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1. 发明申请

US20090117145A1 Composition and Method For Enhancing Immune Response 有权
标题翻译：用于增强免疫反应的组合物和方法
公开(公告)号：US20090117145A1
公开(公告)日：2009-05-07
申请号：US12211544
申请日：2008-09-16
申请人： Tsafrir S. Mor , Nobuyuki Matoba , Charles J. Arntzen
发明人： Tsafrir S. Mor , Nobuyuki Matoba , Charles J. Arntzen
IPC分类号： A61K39/00 , A61K38/16
CPC分类号： C07K14/005 , A61K39/39 , A61K2039/541 , A61K2039/55516 , A61K2039/6037 , A61K2039/6075 , C12N2740/16122
摘要： A composition and method for enhancing immune response in a living organism is disclosed. In particular, the present disclosure provides an adjuvant peptide for use in raising an immune response to an antigen. The adjuvant peptide is selected from a group of peptides with an HIV-related sequence. Additionally, the adjuvant peptide can comprise a fusion-protein that acts as a mucosal adjuvant. The adjuvant peptide can be transformed into one or more living cells, such that the mucosal adjuvant can be produced in living cells and then administered by systemic, mucosal or epidermal delivery.
摘要翻译：公开了一种增强活体内免疫应答的组合物和方法。特别地，本公开提供了用于提高对抗原的免疫应答的佐剂肽。佐剂肽选自具有HIV相关序列的肽组。另外，佐剂肽可以包含充当粘膜佐剂的融合蛋白。辅助肽可以转化成一个或多个活细胞，使得粘膜佐剂可以在活细胞中产生，然后通过全身，粘膜或表皮递送进行施用。

2. 发明申请

US20090274679A1 PRODUCTION AND USE OF HUMAN BUTYRYLCHOLINESTERASE 有权
标题翻译：人类丁基胆碱酯酶的生产和使用
公开(公告)号：US20090274679A1
公开(公告)日：2009-11-05
申请号：US11792985
申请日：2005-12-01
申请人： Tsafrir S. Mor , Brian C. Geyer
发明人： Tsafrir S. Mor , Brian C. Geyer
IPC分类号： A61K38/46 , A01H5/00 , C12N15/82 , C12N5/10
CPC分类号： C12N15/8257
摘要： The present invention concerns the production of human butyrylcholinesterase (BuChE) in transgenic plants and use of the derived BuChE as effective countermeasures against toxic agents such as pesticides, toxins, certain drugs and non-conventional warfare agents, as well as treatments for diseases and conditions associated with depressed cholinesterase levels.
摘要翻译：本发明涉及转基因植物中人丁酰胆碱酯酶（BuChE）的生产，并且使用衍生的BuChE作为对杀虫剂，毒素，某些药物和非常规作战剂等有毒物质的有效对策，以及用于疾病和病症的治疗与抑制胆碱酯酶水平相关。

3. 发明授权

US06770799B2 Expression of recombinant human acetylcholinesterase in transgenic plants 有权
公开(公告)号：US06770799B2
公开(公告)日：2004-08-03
申请号：US09810861
申请日：2001-03-16
申请人： Tsafrir S. Mor , Hermona Soreq , Charles J. Arntzen , Hugh S. Mason
发明人： Tsafrir S. Mor , Hermona Soreq , Charles J. Arntzen , Hugh S. Mason
IPC分类号： A01H100
CPC分类号： C12N15/8242 , C12N9/18 , C12N15/8257
摘要： Briefly stated, the invention includes a method of making a transgenic plant that is capable of expressing a physiologically active human acetylcholinesterase, comprising the steps of introducing into at least one plant cell a polynucleotide that encodes a human acetylcholinesterase, and regenerating from the plant cell a transgenic plant that is capable of expressing a physiologically active human acetylcholinesterase in at least one tissue type of the transgenic plant. Another embodiment of the invention includes a method of making a physiologically active human acetylcholinesterase, comprising the steps of introducing into at least one plant cell a polynucleotide that encodes a human acetylcholinesterase, regenerating from the plant cell a transgenic plant that is capable of expressing a physiologically active human acetylcholinesterase in at least one tissue type of the transgenic plant, and isolating or purifying from the transgenic plant or a part thereof a physiologically active human acetylcholinesterase.

4. 发明授权

US07438914B2 Composition and method for enhancing immune response 失效
标题翻译：用于增强免疫应答的组合物和方法
公开(公告)号：US07438914B2
公开(公告)日：2008-10-21
申请号：US10506796
申请日：2003-03-06
申请人： Tsafrir S. Mor , Nobuyuki Matoba , Charles J. Arntzen
发明人： Tsafrir S. Mor , Nobuyuki Matoba , Charles J. Arntzen
IPC分类号： A61K38/16 , A61K38/31 , A61K39/02 , A61K39/20 , A61K35/00 , A61K39/16 , C12N15/00
CPC分类号： C07K14/005 , A61K39/39 , A61K2039/541 , A61K2039/55516 , A61K2039/6037 , A61K2039/6075 , C12N2740/16122
摘要： A composition and method for enhancing immune response in a living organism is disclosed. In particular, the present disclosure provides an adjuvant peptide for use in raising an immune response to an antigen. The adjuvant peptide is selected from a group of peptides with an HIV-related sequence. Additionally, the adjuvant peptide can comprise a fusion-protein that acts as a mucosal adjuvant. The adjuvant peptide can be transformed into one or more living cells, such that the mucosal adjuvant can be produced in living cells and then administered by systemic, mucosal or epidermal delivery.
摘要翻译：公开了一种增强活体内免疫应答的组合物和方法。特别地，本公开提供了用于提高对抗原的免疫应答的佐剂肽。佐剂肽选自具有HIV相关序列的肽组。另外，佐剂肽可以包含充当粘膜佐剂的融合蛋白。辅助肽可以转化成一个或多个活细胞，使得粘膜佐剂可以在活细胞中产生，然后通过全身，粘膜或表皮递送进行施用。

