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1. 发明申请

WO2005116185A3 BINDING ASSAY DEVICE WITH RESERVOIR 审中-公开
公开(公告)号：WO2005116185A3
公开(公告)日：2005-12-08
申请号：PCT/US2005/017240
申请日：2005-05-17
申请人： IMMUNETICS, INC. , LEVIN, Andrew, E. , PHINNEY, Kurt
发明人： LEVIN, Andrew, E. , PHINNEY, Kurt
IPC分类号： G01N33/00 , G01N15/06 , G01N33/566 , B32B5/02 , C12M1/00 , C12M1/36 , C12M3/00 , C12M1/34
摘要： A binding assay device can provide an array of parallel channels with reservoirs for accommodating varying volumes of liquid samples for assay. The device generally can comprise a substantially planar base and a substantially planar top plate with open channels formed in its bottom surface. One embodiment includes a removable cassette, which forms the open channels when placed between the base and top plates. Reservoirs can be formed at the ends of the open channels with closed channels extending from the reservoirs to the top surface of the top plate. Open channels or elongated grooves or sockets can be formed in the top surface of the top plate to accommodate plug-in manifolds that can be in fluid communication with the closed channels. By allowing varying volumes of liquid samples t~ be placed in the reservoirs, the device can provide improved and/or optimized binding assay reactivities and/or band intensities.

2. 发明申请

WO2011044234A3 RAPID PEPTIDOGLYCAN-BASED ASSAY FOR DETECTION OF BACTERIAL CONTAMINATION 审中-公开
标题翻译：快速肽多糖基检测细菌污染的方法
公开(公告)号：WO2011044234A3
公开(公告)日：2011-08-18
申请号：PCT/US2010051627
申请日：2010-10-06
申请人： IMMUNETICS INC , KOVALENKO VICTOR , LEVIN ANDREW E
发明人： KOVALENKO VICTOR , LEVIN ANDREW E
IPC分类号： C12Q1/04 , G01N33/52
CPC分类号： C12Q1/26 , C12Q1/04 , C12Q1/22 , C12Q2304/20 , G01N21/25 , G01N21/255 , G01N33/56911 , G01N2333/195 , G01N2333/43552 , G01N2333/90245 , G01N2400/24 , G01N2800/26
摘要： The invention relates to a colorimetric method for detecting bacterial or fungal pathogens by detecting peptidoglycan or (l-3)-ß-D-glucan in a sample.
摘要翻译：本发明涉及通过检测样品中的肽聚糖或（1-3）-β-D-葡聚糖来检测细菌或真菌病原体的比色法。

3. 发明申请

WO2009135158A2 DETECTION OF MICROBIAL NUCLEIC ACIDS 审中-公开
标题翻译：检测微生物核酸
公开(公告)号：WO2009135158A2
公开(公告)日：2009-11-05
申请号：PCT/US2009/042578
申请日：2009-05-01
申请人： IMMUNETICS, INC. , WASHBURN, Brian, K. , LEVIN, Andrew, E.
发明人： WASHBURN, Brian, K. , LEVIN, Andrew, E.
IPC分类号： C12Q1/04 , C12N1/00
CPC分类号： C12Q1/689 , C07K14/24 , C12Q1/6837 , C12Q2600/166
摘要： The present invention features, inter alia , compositions and methods useful for identifying one or more types of microorganisms, if and when present, in a sample or plurality of samples ( e.g ., in one or more samples tested in parallel). More specifically, the present compositions and methods can be used in, e.g., determining whether a subject has a microbial infection ( e.g ., a bacterial, fungal, protozoal, or viral infection), determining the identity of the microbe(s) causing the infection, and/or determining, or helping to determine, an appropriate anti-microbial treatment regimen for a subject identified as having an infection ( e.g. , an appropriate antibiotic, anti-fungal, anti-viral, or other treatment regimen).
摘要翻译：本发明特别地特征在于用于鉴定一种或多种类型的微生物的组合物和方法，如果和存在于样品或多个样品中（例如在一个或多个并行测试的样品中）。更具体地，本发明的组合物和方法可以用于例如确定受试者是否具有微生物感染（例如细菌，真菌，原生动物或病毒感染），确定导致感染的微生物的身份，和/或确定或帮助确定被鉴定为具有感染（例如适当的抗生素，抗真菌，抗病毒或其它治疗方案）的受试者的适当的抗微生物治疗方案。

