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1. 发明申请

WO2005071117A3 PRIMER AND PROBE DESIGN FOR EFFICIENT AMPLIFICATION AND DETECTION OF HCV 3′ NON-TRANSLATING REGION 审中-公开
公开(公告)号：WO2005071117A3
公开(公告)日：2005-08-04
申请号：PCT/US2005/002415
申请日：2005-01-21
申请人： BIOMERIEUX, INC. , WANG, Hwa-Tang, Thomas , WASHBURN, Brian
发明人： WANG, Hwa-Tang, Thomas , WASHBURN, Brian
IPC分类号： C12Q1/70
摘要： The present invention provides selected oligonucleotides corresponding to portions of the 3′ non-translating region of Hepatitis C virus. The invention also includes methods of detecting and of quantitating HCV nucleic acids in a sample using these oligonucleotides.

2. 发明申请

WO2011142849A3 GAS FILLED HOLLOW FIBER LASER 审中-公开
标题翻译：气体填充中空纤维激光
公开(公告)号：WO2011142849A3
公开(公告)日：2012-02-23
申请号：PCT/US2011022080
申请日：2011-01-21
申请人： RUDOLPH WOLFGANG G , RATANAVIS AMARIN , NAMPOOTHIRI VASUDEVAN , CORWIN KRISTAN L , JONES ANDREW M , WASHBURN BRIAN R , KADEL RAJESH , ZAVADA JOHN M
发明人： RUDOLPH WOLFGANG G , RATANAVIS AMARIN , NAMPOOTHIRI VASUDEVAN , CORWIN KRISTAN L , JONES ANDREW M , WASHBURN BRIAN R , KADEL RAJESH , ZAVADA JOHN M
IPC分类号： H01S3/067 , H01S3/097 , H01S3/22
CPC分类号： H01S3/223 , H01S3/06741 , H01S3/094003 , H01S3/0943 , H01S3/2232
摘要： Apparatus, systems, and methods using an optically pumped gas filled hollow fiber laser can be implemented in a variety of applications. In various embodiments, operation of an optically pumped gas filled hollow fiber laser is based on population inversion in the gas. Additional apparatus, systems, and methods are disclosed.
摘要翻译：使用光泵浦气体填充中空纤维激光器的装置，系统和方法可以在各种应用中实现。在各种实施例中，光泵浦气体填充中空纤维激光器的操作基于气体中的群体反转。公开了附加装置，系统和方法。

3. 发明申请

WO2009135158A3 DETECTION OF MICROBIAL NUCLEIC ACIDS 审中-公开
标题翻译：检测微生物核酸
公开(公告)号：WO2009135158A3
公开(公告)日：2010-02-18
申请号：PCT/US2009042578
申请日：2009-05-01
申请人： IMMUNETICS INC , WASHBURN BRIAN K , LEVIN ANDREW E
发明人： WASHBURN BRIAN K , LEVIN ANDREW E
IPC分类号： C12Q1/04 , C12N1/00
CPC分类号： C12Q1/689 , C07K14/24 , C12Q1/6837 , C12Q2600/166
摘要： The present invention features, inter alia, compositions and methods useful for identifying one or more types of microorganisms, if and when present, in a sample or plurality of samples (e.g., in one or more samples tested in parallel). More specifically, the present compositions and methods can be used in, e.g., determining whether a subject has a microbial infection (e.g., a bacterial, fungal, protozoal, or viral infection), determining the identity of the microbe(s) causing the infection, and/or determining, or helping to determine, an appropriate anti-microbial treatment regimen for a subject identified as having an infection (e.g., an appropriate antibiotic, anti-fungal, anti-viral, or other treatment regimen).
摘要翻译：本发明特别地特征在于用于鉴定一种或多种类型的微生物的组合物和方法，如果和存在于样品或多个样品中（例如在一个或多个并行测试的样品中）。更具体地，本发明的组合物和方法可以用于例如确定受试者是否具有微生物感染（例如细菌，真菌，原生动物或病毒感染），确定导致感染的微生物的身份，和/或确定或帮助确定被鉴定为具有感染（例如适当的抗生素，抗真菌，抗病毒或其它治疗方案）的受试者的适当的抗微生物治疗方案。

