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1. 发明申请

US20130209464A1 POLYPEPTIDES HAVING ANTIVIRAL ACTIVITY AND METHODS FOR USE THEREOF 有权
标题翻译：具有抗病毒活性的多肽及其使用方法
公开(公告)号：US20130209464A1
公开(公告)日：2013-08-15
申请号：US13808444
申请日：2011-07-07
申请人： Nobuyuki Matoba , Adam Husk , Sudha Sankaran
发明人： Nobuyuki Matoba , Adam Husk , Sudha Sankaran
IPC分类号： A61K38/16 , C07K16/00 , A61K39/395 , C07K14/42
CPC分类号： A61K38/168 , A61K38/00 , A61K39/395 , C07K14/36 , C07K14/37 , C07K14/42 , C07K16/00 , C07K2319/01 , C07K2319/30
摘要： A polypeptide is provided that comprises an actinohivin variant polypeptide having an amino acid sequence selected from SEQ ID NOS: 4-12. The polypeptide can be provided as part of a fusion protein that includes the actinohivin variant polypeptide and either a fragment crystallizable domain of an antibody (Fc), a fragment antigen-binding domain of an antibody (Fab), or a single chain variable fragment of an antibody (scFv). Isolated nucleic acid molecules encoding the polypeptides are also provided along with vectors and plant cells capable of expressing the polypeptides. Methods of treating an infection of a subject by an enveloped virus are further provided and include administering an effective amount of the polypeptides to a subject.
摘要翻译：提供了包含具有选自SEQ ID NO：4-12的氨基酸序列的肌动蛋白变体多肽的多肽。可以将多肽作为融合蛋白的一部分提供，其包括肌动蛋白变体多肽和抗体（Fc）的片段可结晶结构域，抗体（Fab）的片段抗原结合结构域或单链可变片段抗体（scFv）。编码多肽的分离的核酸分子也与能够表达多肽的载体和植物细胞一起提供。还提供了通过包膜病毒治疗受试者感染的方法，包括向受试者施用有效量的多肽。

2. 发明授权

US07927833B2 Composition and method for enhancing immune response 有权
标题翻译：用于增强免疫应答的组合物和方法
公开(公告)号：US07927833B2
公开(公告)日：2011-04-19
申请号：US12211544
申请日：2008-09-16
申请人： Tsafrir S. Mor , Nobuyuki Matoba , Charles J. Arntzen
发明人： Tsafrir S. Mor , Nobuyuki Matoba , Charles J. Arntzen
IPC分类号： C12N15/00 , A61K39/395
CPC分类号： C07K14/005 , A61K39/39 , A61K2039/541 , A61K2039/55516 , A61K2039/6037 , A61K2039/6075 , C12N2740/16122
摘要： A composition and method for enhancing immune response in a living organism is disclosed. In particular, the present disclosure provides an adjuvant peptide for use in raising an immune response to an antigen. The adjuvant peptide is selected from a group of peptides with an HIV-related sequence. Additionally, the adjuvant peptide can comprise a fusion-protein that acts as a mucosal adjuvant. The adjuvant peptide can be transformed into one or more living cells, such that the mucosal adjuvant can be produced in living cells and then administered by systemic, mucosal or epidermal delivery.
摘要翻译：公开了一种增强活体内免疫应答的组合物和方法。特别地，本公开提供了用于提高对抗原的免疫应答的佐剂肽。佐剂肽选自具有HIV相关序列的肽组。另外，佐剂肽可以包含充当粘膜佐剂的融合蛋白。辅助肽可以转化成一个或多个活细胞，使得粘膜佐剂可以在活细胞中产生，然后通过全身，粘膜或表皮递送进行施用。

3. 发明授权

US08802822B2 Polypeptides having antiviral activity and methods for use thereof 有权
标题翻译：具有抗病毒活性的多肽及其使用方法
公开(公告)号：US08802822B2
公开(公告)日：2014-08-12
申请号：US13808444
申请日：2011-07-07
申请人： Nobuyuki Matoba , Adam Husk , Sudha Sankaran
发明人： Nobuyuki Matoba , Adam Husk , Sudha Sankaran
IPC分类号： A61K38/00 , A61K38/16 , A61K35/74 , A61K39/395 , C12N5/04 , C12N15/00 , A61P31/12 , A61P31/18 , C07K14/195 , C07K19/00 , C07K14/36
CPC分类号： A61K38/168 , A61K38/00 , A61K39/395 , C07K14/36 , C07K14/37 , C07K14/42 , C07K16/00 , C07K2319/01 , C07K2319/30
摘要： A polypeptide is provided that comprises an actinohivin variant polypeptide having an amino acid sequence selected from SEQ ID NOS: 4-12. The polypeptide can be provided as part of a fusion protein that includes the actinohivin variant polypeptide and either a fragment crystallizable domain of an antibody (Fc), a fragment antigen-binding domain of an antibody (Fab), or a single chain variable fragment of an antibody (scFv). Isolated nucleic acid molecules encoding the polypeptides are also provided along with vectors and plant cells capable of expressing the polypeptides. Methods of treating an infection of a subject by an enveloped virus are further provided and include administering an effective amount of the polypeptides to a subject.
摘要翻译：提供了包含具有选自SEQ ID NO：4-12的氨基酸序列的肌动蛋白变体多肽的多肽。可以将多肽作为融合蛋白的一部分提供，其包括肌动蛋白变体多肽和抗体（Fc）的片段可结晶结构域，抗体（Fab）的片段抗原结合结构域或单链可变片段抗体（scFv）。编码多肽的分离的核酸分子也与能够表达多肽的载体和植物细胞一起提供。还提供了通过包膜病毒治疗受试者感染的方法，包括向受试者施用有效量的多肽。