4. 发明申请

WO2007127459A3 RAPID PEPTIDOGLYCAN-BASED ASSAY FOR DETECTION OF BACTERIAL CONTAMINATION OF PLATELETS 审中-公开
标题翻译：用于检测细菌的细菌污染的快速基于肽酶的测定
公开(公告)号：WO2007127459A3
公开(公告)日：2008-07-31
申请号：PCT/US2007010397
申请日：2007-04-30
申请人： IMMUNETICS INC , KOVALENKO VICTOR , LEVIN ANDREW E , BEAUSANG LEE ANNE
发明人： KOVALENKO VICTOR , LEVIN ANDREW E , BEAUSANG LEE ANNE
IPC分类号： C12N9/36 , C12Q1/26
CPC分类号： C12Q1/04 , C12Q1/26 , C12Q2304/20 , G01N2400/24
摘要： The invention relates to a colorimetric method for detecting bacterial or fungal pathogens by detecting peptidoglycan or (1-3)-ß-D-glucan in a sample.
摘要翻译：本发明涉及通过检测样品中的肽聚糖或（1-3）-β-D-葡聚糖来检测细菌或真菌病原体的比色法。

5. 发明申请

WO2009135158A3 DETECTION OF MICROBIAL NUCLEIC ACIDS 审中-公开
标题翻译：检测微生物核酸
公开(公告)号：WO2009135158A3
公开(公告)日：2010-02-18
申请号：PCT/US2009042578
申请日：2009-05-01
申请人： IMMUNETICS INC , WASHBURN BRIAN K , LEVIN ANDREW E
发明人： WASHBURN BRIAN K , LEVIN ANDREW E
IPC分类号： C12Q1/04 , C12N1/00
CPC分类号： C12Q1/689 , C07K14/24 , C12Q1/6837 , C12Q2600/166
摘要： The present invention features, inter alia, compositions and methods useful for identifying one or more types of microorganisms, if and when present, in a sample or plurality of samples (e.g., in one or more samples tested in parallel). More specifically, the present compositions and methods can be used in, e.g., determining whether a subject has a microbial infection (e.g., a bacterial, fungal, protozoal, or viral infection), determining the identity of the microbe(s) causing the infection, and/or determining, or helping to determine, an appropriate anti-microbial treatment regimen for a subject identified as having an infection (e.g., an appropriate antibiotic, anti-fungal, anti-viral, or other treatment regimen).
摘要翻译：本发明特别地特征在于用于鉴定一种或多种类型的微生物的组合物和方法，如果和存在于样品或多个样品中（例如在一个或多个并行测试的样品中）。更具体地，本发明的组合物和方法可以用于例如确定受试者是否具有微生物感染（例如细菌，真菌，原生动物或病毒感染），确定导致感染的微生物的身份，和/或确定或帮助确定被鉴定为具有感染（例如适当的抗生素，抗真菌，抗病毒或其它治疗方案）的受试者的适当的抗微生物治疗方案。

6. 发明申请

WO2007127459A2 RAPID PEPTIDOGLYCAN-BASED ASSAY FOR DETECTION OF BACTERIAL CONTAMINATION OF PLATELETS 审中-公开
标题翻译：用于检测细胞的细菌污染的基于肽酶的快速测定
公开(公告)号：WO2007127459A2
公开(公告)日：2007-11-08
申请号：PCT/US2007/010397
申请日：2007-04-30
申请人： IMMUNETICS, INC. , KOVALENKO, Victor , LEVIN, Andrew, E. , BEAUSANG, Lee, Anne
发明人： KOVALENKO, Victor , LEVIN, Andrew, E. , BEAUSANG, Lee, Anne
IPC分类号： C12Q1/26 , C12N9/00
CPC分类号： C12Q1/04 , C12Q1/26 , C12Q2304/20 , G01N2400/24
摘要： The invention relates to a colorimetric method for detecting bacterial or fungal pathogens by detecting peptidoglycan or (1-3)-β-D-glucan in a sample.
摘要翻译：本发明涉及通过检测样品中的肽聚糖或（1-3）-β-D-葡聚糖来检测细菌或真菌病原体的比色法。

