会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 9. 发明申请
    • Preparation of Aqueous Clear Solution Dosage Forms with Bile Acids
    • 用胆汁酸制备水性澄清溶液剂型
    • US20080057133A1
    • 2008-03-06
    • US11934505
    • 2007-11-02
    • Seo Yoo
    • Seo Yoo
    • A61K35/413A61P1/04
    • A61K9/0095A61K31/575A61K47/28A61K47/36
    • Compositions for pharmaceutical and other uses comprising clear aqueous solutions of bile acids which do not form any detectable precipitates over selected ranges of pH values of the aqueous solution and methods of making such solutions. The compositions of the invention comprise water; a bile acid in the form of a bile acid, bile acid salt, or a bile acid conjugated with an amine by an amide linkage; and either or both an aqueous soluble starch conversion product and an aqueous soluble non-starch polysaccharide. The composition remains in solution without forming a precipitate over a range of pH values and, according to one embodiment, remains in solution for all pH values obtainable in an aqueous system. The composition, according to some embodiments, may further contain a pharmaceutical compound in a pharmaceutically effective amount. Non-limiting examples of pharmaceutical compounds include insulin, heparin, bismuth compounds, amantadine and rimantadine
    • 用于药物和其它用途的组合物,其包含在水溶液的pH值的选定范围内不形成任何可检测的沉淀物的澄清的胆汁酸水溶液和制备这些溶液的方法。 本发明的组合物包含水; 胆汁酸形式的胆汁酸,胆汁酸盐或通过酰胺键与胺缀合的胆汁酸; 以及水溶性淀粉转化产物和水溶性非淀粉多糖中的任一种或两者。 组合物保留在溶液中,而不在一定pH值范围内形成沉淀物,并且根据一个实施方案,在水系统中可获得的所有pH值保留在溶液中。 根据一些实施方案,组合物还可以含有药学有效量的药物化合物。 药物化合物的非限制性实例包括胰岛素,肝素,铋化合物,金刚烷胺和金刚乙胺