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1. 发明申请

WO2006120605A1 MULTI-CAP DETECTORS FOR NUCLEAR MEDICINE 审中-公开
标题翻译：多核心药物检测器
公开(公告)号：WO2006120605A1
公开(公告)日：2006-11-16
申请号：PCT/IB2006/051355
申请日：2006-05-01
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , U.S. PHILIPS CORPORATION , WIECZOREK, Herfried, K. , BIPPUS, Rolf, D. , BOTTERWECK, Henrik , GOEDICKE, Andreas
发明人： WIECZOREK, Herfried, K. , BIPPUS, Rolf, D. , BOTTERWECK, Henrik , GOEDICKE, Andreas
IPC分类号： G01T1/164
CPC分类号： G01T1/1648 , A61B6/037 , A61B6/4258 , G01T1/1642
摘要： An imaging system (10) comprises at least one radiation detector unit (16) disposed adjacent a field of view (20) to detect and measure radiation from the field of view (20). The detector unit (16) includes multiple detection modules (18) which each detects radiation from a prespecified region of the field of view (20), each region being a fraction of the field of view. One or more pinholes (52) are associated with the detector unit (16). Each pinhole (52) receives radiation from the prespecified region of the field of view (20) and transmits radiation to one or more associated detection modules (18).
摘要翻译：成像系统（10）包括邻近视场（20）设置的至少一个辐射检测器单元（16），用于检测和测量来自视场（20）的辐射。检测器单元（16）包括多个检测模块（18），每个检测模块检测来自视场（20）的预定区域的辐射，每个区域是视场的一部分。一个或多个针孔（52）与检测器单元（16）相关联。每个针孔（52）接收来自视场（20）的预定区域的辐射，并将辐射传输到一个或多个相关检测模块（18）。

2. 发明申请

WO2010041192A2 PRACTICAL SPECT CALIBRATION METHOD FOR QUANTIFICATION OF NUCLIDES WITH HIGH-ENERGY CONTRIBUTIONS 审中-公开
标题翻译：用于高能源核素定量的实际SPECT标定方法
公开(公告)号：WO2010041192A2
公开(公告)日：2010-04-15
申请号：PCT/IB2009/054352
申请日：2009-10-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , BOTTERWECK, Henrik
发明人： BOTTERWECK, Henrik
CPC分类号： G01T1/1648 , G01T7/005
摘要： When calibrating a nuclear camera, such as a SPECT camera, point spread functions (PSF) are simulated for all possible photon energies and detection distances that the camera may experience. During manufacturer-side calibration, a point source (14) is imaged by the nuclear camera and a PSF therefor is measured. The measured PSF is compared to one or more simulated PSFs and a difference therebetween is determined. To calibrate the measured PSF, simulated PSF data is interpolated into the measured PSF to minimize the difference between the measured and simulated PSFs. The calibrated PSF is stored to memory and accessed during user-side calibration. A user then images a tracer sample during a routine camera calibration, and a PSF for the tracer sample is compared to the calibrated PSF to determine a level of contamination in the tracer sample. The tracer sample PSF is then calibrated for use in reconstructing nuclear images.
摘要翻译：当校准诸如SPECT相机的核相机时，针对相机可能经历的所有可能的光子能量和检测距离来模拟点扩散函数（PSF）。在制造商侧校准期间，由核相机对点源（14）进行成像并且对其进行PSF测量。将测得的PSF与一个或多个模拟的PSF进行比较，并确定它们之间的差异。为了校准测得的PSF，将模拟的PSF数据内插到测量的PSF中，以最小化测量的和模拟的PSF之间的差异。校准后的PSF存储到内存中，并在用户侧校准期间进行访问。然后用户在常规相机校准期间对示踪剂样品进行成像，并将示踪剂样品的PSF与校准的PSF进行比较以确定示踪剂样品中的污染水平。然后校准示踪剂样品PSF用于重建核图像。

3. 发明申请

WO2009147605A1 RECONSTRUCTION OF DYNAMICAL CARDIAC SPECT FOR MEASURING TRACER UPTAKE AND REDISTRIBUTION 审中-公开
标题翻译：用于测量跟踪检测和重新分配的动态心脏检测重建
公开(公告)号：WO2009147605A1
公开(公告)日：2009-12-10
申请号：PCT/IB2009/052282
申请日：2009-05-29
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , BOTTERWECK, Henrik
发明人： BOTTERWECK, Henrik
IPC分类号： G06T15/20
CPC分类号： G06T15/20 , G06T11/008
摘要： When performing a static image reconstruction of acquired single photon emission computed tomography (SPECT) data for myocardium, dynamic tracer uptake, redistribution, and washout information is generated with reduced or eliminated artifacts by back-projecting SPECT ray projections onto a reconstructed myocardial surface. A complete SPECT scan is performed after tracer injection, and a static image of the myocardial surface is reconstructed. The reconstructed image is segmented and a polar plot of it is generated. A contemporaneously acquired subset of the SPECT projection data is then backprojected onto the segmented surface of the polar plot. Contributions from emissions not originating from the myocardium (e.g., from adjacent anatomical structures) are compensated. The resultant image data, which describes tracer distributions across heart segments per projection time, are overlaid on the polar plot and presented to a user. In this manner, time-dependent tracer perfusion is supplied to the user despite the static nature of SPECT imaging systems.
摘要翻译：当进行心肌采集的单光子发射计算机断层扫描（SPECT）数据的静态图像重建时，通过将SPECT射线投影反向投影到重建的心肌表面上，产生具有减少或消除伪像的动态示踪剂摄取，再分布和清除信息。在示踪剂注射后进行完整的SPECT扫描，重建心肌表面的静态图像。重建的图像被分割，并且产生它的极坐标图。然后将同时获取的SPECT投影数据的子集反投影到极地图的分段表面上。来自不是源自心肌的排放物的贡献（例如，来自相邻的解剖结构）被补偿。所述图像数据描述了每个投影时间在心脏区段上的跟踪器分布，被叠加在极坐标图上并呈现给用户。以这种方式，尽管SPECT成像系统具有静态特性，但仍然向使用者提供时间依赖的示踪剂灌注。