7. 发明申请

WO2005045065A1 RAPID PEPTIDOGLYCAN-BASED ASSAY FOR DETECTION OF BACTERIAL CONTAMINATION OF PLATELETS 审中-公开
标题翻译：用于检测细菌的细菌污染的快速基于肽酶的测定
公开(公告)号：WO2005045065A1
公开(公告)日：2005-05-19
申请号：PCT/US2004/035160
申请日：2004-10-22
申请人： IMMUNETICS, INC. , KOVALENKO, Victor , LEVIN, Andrew, E. , BEAUSANG, Lee, Anne
发明人： KOVALENKO, Victor , LEVIN, Andrew, E. , BEAUSANG, Lee, Anne
IPC分类号： C12Q1/04
CPC分类号： C12Q1/04
摘要： The invention relates to a colorimetric method for detecting bacterial or fungal pathogens by detecting peptidoglycan or (1-3)-β-D-glucan in a sample.
摘要翻译：本发明涉及通过检测样品中的肽聚糖或（1-3）-β-D-葡聚糖来检测细菌或真菌病原体的比色法。

8. 发明申请

WO2011044234A2 RAPID PEPTIDOGLYCAN-BASED ASSAY FOR DETECTION OF BACTERIAL CONTAMINATION 审中-公开
标题翻译：用于检测细菌污染的快速基于肽酶的测定
公开(公告)号：WO2011044234A2
公开(公告)日：2011-04-14
申请号：PCT/US2010/051627
申请日：2010-10-06
申请人： IMMUNETICS, INC. , KOVALENKO, Victor , LEVIN, Andrew, E.
发明人： KOVALENKO, Victor , LEVIN, Andrew, E.
IPC分类号： C12Q1/04 , G01N33/52
CPC分类号： C12Q1/26 , C12Q1/04 , C12Q1/22 , C12Q2304/20 , G01N21/25 , G01N21/255 , G01N33/56911 , G01N2333/195 , G01N2333/43552 , G01N2333/90245 , G01N2400/24 , G01N2800/26
摘要： The invention relates to a colorimetric method for detecting bacterial or fungal pathogens by detecting peptidoglycan or (l-3)-β-D-glucan in a sample.
摘要翻译：本发明涉及通过检测样品中的肽聚糖或（1-3）-β-D-葡聚糖来检测细菌或真菌病原体的比色法。

9. 发明申请

WO2005116185A2 BINDING ASSAY DEVICE WITH RESERVOIR 审中-公开
标题翻译：带储存器的绑定测试装置
公开(公告)号：WO2005116185A2
公开(公告)日：2005-12-08
申请号：PCT/US2005017240
申请日：2005-05-17
申请人： IMMUNETICS INC , LEVIN ANDREW E , PHINNEY KURT
发明人： LEVIN ANDREW E , PHINNEY KURT
IPC分类号： B01L3/00 , C12M1/34
CPC分类号： B01L3/5025 , B01L2200/0689 , B01L2400/0487
摘要： A binding assay device can provide an array of parallel channels with reservoirs for accommodating varying volumes of liquid samples for assay. The device generally can comprise a substantially planar base and a substantially planar top plate with open channels formed in its bottom surface. One embodiment includes a removable cassette, which forms the open channels when placed between the base and top plates. Reservoirs can be formed at the ends of the open channels with closed channels extending from the reservoirs to the top surface of the top plate. Open channels or elongated grooves or sockets can be formed in the top surface of the top plate to accommodate plug-in manifolds that can be in fluid communication with the closed channels. By allowing varying volumes of liquid samples t~ be placed in the reservoirs, the device can provide improved and/or optimized binding assay reactivities and/or band intensities.
摘要翻译：结合测定装置可以提供具有储存器的平行通道阵列，用于容纳用于测定的不同体积的液体样品。该装置通常可以包括基本上平坦的基部和在其底表面中形成有开放通道的基本平坦的顶板。一个实施例包括可拆卸的盒，当放置在基板和顶板之间时，其形成开放的通道。储存器可以在开放通道的端部处形成，封闭的通道从储存器延伸到顶板的顶表面。可以在顶板的顶表面中形成开放通道或细长槽或插座，以容纳可与封闭通道流体连通的插入式歧管。通过允许将不同体积的液体样品置于储存器中，该装置可以提供改进的和/或优化的结合测定反应性和/或带强度。

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