4. 发明授权

US10160789B2 Polypeptides having immunoactivating activity and methods of producing the same 有权
公开(公告)号：US10160789B2
公开(公告)日：2018-12-25
申请号：US14005388
申请日：2012-03-14
申请人： Nobuyuki Matoba , Krystal Hamorsky
发明人： Nobuyuki Matoba , Krystal Hamorsky
IPC分类号： C07K14/28 , A61K39/106 , C12N15/82 , A61K39/02 , A61K38/00 , A61K39/00
摘要： Isolated polypeptides are provided that comprise a cholera toxin B subunit variant having one or more modifications to increase the expression of the polypeptide in a plant cell. Nucleic acids sequences, vectors, and plant cells for expressing the cholera toxin B subunit variant polypeptides are also provided. Further provided are methods for producing the cholera toxin B subunit variant polypeptides that include the steps of transforming a plant cell with a nucleic acid encoding the cholera toxin B subunit variant polypeptides; expressing the variant polypeptides; and purifying the polypeptides. Still further provided are methods of isolating the variant polypeptides that include the steps of obtaining a plant cell expressing the cholera toxin B subunit variant polypeptides; extracting the cholera toxin B subunit variant polypeptides from the plant cell; and purifying the cholera toxin B subunit variant polypeptides. Methods of eliciting an immune response are also provided.

5. 发明授权

US07438914B2 Composition and method for enhancing immune response 失效
标题翻译：用于增强免疫应答的组合物和方法
公开(公告)号：US07438914B2
公开(公告)日：2008-10-21
申请号：US10506796
申请日：2003-03-06
申请人： Tsafrir S. Mor , Nobuyuki Matoba , Charles J. Arntzen
发明人： Tsafrir S. Mor , Nobuyuki Matoba , Charles J. Arntzen
IPC分类号： A61K38/16 , A61K38/31 , A61K39/02 , A61K39/20 , A61K35/00 , A61K39/16 , C12N15/00
CPC分类号： C07K14/005 , A61K39/39 , A61K2039/541 , A61K2039/55516 , A61K2039/6037 , A61K2039/6075 , C12N2740/16122
摘要： A composition and method for enhancing immune response in a living organism is disclosed. In particular, the present disclosure provides an adjuvant peptide for use in raising an immune response to an antigen. The adjuvant peptide is selected from a group of peptides with an HIV-related sequence. Additionally, the adjuvant peptide can comprise a fusion-protein that acts as a mucosal adjuvant. The adjuvant peptide can be transformed into one or more living cells, such that the mucosal adjuvant can be produced in living cells and then administered by systemic, mucosal or epidermal delivery.
摘要翻译：公开了一种增强活体内免疫应答的组合物和方法。特别地，本公开提供了用于提高对抗原的免疫应答的佐剂肽。佐剂肽选自具有HIV相关序列的肽组。另外，佐剂肽可以包含充当粘膜佐剂的融合蛋白。辅助肽可以转化成一个或多个活细胞，使得粘膜佐剂可以在活细胞中产生，然后通过全身，粘膜或表皮递送进行施用。