4. 发明申请

WO2009135158A2 DETECTION OF MICROBIAL NUCLEIC ACIDS 审中-公开
标题翻译：检测微生物核酸
公开(公告)号：WO2009135158A2
公开(公告)日：2009-11-05
申请号：PCT/US2009/042578
申请日：2009-05-01
申请人： IMMUNETICS, INC. , WASHBURN, Brian, K. , LEVIN, Andrew, E.
发明人： WASHBURN, Brian, K. , LEVIN, Andrew, E.
IPC分类号： C12Q1/04 , C12N1/00
CPC分类号： C12Q1/689 , C07K14/24 , C12Q1/6837 , C12Q2600/166
摘要： The present invention features, inter alia , compositions and methods useful for identifying one or more types of microorganisms, if and when present, in a sample or plurality of samples ( e.g ., in one or more samples tested in parallel). More specifically, the present compositions and methods can be used in, e.g., determining whether a subject has a microbial infection ( e.g ., a bacterial, fungal, protozoal, or viral infection), determining the identity of the microbe(s) causing the infection, and/or determining, or helping to determine, an appropriate anti-microbial treatment regimen for a subject identified as having an infection ( e.g. , an appropriate antibiotic, anti-fungal, anti-viral, or other treatment regimen).
摘要翻译：本发明特别地特征在于用于鉴定一种或多种类型的微生物的组合物和方法，如果和存在于样品或多个样品中（例如在一个或多个并行测试的样品中）。更具体地，本发明的组合物和方法可以用于例如确定受试者是否具有微生物感染（例如细菌，真菌，原生动物或病毒感染），确定导致感染的微生物的身份，和/或确定或帮助确定被鉴定为具有感染（例如适当的抗生素，抗真菌，抗病毒或其它治疗方案）的受试者的适当的抗微生物治疗方案。

5. 发明申请

WO2005070027A8 A NOVEL NUCLEOTIDE MIXTURE FOR IMPROVED NUCLEIC ACID AMPLIFICATION PERFORMANCE 审中-公开
标题翻译：用于改善核酸放大性能的新型核糖体混合物
公开(公告)号：WO2005070027A8
公开(公告)日：2006-07-27
申请号：PCT/US2005002414
申请日：2005-01-21
申请人： BIO MERIEUX INC , WASHBURN BRIAN , LOVERN DOUGLAS
发明人： WASHBURN BRIAN , LOVERN DOUGLAS
IPC分类号： C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/707 , C12Q1/6806 , C12Q1/6844 , C12Q1/6846 , C12Q1/6851 , C12Q1/686 , C12Q2527/137 , C12Q2527/125 , C12Q2527/107 , C12Q2527/101 , C12Q2527/113
摘要： The present invention relates to modification of amplification buffer used in amplification reactions. The modifications result in a significant improvement in results of amplification In particular, the present invention provides methods and buffers for performing an amplification reaction utilizing a buffer comprising nucleotide triphosphates comprising treating the buffer to substitute a portion of the nucleotide triphosphates with nucleotide diphosphates.
摘要翻译：本发明涉及用于扩增反应的扩增缓冲液的修饰。修饰导致扩增结果的显着改善。特别地，本发明提供了利用包含三磷酸核苷酸的缓冲液进行扩增反应的方法和缓冲液，其包括用核苷酸二磷酸处理缓冲液以替代部分核苷酸三磷酸。

6. 发明申请

WO2005070027A3 A NOVEL NUCLEOTIDE MIXTURE FOR IMPROVED NUCLEIC ACID AMPLIFICATION PERFORMANCE 审中-公开
标题翻译：一种新型核苷酸混合物，用于改善核酸扩增性能
公开(公告)号：WO2005070027A3
公开(公告)日：2006-04-06
申请号：PCT/US2005002414
申请日：2005-01-21
申请人： BIO MERIEUX INC , WASHBURN BRIAN , LOVERN DOUGLAS
发明人： WASHBURN BRIAN , LOVERN DOUGLAS
IPC分类号： C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/707 , C12Q1/6806 , C12Q1/6844 , C12Q1/6846 , C12Q1/6851 , C12Q1/686 , C12Q2527/137 , C12Q2527/125 , C12Q2527/107 , C12Q2527/101 , C12Q2527/113
摘要： The present invention relates to modification of amplification buffer used in amplification reactions. The modifications result in a significant improvement in results of amplification In particular, the present invention provides methods and buffers for performing an amplification reaction utilizing a buffer comprising nucleotide triphosphates comprising treating the buffer to substitute a portion of the nucleotide triphosphates with nucleotide diphosphates.
摘要翻译：本发明涉及用于扩增反应的扩增缓冲液的修饰。所述修饰导致扩增结果的显着改善。具体而言，本发明提供了用于利用包含三磷酸核苷酸的缓冲液进行扩增反应的方法和缓冲液，其包括处理所述缓冲液以用核苷酸二磷酸替代一部分核苷酸三磷酸。

