中的第二端。热交换器位于冷冻室中并与热管的第一端接触。热块位于冷藏室中并与热管的第二端接触。可拆卸的冰块托盘安装在加热块上，其表面与加热块接触，使得当可移除的冰块托盘充满水时，冰从与块接触的可移除冰块托盘的表面形成。

7. 发明授权

US06830239B1 Semi-frozen food product carbonator 有权
标题翻译：半冷冻食品碳酸化器
公开(公告)号：US06830239B1
公开(公告)日：2004-12-14
申请号：US09639868
申请日：2000-08-16
申请人： Paul R. Weber , William G. Nelson , Randy Alberg
发明人： Paul R. Weber , William G. Nelson , Randy Alberg
IPC分类号： B01F304
CPC分类号： A23G9/46 , A23G9/045 , A23G9/163 , A23G9/224 , H02K1/2753 , H02K5/128 , H02K7/116 , H02K7/14 , H02K21/16 , H02K49/108 , H02K2207/03 , Y10S261/07
摘要： A carbonator tank includes a liquid inlet, a gas inlet and a liquid outlet. A liquid level sensor includes a liquid level sensing portion extending along and within the interior of the carbonator and provides for determining a full and minimal liquid level therein. The level sensor includes an outer contact portion for connection to an electronic control and the contact portion is integral with the liquid inlet. Additionally, the level sensor includes a deflection plate extending from the liquid level sensing portion in a direction there from that is transverse to the direction of flow of liquid into the carbonator interior through the liquid inlet. The liquid then flows into the carbonator interior and contacts the deflection plate and is deflected thereby so that such liquid flow does not disrupt the operation of the level sensing portion of the level sensor.
摘要翻译：碳酸化器罐包括液体入口，气体入口和液体出口。液位传感器包括沿碳酸化器内部和内部延伸的液面感测部分，并且用于确定其中的完整和最小液位。液位传感器包括用于连接到电子控制器的外部接触部分，并且接触部分与液体入口成一体。此外，液位传感器包括偏转板，该偏转板从液面检测部分沿着与液体流动方向横向于通过液体入口进入碳酸器内部的方向延伸。液体然后流入碳酸化器内部并接触偏转板并由此偏转，使得这种液体流动不会破坏液位传感器的液位感测部分的操作。

8. 发明申请

US20090197263A1 Compare-MS: Method Rapid, Sensitive and Accurate Detection of DNA Methylation 有权
标题翻译：比较MS：方法快速，灵敏和准确地检测DNA甲基化
公开(公告)号：US20090197263A1
公开(公告)日：2009-08-06
申请号：US12159081
申请日：2007-01-04
申请人： William G. Nelson , Xiaohui S. Lin , Angelo M. Demarzo , Srinivasan Nasubramanian
发明人： William G. Nelson , Xiaohui S. Lin , Angelo M. Demarzo , Srinivasan Nasubramanian
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/683 , C12Q2521/331
摘要： The present invention provides methods and kits useful for enriching, identifying and quantifying methylated DNA3 particularly hypermethylated CpG islands by digesting a sample with a methylation-sensitive restriction endonuclease and capturing methylated restriction fragments with a methyl-binding capture reagent. The methods of the invention may be used in the detection of cancer, particularly detection of prostate cancer.
摘要翻译：本发明提供用于通过用甲基化敏感性限制性内切核酸酶消化样品并用甲基结合捕获试剂捕获甲基化限制性片段来富集，鉴定和定量甲基化DNA3，特别是高甲基化CpG岛的方法和试剂盒。本发明的方法可用于癌症的检测，特别是前列腺癌的检测。

9. 发明授权

US5799504A Refrigerator system with float valve flow control 失效
标题翻译：具有浮阀流量控制的冰箱系统
公开(公告)号：US5799504A
公开(公告)日：1998-09-01
申请号：US760048
申请日：1996-12-04
申请人： William G. Nelson
发明人： William G. Nelson
IPC分类号： F25B41/06 , F25B43/00
CPC分类号： F25B41/065 , F25B43/003 , F25B41/067 , Y10T137/7319
摘要： A vapor compression refrigeration system having a condenser, a regulating device, and a capillary tube. The regulating device has a housing defining an inner chamber for receiving refrigerant from the condenser. A float is disposed within the chamber and includes a resilient surface. An outlet line connected to the capillary tube extends through a bottom wall of the housing and into the chamber. The float is movable in response to changes in level of refrigerant in the chamber. The float moves downward to close the outlet line when refrigerant in the chamber drops below a minimum level, and moves upward to open the outlet line when refrigerant in the chamber rises above the minimum level. A filter assembly for removing contaminants from the refrigerant is disposed within the chamber above the float.
摘要翻译：一种具有冷凝器，调节装置和毛细管的蒸气压缩式制冷系统。调节装置具有限定用于从冷凝器接收制冷剂的内室的壳体。浮子设置在室内并且包括弹性表面。连接到毛细管的出口管线延伸穿过壳体的底壁并进入腔室。浮子可响应腔室中的制冷剂水平的变化而移动。当室中的制冷剂下降到最低水平时，浮子向下移动以关闭出口管线，并且当室中的制冷剂升高到最低水平时，向上移动以打开出口管路。用于从制冷剂中除去污染物的过滤器组件设置在浮子上方的腔室内。

10. 发明公开

US20230405690A1 METHOD AND APPARATUS FOR MOUNTING A FIXTURE TO A VERTICAL SURFACE 审中-公开
公开(公告)号：US20230405690A1
公开(公告)日：2023-12-21
申请号：US18210164
申请日：2023-06-15
申请人： William G. Nelson
发明人： William G. Nelson
IPC分类号： B23B51/00
CPC分类号： B23B51/0054
摘要： Various examples embodiments are directed to issues such as those addressed above and/or others which may become apparent from the following disclosure concerning the involving the attachment of a fixture to a vertical surface.

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