6. 发明申请

US20140286986A1 POLYPEPTIDES HAVING IMMUNOACTIVATING ACTIVITY AND METHODS OF PRODUCING THE SAME 审中-公开
标题翻译：具有免疫活性的多肽及其生产方法
公开(公告)号：US20140286986A1
公开(公告)日：2014-09-25
申请号：US14005388
申请日：2012-03-14
申请人： Nobuyuki Matoba , Krystal Hamorsky
发明人： Nobuyuki Matoba , Krystal Hamorsky
IPC分类号： C07K14/28
CPC分类号： C07K14/28 , A61K38/00 , A61K39/107 , A61K2039/542 , C07K2319/02 , C07K2319/04 , C12N15/8258
摘要： Isolated polypeptides are provided that comprise a cholera toxin B subunit variant having one or more modifications to increase the expression of the polypeptide in a plant cell. Nucleic acids sequences, vectors, and plant cells for expressing the cholera toxin B subunit variant polypeptides are also provided. Further provided are methods for producing the cholera toxin B subunit variant polypeptides that include the steps of transforming a plant cell with a nucleic acid encoding the cholera toxin B subunit variant polypeptides; expressing the variant polypeptides; and purifying the polypeptides. Still further provided are methods of isolating the variant polypeptides that include the steps of obtaining a plant cell expressing the cholera toxin B subunit variant polypeptides; extracting the cholera toxin B subunit variant polypeptides from the plant cell; and purifying the cholera toxin B subunit variant polypeptides. Methods of eliciting an immune response are also provided.
摘要翻译：提供了分离的多肽，其包含具有一种或多种修饰以增加多肽在植物细胞中的表达的霍乱毒素B亚基变体。还提供了用于表达霍乱毒素B亚基变体多肽的核酸序列，载体和植物细胞。还提供了用于产生霍乱毒素B亚基变体多肽的方法，其包括用编码霍乱毒素B亚基变体多肽的核酸转化植物细胞的步骤; 表达变体多肽; 并纯化多肽。还提供了分离变体多肽的方法，其包括获得表达霍乱毒素B亚基变体多肽的植物细胞的步骤; 从植物细胞中提取霍乱毒素B亚基变体多肽; 并纯化霍乱毒素B亚基变体多肽。还提供了引发免疫应答的方法。

7. 发明申请

US20090117145A1 Composition and Method For Enhancing Immune Response 有权
标题翻译：用于增强免疫反应的组合物和方法
公开(公告)号：US20090117145A1
公开(公告)日：2009-05-07
申请号：US12211544
申请日：2008-09-16
申请人： Tsafrir S. Mor , Nobuyuki Matoba , Charles J. Arntzen
发明人： Tsafrir S. Mor , Nobuyuki Matoba , Charles J. Arntzen
IPC分类号： A61K39/00 , A61K38/16
CPC分类号： C07K14/005 , A61K39/39 , A61K2039/541 , A61K2039/55516 , A61K2039/6037 , A61K2039/6075 , C12N2740/16122
摘要： A composition and method for enhancing immune response in a living organism is disclosed. In particular, the present disclosure provides an adjuvant peptide for use in raising an immune response to an antigen. The adjuvant peptide is selected from a group of peptides with an HIV-related sequence. Additionally, the adjuvant peptide can comprise a fusion-protein that acts as a mucosal adjuvant. The adjuvant peptide can be transformed into one or more living cells, such that the mucosal adjuvant can be produced in living cells and then administered by systemic, mucosal or epidermal delivery.
摘要翻译：公开了一种增强活体内免疫应答的组合物和方法。特别地，本公开提供了用于提高对抗原的免疫应答的佐剂肽。佐剂肽选自具有HIV相关序列的肽组。另外，佐剂肽可以包含充当粘膜佐剂的融合蛋白。辅助肽可以转化成一个或多个活细胞，使得粘膜佐剂可以在活细胞中产生，然后通过全身，粘膜或表皮递送进行施用。

8. 发明申请

US20060013831A1 Composition and method for enhancing immune response 失效
标题翻译：用于增强免疫应答的组合物和方法
公开(公告)号：US20060013831A1
公开(公告)日：2006-01-19
申请号：US10506796
申请日：2003-03-06
申请人： Tsafrir Mor , Nobuyuki Matoba , Charles Arntzen
发明人： Tsafrir Mor , Nobuyuki Matoba , Charles Arntzen
IPC分类号： C12Q1/68 , G01N33/53 , A61K39/12
CPC分类号： C07K14/005 , A61K39/39 , A61K2039/541 , A61K2039/55516 , A61K2039/6037 , A61K2039/6075 , C12N2740/16122
摘要： A composition and method for enhancing immune response in a living organism is disclosed. In particular, the present disclosure provides an adjuvant peptide for use in raising an immune response to an antigen. The adjuvant peptide is selected from a group of peptides with an HIV-related sequence. Additionally, the adjuvant peptide can comprise a fusion-protein that acts as a mucosal adjuvant. The adjuvant peptide can be transformed into one or more living cells, such that the mucosal adjuvant can be produced in living cells and then administered by systemic, mucosal or epidermal delivery.
摘要翻译：公开了一种增强活体内免疫应答的组合物和方法。特别地，本公开提供了用于提高对抗原的免疫应答的佐剂肽。佐剂肽选自具有HIV相关序列的肽组。另外，佐剂肽可以包含充当粘膜佐剂的融合蛋白。辅助肽可以转化成一个或多个活细胞，使得粘膜佐剂可以在活细胞中产生，然后通过全身，粘膜或表皮递送进行施用。

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