7. 发明申请

WO2011142849A2 GAS FILLED HOLLOW FIBER LASER 审中-公开
标题翻译：气体填充中空纤维激光
公开(公告)号：WO2011142849A2
公开(公告)日：2011-11-17
申请号：PCT/US2011022080
申请日：2011-01-21
申请人： RUDOLPH WOLFGANG G , RATANAVIS AMARIN , NAMPOOTHIRI VASUDEVAN , CORWIN KRISTAN L , JONES ANDREW M , WASHBURN BRIAN R , KADEL RAJESH , ZAVADA JOHN M
发明人： RUDOLPH WOLFGANG G , RATANAVIS AMARIN , NAMPOOTHIRI VASUDEVAN , CORWIN KRISTAN L , JONES ANDREW M , WASHBURN BRIAN R , KADEL RAJESH , ZAVADA JOHN M
IPC分类号： H01S3/067 , H01S3/097 , H01S3/22
CPC分类号： H01S3/223 , H01S3/06741 , H01S3/094003 , H01S3/0943 , H01S3/2232
摘要： Apparatus, systems, and methods using an optically pumped gas filled hollow fiber laser can be implemented in a variety of applications. In various embodiments, operation of an optically pumped gas filled hollow fiber laser is based on population inversion in the gas. Additional apparatus, systems, and methods are disclosed.
摘要翻译：使用光泵浦气体填充中空纤维激光器的装置，系统和方法可以在各种应用中实现。在各种实施例中，光泵浦气体填充中空纤维激光器的操作基于气体中的群体反转。公开了附加装置，系统和方法。

8. 发明申请

WO2011142849A9 GAS FILLED HOLLOW FIBER LASER 审中-公开
公开(公告)号：WO2011142849A9
公开(公告)日：2011-11-17
申请号：PCT/US2011/022080
申请日：2011-01-21
申请人： RUDOLPH, Wolfgang, G. , RATANAVIS, Amarin , NAMPOOTHIRI, Vasudevan , CORWIN, Kristan, L. , JONES, Andrew, M. , WASHBURN, Brian, R. , KADEL, Rajesh , ZAVADA, John, M.
发明人： RUDOLPH, Wolfgang, G. , RATANAVIS, Amarin , NAMPOOTHIRI, Vasudevan , CORWIN, Kristan, L. , JONES, Andrew, M. , WASHBURN, Brian, R. , KADEL, Rajesh , ZAVADA, John, M.
IPC分类号： H01S3/067 , H01S3/097 , H01S3/22
摘要： Apparatus, systems, and methods using an optically pumped gas filled hollow fiber laser can be implemented in a variety of applications. In various embodiments, operation of an optically pumped gas filled hollow fiber laser is based on population inversion in the gas. Additional apparatus, systems, and methods are disclosed.

9. 发明申请

WO2005071117A2 PRIMER AND PROBE DESIGN FOR EFFICIENT AMPLIFICATION AND DETECTION OF HCV 3' NON-TRANSLATING REGION 审中-公开
标题翻译：用于有效放大和检测HCV 3'非转录区域的初步设计和探针设计
公开(公告)号：WO2005071117A2
公开(公告)日：2005-08-04
申请号：PCT/US2005002415
申请日：2005-01-21
申请人： BIO MERIEUX INC , WANG HWA-TANG THOMAS , WASHBURN BRIAN
发明人： WANG HWA-TANG THOMAS , WASHBURN BRIAN
IPC分类号： C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/707 , C12Q1/6806 , C12Q1/6844 , C12Q1/6846 , C12Q1/6851 , C12Q1/686 , C12Q2527/137 , C12Q2527/125 , C12Q2527/107 , C12Q2527/101 , C12Q2527/113
摘要： The present invention provides selected oligonucleotides corresponding to portions of the 3' non-translating region of Hepatitis C virus. The invention also includes methods of detecting and of quantitating HCV nucleic acids in a sample using these oligonucleotides.
摘要翻译：本发明提供了对应于丙型肝炎病毒的3'非翻译区的部分的选定的寡核苷酸。本发明还包括使用这些寡核苷酸检测和定量样品中HCV核酸的方法。

10. 发明申请

WO2005070027A2 APPLICATION FOR LETTERS PATENT 审中-公开
标题翻译：用于改善核酸放大性能的新型核糖体混合物
公开(公告)号：WO2005070027A2
公开(公告)日：2005-08-04
申请号：PCT/US2005/002414
申请日：2005-01-21
申请人： BIOMERIEUX, INC. , WASHBURN, Brian , LOVERN, Douglas
发明人： WASHBURN, Brian , LOVERN, Douglas
IPC分类号： C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/707 , C12Q1/6806 , C12Q1/6844 , C12Q1/6846 , C12Q1/6851 , C12Q1/686 , C12Q2527/137 , C12Q2527/125 , C12Q2527/107 , C12Q2527/101 , C12Q2527/113
摘要： The present invention relates to modification of amplification buffer used in amplification reactions. The modifications result in a significant improvement in results of amplification In particular, the present invention provides methods and buffers for performing an amplification reaction utilizing a buffer comprising nucleotide triphosphates comprising treating the buffer to substitute a portion of the nucleotide triphosphates with nucleotide diphosphates.
摘要翻译：本发明涉及用于扩增反应的扩增缓冲液的修饰。修饰导致扩增结果的显着改善。特别地，本发明提供了利用包含三磷酸核苷酸的缓冲液进行扩增反应的方法和缓冲液，其包括用核苷酸二磷酸处理缓冲液以替代部分核苷酸三磷酸。

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