5. 发明授权

US06392121B1 Gemini virus vectors for gene expression in plants 有权
标题翻译：双子座病毒载体，用于植物中的基因表达
公开(公告)号：US06392121B1
公开(公告)日：2002-05-21
申请号：US09414276
申请日：1999-10-07
申请人： Hugh S. Mason , Kenneth E. Palmer , Kathleen L. Hefferon , Tsafrir S. Mor , Charles Arntzen
发明人： Hugh S. Mason , Kenneth E. Palmer , Kathleen L. Hefferon , Tsafrir S. Mor , Charles Arntzen
IPC分类号： C12N504
CPC分类号： C12N15/8216 , C12N15/8203 , Y10S977/804
摘要： A gene amplification system based on plant viral genetic elements dramatically increases foreign protein production in plants. A safer and more economical production system for vaccines and antibodies in recombinant plants grown using agricultural practice is described. The high-level expression system uses the replicative process of a plant mastrevirus, exemplified by bean yellow dwarf virus (BeYDV). The expression system is preferably inducible to avoid interference with plant growth and development. Developmental cues, such as fruit ripening, are employed to trigger expression of the foreign protein using a tissue-specific promoter. A single, stably integrated expression cassette for foreign protein is replicated extrachromosomally in ripening fruit, forming hundreds of transcriptionally competent copies. Preferred plant hosts include tomato as a model system and soybean for production of large quantities of protein at high total protein levels.
摘要翻译：基于植物病毒遗传元件的基因扩增系统大大增加了植物中的外来蛋白质产量。描述了使用农业实践生长的重组植物中更安全和更经济的疫苗和抗体生产系统。高水平的表达系统使用植物重症病毒的复制过程，以豆黄矮病毒（BeYDV）为例。表达系统优选可诱导以避免干扰植物生长和发育。使用诸如果实成熟的发育提示来使用组织特异性启动子来引发外源蛋白的表达。用于外来蛋白质的单一稳定整合的表达盒在成熟果实中被染色体外复制，形成数百个可转录的拷贝。优选的植物宿主包括番茄作为模型系统，大豆用于生产高蛋白总量的大量蛋白质。

6. 发明授权

US07927833B2 Composition and method for enhancing immune response 有权
标题翻译：用于增强免疫应答的组合物和方法
公开(公告)号：US07927833B2
公开(公告)日：2011-04-19
申请号：US12211544
申请日：2008-09-16
申请人： Tsafrir S. Mor , Nobuyuki Matoba , Charles J. Arntzen
发明人： Tsafrir S. Mor , Nobuyuki Matoba , Charles J. Arntzen
IPC分类号： C12N15/00 , A61K39/395
CPC分类号： C07K14/005 , A61K39/39 , A61K2039/541 , A61K2039/55516 , A61K2039/6037 , A61K2039/6075 , C12N2740/16122
摘要： A composition and method for enhancing immune response in a living organism is disclosed. In particular, the present disclosure provides an adjuvant peptide for use in raising an immune response to an antigen. The adjuvant peptide is selected from a group of peptides with an HIV-related sequence. Additionally, the adjuvant peptide can comprise a fusion-protein that acts as a mucosal adjuvant. The adjuvant peptide can be transformed into one or more living cells, such that the mucosal adjuvant can be produced in living cells and then administered by systemic, mucosal or epidermal delivery.
摘要翻译：公开了一种增强活体内免疫应答的组合物和方法。特别地，本公开提供了用于提高对抗原的免疫应答的佐剂肽。佐剂肽选自具有HIV相关序列的肽组。另外，佐剂肽可以包含充当粘膜佐剂的融合蛋白。辅助肽可以转化成一个或多个活细胞，使得粘膜佐剂可以在活细胞中产生，然后通过全身，粘膜或表皮递送进行施用。

7. 发明授权

US09062321B2 Codon-optimized polynucleotides encoding human butyrylcholinesterase and plant expression systems therof 有权
标题翻译：编码人丁酰胆碱酯酶和植物表达系统的密码子优化多核苷酸
公开(公告)号：US09062321B2
公开(公告)日：2015-06-23
申请号：US11792985
申请日：2005-12-01
申请人： Tsafrir S. Mor , Brian C. Geyer
发明人： Tsafrir S. Mor , Brian C. Geyer
IPC分类号： C12N15/82 , A01H5/00
CPC分类号： C12N15/8257
摘要： The present invention concerns the production of human butyrylcholinesterase (BuChE) in plants expressing a codon-optimized polynucleotides for the production thereof and use of the derived BuChE as effective counter measures against toxic agents such as pesticides, toxins, certain drugs and non-conventional warfare agents, as well as treatments for diseases and conditions associated with depressed cholinesterase levels.
摘要翻译：本发明涉及在表达用于生产密码子优化的多核苷酸的植物中生产人丁酰胆碱酯酶（BuChE），并且使用衍生的BuChE作为有效的对抗毒性剂如农药，毒素，某些药物和非常规战争的对策药物，以及与抑制胆碱酯酶水平相关的疾病和病症的治疗。

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