4. 发明申请

WO2004067091A1 RECONSTRUCTION OF LOCAL PATIENT DOSES IN COMPUTED TOMOGRAPHY 审中-公开
标题翻译：重建计算机图像中的局部患者剂量
公开(公告)号：WO2004067091A1
公开(公告)日：2004-08-12
申请号：PCT/IB2004/000176
申请日：2004-01-19
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N.V. , BOTTERWECK, Henrik , SPIES, Lothar
发明人： BOTTERWECK, Henrik , SPIES, Lothar
IPC分类号： A61N5/10
CPC分类号： A61B6/032 , A61N5/1031 , Y10S128/922
摘要： In order to reduce an x-ray dose applied to a patient, it is necessary to know the dose absorbed by the patient. According to the present invention, there is provided a method of determining a local patient dose applied to a patient where after the reconstruction of the scan data into a diagnostic image, the scan data are backprojected into the patient volume, using the attenuation information of the diagnostic image to form a spatially varying photon fluence map. In parallel, the diagnostic image is segmented into anatomical structures to which dose-weighting factors are assigned. The locally absorbed dose is then calculated on the basis of the fluence map and the corresponding dose weights.
摘要翻译：为了减少施加到患者的x射线剂量，需要知道患者吸收的剂量。根据本发明，提供了一种确定施用于患者的局部患者剂量的方法，其中在将扫描数据重建为诊断图像之后，使用所述扫描数据的衰减信息将扫描数据反向投影到患者体积中诊断图像形成空间变化的光子注量图。并行地，诊断图像被分割成分配给剂量加权因子的解剖结构。然后根据注量图和相应的剂量重量计算局部吸收剂量。

5. 发明申请

WO2004080309A3 DEVICE AND METHOD FOR ADAPTING THE RECORDING PARAMETERS OF A RADIOGRAPH 审中-公开
公开(公告)号：WO2004080309A3
公开(公告)日：2004-09-23
申请号：PCT/IB2004/000527
申请日：2004-02-27
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N. V. , SPIES, Lothar , BOTTERWECK, Henrik , WEESE, Jürgen
发明人： SPIES, Lothar , BOTTERWECK, Henrik , WEESE, Jürgen
IPC分类号： A61B6/03
摘要： The invention relates to a method of adapting imaging parameters for a computer tomographic radiograph of a body volume, comprising the following steps: obtaining a three-dimensional pilot radiograph with a low dose of radiation (1); determining a region of interest and a desired image quality in the pilot radiograph (2) with the aid of a patient model (4) or interactively (3); determining optimal imaging parameters (5); generating an X-ray image using the determined imaging parameters (6). Optionally, the X-ray image is combined (7) with the pilot radiograph.

6. 发明授权

EP1590045B1 RECONSTRUCTION OF LOCAL PATIENT DOSES IN COMPUTED TOMOGRAPHY 有权转让
标题翻译：重建计算出的局部病人可以的
公开(公告)号：EP1590045B1
公开(公告)日：2008-10-15
申请号：EP04703226.3
申请日：2004-01-19
申请人： Philips Intellectual Property & Standards GmbH , Koninklijke Philips Electronics N.V.
发明人： BOTTERWECK, Henrik , SPIES, Lothar
IPC分类号： A61N5/10 , A61B6/03
CPC分类号： A61B6/032 , A61N5/1031 , Y10S128/922
摘要： In order to reduce an x-ray dose applied to a patient, it is necessary to know the dose absorbed by the patient. According to the present invention, there is provided a method of determining a local patient dose applied to a patient where after the reconstruction of the scan data into a diagnostic image, the scan data are backprojected into the patient volume, using the attenuation information of the diagnostic image to form a spatially varying photon fluence map. In parallel, the diagnostic image is segmented into anatomical structures to which dose-weighting factors are assigned. The locally absorbed dose is then calculated on the basis of the fluence map and the corresponding dose weights.

