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    • 10. 发明申请
    • DYNAMIC PET IMAGING WITH ISOTOPE CONTAMINATION COMPENSATION
    • 动态PET成像与同位素污染补偿
    • WO2011004273A3
    • 2011-12-15
    • PCT/IB2010052671
    • 2010-06-15
    • KONINKL PHILIPS ELECTRONICS NVPHILIPS INTELLECTUAL PROPERTYWIECZOREK HERFRIEDTHIELE FRANK ONARAYANAN MANOJ V
    • WIECZOREK HERFRIEDTHIELE FRANK ONARAYANAN MANOJ V
    • G01T1/29
    • G01T1/2985A61B6/037
    • A nuclear imaging system includes a scanner (8), such as a PET scanner. A patient is injected with a [ 13 N]ammonia radioisotope tracer which is contaminated with a small percent of 18 F contamination. The scanner receives radiation from the injected tracer and a reconstruction processor (28) reconstructs the detected radiation into image representations. A warning generator (12) generates warnings to the clinician concerning the effects of the 18 F contamination. A calibration processor (16) generates an estimated decay curve based on a time since the end of the proton bombardment which created the tracer and a priori information about the tracer. An activity meter (42) measures radiation emitted from a sample of the tracer and a dose calibrator (44) determines a decay curve from the measured radiation. Either the detected radiation is corrected in accordance with one of the decay curves during reconstruction or a correction processor (50) corrects reconstructed images in accordance with one or both of the decay curves. A display (14) displays uncorrected reconstructed images and the decay curve and/or the corrected images.
    • 核成像系统包括扫描仪(8),例如PET扫描仪。 患者注射[13 N]氨放射性同位素示踪剂,其中含有少量18 F污染物。 扫描仪接收来自注入示踪剂的辐射,并且重建处理器(28)将检测到的辐射重建为图像表示。 警告发生器(12)向临床医生发出关于18 F污染的影响的警告。 校准处理器(16)基于自产生示踪剂的质子轰击结束后的时间和关于示踪剂的先验信息产生估计的衰减曲线。 活动计量器(42)测量从示踪剂样本发射的辐射,并且剂量校准器(44)根据测量的辐射确定衰减曲线。 根据重建期间的衰减曲线之一校正检测到的辐射,或者校正处理器(50)根据衰减曲线中的一个或两个校正重构图像。 显示器(14)显示未经校正的重建图像和衰减曲线和/或经校正的图像。