7. 发明公开

EP1603461A2 DEVICE AND METHOD FOR ADAPTING THE RECORDING PARAMETERS OF A RADIOGRAPH 审中-公开
标题翻译： DEVICE AND METHOD FOR调整X光片记录参数的
公开(公告)号：EP1603461A2
公开(公告)日：2005-12-14
申请号：EP04715413.3
申请日：2004-02-27
申请人： Philips Intellectual Property & Standards GmbH , Koninklijke Philips Electronics N.V.
发明人： SPIES, Lothar , BOTTERWECK, Henrik , WEESE, Jürgen
IPC分类号： A61B6/03
CPC分类号： A61B6/488 , A61B6/00 , A61B6/469 , A61B6/542 , A61B6/544
摘要： The invention relates to a method of adapting imaging parameters for a computer tomographic radiograph of a body volume, comprising the following steps: obtaining a three-dimensional pilot radiograph with a low dose of radiation (1); determining a region of interest and a desired image quality in the pilot radiograph (2) with the aid of a patient model (4) or interactively (3); determining optimal imaging parameters (5); generating an X-ray image using the determined imaging parameters (6). Optionally, the X-ray image is combined (7) with the pilot radiograph.

8. 发明公开

EP2347282A2 PRACTICAL SPECT CALIBRATION METHOD FOR QUANTIFICATION OF NUCLIDES WITH HIGH-ENERGY CONTRIBUTIONS 审中-公开
标题翻译：实用SPECT在定量具有高能量贡献校准核素
公开(公告)号：EP2347282A2
公开(公告)日：2011-07-27
申请号：EP09744752.8
申请日：2009-10-05
申请人： Koninklijke Philips Electronics N.V. , Philips Intellectual Property & Standards GmbH
发明人： BOTTERWECK, Henrik
IPC分类号： G01T1/164 , G01T1/29 , G01T7/00
CPC分类号： G01T1/1648 , G01T7/005
摘要： When calibrating a nuclear camera, such as a SPECT camera, point spread functions (PSF) are simulated for all possible photon energies and detection distances that the camera may experience. During manufacturer-side calibration, a point source (14) is imaged by the nuclear camera and a PSF therefor is measured. The measured PSF is compared to one or more simulated PSFs and a difference therebetween is determined. To calibrate the measured PSF, simulated PSF data is interpolated into the measured PSF to minimize the difference between the measured and simulated PSFs. The calibrated PSF is stored to memory and accessed during user-side calibration. A user then images a tracer sample during a routine camera calibration, and a PSF for the tracer sample is compared to the calibrated PSF to determine a level of contamination in the tracer sample. The tracer sample PSF is then calibrated for use in reconstructing nuclear images.

9. 发明公开

EP1882198A1 MULTI-CAP DETECTORS FOR NUCLEAR MEDICINE 审中-公开
标题翻译：更多CAPS探测器核医学
公开(公告)号：EP1882198A1
公开(公告)日：2008-01-30
申请号：EP06728095.8
申请日：2006-05-01
申请人： Koninklijke Philips Electronics N.V. , Philips Intellectual Property & Standards GmbH
发明人： WIECZOREK, Herfried, K. , BIPPUS, Rolf, D. , BOTTERWECK, Henrik , GOEDICKE, Andreas
IPC分类号： G01T1/164
CPC分类号： G01T1/1648 , A61B6/037 , A61B6/4258 , G01T1/1642
摘要： An imaging system (10) comprises at least one radiation detector unit (16) disposed adjacent a field of view (20) to detect and measure radiation from the field of view (20). The detector unit (16) includes multiple detection modules (18) which each detects radiation from a prespecified region of the field of view (20), each region being a fraction of the field of view. One or more pinholes (52) are associated with the detector unit (16). Each pinhole (52) receives radiation from the prespecified region of the field of view (20) and transmits radiation to one or more associated detection modules (18).

10. 发明公开

EP1590045A1 RECONSTRUCTION OF LOCAL PATIENT DOSES IN COMPUTED TOMOGRAPHY 有权转让
标题翻译：重建计算出的局部病人可以的
公开(公告)号：EP1590045A1
公开(公告)日：2005-11-02
申请号：EP04703226.3
申请日：2004-01-19
申请人： Philips Intellectual Property & Standards GmbH , Koninklijke Philips Electronics N.V.
发明人： BOTTERWECK, Henrik , SPIES, Lothar
IPC分类号： A61N5/10 , A61B6/03
CPC分类号： A61B6/032 , A61N5/1031 , Y10S128/922
摘要： In order to reduce an x-ray dose applied to a patient, it is necessary to know the dose absorbed by the patient. According to the present invention, there is provided a method of determining a local patient dose applied to a patient where after the reconstruction of the scan data into a diagnostic image, the scan data are backprojected into the patient volume, using the attenuation information of the diagnostic image to form a spatially varying photon fluence map. In parallel, the diagnostic image is segmented into anatomical structures to which dose-weighting factors are assigned. The locally absorbed dose is then calculated on the basis of the fluence map and the corresponding dose weights.

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